정상 관동맥을 가진 심장 점액종 환자에서 발생한 급성 심근 경색증 1예

이정민,이현승,전은정,윤호중,정욱성,오용석,김철민,김재형,최규보,홍순조,이교영,심상인 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.9

유구치 I급 와동에서 와동벽 위치와 중합광원에 따른 Microtensile Bond Strength 비교 연구

이현헌,장철호,김영재,김정욱,장기택 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.1

이번 실험에서는 중합수축 응력이 가장 크게 나타나는 유구치 I급 와동에서 와동벽의 위치와 중합광원의 변화에 의해 다르게 나타나는 응력의 차이를 microtensile bond strength (MTBS)를 이용하여 알아보는 것을 목적으로 하였다. 교합면 법랑질을 제거한 하악 제 2유구치 30개를 준비하여 I급 와동을 형성하였다. 제조사의 지시에 따라 상아질 접착제를 도포 후 3가지 중합광원: 할로겐 램프, 플라즈마, 발광다이오드를 이용하여 10개씩 광중합하였다. 복합레진을 한꺼번에 충전 후 각각의 중합기로 광중합하였다. 동일 치아에서 각각 치수벽과 축벽의 MTBS 측정용 시편을 제작하고 각 군을 중합광원과 와동벽 위치에 따라 할로겐 램프-축군, 할로겐 램프-치수벽군, 플라즈마-축벽군, 플라즈마-치수벽군, 발광다이오드-축벽군, 발광다이오드-치수벽군의 6개 군으로 분류하였다. 만능시험기에서 MTBS를 측정하고 파절편과 와동의 단면을 SEM을 이용하여 관찰하였다. 동일 중합광원에서 와동벽 간 비교는 T-test, 동일 와동벽에서 중합광원 간 비교는 One-way ANOVA와 Tukey's post hoc test를 이용하였고 Weibull 분포분석을 하였다. 동일 중합광원 군간 비교에서 모두 치수벽 시편의 접착강도가 축벽 시편에 비해 유의하게 높았으며 동일 와동벽 군간 비교에서 모두 중합광원에 따른 접착강도가 유의한 차이를 보이지 않았다. 축벽 시편이 치수벽 시편보다 낮은 Weibull 변수(m)를 나타내었고 SEM 관찰 결과 축벽 시편에서 보다 더 불균일한 접착이 이루어진 것을 알 수 있었다. The purpose of present study was to determine whether different kinds of curing lights can alter microtensile bond strength(MTBS) of class I cavity pulpal and axial wall specimens in primary molar. Thirty clean mandibular 2nd primary molar's occlusal enamel were removed and class I cavity, size of 2×4×2 mm was prepared. Dentin bonding agent was applied according to manufacturer' s manual. Each group was cured with Halogen Curing Unit, Plasma Curing Unit and LED Curing Unit. Composite resin was bulk filled and photo cured with same curing unit. MTBS specimens which size is 0.7×0.7×4 mm were prepared with low speed saw. Specimens were coded by their curing lights and wall positions (Halogen - Axial wall group, Halogen - Pulpal wall group, Plasma - Axial wall group, Plasma - Pulpal wall group, LED - Axial wall group, LED - Pulpal wall group). MTBS were tested at 1 mm/min cross Head speed by Universal Testing Machine. Fractured surface and bonding surface was observed with SEM. T-test between axial and pulpal specimens in each curing lights, one-way ANOVA among different curing light specimens in each wall positions were done. Weibull distribution analysis was done. The results were as follows: Mean MTBS of pulpal wall specimens were significantly greater than that of axial wall specimens at each curing units(p<.05). There was no significant difference in the MTBS among three curing units at axial wall and pulpal wall. In Weibull distribution, pulpal wall specimens were more homogeneous than axial wall specimens.

