Stability and electronic properties of CuAlO2 (112 0) surfaces

Cheng-Lu Jiang,Qi-Jun Liu,Fu-Sheng Liu,Zheng-Tang Liu 한국물리학회 2017 Current Applied Physics Vol.17 No.2

We have studied the stability and electronic properties of CuAlO2 ð112 『 0Þ surfaces using the firstprinciples calculations. The structural parameters, band structures, surface energies, work functions, densities of states and charge densities of CuAlO2 ð112 『 0Þ surfaces have been investigated. The calculated results show that five layers are needed to maintain convergence. After the formation of surfaces, the bandgaps of stable surfaces decrease, the covalency between Cu and O atoms in surfaces increases, and the positive charge layer in the fisrt layer appears.

Intravenous Tenecteplase for Acute Ischemic Stroke Within 4.5–24 Hours of Onset (ROSE-TNK): A Phase 2, Randomized, Multicenter Study

Wang Lu,Dai Ying-Jie,Cui Yu,Zhang Hong,Jiang Chang-Hao,Duan Ying-Jie,Zhao Yong,Feng Ye-Fang,Geng Shi-Mei,Zhang Zai-Hui,Lu Jiang,Zhang Ping,Zhao Li-Wei,Zhao Hang,Ma Yu-Tong,Song Cheng-Guang,Zhang Yi,Ch 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.3

Background and Purpose Intravenous tenecteplase (TNK) efficacy has not been well demonstrated in acute ischemic stroke (AIS) beyond 4.5 hours after onset. This study aimed to determine the effect of intravenous TNK for AIS within 4.5 to 24 hours of onset. Methods In this pilot trial, eligible AIS patients with diffusion-weighted imaging (DWI)-fluid attenuated inversion recovery (FLAIR) mismatch were randomly allocated to intravenous TNK (0.25 mg/kg) or standard care within 4.5–24 hours of onset. The primary endpoint was excellent functional outcome at 90 days (modified Rankin Scale [mRS] score of 0–1). The primary safety endpoint was symptomatic intracranial hemorrhage (sICH). Results Of the randomly assigned 80 patients, the primary endpoint occurred in 52.5% (21/40) of TNK group and 50.0% (20/40) of control group, with no significant difference (unadjusted odds ratio, 1.11; 95% confidence interval 0.46–2.66; <i>P</i>=0.82). More early neurological improvement occurred in TNK group than in control group (11 vs. 3, <i>P</i>=0.03), but no significant differences were found in other secondary endpoints, such as mRS 0–2 at 90 days, shift analysis of mRS at 90 days, and change in National Institutes of Health Stroke Scale score at 24 hours and 7 days. There were no cases of sICH in this trial; however, asymptomatic intracranial hemorrhage occurred in 3 of the 40 patients (7.5%) in the TNK group. Conclusion This phase 2, randomized, multicenter study suggests that intravenous TNK within 4.5–24 hours of onset may be safe and feasible in AIS patients with a DWI-FLAIR mismatch.

New Compounds from Euphorbia helioscopia and Absolute Configuration Determination by Computational Methods

He, Jiang-Bo,Zhu, Hua-Jie,Luo, Gui-Fen,Liu, Guang-Ming,Chen, Hao,Li, Yan,Chen, Shaopeng,Lu, Xin,Zhou, Guochun,Cheng, Yong-Xian Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.8

The whole plant of Euphorbia helioscopia is an important traditional Chinese medicine. Fom its BuOH soluble extract, one new lactam (1), three new terpenoids (2-4) including a new naturally occurring compound, and three known compounds were isolated. Their structures were identified by spectroscopic evidences. In particular, the absolute configurations of side chain of compounds 1 and 2 were determined using computational methods.

