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Qian, Ying-Ying,Liu, Xin-You,Wu, Qian,Song, Xian,Chen, Xiao-Feng,Liu, Yi-Qian,Pei, Dong,Shen, Li-Zong,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19
Background: Although the predictive value of the excision repair cross-complementing group 1 (ERCC1) C118T polymorphism in clinical outcomes of patients with colorectal cancer (CRC) receiving oxaliplatin-based chemotherapy has been evaluated in numerous published studies, the conclusions are conflicting. Therefore, we performed the present meta-analysis to determine the precise role of the ERCC1 C118T polymorphism in this clinical situation and help optimize individual chemotherapy. Materials and Methods: A multiple search strategy was used to identify eligible studies. Pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were used to estimate objective response and oxaliplatin-induced toxicity, with hazard ratios (HRs) with 95%CIs for progression-free survival (PFS) and overall survival (OS). Results: A total of 22 studies including 2,846 CRC patients were eligible in the analysis. Overall, no significant correlation was found between the ERCC1 C118T polymorphism and objective response to oxaliplatin-based chemotherapy, in all patients or in the Asian and Caucasian subgroups. However, the pooled analysis showed that the PFS and OS were significantly shorter in patients who carried T/T or T/C genotypes of ERCC1 C118T as compared to the C/C genotype. On stratified analysis by ethnicity, the ERCC1 118T allele was associated with a favorable prognosis in Caucasians (PFS, HR=0.58, 95%CI: 0.24-1.44; OS, HR=0.38, 95%CI: 0.22-0.64) but an unfavorable prognosis in Asians (PFS, HR=2.49, 95%CI: 1.87-3.33; OS, HR=2.63, 95%CI: 1.87-3.69) based on a dominant model. In addition, we failed to find a statistically significant impact of ERCC1 C118T polymorphism on oxaliplatin-induced toxicity. Conclusions: The ERCC1 C118T polymorphism may have prognostic value in patients with CRC undergoing oxaliplatin-based chemotherapy.
On-vehicle triboelectric nanogenerator enabled self-powered sensor for tire pressure monitoring
Qian, Jingui,Kim, Dong-Su,Lee, Dong-Weon Elsevier 2018 Nano energy Vol.49 No.-
<P><B>Abstract</B></P> <P>Tire pressure monitoring systems (TPMS) are becoming increasingly important in an effort to ensure safe and efficient use of tires in the automotive sector. There is growing interest in using energy harvesting technologies to provide power for TPMS because battery supply has serious drawbacks such as replacement difficulty, limited durability and environmental pollution. In this study, we proposed an on-vehicle magnetically triboelectric nanogenerator (V-TENG) scavenging rotating energy from tires and serves as a direct power source for tire pressure sensor. The V-TENG incorporates two different triboelectric materials with opposite polarities based on contact-electrification effect. The unique advantages of the seesaw balance structure are to overcome the influence of a large centrifugal force at high operating speed as well quadruple the efficiency contact areas of a miniaturized device. Noncontact magnets mounted on the brake calliper periodically actuate swing motion of multiple V-TENGs placed on the wheel hub. The V-TENG effectively generates electrical energy at the alarm temperature through a thermally stable polymer film. High electrical output has been achieved among the wide ranges of rotation speed and magnetic force through systematically experiments test. Meanwhile, there is no obvious decrease in the output voltage of the V-TENG after continuous working for about 12 h. Moreover, a battery-less pressure sensor was enabled by a single V-TENG device to measure barometric values of the ambient environment. The V-TENG also have been demonstrated to power a commercial wireless sensor for sending the real-time temperature data to a receiver and displaying on a monitor interface.</P> <P><B>Highlights</B></P> <P> <UL> <LI> On-vehicle triboelectric nanogenerator (V-TENG) as a direct power source for tire pressure monitoring system is developed. </LI> <LI> The unique seesaw balance structure minimizes the influence of large centrifugal force and quadruples the contact areas. </LI> <LI> High performance of the V-TENG is achieved with wide ranges of temperature, rotation speed and magnetic force. </LI> <LI> Durability and reliability of V-TENG are dramatically improved for long-term operation. </LI> <LI> The V-TENG successfully power small electronics, barometric pressure sensor and wireless sensor node. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Clinical Safety of Chemotherapy for Elderly Cancer Patients Complicated with Hypertension
