Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study

Choi, Yoon Jin,Lee, Dong Ho,Choi, Myung-Gyu,Lee, Sung Joon,Kim, Sung Kook,Song, Geun Am,Rhee, Poong-Lyul,Jung, Hwoon-Yong,Kang, Dae-Hwan,Lee, Yong Chan,Lee, Si Hyung,Choi, Suck Chei,Shim, Ki-Nam,Seol, KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11

<P>This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was −0.4% (95% confidence interval, −9.8% to 9.1%), which was above the non-inferiority margin of −14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670)</P>

관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

미곡 산지 건조ㆍ저장시설의 확충방안

최윤상,박동규 한국농업정책학회, 한국축산경영학회 2001 농업경영정책연구 Vol.28 No.3

This study evaluates the efficient plans to extend a dry and storage center (DSC), the division in a rice processing complex, which is in need of extension. The results imply that its extension should be designed in the direction of building DSC's in size larger than 10,000 ton/year rather than building many small-scale DSC's. They also show that the current drying fee is far below the optimal level and the government supports to the DSC's should consider the regional differences.

지역학으로서의 독일학 육성을 위한 정보자료의 디지털화와 활용방안에 관한 연구

최병진,정동규,천미애,남유선 한국독어독문학회 2003 獨逸文學 Vol.88 No.-

In dieser Arbeit wurde vor allem versucht, den Blick auf zwei Punkte zu richten: Erstens sollte das Forschungsvorhaben, das im Rahmen eines zweija¨hrigen Projekts unter finanzieller Unterstu¨tzung des Koreanischen Research Foundation (KRF) durchgefu¨hrt wurde, in grobem Abriss vorgestellt werden. Zweitens werden die Probleme skizziert, die wa¨hrend der Durchfu¨hrung des Projekts auftauchten, und aus denen sich schließlich unmittelbar einige Verbesserungs- vorschla¨ge ergeben. Das Projekt hatte die Aufgabe, ein auf digitalisierten Daten basierendes Informationssystem u¨ber Deutschland zu erstellen. Das System der Wissenschaftsinformationen, das in der vorliegenden Arbeit vorgestellt wurde, wird beispielsweise aufgrund seiner umfangreichen Informationsdaten dem Fach Germanistik zur weiteren und vertiefenden deutschlandeskundlichen Forschung von großem Nutzen sein. Daru¨ber hinaus aber kommt es auch den Lehrenden zugute, da ihnen dann ein vielseitiges und reichhaltiges Lehrveranstaltungsmaterial als Veranstaltungsthemen zur Verfu¨gung steht. Um ein solches Wissenschaftssystem der Deutschlandforschung zu erstellen und weiter zu entwickeln, wird jedoch nicht nur vie1 Zeit, sondern eine sta¨ndige Aktualisierung der Datenbank no¨tig werden. Um diese Aufgaben zu bewa¨ltigen, sollten mo¨glichst viele Germanisten fu¨r das Projekt zur Verfu¨gung stehen. Zurzeit findet das Internet im privaten und o¨ffentlichen Bereich breite Anwendung wie noch nie zu vor, und diese Tendenz wird sich noch versta¨rken. Forscher suchen und sammeln Informationen anhand des Internets. So nimmt es im Forschungsleben als Forschungswerkzeug einen wichtigen Platz ein. In Zukunft wird sich der Service im Bereich des Netzwerks weiter entwickeln/verbessern. Dies bedeutet fu¨r die Forscher eine Chance im Hinblick auf die Zukunft der Forschung, wenn sie gemeinsam ein wissenschaftliches Kooperationssystem entwickeln, um Wissen unter einander auszutauschen.

다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예

최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.