Wiskott-Aldrich 증후군 환아의 증례보고

이연주,현홍근,장철호,김영재,김정욱,장기택,김종철,한세현,이상훈 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.3

폐경 전후 여성의 신체활동 및 생활습관과 골 밀도 수치와의 관련성

배성욱,남철현,홍성철,최연희,이정옥,양숙희 대한보건협회 2002 대한보건연구 Vol.28 No.3

To evaluate the degree of bone mineral density according to physical activity, lifestyle in pre- and postmenopausal women. The subjects were 951 premenopausal and 1,167 postmenopausal women who have examined in health promotion center of Yeungnam University Hospital in Daegu city from January, 1999 to Januaty, 2001. The test for bone mineral density. The physical activity and life style were evaluated by questionaire through interview. The results were summarized as follow. 1) The prevalence rates of reduced bone mineral density and osteoporosis in premenopausal women were 23.8% and 1.6%, respectively. However, these values were increased to 46.1% and 28.1% in postmenopausal women. 2) The regular exercise was revealed to have preventive effect for osteoporosis in pre- and postmenopausal women. Among the types of exercise, the most effective exercise was bowling and moderately effective exercise was swimming on prevention of osteoporosis, however, bare hand physical exercise was not significant effect on bone mineral density. 3) The risk for reducing bone mineral density was decreased in women who have higher educational background and income in pre- and postmenopausal. The bone mineral density was highest in white color worker and lowest in blue color worker. 4) The premenopausal women who favor meat were revealed higher bone mineral density than the women who favor vegetable. The women who have drunk none or small amount of alcohol were revealed increased bone mineral density and smoking was a risk factor for osteoporosis. These results suggested that to prevent osteoporosis, the systemized program for promoting anti-osteoporotic factor have to be developed and apply from the thirties whom have maximal bone mineral density.

이차성 기질화 폐렴이 동반된 피부근염 1예

박철연,권정석,정진욱,이충기,현대성,최정윤 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Dermatomyositis is characterized by progressive, symmetric, Proximal muscle weakness and a nonsuppurative inflammatory myopathy of unknown etiology involving predominantly skeletal muscles. It is also characterized by typical skin lesions. Interstitial lung disease has a poor prognosis when it is associated with dermatomyositis. Organizing pneumonia is a disease in which granulation tissue fills the lumina of terminal and respiratory bronchioles and extends into the distal airspaces. The cryptogenic nature of the process is appreciated in that organizing pneumonia patterns of injury can be seen in secondary forms of the disease (secondary organizing pneumonia). Organizin pneumonia has been reported to occur in 5~10% in dermatomyositis-polymyositis patients Anti-histidyl tRNA synthetase antibody (anti-Jo-1) is a Predictive disease marker that is reported to occur in up to 70% of patients. We describe a 49-year-old male dermatomyosits patient who presented with organizing pneumonia and was found to have negative anti-Jo-1 antibody.

당뇨병 환자에서 혈장 Thrombin-Antithrombin Ⅲ 및 Plasmin-α_2-Plasmin Inhibitor 복합체의 임상적 의의

김경욱,김은숙,정상수,윤수지,박우일,이준희,남수연,안철우,문병수,김경래,차봉수,송영득,임승길,이현철,허갑범 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.5

