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The macrophage migration inhibitory factor protein superfamily in obesity and wound repair
김봉성,Norbert Pallua,Jürgen Bernhagen,Richard Bucala 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-
The rising number of obese individuals has become a major burden to the healthcare systems worldwide. Obesity includes not only the increase of adipose tissue mass but importantly also the altered cellular functions that collectively lead to a chronic state of adipose tissue inflammation, insulin resistance and impaired wound healing. Adipose tissue undergoing chronic inflammation shows altered cytokine expression and an accumulation of adipose tissue macrophages (ATM). The macrophage migration inhibitory factor (MIF) superfamily consists of MIF and the recently identified homolog D-dopachrome tautomerase (D-DT or MIF-2). MIF and D-DT, which both bind to the CD74/CD44 receptor complex, are differentially expressed in adipose tissue and have distinct roles in adipogenesis. MIF positively correlates with obesity as well as insulin resistance and contributes to adipose tissue inflammation by modulating ATM functions. D-DT, however, is negatively correlated with obesity and reverses glucose intolerance. In this review, their respective roles in adipose tissue homeostasis, adipose tissue inflammation, insulin resistance and impaired wound healing will be reviewed.
Enhancement of photoluminescence properties of SrAl2Si2O8:Eu2+ by a large amount of SiO2 addition
김봉성,조덕수 한양대학교 세라믹연구소 2013 Journal of Ceramic Processing Research Vol.14 No.S1
SiO2 added phosphors, SrAl2Si2O8:Eu2++ xSiO2 (x = 0, 1, 2 and 3 mol) were synthesized by a novel liquid phase precursor (LPP) method. The photoluminescence properties of phosphor added by 2 mol of SiO2 showed 71% increase in the emission intensity compared with the SrAl2Si2O8:Eu2+ phosphor. A broad emission and excitation wavelength was observed approximately from 400 nm to 600 nm centered at 430 nm and from 300 nm to 400 nm centered at 350 nm, respectively. Photoluminescence intensity of the phosphors increased continuously by SiO2 addition up to x = 2 mol and then it decreased at 3 mol of SiO2. The observed photoluminescence properties of the phosphors were discussed by their crystalline structure and morphology