Iterative Generation Method of Arc Length Parameterized Curve Tool Path for Surface Machining from Short-Line Tool Path

Lei Lu,Jiang Han,Lian Xia,Cheng Fan,Haijun Liu,Shan Chen 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.10

To improve the application of the parametric curve tool path in surface machining, a method for generating arc-length parameterized toolpaths based on short-line toolpaths is proposed. The method first uses commercial CAM software to plan the short-line tool path. Then, the machining tool path with smooth continuous features is extracted. The smooth and continuous features are determined according to the chord length of the short-line tool path, and the extraction method is based on Chebyshev’s inequality of large numbers. After obtaining the smooth short-line trajectory, the iterative arc-length parameterized curve toolpath generation method is used to fit the discrete short-line toolpath. In the iterative process, the B-spline toolpath with parameterized chord length is obtained first. It is discretized according to the arc length difference information of the chord length B-spline. Finally, by continuously checking and inserting B-spline nodes, and fitting according to discrete points, the arc-length parameterized B-spline tool path is obtained. The feasibility of the method is verified with a part containing a sculpted surface, and two smooth arc-length parametric toolpaths are generated. In the end, the part is machined with the arc-length parameterized curve tool path.

A novel class of pyranocoumarin anti-androgen receptor signaling compounds.

Guo, Junming,Jiang, Cheng,Wang, Zhe,Lee, Hyo-Jeong,Hu, Hongbo,Malewicz, Barbara,Lee, Hyo-Jung,Lee, Jae-Ho,Baek, Nam-In,Jeong, Jin-Hyun,Kim, Dae-Keun,Kang, Kyung-Sun,Kim, Sung-Hoon,Lu, Junxuan American Association for Cancer Research 2007 Molecular Cancer Therapeutics Vol.6 No.3

<P>Androgen and the androgen receptor (AR)-mediated signaling are crucial for prostate cancer development. Novel agents that can inhibit AR signaling in ligand-dependent and ligand-independent manners are desirable for the chemoprevention of prostate carcinogenesis and for the treatment of advanced prostate cancer. We have shown recently that the pyranocoumarin compound decursin from the herb Angelica gigas possesses potent anti-AR activities distinct from the anti-androgen bicalutamide. Here, we compared the anti-AR activities and the cell cycle arrest and apoptotic effects of decursin and two natural analogues in the androgen-dependent LNCaP human prostate cancer cell culture model to identify structure-activity relationships and mechanisms. Decursin and its isomer decursinol angelate decreased prostate-specific antigen expression with IC(50) of approximately 1 mumol/L. Both inhibited the androgen-stimulated AR nuclear translocation and transactivation, decreased AR protein abundance through proteasomal degradation, and induced G(0/1) arrest and morphologic differentiation. They also induced caspase-mediated apoptosis and reactive oxygen species at higher concentrations. Furthermore, they lacked the agonist activity of bicalutamide in the absence of androgen and were more potent than bicalutamide for suppressing androgen-stimulated cell growth. Decursinol, which does not contain a side chain, lacked the reactive oxygen species induction and apoptotic activities and exerted paradoxically an inhibitory and a stimulatory effect on AR signaling and cell growth. In conclusion, decursin and decursinol angelate are members of a novel class of nonsteroidal compounds that exert a long-lasting inhibition of both ligand-dependent and ligand-independent AR signaling. The side chain is critical for sustaining the anti-AR activities and the growth arrest and apoptotic effects.</P>

Research on Synchronous Phase Shift Control Strategy of Bilateral Converter in Bidirectional Inductive Power Transfer System

Wang Songcen,Jiang Cheng,Lu Qiang,Xia Chenyang,Wei Nan 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.5

It is the key to realize the precise control of power transfer direction and energy to ensure the synchronous phase shift of the bilateral converters in bidirectional inductive power transfer (BD-IPT) system. In order to solve the problem that wireless communication is adopted in bidirectional inductive power transfer system, and the delay caused by the power oscillation aff ects power transfer. A method for synchronizing the control signals of the bilateral converters that track the extreme value of the output DC current is proposed in this paper, and dual phase-shift control is adopted to make the system effi cient when it operates in a wide output power range. First, the power and effi ciency characteristics of the BDIPT system are analyzed in the paper. Next, a method to track the extreme value of the output DC current is designed for synchronization. Then, in order to ensure that the system maintains high-effi ciency operation in a wide power range, a bilateral phase shift control is proposed. Finally, the validity of the scheme is verifi ed through simulation and experiment.

