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구성태,송문영,강정묵,김용명,박보라,이은석,홍정아,김경식,손인철 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1
Literally, the mean of Tae-gye is highest brook. And on the basis of the acupuncture theory, Tae-gye point is the Soo earth point and source point of the Kidney Channel as well. In addition, Tae-gye point is one of the Yang-Returning Nine points. We were trying to study bibliographically on the Tae-gye point because Tae-gye point can be used very broadly across the symptoms in the theoretical aspect described above. As a results, we found out that according to the classical books of acupuncture, Tae-gye point is entering point of the Meridian Water as a source point and can be used at both Kidney-Sufficient Syndrom and Kidney-Deficient Syndrom. And Tae-gye can be applied to the disease of kidney or bladder that is urogenital symtoms, Also, Tae-gye is an useful option of tooth-ache, asthma, indigestion, constipation, edema etc whose cause is related with decrease of Kidney ki.
이은영,장태원,정만홍,옥철호,이규원,손창배,이지숙,신은경,서정아,백종현,김영옥 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2
Actinomycosis is a chronic suppurative infection, whitch infiltrates mucosa-associated tissues. Thoracic, pelvic and cervicofacial infections of actinomyces are not uncommon, but endobronchial actinomycosis is rarely reported. We report a case of a 29 year old man who presented with a recurrent pneumonia and chronic cough. Fiberoptic bronchoscopy revealed occlusion of the right. lower medio-basal segment bronchus with exophytic endobronchial mass. The diagnosis was confirmed histologically by demonstration of sulfur granules in the bronchoscopic biopsy of the mass. Intravenous administration of amoxacillin and clindamycin followed by oral amoxacillin and clindamycin therapy resulted in complete recovery.
김태유,김상윤,최성혜,양동원,김재우,손정은,임병훈,인연권 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.2
Background: Confrontational naming test is useful in evaluating the language function. It reveals memory and cognitive processing dysfunctions in many neurologic diseases including dementia. Although the Korean version of the Boston Naming Test (K-BNT) has been a popular and useful test, it takes much time and effort in dementia patients of moderate to severe stage of disease or in elderly individual with low educational level. So we developed the Korean Naming Test (KNT). Methods: KNT consists of relatively easy 40 items. Each item was familar materials around us and simplified figures with black thick line. Ninety two of probable Alzheimer's patients received the Korean version of Mini-Mental State Examination (K-MMSE), the Korean version of expanded Clinical Dementia Rating Scale (CDR), K-BNT and KNT. We tested reliability and validity of KNT and also evaluated scores of the KNT along with CDR. Results: The KNT correlated with K-BNT [0.75(p;0.01)], CDR [-0.49(p;0.01)], K-MMSE [0.55(p;0.01)]. The internal consistency was 0.91 (Cronbach's alpha). The KNT score decreased as the disease progressed. Conclusions: The KNT is a brief and good test for evaluating language function of moderate to severe dementia patients with low educational level. Also it is sensitive to mild stage of disease and has a excellent reliability and validity.
이애영,손은희,김태우 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1
Background: Cerebral white matter changes can be observed frequently in Alzheimer′s disease or healthy elderly as well as vascular dementia the clinical significance and injury mechanism of cerebral white matter changes have not been clarified Objectives: To evaluate the significance of cerebral white matter changes in elderly patients Methods: We assessed cognitive function and radiological features in patients with white matter changes to evaluate the effect of cerebral white matter changes and cortical central brain atrophy on cognition Grading of white matter changes was measured by the Scheltens scale The cortical atrophy was graded with visual inspection by two independent neurologists and the central atrophy was assessed with ventricular indices The cognitive status was evaluated with Mini-Mental state examination and the modified Mini-mental State examination Results: Identified risk factors for white matter changes were older age, hypertension, and female gender The degree of cerebral white matter changes was significantly associated with cognitive disturbances and their main effect on cognition was fluency and attention deficits There was no difference in the severity of cortical atrophy between the two groups Visual rating for cortical atrophy and measurement of ventricular indices showed good intra-and -observer reliability Conclusion: Our results support the hypothesis that cerebral white matter changes contribute to cognitive disturbances, especially frontal lobe dysfunctions in elderly irrespective of cortical brain atrophy.
Jeong Eun Seo,Sung Eun Oh,Jeong Eun Seo,Ji Yeong An,Min-Gew Choi,Tae Sung Sohn,Jae Moon Bae,Sung Kim,Jun Ho Lee 대한종양외과학회 2019 Korean Journal of Clinical Oncology Vol.15 No.2
Purpose: Preoperative endoscopic clipping is a popular method in identifying the location of tumors during total laparoscopic or robotic gastrectomy. We investigated the usefulness of additional intraoperative abdominal radiographs to identify the location of clips. Methods: We retrospectively analyzed 331 patients with early gastric cancer who underwent endoscopic clipping before total laparoscopic or robotic gastrectomy between September 2012 and September 2018. Endoscopists applied two clips 1 cm from the proximal aspect of the upper margin of the tumor which was located above the angle of the stomach. We compared outcomes of patients who underwent preoperative abdominal radiographs only (group A) and those who underwent additional abdominal radiographs (group B). Results: Of the total patients, 80 (24.2%) underwent additional intraoperative abdominal radiographs. The rates of positive frozen biopsy in the two groups were not significantly different (group A vs. group B: 2.8% vs. 3.8%, P=0.456). The additional resection rate was significantly higher in group B compared to group A (8.8% vs. 2.8%, P=0.048). The mean distance from the tumor was 3.3 cm (±2.4) in group A and 2.4 cm (±1.3) in group B (P<0.001). Large tumor size (≥2.4 cm) was significantly associated with additional resection (odds ratio, 5.53; 95% confidence interval, 1.17–26.30; P=0.031). Conclusion: Additional intraoperative abdominal radiographs may be unnecessary for confirmation of proximal resection margin, if the resection line can be predetermined with preoperative abdominal radiographs. For large tumors, to avoid additional resection, the resection line should be placed 1 cm or more proximally from the preoperatively applied clips.
