Ferromagnetic CoPt₃ Nanowires : Structural Evolution from fcc to Ordered L1₂

Chao-Yuan Huang,Hao Ming Chen,Chia Fen Hsin,Po Yuan Chen,Ru-Shi Liu,Shu-Fen Hu,Jyh-Fu Lee,Ling-Yun Jang 한국자기학회 2010 한국자기학회 학술연구발표회 논문개요집 Vol.2010 No.12

A case study on safety integrity level analysis for shale gas station

Yuan-Jian Yang,Chao Huang,Qiu-Yang Zhong,Hai-Jun Chen,Hong-Zhong Huang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.12

Safety integrity level (SIL), as defined in IEC 61511, is a widely used safety performance measure for safety instrumented functions. Shale gas station is an important part of shale gas gathering and transportation system. To ensure the safety of its instrument system is of great significance to the safe and stable operation of the whole gathering and transportation system. This paper is motivated to conduct a case study on safety integrity analysis for shale gas station by using the layer of protection analysis method (LOPA). Firstly, the equipment under control (EUC) is identified. It is followed by the analysis of reaction reasons on safety instrumented function (SIF) from safety instrumented system (SIS). Finally, according to the identification of independent protection layer (IPL) and probability of failure on demand (PFD), the SIL analysis for every SIF is carried out. The result shows that the SIS of this shale gas station has reached the required of SIL and there is no need for further increase in SIS. Utilizing this method can accurately determine the reliability of the SIS in the station, and it can also be the reference of safe operation for this shale gas station.

A Systemic Review and Experts’ Consensus for Long-acting Injectable Antipsychotics in Bipolar Disorder

Yuan-Hwa Chou,Po-Chung Chu,Szu-Wei Wu,Jen-Chin Lee,Yi-Hsuan Lee,I-Wen Sun,Chen-Lin Chang,Chien-Liang Huang,I-Chao Liu,Chia-Fen Tsai,Yung-Chieh Yen 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.2

Bipolar disorder (BD) is a major psychiatric disorder that is easily misdiagnosed. Patient adherence to a treatment regimen is of utmost importance for successful outcomes in BD. Several trials of antipsychotics suggested that depot antipsychotics, including long-acting first- and second-generation agents, are effective in preventing non-adherence, partial adherence, and in reducing relapse in BD. Various long-acting injectable (LAI) antipsychotics are available, including fluphenazine decanoate, haloperidol decanoate, olanzapine pamoate, risperidone microspheres, paliperidone palmitate, and aripiprazole monohydrate. Due to the increasing number of BD patients receiving LAI antipsychotics, treatment guidelines have been developed. However, the clinical applicability of LAI antipsychotics remains a global cause for concern, particularly in Asian countries. Expert physicians from Taiwan participated in a consensus meeting, which was held to review key areas based on both current literature and clinical practice. The purpose of this meeting was to generate a practical and implementable set of recommendations for LAI antipsychotic use to treat BD; target patient groups, dosage, administration, and adverse effects were considered. Experts recommended using LAI antipsychotics in patients with schizophrenia, rapid cycling BD, BD I, and bipolar-type schizoaffective disorder. LAI antipsychotic use was recommended in BD patients with the following characteristics: multiple episodes and low adherence; seldom yet serious episodes; low adherence potential per a physician’s clinical judgment; preference for injectable agents over oral agents; and multiple oral agent users still experiencing residual symptoms.

Case Study on Rock Support Technology for Roadways Based on Characteristics of Plastic Area

Chao Yuan,Liming Cao,Wenjun Wang,Lei Fan,Cong Huang 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.2

Rocks surrounding deep, high-stress roadways typically undergo a vicious cycle of destruction → repair → re-destruction → re-repair over a long time. This article uses the roadway restoration project of Pingmei Mine No. 6 (400 m underground) as research object. Starting from the plastic area, the characteristics of the distribution of rock surrounding the circular roadway are analyzed, and the influence of the side pressure coefficient, cohesive force, inside friction angle, support strength, and roadway radius on the plastic area is studied. Four types of distribution patterns were observed in rocks surrounding the plastic area of the roadway: round, oval, rounded rectangle, and butterfly. The side pressure coefficient, cohesive force, and inside friction angle affected the distribution and range of rocks surrounding the plastic area of the roadway. The support radius of the roadway and the support strength of its face did not change the distribution of the plastic area, but only affected its size. Therefore, to maintain the long-term stability of weak and broken roadways, the strength of the surrounding rocks must be increased, and roadway renovation should be avoided as it affects the distribution of the plastic area and reduces its scope. Engineering practice has shown that the “anchor net spray + hollow grouting anchor cable” technology for the combined, step-by-step repair and support of roadways, with a hollow grouting anchor cable as core, can suppress the distribution and scope of the plastic area to guarantee safe and long-term use of the roadway.