연구배경:당뇨병 환자에서 혈액응고 및 섬유소용해 체계의 이상경향이 있어 그 결과로 여러 혈관합병증의 발생위험이 높다는 사실은 널리 알려져 있다. 그 기전은 아직 확실히 밝혀지지 않았으나, 고혈당으로 인한 혈장 단백질들의 비효소성 당화작용이나 산화성 스트레스로 인한 유리 라티칼 작용으로 응고항진이나 섬유소용해 활성의 저하를 유발하는 것으로 생각되고 있다. 최근 응고 및 용해인자와 그 억제자의 복합체들의 증가가 이 상태를 비교적 예민하게 반영한다고 알려져 있다. 방법:본 연구에서는 당뇨병 환자 101명과 정상 대조군 20명에서 혈장내 thrombin­antithrombin complex(TAT)와 plasmin­α₂­plasmin inhibitor complex(PIC)를 측정하여 비교하고, 당뇨병 환자에서 미세혈관 합병증과 대혈관합병증의 유무에 따른 차이와, 이미 혈관 질환의 위험인자로 알려져 있는 인자들간의 상관성을 알아보고자 하였다. 결과:1. 환자의 분포를 살펴보면 혈관합병증이 있는 군은 85명, 혈관합병증이 없는 군은 16명이었고, 평균연령은 각각 57.9±14.1세, 49.9±16.6세로 혈관 합병증이 있는 군에서 더 나이가 많았고, 체질량지수는 23.2±3.4㎏/㎡, 24.1±3.4㎏/㎡로 두 군간 유의한 차이는 없었다. 또 두 군간의 혈압 및 HbA1c, 공복혈당 및 인슐린과 C­peptide, 총 콜레스테롤, 중성지방, HDL­콜레스테롤, Lp⒜는 유의한 차이가 없었고, 미세혈관합병증이 있는 군에서 당뇨병의 유병기간이 길었다. 2. TAT 및 PIC의 농도는 정상 대조군에서는 2.8±1.2 ng/mL, 240.4±69.7 ng/mL이었고, 당뇨병 환자군에서는 9.5±22.6 ng/mL, 472.2±258.7 ng/mL이었다. TAT와 PIC 모두 당뇨병 환자군에서 정상 대조군에 비해 유의하게 증가되어 있었고(p<0.001), TAT/PIC ratio는 두 군간 차이가 없었다. 3. 당뇨병 환자의 혈관합병증에 따른 TAT 및 PIC, fibrinogen 농도는 합병증이 없는 군은 각각 4.1±2.4ng/mL, 362.2±272.0ng/mL, 322.7±102.4mg/mL으로 PIC와 fibrinogen의 증가를 보였으나, 연령을 보정한 후에는 통계학적 유의성은 없었다. 또 대혈관 합병증군에서는 각각 6.0±4.9 ng/mL, 507.4±321.6 ng/mL, 427.1±194.7 mg/dL이었으며 미세·대혈관 합병증군에서는 10.4±6.4 ng/mL, 484.8±269.7 ng/mL, 388.4±132.4 mg/dL으로 TAT의 증가를 보였으나 역시 연령을 보정한 후에는 통계학적 유의성은 없었다. 4. 미세혈관합병증군에서 HbA1c(>8%)가 높은 군의 PIC 농도가 유의하게 높았고(p=0.049), 대혈관합병증군에서 HbA1c(>8%)가 높은 군의 총 콜레스테롤 농도가 유의하게 높았다(p=0.042). 5. 총 당뇨병 환자군에서 PIC는 fibrinogen과 HbA1c와 양의 상관관계를, BMI와 음의 상관관계를 보였으며(r=0.47, 0.31,-0.25), 혈관 합병증이 없는 당뇨병 환자군에서만 TAT는 HbA1c와 양의 상관관계를 보였다(r=0.67). 결론:이상의 결과에서 혈장 TAT 및 PIC 농도는 당뇨병 환자에서 정상 대조군에 비해 의미있게 증가되어 있었고, 당뇨병 환자군에서는 연령의 증가와 유병기간이 혈액응고항진 및 용해의 장애에 큰 역할을 함을 알 수 있었으며, 총 당뇨병 환자군에 PIC와 HbA1c와 양의 상관관계를, BMI와 음의 상관관계를 보였으며 혈관 합병증이 없는 당뇨병 환자군에서만 TAT는 HbA1c와 양의 상관관계를 보였다. 따라서 당뇨병 환자에서 혈액응고 및 용해의 장애가 동반되어 있다고 볼 수 있으며, 혈장 TAT 및 PIC는 혈관합병증으로의 진행을 예측하는 지표로서 유용하리라 생각된다. 또 혈당조절정도와 상관성이 있으므로 혈당조절후에 추적검사를 시행하여 합병증의 예방이 가능한지 추후 연구가 필요하리라 생각된다. Background : Abnormality of coagulation and fibrinolystic system is known as a predisposing factor of vascular complication in diabetes. Although the pathogenesis is not well known, non-enzymatic glycation reaction and the increase in production of free radicals due to an increased oxidative stress may be linked to the hypercoagulibility and hypofibrinolytic activity. As indices of abnormality in coagulation and firinolysis in peripheral blood, plasma thrombin-antithrombin Ⅲ complex (TAT) and plasmin-α_2-plasmin inhibitor complex (PIC) were measured. The purpose of this study was to clarify whether hypercoagulability exists in diabetic patients with or without vascular complication. Methods : In our study, we measured plasma thrombin-antithrombin Ⅲ compelx (TAT) and plasmin-α_2-plasmin inhibit or complex (PIC) in 101 diabetic subjects and 20 controls. Comparing TAT and PIC levels in diabetic microvascular complication group, diabetic macrovascular complication group and controls, we examined correlation between risk factors associated with diabetic vascular complication. Results : 1. The group with diabetic vascular complication was older than group without complication. There was no significant difference in BMI, blood pressure, HbA_ic, blood sugar level, insulin, C-peptide, serum creatinine, total cholesterol, triglyceride, HDL-cholesterol, Lp (a) between two groups. The group with diabetic microvascular complication had longer duration of diabetes. 2. Concentration of TAT and PIC were 2.8±1.2 ng/ mL, 240.4±69.7 ng/ mL in controls and 9.5±22.6 ng/ mL, 472.2±258.7 ng/ mL in diabetic patients, respectively. TAT and PIC were significantly higher in diabetic patients than in control (p<0.001). But TAT/PIC ratio was no significant difference between two groups. 3. In diabetic patients, concentration of TAT and PIC and fibrinogen were respectively 4.1±2.4 ng/ mL, 362.2±272.0 ng/ mL, 322.7±102.4 mg/ dL in group without vascular complication and 5.3±4.1 ng/ mL, 529.5±258.7 ng/ mL, 374.9±106.2 mg/ dL in group with microvascular complication, which group had increase in PIC and Fibrinogen but no significance after correction of age. Concentration of TAT and PIC and Fibrinogen were 60.±4.9 ng/ mL, 507.4±321.6 ng/ mL, 427.1±194.7 mg/ dL in macrovascular complication, and 10.4±6.7 mg/ mL, 484.8±269.7 ng/ mL, 388.4±132.4 mg/ dL in combined vascular complication which group showed increase of TAT but also had no significant increase after correction of age. 4. In diabetic microvascular complication patients, group of high HbA_1c (>8%) (p=0.049) had significant high PIC concentration. In diabetic macrovascular complication patients, group of high HbA_1c (>8%) (p=0.042) had significant high total cholesterol concentration. 5. In all diabetic patients, PIC was positively correlated with fibrinogen and HbA_1c and negatively correlated BMI (r=0.47, 0.31, -0.25). Only in daibetic patients without angiopathy, TAT was positively correlated with HbA_1c (r=0.67). Conclusion : In this study, plasma TAT and PIC concentration significantly increased in diabetic patients compared with controls, and PIC was increased in group with microvascular complication, TAT were increased in group with combined micro macrovascular complication. However, there was no significance relationship existed when correctinf for age. PIC was correlated with HbA_1c. TAT was correlated with HbA_1c only in the group without angiopathy. Abnormality of coagulation and fibrinolysis were combined in diabetes, plasma TAT and PIC can be used as an index of vascular complication. Also we found the correlation with the degree of the blood glucose control. Therefore we need follow up study for the possibility of prevention of vascular complication after controlling the blood glucose to age-matched patients (J Kor Diaabetes Asso 25:354~363, 2001).

