우리나라 여성의 삶의 질에 관한 연구

강한솔,정수현,황은진,이정주,노승용 서울여자대학교 여성연구소 2011 여성연구논총 Vol.26 No.-

People are getting more interested in their “quality of life” as they achieved certain level of economic development. Governments pay great attention on well-being and happiness of people as well and try to find the best way to improve citizens' quality of life. However, South Korea is still on 27th out of 39 OECD and G20 countries in quality of life index, which means that there are great needs to improve Koreans' quality of life. Moreover, it is expected that Korean women's quality of life might be worse than this in its patriarchal environments. In fact, there are few research regarding Korean women's quality of life and it is unknown what personal and social factors affect Korean women's quality of life and how we can improve it. This research attempts to find out factors related to Korean women's quality of life through the surveys of 536 Korean women. The results show that quality of life is most influenced by factors such as self-fulfillment, socio-economic independence, satisfaction with the residence, and satisfaction with cultural activities. In addition, happiness of Korean womem is greatly affected by various factors such as mental health, interpersonal relationship, self-respect, self-fulfillment, socio-economic independence, satisfaction with the residence, and satisfaction with cultural activities. Among various factors related to quality of life and happiness of Korean women, scores of self-respect, self-fulfillment, and interpersonal relationship are high, while scores regarding income are relatively low. Key words:Quality of Life, Happiness, Maslow

시민참여와 정부신뢰

정수현,강한솔,황은진,이정주,노승용 서울여자대학교 사회과학연구소 2012 사회과학논총 Vol.19 No.-

이 연구는 시민참여와 정부신뢰와의 관계를 분석하는데 그 목적이 있다. 이를 위하여, 이 연구에서는 시민참여를 전통적인 오프라인 시민참여와 디지털 방식인 온라인 시민참여로 그 유형을 분류하고, 오프라인 시민참여와 온라인 시민참여의 경험이 정부신뢰와 어떤 관계가 있는지를 분석하였다. 2차 자료를 활용하여 빈도분석, 교차분석, t-test, 분산분석, 회귀분석 등을 실시한 결과 먼저, 우리나라 시민참여 경험자는 약 22% 정도이며, 오프라인 시민참여 경험자는 약 12%, 온라인 시민참여 경험자는 약 15%, 그리고 온라인과 오프라인 시민참여를 모두 경험한 시민은 약 5% 정도인 것으로 나타났다. 또한, 시민참여와 정부신뢰와는 관계를 분석한 결과 통계적으로 유의미한 관계가 없는 것으로 나타났다. 오히려, t-test 및 분산분석 결과 오프라인 및 온라인 시민참여 경험자에 비하여 무경험자의 정부신뢰 수준이 상대적으로 약간 더 높은 것으로 나타났다. 시민참여의 경험 유무 만으로 정부신뢰를 설명하는데는 한계가 있음을 보여 주는 결과일 뿐만 아니라 시민참여를 제도적으로 보장하는 것에서 나아가서 시민참여가 실질적 효과를 높일 수 있도록 시민참여과정에서 정부와 시민의 보다 적극적인 노력이 필요함을 보여주는 결과라 하겠다. Trust in government adds legitimacy to political system, provides social stability, and helps government to work effectively. In addition it increases cooperation between governments and citizens, and improves effectiveness of government affairs. However, citizens' trust in government has been quite low sine 1990s. In Korea, citizens' trust in government dropped after financial crisis in late 1990s. Various literatures indicated that citizen participation is one of the best ways to increase citizens' trust in governments. Especially as information technology increases, it is expected that citizens acquire information about different policy areas, and actively participate in surveys, discussion, and policy evaluation through internet. This research attempts to prove the relationship between citizen participation and trust in government by comparing online and offline citizen participation. The research utilized 2nd dataset from 'the influence of information on citizens' participation in policy-making.' With various statistical techniques such as frequency analysis, cross tabulation, ANOVA, and regression analysis, the characteristics of offline and online policy participants are examined. The results showed that citizens, who participate in policy-making processes more actively both online and offline, trust in government less. Comparing online and offline participation, online participants distrusted government more than offline participants. Such variables as policy competitiveness, democracy in government, quality of government, and transparency in government have direct influences on trust in government. However, citizen participation is not statistically significant. Key Words:Citizen Participation, Traditional Citizen Pariticipation, Digital Citizen Participation, Trust in Government.