EDAP LT-01+ 체외충격파쇄석기를 이용한 요로결석 치험 1,816례 : A Report of 1,816 Cases

최동규,서기석,임정식 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2

Between February 8. 1990 and December 31. 1994, 1.816 renal units in 1.611 patients with urinary stones were treated with extracorporeal shock wave lithotripsy(ESWL) using the EDAP LT-01+ lithotriptor. The patients' mean age was 44.3 years with the range of 16 months to 92 years. Sex ratio was 1.39:1 with 936(58.2%) male and 675(41.8%) female patients. Locations of the stones were kidney in 746(41.1%) including 39 cases of staghorn calculi, ureter in 1061(58.4%) and bladder in 9 cases(0.5%). And mean diameter of the stones was 13mm ranging from 2mm to 80mm. Average number of treatments, average treatment time per session and average total storage per patient were 4.0 sessions, 37.6 minutes and 134.4. respectively. Of the 1,816 cases. 141 cases(7.8%) complained of severe pain requiring intravenous or intramuscular analgesics. Success rates by stone size were 98.0%(1,069 cases/1,091 cases, storage/treatment number: 74.7/2.7) in less than 10㎜, 94.4%(453 cases/480 cases, 146.1/4.5) in 10㎜ to 19㎜. 73.4%(116 cases/158 cases, 242.4/7.1) in 20㎜ to 29㎜ and 60.9%(53 cases/87 cases. 402.6/11.2) in more than 30㎜. Success rates by stone location were 66.7%(6/9) in bladder stones. 66.7%(26/39) in staghorn calculi. 77.9%(60/77) in ureteropelvic junction(UPJ) stones. 93.1%(658/707) in renal stones, 94.8%(458/483) in upper ureteral stones and 96.4%(483/501) in lower ureteral stones. Success rate(when patients having stone particles less than 4mm in diameter without causing urinary tract obstrution, were considered to be treated successfully) was 93.l%( 1,691/1,816) and stone-free rates was 88.9% (1,615/1.816). Additional measures used were double-J stenting in 91 cases, percutaneous nephrostomy in 42 cases and push-up in 39 cases. Post-ESWL complications were persistent gross hematuria lasting more than three days in 29 cases, high fever(>38℃) in 38 cases and steinstrasse in 109 cases. We conclude that extracorporeal shock wave lithotripsy with EDAP LT-01 + lithotriptor is an effective treatment modality for urinary stone less than 2.0㎝ in diameter even though retreatment rate is high.

內燃機關用 사이클론形 空氣淸淨器의 開發에 關한 硏究 : 第1報 小型 自動車用 內燃機關에 對하여 1st Report, For Internal Combustion Engine as Applied to Small-size Motorcar

崔東珪,鄭炅樂,金起柱 全北大學校 1979 論文集 Vol.21 No.-

The dust collection efficiency and pressure loss of a cyclone type air cleaner (Multi microcyclone described in this report) as applied to a four-cylinder four-stroke internal combustion engine and the effect of this aircleaner on the volumetric efficiency of the engine were researched in a series of engine motoring tests. The test results were compared with those obtained in a series of tests by using a blower. The performances of a paper filter were also tested by the same methods. The experimental results are summarized as follows; In the engine test, the dust collection efficiency of the multi microcyclone was about 98% at 3,500 r.p.m. and about 96% at 700 r.p.m. The efficiency of the paper filter was 98~99% at low speed but decreased to 86% at 3,500.r.p.m of engine. The multi micro-cyclone had a little air flow resistance. The test engine with the above cyclone showed rather a higher volumetric efficiency by about 8% than one without any air cleaner at the engine speed of the maximum volumetric efficiency.

자본시장에서 경제적부가가치의 정보효과에 관한 연구

최동규,이춘의 朝鮮大學校 經營經濟硏究所 2006 經營經濟硏究 = Management and economics research Vol.29 No.1

전통적으로 회계정보이용자들은 발생주의(accrual basis) 기초 하에 측정한 회계이익 및 현금주의(cash basis) 하의 현금흐름에 관한 정보를 그들의 경제적 의사결정 과정에 사용해 왔다. 따라서 기업들은 경영목표를 당기순이익 증대란 S 양적목표에 두어 왔다. 그러나 최근에는 이에 대한 문제점이 지적되어 기업의 가치를 평가하는데 있어서 전통적 회계이익 정보는 기업의 성과측정치로는 부적합하고 문제점이 내재되어 있는 것으로 지적되고 있다. 이의 주된 문제점은 투하한 자본에 대한 비용(cost of capital) 특히 지분자본비용(cost of equity capital)의 인식문제가 간과되었다는 것이다. 따라서 대체적 성과측정치로서의 경제적부가가치(EVA)가 중요한 성과측정치로 최근 관심의 대상이 되고 있다. 이런 관점에서 본 연구는 실증적으로 경제적부가가치의 상대적 정보효과를 분석하였다. 기업의 가치지표로 누적초과수익율(CAR)을 사용하였고 성과측정치로 회계이익인 당기순이익 (NI) 및 현금기준 하의 성과지표인 영업현금흐름(CFO)과 함께 경제적부가가치(EVA)를 사용하였다. 분석은 피어슨상관관계 분석을 하였고,단순회귀분석 및 다중회귀분석을 하였다. 상관관계분석에서 CAR과 가장 높은 관계를 갖는 변수는 당기순이익 특히 당기순이익의 변동변수(ΔNI)가 가장 높은 관계를 보이고 있고, EVA가 가장 낮은 상관관계를 보였다. 성과측정치별 회귀분석 결과에서는 누적초과수익율에 대한 가장 높은 설명력을 갖는 성과측 정치는 역시 ΔNI이며, EVA가 가장 낮은 설명력을 갖는 것으로 일관되게 보이고 있다. 모든 변수를 사용한 다중회귀분석에서도 EVA가 낮은 설명력을 보여주었다. 이에 추가하여 각 변수들의 종속변수에 대한 설명력을 파악하기 위해 stepwise method에 의해 회귀분석 하였다. 아울러 세 영역의 설명변수 중 유의적인 설명력을 보이는 세 개의 변수에 의한 회귀분석도 병행하여 수행하였으나 이의 결과에서도 두 변수 즉 전통적인 성과측정치는 모두 추가적인 설명력을 갖는 반면, EVA는 오히려 추가적인 설명력이 없는 것으로 분석되었다. 변수 전체에 대한 다중회귀분석에서도 높은 설명력을 보이는 변수는 변동변수인 ΔNI와 수준변수인 CFO이다. 이 두 변수 중에서도 ΔNI가 더 높은 누적초과수익율에 대한 설명력을 보였으며, EVA는 일관되게 낮은 설명력을 보였다. 이는 국내 선행연구 중 백원선·이건창·박연희(2001)와 Biddle et. al(1997)의 결과와 같이 일관된 것이다. 이러한 결과로 볼 때 경제적부가가치가 전통적인 성과측정치에 비하여 더 나은 성과측정치로 보기는 어렵다는 결론을 내릴 수 있다.