Microarray and Next-Generation Sequencing to Analyse Gastric Cancer

Dang, Yuan,Wang, Ying-Chao,Huang, Qiao-Jia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Gastric cancer is the second after lung cause of cancer-related mortality in the world. Early detection and treatment can lead to a long survival time. Recently microarrays and next generation sequencing (NGS) have become very useful tools of comprehensive research into gastric cancer, facilitating the identification of treatment targets and personalized treatments. However, there are numerous challenges from cancer target discovery to practical clinical benefits. Although there are many biomarkers and target agents, only a minority of patients are tested and treated accordingly. Microarray technology with maturity was established more than 10 years ago, and has been widely used in the study of functional genomics, systems biology, and genomes in medicine. Second generation sequencing technology is more recent, but development is very fast, and it has been applied to the genome, including sequencing and epigenetics and many aspects of functional genomics. Here we review insights gained from these studies regarding the technology of microarray and NGS, how to elucidate the molecular basis of gastric cancer and identify potential therapeutic targets, and how to analyse candidate genes. We also discuss the challenges and future directions of such efforts.

Privet golden leaves adapt unexpectedly well to light changes

Ming Yuan,Bo Huang,Li-Hua Dong,Qiao-Hong Han,Yong Yang,Chun-Bang Ding,Chao Hu,Yang-Er Chen,Zhong-Wei Zhang,Shu Yuan 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.4

Golden-leaf privet ( Ligustrum × vicaryi ) is widely used as a horticultural shrub because of its upper golden leaves, butits lower leaves are green. However, the putative mechanisms of its upper golden leaves and the leaf color changes inresponse to light shifts have not been well studied so far. Here, chlorophylls (Chl), carotenoids, and Chl precursors from bothgolden and green leaves grown in full sunlight (approximately 1200 μmol photons m −2 s −1 at noon) or low-light conditions(180 μmol m −2 s −1 ) were determined spectrophotometrically. In addition, their gas exchange parameters and Chl fl uorescencewere measured in situ. Metabolic fl ux analysis of chlorophyll intermediates indicated that the conversion of prochlorophyllideto chlorophyllide was signifi cantly blocked in golden leaves when compared with green leaves. Green leaves showed higherphotosynthetic capacity in low light than golden leaves, but golden leaves presented unexpectedly stronger photosyntheticcapacity and lower reactive oxygen species accumulation under the high-light condition. Furthermore, golden leaves showeda higher level of nonphotochemical quenching (NPQ) after the light-to-dark shift and presented a stronger adaptive abilityto a broad range of light environments. Higher NPQ values and less oxidative damage in golden leaves may be correlatedwith their higher carotenoid levels. The results imply that lower chlorophyll levels and higher carotenoid levels in canopyleaves may help privet plants acclimate better to illumination changes. This study demonstrates the key role of irradiance ingenerating the two types of Ligustrum × vicaryi leaves and sheds a light on cultivation of other ornamental foliage plants.

D₂(2317) and D₂(2457) from HQET Sum Rules

Chun Liu,Chao-Shang Huang,Shi-Lin Zhu,Yuan-Ben Dai 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.2

Within the framework of the heavy quark effective theory, QCD sum rules are used to calculate the masses of p-wave cs states. The results for 0+ and 1+ states with the angular momentum of the light component jl = 1=2 are consistent with the experimental values for Ds(2317) and Ds(2457), respectively.

The Effects of Chicken Leg Bone Extract on Antioxidative Properties under Different Heating Condition

Cheng, Fu-Yuan,Wan, Tien-Chun,Huang, Chao-Wei,Tominaga, Kana,Lin, Liang-Chuan,Sakata, Ryoichi Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.12

The aim of this study was to extract chicken leg bone, which is a by-product of industrial poultry processing, using different heating temperatures (80, 90 and $100^{\circ}C$) and durations (5, 10 and 15 min). The pH value, soluble protein content, peptide content and antioxidative properties, including superoxide anion scavenging ability, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging ability, reducing capacity and inhibitory activity of linoleic acid peroxidation, were measured. The results showed no significant differences (p>0.05) in pH value among all treatments. Decreased soluble protein content and peptide content were observed in chicken leg bone extract obtained under higher heating temperatures (90 or $100^{\circ}C$) and longer heating durations (10 or 15 min). In antioxidative properties, the extracts which were heated at 90 or $100^{\circ}C$ for 15 min exhibited significantly higher superoxide anion scavenging ability, DPPH free radical scavenging ability, reducing capacity and inhibitory activity of linoleic acid peroxidation (p<0.05).