CNC tool path generation for freeform surface machining based on preferred feed direction field

Guanying Huo,Xin Jiang,Cheng Su,Zehong Lu,Yuwen Sun,Zhiming Zheng,Deyi Xue 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.5

This paper presents a novel method to generate three-axis CNC tool paths for machining freeform surfaces based on a preferred feed direction field. This research was initiated from a fluid dynamics behavior that the energy loss can be reduced when the streamlines of fluid and the small grooves on a surface are in the same directions. In this research, the fluid streamlines above the surface are defined by a collection of vectors. These vectors are regularized into a grid of vectors, and these regularized vectors are further projected onto the tangent planes of a grid of points on the surface to create the preferred feed direction field. Based on the parametric model of the surface, the vectors on the tangent planes of the surface are mapped into vectors in the parametric domain. A scalar function is constructed such that the isolines of this scalar function and the preferred feed direction vectors in the parametric domain are in the same directions. A group of isolines of the scalar function are identified and these isolines are mapped back onto the 3-D surface as the created tool paths considering the tolerance requirement. The developed method has been applied to generate the tool paths for machining surfaces of a compressor blade.

Management Strategy for Congenital Choledochal Cyst with Co-existing Intrahepatic Dilation and Aberrant Bile Duct As Well As Other Complicated Biliary Anomalies

Qian Dong,Buxian Jiang,Hong Zhang,Zhong Jiang,Hongting Lu,Chuanmin Yang,Yu Cheng,Xiwei Hao 연세대학교의과대학 2006 Yonsei medical journal Vol.47 No.6

The purpose of this study was to investigate and discuss imaging methods and management strategies for congenital choledochal cyst with co-existing intrahepatic dilation and aberrant bile duct as well as other complicated biliary anomalies. In this study we reviewed and analyzed 72 patients with congenital choledochal cyst, ranging in age from 15 days to 12 years old and who were seen at our hospital during the past 12 years, from January 1993 to October 2005. The image manifestation and clinical significance of patients with co- xisting intrahepatic biliary dilation and aberrant bile duct were carefully examined during operation via MRCP, cholangiography and choledochoscope. Twenty-two cases (30.1%) presented with intrahepatic bile duct dilation and 12 of these were of the cystic type. That is, the orifice of the dilated intrahepatic tract that converged into the common hepatic duct showed membrane or septum-like stenosis. In 10 cases the dilation tapered off from the porta hepatis to the initiating terminals of the intra-hepatic bile ducts and was not accompanied by stenosis. An aberrant bile duct was observed in 2 of the cases. In 3 cases, the right and left hepatic ducts converged at the choledochal cyst. In conclusion, the imaging methods for intrahepatic bile duct dilation possess important clinical significance. Further, for hepatojejunostomy with radical excision of a choledochal cyst, additional operative procedures for intrahepatic stenosis, possible bile duct malformation and pancreaticobiliary common duct calculi can potentially reduce postoperative complications.

Heavy concrete shielding properties for carbon therapy

Jin-Long Wang,Jiade J Lu,Da-Jun Ding,Wen-Hua Jiang,Ya-Dong Li,Rui Qiu,Hui Zhang,Xiao-Zhong Wang,Huo-Sheng Ruan,Yan-Bing Teng,Xiao-Guang Wu,Yun Zheng,Zi-Hao Zhao,Kai-Zhong Liao,Huan-Cheng Mai,Xiao-Dong Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.6