충남 일부지역 초등학생의 인두에 분포하는 세균 실태조사

하서영,박수진,이보미,박솔기,박창은 남서울대학교 2012 남서울대학교 논문집 Vol.18 No.2

The distributed species and the kinds of variable microorganism in Pharynx were monitored to the elementary school child. Our purpose was to investigate the distribution of bacteria in Pharynx of child except for adults. Analysis performed the collected sample from 15 students in Chungnam area for 2 days from July 30 to July 31 in 2012. The isolated bacteria were identified by Gram stain and biochemical test using VITEKⅡsystems. The experiment on microorganism concentration of contact parts carried out and the average of total microorganism was measured. The elementary child's Pharynx were isolated and identified. The isolation rates were major distributied to Gram positive cocci, another Gram negative bacilli and Gram positive bacilli. respectively. The frequently isolated bacteria were G. adiacens. The Granulicatella adiacens is one of the fastidious Gram positive cocci previously described as nutritionally variant streptococci due to their requirement of L-cysteine, pyridoxal, or thiol compounds for growth. These bacteria have been identified as significant causative agents of endocarditis, opthalmic infections, and meningitis. Further systematic studies are necessary with an emphasis on species identification. Key Words : Microorganism, Elementary child, Pharynx and Larynx

Sodium butyrate has context-dependent actions on dipeptidyl peptidase-4 and other metabolic parameters

Lee, Eun-Sol,Lee, Dong-Sung,Pandeya, Prakash Raj,Kim, Youn-Chul,Kang, Dae-Gil,Lee, Ho-Sub,Oh, Byung-Chul,Lee, Dae Ho The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.5

Sodium butyrate (SB) has various metabolic actions. However, its effect on dipeptidyl peptidase 4 (DPP-4) needs to be studied further. We aimed to evaluate the metabolic actions of SB, considering its physiologically relevant concentration. We evaluated the effect of SB on regulation of DPP-4 and its other metabolic actions, both in vitro (HepG2 cells and mouse mesangial cells) and in vivo (high fat diet [HFD]-induced obese mice). Ten-week HFD-induced obese C57BL/6J mice were subjected to SB treatment by adding SB to HFD which was maintained for an additional 16 weeks. In HepG2 cells, SB suppressed DPP-4 activity and expression at sub-molar concentrations, whereas it increased DPP-4 activity at a concentration of $1,000{\mu}M$. In HFD-induced obese mice, SB decreased blood glucose, serum levels of insulin and $IL-1{\beta}$, and DPP-4 activity, and suppressed the increase in body weight. On the contrary, various tissues including liver, kidney, and peripheral blood cells showed variable responses of DPP-4 to SB. Especially in the kidney, although DPP-4 activity was decreased by SB in HFD-induced obese mice, it caused an increase in mRNA expression of $TNF-{\alpha}$, IL-6, and $IL-1{\beta}$. The pro-inflammatory actions of SB in the kidney of HFD-induced obese mice were recapitulated by cultured mesangial cell experiments, in which SB stimulated the secretion of several cytokines from cells. Our results showed that SB has differential actions according to its treatment dose and the type of cells and tissues. Thus, further studies are required to evaluate its therapeutic relevance in metabolic diseases including diabetes and obesity.

Alteration of Lipid Profiles in Patients with Subclinical Hypothyroidism

Jung Eun Lee,Su Jin Jeong,Sol Jae Lee,Young Hoon Lee,Yuchang Lee,Sook Jung Lee,Chong-Hwa Kim 한국지질동맥경화학회 2017 지질·동맥경화학회지 Vol.7 No.2

Objectives: Overt hypothyroidism has been associated with abnormalities of lipid metabolism; however conflicting resultsregarding the degree of lipid changes in subclinical hypothyroidism (SCH) have been reported. The aim of this study wasto assess differences in lipid profile parameters between people with and without SCH in Korean population. Methods: Serum lipid parameters of 37 patients with SCH and 44 euthyroid control subjects were evaluated in a retrospectivecross-sectional study. Results: The mean serum triglycerides (TG) level was significantly higher in patients with SCH than in controls (p<0.05). The mean serum high-density lipoprotein cholesterol (HDL-C) level was significantly lower in patients with SCH than incontrols (p<0.05). When adjusted by age, the odds ratio for the association of HDL-C with SCH was significant at 0.893(95% confidence interval 0.809-0.986) compared with that of the euthyroid controls. No association with SCH was foundwith total cholesterol level, low-density lipoprotein cholesterol level or serum thyroid-stimulating hormone level. In addition,the lipid profile did not differ significantly between premenopausal and postmenopausal women. Conclusions: We found variations of lipid profiles in patients with SCH, characterized by a significantly lower HDL-C level. (J Lipid Atheroscler 2017 December;6(2):84-88)