Disturbance Observer-based Neural Network Integral Sliding Mode Control for a Constrained Flexible Joint Robotic Manipulator

Quanwei Wen,Xiaohui Yang,Chao Huang,Junping Zeng,Zhixin Yuan,Peter Xiaoping Liu 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.4

In this paper, the tracking control problem of flexible joint robotic manipulator (FJRM) system subjected to system uncertainties and time-varying external disturbances (TVED) is addressed. A new disturbance observerbased neural network integral sliding mode controller with output constraints (DNISMCOC) that comprises the merits of neural networks, disturbance observer and integral sliding mode is proposed. Considering that the radial basis function neural network (RBFNN) has a fast learning convergence speed and great approximation ability, two matrices of RBFNN are utilized to estimate the parameter matrices of the dynamic model of FJRM. In view of the estimation errors of RBFNNs and TVED in the system, a disturbance observer is introduced to estimate the lump uncertainties which consist of them. Integral sliding mode is introduced for eliminating steady errors further. For ensuring security in some high-accuracy using occasions, a barrier lyapunov functions (BLF) is adopted to achieve output constraints of FJRM. To validate the effectiveness of the proposed control scheme, numerical simulations on 2-link FJRM are conducted. According to the comparisons among DNISMCOC and other state-ofthe-art controllers, the superiorities of DNISMCOC in several aspects are proved.

Efficacy and Safety of 12 Weeks of Daclatasvir, Asunaprevir Plus Ribavirin for the Treatment of HCV Genotype 1b Infection without Baseline NS5A Resistance-Associated Variants (DARING)-Interim Report

( Ming-lung Yu ),( Chao-hung Hung ),( Yi-hsiang Huang ),( Cheng-yuan Peng ),( Chun-yen Lin ),( Pin-nan Cheng ),( Rong-nan Chien ),( Shih-jer Hsu ),( Chen-hua Liu ),( Jee-fu Huang ),( Chung-feng Huang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The current study aims to elucidate the treatment efficacy (defined as undetectable HCV RNA throughout 12 weeks of post-treatment follow-up, SVR12) and safety DCV/ASV plus ribavirin for 12 weeks in HCV-1b patients without NS5A RAS. Methods: This is a single-arm, open-label phase 2 study. Seventy directly acting antivirals (DAA)-naïve HCV-1b patients without L31/Y93 RAS are planned to receive daclatasvir (60 mg/ day) and asunaprevir (100 mg twice daily) plus weight-based ribavirin (1000-1200 mg/day) for 12 weeks. After treatment they were followed up for 12 weeks. Results: As of 31 Oct 2017, 58 eligible patients are allocated to treatment, with a mean age of 59.3 years and female predominance (67.2%, 39/58). The mean HCV RNA was 5.87+0.77 log10 IU/mL; 23 patients (39.7 %) had significant hepatic fibrosis (>F2). In the modified intention-to-treat analysis, the rate of undetectable HCV at week 1, week 2, week 4, week 8 and endof- treatment was 25 % (14/56), 84.8 % (39/46), 100 % (46/46), 100 % (38/38) and 100 % (27/27), respectively. Undetectable HCV RNA were observed in all of the patients with HCV RNA assessable 4 weeks (SVR4, 18/18) and 12 weeks (SVR12, 12/12) post treatment. None of the 18 patients who completed the 12-week treatment experienced relapse during post-treatment follow-up. The most common adverse event was fatigue (78.3 %), followed by pruritus (65.2 %) and dizziness (52.2 %), of which were considered as ribavirin related. None of the participating subjects withdrew treatment or follow-up throughout the trial peroid. Three serious adverse events were reported which included urosepsis, appendicitis and left ureteral stone. All were unrelated to the investigating drugs. Conclusions: 12 weeks of DCV/ASV plus ribavirin was highly effective and safe in HCV-1b patients without NS5A RAS in the interim analysis. The satisfactory results would be anticipated in the full patient set.