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      • Stress Model of Axial Flow Threshing & Separating Device and Trajectory Simulation of Rice Grains

        Liu Ying-Nan,Yi Shu-Juan 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.11

        To reveal stress distribution rules of grain separating process in assembled axial flow threshing and separating device, regarding assembled axial flow threshing and separating device as object, High speed imaging technology is adopted in the shooting technique, stress model was set based on the stress principle, and stress distribution rules was obtained by simulation technology. Grain, broken ear movement and the movement as a whole and free movement of the grain threshing process is through the analysis of the EXCEL drawing, The test results show that distribution rules is irregular in grain separating process, is that, stress fluctuates at axial direction, and two peak values appear at early and middle threshing stage respectively; threshing and separating process finishes about 2.35 meters from the feeding mouth at axial direction. Off the spike in threshing and separating space motion unstable trajectory is a parabola, the speed decreased with the passage of time. No outside interference in the most free grain for approximate straight movement, in the medium of motion state, and axis direction and a certain angle.Therefore, grain rotors distribute at axial direction and rest results are consistent with theory analysis.

      • Large-Scale Production of Graphene Nanoribbons from Electrospun Polymers

        Liu, Nan,Kim, Kwanpyo,Hsu, Po-Chun,Sokolov, Anatoliy N.,Yap, Fung Ling,Yuan, Hongtao,Xie, Yanwu,Yan, Hao,Cui, Yi,Hwang, Harold Y.,Bao, Zhenan American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.49

        <P>Graphene nanoribbons (GNRs) are promising building blocks for high-performance electronics due to their high electron mobility and dimensionality-induced bandgap. Despite many past efforts, direct synthesis of GNRs with controlled dimensions and scalability remains challenging. Here we report the scalable synthesis of GNRs using electrospun polymer nanofiber templates. Palladium-incorporated poly(4-vinylphenol) nanofibers were prepared by electrospinning with controlled diameter and orientation. Highly graphitized GNRs as narrow as 10 nm were then synthesized from these templates by chemical vapor deposition. A transport gap can be observed in 30 nm-wide GNRs, enabling them to function as field-effect transistors at room temperature. Our results represent the first success on the scalable synthesis of highly graphitized GNRs from polymer templates. Furthermore, the generality of this method allows various polymers to be explored, which will lead to understanding of growth mechanism and rational control over crystallinity, feature size and bandgap to enable a new pathway for graphene electronics.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-49/ja509871n/production/images/medium/ja-2014-09871n_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja509871n'>ACS Electronic Supporting Info</A></P>

      • SCOPUSKCI등재

        Attenuation of airway inflammation by simvastatin and the implications for asthma treatment: is the jury still out?

        Liu, Jing-Nan,Suh, Dong-Hyeon,Yang, Eun-Mi,Lee, Seung-Ihm,Park, Hae-Sim,Shin, Yoo Seob Nature Publishing Group 2014 Experimental and molecular medicine Vol.46 No.9

        <P>Although some studies have explained the immunomodulatory effects of statins, the exact mechanisms and the therapeutic significance of these molecules remain to be elucidated. This study not only evaluated the therapeutic potential and inhibitory mechanism of simvastatin in an ovalbumin (OVA)-specific asthma model in mice but also sought to clarify the future directions indicated by previous studies through a thorough review of the literature. BALB/c mice were sensitized to OVA and then administered three OVA challenges. On each challenge day, 40 mg kg<SUP>−1</SUP> simvastatin was injected before the challenge. The airway responsiveness, inflammatory cell composition, and cytokine levels in bronchoalveolar lavage (BAL) fluid were assessed after the final challenge, and the T cell composition and adhesion molecule expression in lung homogenates were determined. The administration of simvastatin decreased the airway responsiveness, the number of airway inflammatory cells, and the interleukin (IL)-4, IL-5 and IL-13 concentrations in BAL fluid compared with vehicle-treated mice (<I>P</I><0.05). Histologically, the number of inflammatory cells and mucus-containing goblet cells in lung tissues also decreased in the simvastatin-treated mice. Flow cytometry showed that simvastatin treatment significantly reduced the percentage of pulmonary CD4<SUP>+</SUP> cells and the CD4<SUP>+</SUP>/CD8<SUP>+</SUP> T-cell ratio (<I>P</I><0.05). Simvastatin treatment also decreased the expression of the vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 proteins, as measured in homogenized lung tissues (<I>P</I><0.05) and human epithelial cells. The reduction in the T cell influx as a result of the decreased expression of cell adhesion molecules is one of the mechanisms by which simvastatin attenuates airway responsiveness and allergic inflammation. Rigorous review of the literature together with our findings suggested that simvastatin should be further developed as a potential therapeutic strategy for allergic asthma.</P>

      • Detection and Analysis of Residual Pesticides Based On Surface Raman Spectra of Spinach

        Liu Ying-Nan,Yi Shu-Juan 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.12