신규 한천분해세균 Maribacter sp. SH-1의 분리 및 효소 특성조사

이창은 ( Chang Eun Lee ),이솔지 ( Sol Ji Lee ),이동근 ( Dong Geun Lee ),이상현 ( Sang Hyeon Lee ) 한국미생물생명공학회(구 한국산업미생물학회) 2016 한국미생물·생명공학회지 Vol.44 No.2

본 연구에서는 신규 해양성 한천분해균을 분리하고, 이 균주가 생성하는 한천분해효소의 특성을 조사하였다. 경상남도 남해군 미조면 연안에서 채취한 해수를 Marine agar 2216 배지에 도말하여 한천분해세균을 선별하였다. 선택된 한천분해균주는 16S rDNA 염기서열분석을 통해 Maribacter속 세균과 99% 유사하여 Maribacter sp. SH-1으로 명명하였다. 세포외로 분비되는 agarase는 Maribacter sp. SH-1 균주 배양액에서 획득하였으며, 이를 이용하여 특성을 조사 하였다. Maribacter sp. SH-1 균주의 한천분해효소는 20, 30, 40, 50 및 60℃에서 각각 56, 62, 94, 100, 8%의 상대활성을 나타냈으며, pH 5, 6, 7 및 8에서 각각 15, 100, 60, 21%의 상대활성을 나타냈다. 세포외 agarase는 50℃, pH 6인 20 mM Tris-HCl buffer를 사용하는 조건에서 최대활성(231 units/l)을 보였다. 한천이 sol 상태로 존재하는 50℃에서 최적활성을 보여 이 효소는 응용 가능성이 높다고 할 것이다. 효소 활성은 20, 30 및 40℃에서 30분 동안 열처리하였을 때 약 90% 이상의 상대활성을 보였다. TLC 분석 결과, Maribacter sp. SH-1 균주의 한천분해효소는 한천올리고당인 neoagarohexaose (34.8%), neoagarotetraose (52.2%) 및 neoagarobiose (13.0%)를 생성하는 것으로 보아 β-agarase로 확인되었다. 따라서 Maribacter sp. SH-1 균주와 이 균주가 생산하는 β-agarase는 보습효과, 미백효과, 세균성장 억제 혹은 전분노화 방지 등의 기능을 가지는 한천올리고당의 생산에 유용할 것으로 기대된다. In this study, we isolated a new agar-degrading marine bacterium and characterized its agarase. An agardegrading marine bacterium SH-1 was isolated from seawater, collected from the seashore of Namhae in Gyeongnam province, Korea, and cultured in marine agar 2216 media. It was identified as Maribacter. sp. SH-1 by phylogenetic analyses, based on 16S rRNA gene sequence. The extracellular agarase was extracted from culture media of Maribacter sp. SH-1 and characterized. Its relative activities were 56, 62, 94, 100, and 8% at 20, 30, 40, 50, and 60°C, respectively, whereas 15, 100, 60, and 21% relative activities were observed at pH 5, 6, 7, and 8, respectively. Its extracellular agarase exhibited maximum activity (231 units/l) at pH 6.0 and 50°C, in 20 mM Tris-HCl buffer. Therefore, this agarase would be applicable as it showed the maximum activity at the temperature at which the agar is in a sol state. Furthermore, the agarase activities remained over 90% at 20, 30, and 40°C after 0.5 h exposure at these temperatures. Thin layer chromatography analysis suggested that Maribacter sp. SH-1 produces extracellular β-agarase, as it hydrolyzes agarose to produce neoagarooligosaccharides, such as neoagarohexaose (34.8%), neoagarotetraose (52.2%), and neoagarobiose (13.0%). Maribacter sp. SH-1 and its β-agarase would be useful for the production of neoagarooligosaccharides, which shows functional properties, like skin moisturizing, skin whitening, inhibition of bacterial growth, and delay in starch degradation.

