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Rainfall-induced Landslide Hazard Analysis Based on GIS in Yanbian Region, China
Liu,Xiu Xuan,Quan, He Chun,이병걸 대한공간정보학회 2017 대한공간정보학회지 Vol.25 No.4
This paper mainly studies landslide hazard in Yanbian region,8 landslide factors of soil moisture content, hydrogeology, land use type, slope, slope aspect, fault, river and rainfall are analyzed in the area of Yanbian region. Using the analytic hierarchy process (AHP), the relative weights of 8 landslide factors were obtained, and the internal weights of each factor were determined by the data; the rainfall factors were then divided into three categories such as average annual rainfall, average flood season rainfall, and the maximum average rainfall. And the comparison of the rainfall factors was made. Finally based on the results of these weights to the remote sensing technology(RS) and geographic information system(GIS) technology combined to evaluate its area, we are mapping the risk assessment area for landslide hazard in Yanbian region. According to the map analysis, figure in the dangerous hierarchies result in accordance with the historical landslides is better. At the same time. landslides and hazard area of statistical data analysis showed that the AHP method combined with GIS technology is suitable for promoting the Yanbian regional landslide hazard assessment.
劉俊榮,張勝成 대구대학교 특수교육재활과학연구소 2006 再活科學硏究 Vol.24 No.2
The hearing impairment happened extensively in the elderly and often resulted in the hearing handicap. A lot of study confused the hearing impairment with the hearing handicap and replaced the score of quality of life by the hearing handicap score to calculate the quality adjusted life years and analyzed the cost-utility of aural rehabilitation. In this study, the confusion of hearing impairment and hearing handicap was clarified, and the relevance between hearing handicap and quality of life was explored in order to examine the fitness of replacing the score of quality of life by the hearing handicap score. The result of this study indicated that the correlation between the hearing handicap and the quality of life. The fitness of correlating model of the hearing handicap and the quality of life was not accepted. So, it was not suggested that replacing the score of quality of life by the hearing handicap score. The inventory of disease-specific quality of life should be developed. Secondly, the poor fitness of correlating model of the hearing handicap and the quality of life could be resulted from the other variables that shall be included in the model. It was proposed to include relevant variables into the model in the future. 청각손상은 노년기에 광범위하게 발생하는 문제이다. 심각한 청각장애를 자주 일으킨다. 많은 연구는 청각손상과 청각장애를 혼돈하는 것 뿐 만아니라 자주 청각장애 검목표의 득점으로 피실험자의 생활 품질을 대표한다. 심지어 청각장애 검목표의 득점으로 생활 품질 조정년을 계산한다. 이것으로 청각 재활의 성공 효과를 분석한다. 본 연구는 청각 손상과 청각장애의 다른 점을 밝히는 것 외에도 주요 목적은 청각장애와 생활 품질의 관련성을 이해하고자 하는 것이다. 이것으로 청각장애 검목표를 생활 품질을 삼는 정당성을 관찰한다. 연구결과에 나타나는 것은 청각 표현과 생활품질의 관련성은 높지 않은 결과를 얻었다. 이 두 가지의 관련 양식은 일반화 하기는 제한점을 갖는다. 그래서 이론적 개념에서 청각 표현과 생활품질은 각자 다른 내용을 갖추고 있다. 자료 통계의 분석 결과도 이 두 가지의 관련 양식에 대해서 유의한 결과를 얻지 못했다. 그래서 청각표현 능력으로 피실험자의 생활 품질을 대신할 수 없다. 마땅히 청각 손상자에게 맞는 적합한 생활 품질 설문지를 발행해야한다. 그 다음에 두 가지의 관련 양식의 관련도 적다. 아마도 청각 손상자의 청각 표현과 생활 품질 간에는 많은 변인의 영향이 존재하기 때문이다. 미래의 연구는 더 많은 상관 관련 인소를 귀납해서 이 이론구조를 검증해야한다는 것을 건의한다.
Chun-Yu Liu,Tzu-Ting Huang,Pei-Yi Chu,Chun-Teng Huang,Chia-Han Lee,Wan-Lun Wang,Ka-Yi Lau,Wen-Chun Tsai,Tzu-I Chao,Jung-Chen Su,Ming-Huang Chen,Chung-Wai Shiau,Ling-Ming Tseng,Kuen-Feng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein. Moreover, treatment with either a specific inhibitor of SHP-1 or SHP-1-targeted siRNA reduced the apoptotic effects of nintedanib, which validates the role of SHP-1 in nintedanib-mediated apoptosis. Furthermore, nintedanib-induced apoptosis was attenuated in TNBC cells expressing SHP-1 mutants with constantly open conformations, suggesting that the autoinhibitory mechanism of SHP-1 attenuated the effects of nintedanib. Importantly, nintedanib significantly inhibited tumor growth via the SHP-1/p-STAT3 pathway. Clinically, SHP-1 levels were downregulated, whereas p-STAT3 was upregulated in tumor tissues, and SHP-1 transcripts were associated with improved disease-free survival in TNBC patients. Our findings revealed that nintedanib induces TNBC apoptosis by acting as a SHP-1 agonist, suggesting that targeting STAT3 by enhancing SHP-1 expression could be a viable therapeutic strategy against TNBC.
Shu-Tsen Liu(Shu-Tsen Liu),Sheng-Che Lin(Sheng-Che Lin),Jane Pei-Chen Chang(Jane Pei-Chen Chang),Kai-Jie Yang(Kai-Jie Yang),Che-Sheng Chu(Che-Sheng Chu),Chia-Chun Yang(Chia-Chun Yang),Chih-Sung Liang( 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.
Chun-Guo Liu,Ming Li,Tao Yue 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.6
Springback is adversely affected by mechanical anisotropy in the process of sheet metal forming. In this work, an analytical method was proposed to predict the springback of the double-curved workpiece in multi-point forming process. To characterize the anisotropy of the AA7B04 aluminum plate, the plate was divided into several layers along thickness direction. And in each layer, the calculation of bending moment was done respectively based on von Mises, Hill’s 48 and Yld2004-18p yield criterion. After springback, the neutral surface curvature was calculated and the profile of the neutral surface was constructed by the Bezier surface blending method. To verify the prediction method, finite element simulation and bending experiment were performed. The results show that the predictive accuracy of the method was more accurate than that with the isotropy model. Additionally, the most accurate constitutive model to describe the in-plane anisotropy of AA7B04 aluminum was the Yld2004-18p yield criterion.