골수염의 진단에 있어서의 Tc-99m Hexamethylpropylene amine oxime 백혈구 스캔의 임상적 유용성

최상호,김양수,정준원,정진원,추은주,서동대,배인규,양승오,우준희,류지소 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

배경 : 골수염의 진단에 있어 Technetium-99m을 이용한 삼상 골스캔(Tc-99m MDP스캔)은 단순방사선 검사상 정상소견을 보이는 경우에 쓰이는 1차적 검사로 매우 높은 민감도를 보인다. 그러나 Tc-99m MDP 스캔은 골절이나, 정형외과적 삽입물, 신경병적 관절병변과 같이 뼈의 재형성이 증가되는 상황에서도 양성소견을 보여 특이도가 낮은 단점이 있다. 이러한 단점을 보완하고자 골수염의 진단에 있어 Tc-99m HMPAO 백혈구 스캔의 유용성을 알아보고자 하였다. 대상 및 방법 : 골수염이 의심되어 Tc-99m HMPAO 백혈구 스캔을 시행했던 15명의 의무기록을 후향적으로 분석하였다. 골수염의 확진은 임상관찰 소견과 배양검사 결과와 병리소견을 기준으로 하였다. 결과 : 골수염의 진단에 있어 Tc-99m HMPAO 백혈구 스캔의 민감도와 특이도는 각각 100%와 78%였고 Tc-99m HMPAO 스캔의 경우는 100%와 18%였다. 가장 흔한 원인균은 methicillin-resistant S. aureus였다. Tc-99m MDP 스캔에서 양성소견을 보였던 환자중 3명의 환자가 Tc-99m HMPAO 백혈구 스캔에서 음성 소견을 보였으며 이 환자들은 추적관찰상 골수염이 없는 것으로 확인되었다. 결론 : Tc-99m HMPAO 백혈구 스캔은 골수염의 존재를 진단하는데 있어 민감도와 특이도가 높으며, 특히 뼈의 재형성이 증가되어 Tc-99m MDP 스캔의 특이도가 낮게 나타나는 상황에서 유용하리라 사료된다. Background Three phase bone scintigraphy, performed with technetium-labeled diphosphonates (Tc-99m MDP scan), is the very sensitive radionuclide procedure of choice for diagnosing osteomyelitis. But, Tc-99m MDP scan is less specific when bone remodeling is increased. To overcome this limitation, we evaluated the diagnostic value of technetium-99m hexamethylpropyleneamine oxime (HMPAO) labeled leukocyte scan in osteomyelitis. Methods : We retrospectively reviewed 15 patients with suspected osteomyelitis who performed Tc-99m HMPAO labeled leukocyte scan. The diagnosis of osteomyelitis was based on clinical course and bacterial culture, and pathologic findings. Results The sensitivity and specificity of Tc-99m HMPAO leukocyte scan was 100% and 78%, and those of Tc-99m MDP scan was 100% and 18%, respectively. The most common organism was Methicilein-Resistant S. aureus. Among the patients that showed persistent accumulation on Tc-99m MDP scan, three patients showed no uptake on Tc-99m HMPAO leukocyte scan and these patients were confirmed that had no osteomyelitis. Conclusion : Tc-99m HMPAO leukocyte scan is a useful test for determining the presence or absence of osteomyelitis, especially under condition that bone remodelin is increased.