마우스 대장암 모델 구축 및 항암제 활성 평가를 위한 예비 연구

김예솔,강봉석,이상은,이은주,이경록,정상헌,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract – Aberrant crypt foci (ACF) are early imorphological changes observed in rodents after administration of colon-specific carcinogen such as azoxymethane (AOM). ACF are considered to be putative preneoplastic lesions and are widely used as a surrogate biomarker to rapidly evaluate chemopreventive potential of compounds. The size of colorectal cancer was evaluated after administration of three anticancer drugs, 1 parent drug and 2 prodrugs. The body weights of mice were measured daily and considered as a surrogate for evaluation of general wellbeing. Colons were removed, cut along the longitudinal axis and flushed with phosphate-buffered saline. Each colon was cut into three equal lengths and fixed flat between filter papers. The fixed colon sections were stained with methylene blue. The number of ACF per colon, the number of aberrant crypts observed in each focus and the location of each focus were recorded. After single administration of AOM and multiple doses of anticancer drugs, no significant changes in the body weights of the mice was observed which was recorded for 52 days. However, an expected ACF was not observed in any treated groups. These findings suggest the induction of ACF in mice requires the promotion by dextran sulfate sodium as well as the initiation by AOM.

Clinical characteristics of pediatric patients infected with SARS-CoV-2 versus common human coronaviruses: a national multicenter study

Sol In Suk,Lee Eun,양현종,Lee Yong Ju,Yum Hye Yung,Lee Mi-Hee,Chu Mi Ae,Moon Hui jeong,김효빈,서주희,Shim Jung Yeon,Ahn Ji Young,Jang Yoon Young,Chung Hai Lee,Chung Eun Hee,Kim Kyunghoon,김봉성,김철홍,Park Yang,신미용 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.3

Background: Human coronaviruses (HCoV) cause mild upper respiratory infections; however, in 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged, causing an acute respiratory disease pandemic. Coronaviruses exhibit marked epidemiological and clinical differences.Purpose: This study compared the clinical, laboratory, and radiographic findings of children infected with SARS-CoV-2 versus HCoV.Methods: SARS-CoV-2 data were obtained from the Korea Disease Control and Prevention Agency (KDCA) registry and 4 dedicated coronavirus disease 2019 (COVID-19) hospitals. Medical records of children admitted with a single HCoV infection from January 2015 to March 2020 were collected from 10 secondary/tertiary hospitals. Clinical data included age, sex, underlying disease, symptoms, test results, imaging findings, treatment, and length of hospital stay.Results: We compared the clinical characteristics of children infected with HCoV (n=475) to those of children infected with SARS-CoV-2 (272 from KDCA, 218 from COVID-19 hospitals). HCoV patients were younger than KDCA patients (older than 9 years:3.6% vs. 75.7%; P<0.001) and patients at COVID-19 hospitals (2.0±2.9 vs 11.3±5.3; P<0.001). Patients with SARS-CoV-2 infection had a lower rate of fever (26.6% vs. 66.7%; P<0.001) and fewer respiratory symptoms than those with HCoV infection. Clinical severity, as determined by oxygen therapy and medication usage, was worse in children with HCoV infection. Children and adolescents with SARS-CoV-2 had less severe symptoms.Conclusion: Children and adolescents with COVID-19 had a milder clinical course and less severe disease than those with HCoV in terms of symptoms at admission, examination findings, and laboratory and radiology results.

Paclitaxel-loaded Gelatin Nanoparticles Prepared by Sinlgle Process O/W/O emulsion

Eun Ju LEE,Han Sol KWon,Su Hyeon KIM,You Jin PARK,Jeong Eun KIM,Kwang-Hee LIM 한국생물공학회 2017 한국생물공학회 학술대회 Vol.2017 No.4

A case report of an unusual temporomandibular joint mass: Nodular fasciitis

Lee Han-Sol,Oh Kyu-Young,Kang Ju-Hee,Kim Jo-Eun,Huh Kyung-Hoe,Yi Won-Jin,Heo Min-Suk,Lee Sam-Sun 대한영상치의학회 2023 Imaging Science in Dentistry Vol.53 No.1

Nodular fasciitis (NF) is a benign myofibroblastic proliferation that grows very rapidly, mimicking a sarcoma on imaging. It is treated by local excision, and recurrence has been reported in only a few cases, even when excised incompletely. The most prevalent diagnoses of temporomandibular joint (TMJ) masses include synovial chondromato- sis, pigmented villonodular synovitis, and sarcomas. Cases of NF in the TMJ are extremely rare, and only 3 cases have been reported to date. Due to its destructive features and rarity, NF has often been misdiagnosed as a more aggressive lesion, which could expose patients to unnecessary and invasive treatment approaches beyond repair. This report presents a case of NF in the TMJ, focusing on various imaging features, along with a literature review aiming to determine the hallmark features of NF in the TMJ and highlight the diagnostic challenges