Qian, Ya-Dong,Xu, Xu,Wang, Lin,Huang, Xin-En Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Objective: To access the safety of chemotherapy for elderly cancer patients complicated with hypertension. Methods: Elderly cancer patients who were complicated with hypertension and treated by chemotherapy were recruited. All patients were treated by chemotherapy after an intervention on hypertension by psychotherapy, exercise guidance, salt regulation and nutrition support, therapy on hypertension, as well as prevention on hypertension associated complications. Results: In 68 eligible patients, two suspended chemotherapy because of adverse reactions and 4 because of disease progression. The remaining 62 patients completed chemotherapy smoothly based on good hypertension control. Conclusion: With effective control of blood pressure, chemotherapy for elderly cancer patients complicated with hypertension is generally safe.
Development of Virtual Load Rating Method for Taxiway Bridge under Aircraft Taxiing
Qian Dong,Jianhua Wang,Xianmin Zhang,Hao Wang,Xisha Jin 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.7
This paper presents finite element model (FEM) based virtual load rating method for accurately and efficiently evaluating the bearing capacity of taxiway bridge in the field under aircraft taxiing. A dynamic load coefficient of aircraft loading was first developed considering deck pavement roughness and aircraft lift force. The in situ responses of taxiway bridges under 10 aircraft were collected using instrumentation system with acceleration sensor, strain sensor, and inclinometer. The modal frequency, strain influence lines, and deflections of taxiway bridge were obtained from FE analysis and in situ test. An optimization objective function in terms of fundamental frequency and strain influence lines was formulated to ensure convergence and effectiveness in the model updating process, wherein the bending stiffness, density and boundary conditions of the structures are selected as the design variables. The weighted-average method of model updating parameters was proposed considering the differences in the obtained parameters under different loading conditions. The analysis results of updated FE model were validated using static loading test conducted on taxiway bridge. Finally, the proposed virtual load rating method was applied to Taxiway Bridge V in Guangzhou Baiyun International Airport (CAN).
Qian, Jingui,Wu, Xuan,Kim, Dong-Su,Lee, Dong-Weon Elsevier Sequoia 2017 Sensors and actuators. A Physical Vol.263 No.-
<P><B>Abstract</B></P> <P>This study reports a seesaw-structured triboelectric nanogenerator (S-TENG) for efficiently harvesting electrical energy from rotational motion of mechanical systems. The designed S-TENG with two arms is comprised four contact-pair units with distinctly different triboelectric polarity materials. The generated electric power from the unique structure based on the seesaw system was double at every machine rotation cycle. A magnetically coupled contact mechanism was also utilized to reduce the wear of the polymer material. It was experimentally confirmed that the proposed design significantly improved the reliability and long-term stability in comparison with currently available TENG systems based on the sliding mechanism. In addition, micro-pyramid patterns were formed on the polymer surface to enhance the surface charge density. Through systematic experiments with a variety of operational conditions, an instantaneous maximum output power density of 13.86W/m<SUP>2</SUP> was achieved at a rotation speed of 200rpm under a constant magnetic field strength of 0.2T. The S-TENG has been demonstrated as a direct power source to drive small electronic devices such as commercial LED arrays and to charge an energy storage unit. This study further expanded the potential applications of the S-TENG to realize the self-powered wireless sensor nodes such as structural health and condition monitoring system.