As medical facilities are usually built at urban areas, special concrete aggregates and evaluation methods are needed to optimize the design of concrete walls by balancing density, thickness, material composition, cost, and other factors. Carbon treatment rooms require a high radiation shielding requirement, as the neutron yield from carbon therapy is much higher than the neutron yield of protons. In this case study, the maximum carbon energy is 430 MeV/u and the maximum current is 0.27 nA from a hybrid particle therapy system. Hospital or facility construction should consider this requirement to design a special heavy concrete. In this work, magnetite is adopted as the major aggregate. Density is determined mainly by the major aggregate content of magnetite, and a heavy concrete test block was constructed for structural tests. The compressive strength is 35.7 MPa. The density ranges from 3.65 g/cm³ to 4.14 g/cm³, and the iron mass content ranges from 53.78% to 60.38% from the 12 cored sample measurements. It was found that there is a linear relationship between density and iron content, and mixing impurities should be the major reason leading to the nonuniform element and density distribution. The effect of this nonuniformity on radiation shielding properties for a carbon treatment room is investigated by three groups of Monte Carlo simulations. Higher density dominates to reduce shielding thickness. However, a higher content of high-Z elements will weaken the shielding strength, especially at a lower dose rate threshold and vice versa. The weakened side effect of a high iron content on the shielding property is obvious at 2.5 µSv=h. Therefore, we should not blindly pursue high Z content in engineering. If the thickness is constrained to 2 m, then the density can be reduced to 3.3 g/cm³, which will save cost by reducing the magnetite composition with 50.44% iron content. If a higher density of 3.9 g/cm³ with 57.65% iron content is selected for construction, then the thickness of the wall can be reduced to 174.2 cm, which will save space for equipment installation.

Empirical Selection of Informative Microsatellite Markers within Co-ancestry Pig Populations Is Required for Improving the Individual Assignment Efficiency

Lia, Y.H.,Chu, H.P.,Jiang, Y.N.,Lin, C.Y.,Li, S.H.,Li, K.T.,Weng, G.J.,Cheng, C.C.,Lu, D.J.,Ju, Y.T. Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.5

The Lanyu is a miniature pig breed indigenous to Lanyu Island, Taiwan. It is distantly related to Asian and European pig breeds. It has been inbred to generate two breeds and crossed with Landrace and Duroc to produce two hybrids for laboratory use. Selecting sets of informative genetic markers to track the genetic qualities of laboratory animals and stud stock is an important function of genetic databases. For more than two decades, Lanyu derived breeds of common ancestry and crossbreeds have been used to examine the effectiveness of genetic marker selection and optimal approaches for individual assignment. In this paper, these pigs and the following breeds: Berkshire, Duroc, Landrace and Yorkshire, Meishan and Taoyuan, TLRI Black Pig No. 1, and Kaohsiung Animal Propagation Station Black pig are studied to build a genetic reference database. Nineteen microsatellite markers (loci) provide information on genetic variation and differentiation among studied breeds. High differentiation index ($F_{ST}$) and Cavalli-Sforza chord distances give genetic differentiation among breeds, including Lanyu's inbred populations. Inbreeding values ($F_{IS}$) show that Lanyu and its derived inbred breeds have significant loss of heterozygosity. Individual assignment testing of 352 animals was done with different numbers of microsatellite markers in this study. The testing assigned 99% of the animals successfully into their correct reference populations based on 9 to 14 markers ranking D-scores, allelic number, expected heterozygosity ($H_E$) or $F_{ST}$, respectively. All miss-assigned individuals came from close lineage Lanyu breeds. To improve individual assignment among close lineage breeds, microsatellite markers selected from Lanyu populations with high polymorphic, heterozygosity, $F_{ST}$ and D-scores were used. Only 6 to 8 markers ranking $H_E$, $F_{ST}$ or allelic number were required to obtain 99% assignment accuracy. This result suggests empirical examination of assignment-error rates is required if discernible levels of co-ancestry exist. In the reference group, optimum assignment accuracy was achievable achieved through a combination of different markers by ranking the heterozygosity, $F_{ST}$ and allelic number of close lineage populations.