        This paper with spinach as the research object, to chlorpyrifos pesticide as detection object, using Raman spectroscopy technique surface pesticides in spinach residual detection method and rapid detection research. Starting from the detection method, study of the classic method and method for rapid detection of current situation of the development, Raman spectroscopy detection method as a means of detection, the selected object of study; master the Raman spectroscopy for rapid detection of the basic principles and originpro 9.0 software acquisition function using, lay the foundation for the subsequent detection of. After the actual test to determine Raman spectroscopy instrument laser wavelength to 473nm, acquisition time 2s spinach sample testing effect Best result. After no medicine Raman spectra to obtain the surface of spinach were denoising analysis results show that wavelet de noise method compared to the adjacent averaging, savitzky Golay method smoothing, median method effect better. On Spinach with different concentrations of chlorpyrifos Raman spectroscopy analysis that accorded with the residual linear relationship. The peak intensity method were selected to establish models were detected in spinach surface of pesticide chlorpyrifos. Raman spectroscopy detection method can of spinach surface of pesticide residues detection analysis. It solves the traditional measurement method for sample pretreatment is complex and long detection time, low efficiency of the measured defect

      • Clinicopathologic Characteristics and Prognostic Factors in Patients with Operable HER-2 Overexpressing Breast Cancer

        Liu, Ai-Na,Sun, Ping,Liu, Jian-Nan,Ma, Jin-Bo,Qu, Hua-Jun,Zhu, Hua,Yu, Cai-Yan,Zhang, Liang-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

        Objective: To study the relationship between clinical pathologic characteristics, treatment modalities and prognostic factors in HER-2 (Human Epidermal growth factor Receptor-2) overexpressed breast carcinoma. Materials and Methods: Major clinico-pathological factors including therapeutic modalities and survival status of 371 breast cancer patients with HER2 over-expression, teated at Yantai Yuhuangding Hospital from March of 2002 to December of 2010 were retrospectively studied, with special attention focused on survival-related factors. Results: The median age of the total 371 patients in this study was 48 years at time of diagnosis, among which, the leading pathological type was infiltrating ductal carcinoma (92.5%); 62.8% presented with a primary tomor larger than 2 cm in diameter at diagnosis, 51.0% had axillary lymph node (ALN) metastases; ER (Estrogen receptor)/PR (Progesterone receptor) double negative occured in 52.8% of cases, and PCNA (proliferation cell nuclear antigen) (+++) was found in 55.1%. HER-2 overexpressed patients were usually in advanced stage when the diagnosis was made (72.8% at stages IIA~IIIC). The prognosis and survival were assessed in 259 patients with complete follow-up data. 5-year DFS (disease-free survival) and OS (overall survival) rate was 68.0% and 78.0% respectively. Univariate analysis revealed that age, tumor size, ALN metastases, LVSI (lymph-vascular space involvement), PCNA status, hormonal therapy, chemotherapy cycles, and HER-2 overexpression, correlated closely with the prognosis. ALN metastases, LVSI, PCNA status and chemotherapy cycles were independent predictors of survival. Conclusions: HER-2 overexpressed breast cancer has special clinical and pathological characteristics, with advanced clinical stages and high rate of ER/PR double negative. Lymph node metastases, LVSI, PCNA and chemotherapy cycles are independent predictors of prognosis.

      • KCI등재

        Study on temperature characteristics of gasoline engine particulate filters during fuel cut-off

        Nan Li,Zheng Nan,Qiushi Zhang,Haitao Liu,Lun Hua,Caihong Zhang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.12

        Based on the bench test of a 1.5 L gasoline engine equipped with a catalytic gasoline engine particulate filter(CGPF), the fuel cut-off regeneration characteristics of the next generation with small pore size GPF and the commonGPF under different soot loading and temperatures were studied. The results showed that after the fuel was cutoffduring the regeneration process, the center temperature of the sample rose exponentially, and as the regenerationtime extended, the temperature gradually became flat. The temperature distribution inside the carrier was such that theinlet temperature was low at the axial position, and the temperature near the outlet was high, the radial position showeda trend of high temperature in the middle and low temperature at the edge, and the temperature difference betweenthe edge and the center of the carrier was large. The maximum temperature inside the GPF increased with the increasein soot loading, and the maximum temperature gradient also increased. When the soot loading reached 6 g/L and thefuel cut-off regeneration was conducted at 650 oC, the maximum and maximum temperature gradient inside the GPFexceeded the tolerance limit of the GPF, and the inside of the carrier was damaged to varying degrees. Therefore, theseparameters should be controlled during regeneration.