삼일열 말라리아에 합병된 비장 파열 1예

홍경욱,이정아,김원진,박철민,권혜리,박혜원,엄중식 대한감염학회 2007 감염과 화학요법 Vol.39 No.5

국내의 토착형 말라리아는 삼일열 말라리아로, 1993년부터 재유행이 시작되었다. 말라리아의 중요한 합병증으로 드물지만 비장 파열이 있는데, 이는 주로 삼일열 말라리아에 의해서 발생되며, 국내에서는 1999년 말라리아에 의한 비장 파열로 비장 절제술을 시행한 예가 보고된 바 있다. 현재까지는 비장 파열이 있을 때 비장 절제술이 일차적인 치료로 되어 있으나, 비장 절제술 후의 감염 위험성이 크므로, 활력 징후가 불안정하거나, 출혈이 지속되는 소견이 보이지 않으면 가급적 보존적 치료를 하는 것이 추천된다. 저자들은 비장 파열이 동반된 말라리아 환자에서 비장 절제술을 시행하지 않고 보존적 치료로 호전된 예를 경험하여 보고하는 바이다. Plasmodium vivax has been the predominant Plasmodium species in the Republic of Korea and reemerged in 1993. Spontaneous rupture of malarial spleen is a rare but important complication associated with P. vivax infection. Only one case of spontaneous rupture of malarial spleen was reported in Korea in 1999. Splenectomy is still accepted as the treatment of choice in cases of spontaneous rupture of the spleen. But, considering increased risk of postsplenectomy infecion, splenectomy should be reserved for those patients with severe rupture or those with continued or recurrent bleeding. And conservative treatment should be considered in selected, closely monitored patients. We report a patient with P. vivax malaria who developed a spontaneous splenic rupture and was improved by conservative treatment.