Hong Eun Kyoung,Choi Seung Hong,Shin Dong Jae,Jo Sang Won,Yoo Roh-Eul,Kang Koung Mi,Yun Tae Jin,김지훈,Sohn Chul-Ho,Park Sung-Hye,Won Jae-Kyoung,Kim Tae Min,Park Chul-Kee,Kim Il Han,Lee Soon-Tae 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.2
Objective: To evaluate the association of MRI features with the major genomic profiles and prognosis of World Health Organization grade III (G3) gliomas compared with those of glioblastomas (GBMs). Materials and Methods: We enrolled 76 G3 glioma and 155 GBM patients with pathologically confirmed disease who had pretreatment brain MRI and major genetic information of tumors. Qualitative and quantitative imaging features, including volumetrics and histogram parameters, such as normalized cerebral blood volume (nCBV), cerebral blood flow (nCBF), and apparent diffusion coefficient (nADC) were evaluated. The G3 gliomas were divided into three groups for the analysis: with this isocitrate dehydrogenase (IDH)-mutation, IDH mutation and a chromosome arm 1p/19q-codeleted (IDHmut1p/19qdel), IDH mutation, 1p/19q-nondeleted (IDHmut1p/19qnondel), and IDH wildtype (IDHwt). A prediction model for the genetic profiles of G3 gliomas was developed and validated on a separate cohort. Both the quantitative and qualitative imaging parameters and progression-free survival (PFS) of G3 gliomas were compared and survival analysis was performed. Moreover, the imaging parameters and PFS between IDHwt G3 gliomas and GBMs were compared. Results: IDHmut G3 gliomas showed a larger volume (p = 0.017), lower nCBF (p = 0.048), and higher nADC (p = 0.007) than IDHwt. Between the IDHmut tumors, IDHmut1p/19qdel G3 gliomas had higher nCBV (p = 0.024) and lower nADC (p = 0.002) than IDHmut1p/19qnondel G3 gliomas. Moreover, IDHmut1p/19qdel tumors had the best prognosis and IDHwt tumors had the worst prognosis among G3 gliomas (p < 0.001). PFS was significantly associated with the 95th percentile values of nCBV and nCBF in G3 gliomas. There was no significant difference in neither PFS nor imaging features between IDHwt G3 gliomas and IDHwt GBMs. Conclusion: We found significant differences in MRI features, including volumetrics, CBV, and ADC, in G3 gliomas, according to IDH mutation and 1p/19q codeletion status, which can be utilized for the prediction of genomic profiles and the prognosis of G3 glioma patients. The MRI signatures and prognosis of IDHwt G3 gliomas tend to follow those of IDHwt GBMs.
김지은 ( Ji Eun Kim ),한동수 ( Dong Soo Han ),조현석 ( Hyun Seok Cho ),변태준 ( Tae Joon Byun ),김태엽 ( Tae Yeob Kim ),은창수 ( Chang Soo Eun ),전용철 ( Yong Cheol Jeon ),손주현 ( Joo Hyun Sohn ) 대한장연구학회 2007 Intestinal Research Vol.5 No.1
Background/Aims: Intestinal Behcet’s disease can be diagnosed when Behcet’s disease patient has intestinal ulcers. The aim of this study was to recognize the clinical features and course of intestinal Behcet’s disease according to disease subtypes. Methods: We performed a retrospective chart review of patients who had intestinal lesions associated with Behcet’s disease on colonoscopy between March, 2001 and May, 2006. Results: Of the 38 patients (18 men/20 women) enrolled, the mean age at diagnosis was 40.9±13.6 years. By Japanese criteria, 18 patients were classified in incomplete type, 8 in suspected type, and 8 in possible type. Four patients had only intestinal lesion without Behcet’s manifestation. By International Study Group of Behcet’s Disease criteria, 10 were met Behcet’s disease, and 15 was suspected as Behcet’s disease. Characteristics of intestinal ulcers were aphthous shape and ileocecal location. Five patients were reclassified during clinical course. There was no difference at clinical outcome according to prescribed medications. Conclusions: Not a few of intestinal Behcet’s disease patients were difficult to meet the Behcet’s disease criteria. Because clinical manifestations of intestinal Behcet’s disease patients may be changed, it would be needed to reclassify disease subtypes with long-term follow-up. (Intest Res 2007;5:26-32)