      • KCI등재

        Feasibility Study on Long-Term Continuous Ethanol Production from Cassava Supernatant by Immobilized Yeast Cells in Packed Bed Reactor

        Liu Qingguo,Zhao Nan,Zou Yanan,Ying Hanjie,Dong Liu,Chen Yong 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.8

        In this study, yeast cell immobilization was carried out in a packed bed reactor (PBR) to investigate the effects of the volumetric capacity of carriers as well as the different fermentation modes on fuel ethanol production. An optimal volumetric capacity of 10 g/l was found to obtain a high cell concentration. The productivity of immobilized cell fermentation was 16% higher than that of suspended-cell fermentation in batch and it reached a higher value of 4.28 g/l/h in repeated batches. Additionally, using this method, the ethanol yield (95.88%) was found to be higher than that of other tested methods due to low concentrations of residual sugars and free cells. Continuous ethanol production using four bioreactors showed a higher productivity (9.57 g/l/h) and yield (96.96%) with an ethanol concentration of 104.65 g/l obtained from 219.42 g/l of initial total sugar at a dilution rate of 0.092 h-1. Furthermore, we reversed the substrate-feed flow directions in the in-series bioreactors to keep the cells at their highest activity and to extend the length of continuous fermentation. Our study demonstrates an effective method of ethanol production with a new immobilized approach, and that by switching the flow directions, traditional continuous fermentation can be greatly improved, which could have practical and broad implications in industrial applications.

      • Analysis of Mammographic Breast Density in a Group of Screening Chinese Women and Breast Cancer Patients

        Liu, Jing,Liu, Pei-Fang,Li, Jun-Nan,Qing, Chun,Ji, Yu,Hao, Xi-Shan,Zhang, Xue-Ning Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

        Background: A dense breast not only reduces the sensitivity of mammography but also is a moderate independent risk factor for breast cancer. The percentage of Western women with fat breast tissue is higher aged 40 years or older. To a certain extent, mammography as a first choice of screening imaging method for Western women of this group is reasonable. Hitherto, the frequency and age distribution of mammographic breast density patterns among Chinese women had not been characterized. The purpose of this study was to investigate the frequency and age distribution of mammographic breast density patterns among a group of Chinese screening women and breast cancer patients in order to provide useful information for age-specific guidelines for breast cancer screening in Chinese women. Methods: A retrospective review of a total of 3,394 screening women between August and December 2009 and 2,527 breast cancer patients between July 2011 and June 2012 was conducted. Descriptive analyses were used to examine the association between age and breast density. The significance of differences of breast density between the screening women and the breast cancer patients was examined using nonparametric tests. Results: There was a significant inverse relationship between age and breast density overall (r=-0.37, p< 0.01). Breast density of the breast cancer patients in the subgroups of 40-49 years old was greater compared with that of the screening women, the same in those aged 50-54 years and in those 55 years old or older, less than in the screening group. Conclusions: With regard to the Chinese women younger than 55 years old, the diagnostic efficiency of breast cancer screening imaging examinations may be potentially improved by combining screening mammography with ultrasound.

      • KCI등재

        An intelligent recoil controller for riser system based on fuzzy control theory

        Liu Xiuquan,Liu Zhaowei,Wang Xianglei,Qiu Na,Zhang Nan,Chang Yuanjiang,Chen Guoming 대한조선학회 2022 International Journal of Naval Architecture and Oc Vol.14 No.1

        Riser recoil control is a complicated nonlinear control problem. An intelligent control methodology is proposed to control the complicated riser recoil response based on fuzzy control theory. A dynamic nonlinear model of drilling riser/tensioner coupling system is established for riser recoil analysis. The riser system is divided into several elements and the coupling effect between the riser and discharged mud is considered in the dynamic model. A fuzzy controller for the opening of the recoil control valve is designed for the riser recoil control. A comprehensive analysis method is proposed for riser recoil control simulation. Simulation results show that the designed fuzzy controller can effectively control the riser recoil response. The adaptability of the designed controller is also proved by the simulation results. The application of the designed controller can reduce the risk of accidents during riser recoil process.

      • KCI등재

        The Role of Logistics Information System in Highway Logistics Ports: the Case of Transfar Logistics Base in Zhejiang Province

        Nan Liu,Wen-tong Yao,Chen Zhong 중앙대학교 한국전자무역연구소 2010 전자무역연구 Vol.8 No.1

        최근 들어 물류는 중국의 경제 성장의 핵심적 요소가 되었다. 대부분의 물류회사는 중소형 업체이기 때문에 그들의 정보기술을 발전시킬 충분한 자금을 가지도 있지 않다. 본 논문은 중소형 업체에 정보기술을 전파할 TLB(Transfer Logistics Base)에 의해 개발된 물류정보시스템을 소개한다. 이 정보시스템은 6개의 하부시스템(송장관리시스 템, 창고관리시스템, 운송수단관리시스템, 정보공유시스템, 고객관리 시스템 그리고 재 정관리시스템)으로 구성되어있다. 이 시스템이 중소형업체와 지역기관에 상당한 이익 을 가져다주고 있다는 것을 입증한다. In recent years, logistics has become one of the key industries in China’s economic development. Most of the logistics companies are small and medium enterprises(SMEs) and they do not have sufficient capital to develop their information technologies. This paper presents a logistics information system developed by the Transfar Logistics Base(TLB) to promote the information technology in SMEs. The information system consists of 6 sub‐systems: Invoice Management System, Warehouse Management System, Vehicle Management System, Information Release System, Customer Management System and Finance Management System. It is found that the information system has generated significant benefits to both SMEs and local authorities.

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