군 훈련병의 스트레스, 성인 주의력결핍 과잉행동장애 증상과 자살사고의 연관성에 관한 연구

이동윤,이철순,박철수,손진욱,김봉조,차보석,이소진 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study is conducted to investigate the effect of Attention Deficit and Hyperactivity Disorder(ADHD) symptoms on stress and suicide idea among 224 conscripts. Methods:Total number of subject is 224 conscripts. We evaluate symptoms of adult ADHD with Korean-Wender Utah rating scale(K-WURS) and Korean adult attention-deficit/hyperactivity disorder scale(K-AADHDS), stress with Brief Encounter Psychosocial Instrument-K(BEPSI-K), suicide idea with Scale for suicide ideation(SSI) after basic military training. Multivariate logistic analysis with backward stepwise selection is performed to evaluate risk factors of stress. Multiple linear regression analysis with stepwise selection is performed to evaluate association of suicide idea with adult ADHD symptoms. Results:Stress is significantly associated with K-WURS score, K-AADHDS score and SSI score(p<0.01, p<0.05, p<0.01). K-WURS score are significant risk factor of stress after basic military training(p<0.05, O.R : 1.034, 95% CI : 1.005-1.065). And K-WURS score influence suicide idea after basic military training(p<0.05, β : 0.031). Conclusion:The result suggests that K-WURS score might be a risk factor of stress and could affect suicide idea.

침엽수 구조용 정각재의 천연건조곡선과 함수율분포

정희석,이철현,강욱,엄창득 한국목재공학회 2003 목재공학 Vol.31 No.1

이 논문은 소나무와 일본잎갈나무의 변장 14.0cm와 16.5cm인 큰 정각재의 천연건조과정과 함수율분포에 관한 내용으로서 건조속도는 건조개시 첫 8주 동안 비교적 컸었으나 그 이후부터 점차 감소하였다. 생재에서 규격함수율 18% 수준까지 건조시간은 소나무 14.0cm와 16.5cm가 각각 26주와 32주이고, 일본잎갈나무의 경우는 각각 32주와 48주이었다. 이들 정각재의 재장방향과 두께방향의 수분경사는 비교적 완만하였다. 일본잎갈나무의 수분경사는 소나무의 것보다 컸었고, 일본잎갈나무의 변장의 크기가 수분경사에 미치는 영향은 소나무의 것보다 컸었다. This paper presents the results of air-drying processes and mositure content (MC) distribution of red pine (P. densiflora) and Japanese larch (I. leptolepis) square timber with 14 cm and 16.5 cm of face size, respectively. The air-drying rates of square timber were comparatively high during the first 8 weeks, after that gradually decreased. The time to air dry square timber from initial MC to specified MC of 18 percent required about 26 weeks for 14.0 cm and 32 weeks for 16.5 cm square of red pine, and 32 weeks for 14.0 cm and 48 weeks for 16.5 cm square of Japanese larch. The longitudinal-and transverse MC distribution of these air-dried squares showed slight moisture gradient. The effect of face size on moisture gradient of Japanese larch square was more pronounced comparing with red pine one.

액상 에피탁시법으로 成長시킨 GaAs의 Photoluminescence

裵仁鎬,李哲旭,金仁洙 嶺南大學校 基礎科學硏究所 1992 基礎科學硏究 Vol.12 No.-

Eptaxial layers of undoped GaAs were grown by liquid phase epitaxity(LPE) method on semi-insulating GaAs(100) substrates. GaAs epitaxial layers were characterized by photoluminescence(PL). In the as-grown LPE samples, the emission peaks observed at 1.511, 1.492 and 1.478eV. A PL peak at 5.11eV attributed to the excitons bound to neutral acceptors, and the peaks at 1.492 and 1.478eV were related to carbon and germanium, respectively. The crystal quality of the samples with gallium baking were superior to without baking. Increasing the excitation intensity, the exciton peak varies sensivity, but the peaks due to impurities no significant change. As the anneal temperature is increased, the crystal quality of samples are reduced.