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A seesaw-structured triboelectric nanogenerator for wireless sensor node is proposed. </LI> <LI> The theory analysis of nonparallel contact-mechanism of TENG are presented. </LI> <LI> High output performance are achieved with various rotation speed and magnetic force. </LI> <LI> Long-term stability and reliability of rotating TENG are significantly improved. </LI> <LI> As power source to drive small electronics and wireless sensor node are demonstrated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Qian Dong,Buxian Jiang,Hong Zhang,Zhong Jiang,Hongting Lu,Chuanmin Yang,Yu Cheng,Xiwei Hao 연세대학교의과대학 2006 Yonsei medical journal Vol.47 No.6
The purpose of this study was to investigate and discuss imaging methods and management strategies for congenital choledochal cyst with co-existing intrahepatic dilation and aberrant bile duct as well as other complicated biliary anomalies. In this study we reviewed and analyzed 72 patients with congenital choledochal cyst, ranging in age from 15 days to 12 years old and who were seen at our hospital during the past 12 years, from January 1993 to October 2005. The image manifestation and clinical significance of patients with co- xisting intrahepatic biliary dilation and aberrant bile duct were carefully examined during operation via MRCP, cholangiography and choledochoscope. Twenty-two cases (30.1%) presented with intrahepatic bile duct dilation and 12 of these were of the cystic type. That is, the orifice of the dilated intrahepatic tract that converged into the common hepatic duct showed membrane or septum-like stenosis. In 10 cases the dilation tapered off from the porta hepatis to the initiating terminals of the intra-hepatic bile ducts and was not accompanied by stenosis. An aberrant bile duct was observed in 2 of the cases. In 3 cases, the right and left hepatic ducts converged at the choledochal cyst. In conclusion, the imaging methods for intrahepatic bile duct dilation possess important clinical significance. Further, for hepatojejunostomy with radical excision of a choledochal cyst, additional operative procedures for intrahepatic stenosis, possible bile duct malformation and pancreaticobiliary common duct calculi can potentially reduce postoperative complications.
Qian, Ying-Ying,Liu, Xin-You,Pei, Dong,Xu, Jia-Li,Shen, Hua,Chen, Xiao-Feng,Liu, Yi-Qian,Shen, Li-Zong,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: The predictive value of the xeroderma pigmentosum group D (XPD) Lys751Gln polymorphism regarding clinical outcomes of patients with colorectal cancer (CRC) receiving oxaliplatin-based chemotherapy has been evaluated in numerous published studies, but the results remain inconclusive. Therefore, we performed a meta-analysis to determine the precise role of the XPD Lys751Gln polymorphism in this clinical situation and optimize individual chemotherapy. Materials and Methods: A multiple search strategy was used to identify eligible studies. Pooled odds ratios (ORs), generalized odds ratio (ORG) and their 95% confidence intervals (CIs) were used to estimate the objective response, while hazard ratios (HRs) with 95%CIs were used for progression-free survival (PFS) and overall survival (OS). Results: A total of 17 studies including 2,286 patients met the inclusion criteria. Overall, the XPD 751Gln allele was associated with a non-significant reduced objective response to oxaliplatin-based chemotherapy in all patients or in the Asian and Caucasian subgroups. However, poor PFS and OS of CRC patients treated with oxaliplatin-based regimens were significantly related to the XPD 751Gln allele in the dominant model (PFS: HR=2.10, 95%CI: 1.65-2.67; OS: HR=3.18, 95%CI: 1.57-6.47). On stratified analysis by ethnicity, these relationships were more pronounced in Asians (PFS: HR=2.49, 95%CI: 1.79-3.47; OS: HR=5.25, 95%CI: 3.46-7.94) than in Caucasians (PFS: HR=1.73, 95%CI: 1.22-2.46; OS: HR=1.78, 95%CI: 1.06-2.99). Conclusions: The XPD Lys751Gln polymorphism may have prognostic value in patients with CRC undergoing oxaliplatin-based chemotherapy.