Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice

박한솔,장정은,고명석,우성훈,김범종,김현식,박혜선,박인선,고은희,이기업 대한당뇨병학회 2016 Diabetes and Metabolism Journal Vol.40 No.5

Background: Non-alcoholic fatty liver disease is the most common form of chronic liver disease in industrialized countries. Recent studies have highlighted the association between peroxisomal dysfunction and hepatic steatosis. Peroxisomes are intracellular organelles that contribute to several crucial metabolic processes, such as facilitation of mitochondrial fatty acid oxidation (FAO) and removal of reactive oxygen species through catalase or plasmalogen synthesis. Statins are known to prevent hepatic steatosis and non-alcoholic steatohepatitis (NASH), but underlying mechanisms of this prevention are largely unknown. Methods: Seven-week-old C57BL/6J mice were given normal chow or a methionine- and choline-deficient diet (MCDD) with or without various statins, fluvastatin, pravastatin, simvastatin, atorvastatin, and rosuvastatin (15 mg/kg/day), for 6 weeks. Histological lesions were analyzed by grading and staging systems of NASH. We also measured mitochondrial and peroxisomal FAO in the liver. Results: Statin treatment prevented the development of MCDD-induced NASH. Both steatosis and inflammation or fibrosis grades were significantly improved by statins compared with MCDD-fed mice. Gene expression levels of peroxisomal proliferator- activated receptor α (PPARα) were decreased by MCDD and recovered by statin treatment. MCDD-induced suppression of mitochondrial and peroxisomal FAO was restored by statins. Each statin’s effect on increasing FAO and improving NASH was independent on its effect of decreasing cholesterol levels. Conclusion: Statins prevented NASH and increased mitochondrial and peroxisomal FAO via induction of PPARα. The ability to increase hepatic FAO is likely the major determinant of NASH prevention by statins. Improvement of peroxisomal function by statins may contribute to the prevention of NASH.

대학생이 지각한 초기 부모애착과 연인 간 낭만적 애착의 관계: 거부민감성과 자아존중감의 순차적 매개효과

박한솔,김민 (사)한국청소년문화연구소 2022 청소년 문화포럼 Vol.- No.71

본 연구의 목적은 대학생이 지각한 초기 부모애착과 성장 후 낭만적 애착과의 관계에서 거부민감성과 자아존중감이 순차적 매개효과가 있는지를 탐색하는 데 있다. 연구대상은 부와 모의 애착을 받으며 성장해 현재 대학교에 재학·휴학 중인 20세부터 25세까지로 연애를 최소 1번 이상 경험한 280명의 대학생이다. 자료 분석은 SPSS 23.0을 사용해 기술통계, 상관계수, Cronbach’s α 그리고 위계적 회귀분석을 실시하였으며, PROCESS MACRO 6번을 이용하여 매개효과를 검증하였다. 연구 결과는 다음과 같다. 첫째, 초기 부모애착, 낭만적 애착, 거부민감성, 자아존중감은 서로 통계적으로 유의미한 상관관계가 나타났다. 둘째, 초기 부모애착과 낭만적 애착의 관계에서 거부민감성과 자아존중감의 순차적 매개효과가 확인되었다. 이러한 연구 결과를 토대로 논의 및 후속 연구를 제언하였다.

대중교통 빅데이터의 다차원 네트워크 분석기법

박한솔,조완섭 한국엔터프라이즈아키텍처학회 2016 정보기술아키텍처연구 Vol.13 No.1

We construct a multi-dimensional mass-transit network from the data generated bydaily city-bus operation, understand the structure and characteristics of mass transit through thecentrality analysis, and find the weak area of mass transit in the city. Degree centrality, betweennesscentrality, and eigenvector centrality are used for the analysis. We propose an extension ofthe idea for further multidimensional analysis for the transit data. The result of this study can contributeas basic research data for transportation plan in the city government. 본 논문에서는 시내버스의 운행관련 빅데이터를 활용하여 다차원의 대중교통 네트워크를 구축한 후, 네트워크 중심성 분석을 통해 대중교통의 구조적 특징을 파악하고, 이를 바탕으로 대중교통 취약지를 도출한다. 네트워크 중심성 분석 방법으로 연결 중심성, 매개 중심성, 고유벡터 중심성을 활용한다. 특히, 단순 네트워크보다 다차원 분석에 적합한 네트워크 정보를 구축하며, 확장방안도 제시한다. 네트워크 분석 결과는 시내버스 노선 개편, 대중교통 취약지 확인 등 교통관련 정책을 과학적으로수립하는데 기초연구 자료로 활용될 수 있을 것이다.

건조방법을 달리한 유자껍질 티백차의 품질특성 비교

박한솔,이현정,윤광섭,김동섭,김한수,이영근,성종환,정헌식 한국식품저장유통학회 2017 한국식품저장유통학회지 Vol.24 No.8

This study was conducted to investigate the effects of drying methods for Citrus junos peels on quality characteristics of the hot-water leachate from teabags containing those peels. Fresh peels were hot-air (50℃), cold-air (30℃), or freeze-dried (-45℃), powdered to a size of 40 mesh, packaged with a paper sachet, and then the packaged teabags were leached for 10 min with hot-water (70℃). L*value (lightness) and -a* value (greenness) of the peel powder were the highest in the freeze-dried samples. Soluble solids and titratable acidity of the teabag leachate were in the following order; cold-air, freeze, and hot-air dried samples. Among free sugar contents in all samples, fructose content was the highest, followed by glucose and sucrose. Fructose and glucose contents were not affected by drying methods. There was no significant difference in the flavonoid content among the peels dried using three drying methods. DPPH radical-scavenging activity of the leachate was the highest in the cold-air dried sample. These results suggest that cold-air drying would be an effective method to enhance the quality of hot-water leachate of teabags prepared from C. junos peels.

청소년 자녀를 둔 어머니의 자녀-수반 자기가치감이 자녀에 대한 심리적 통제에 미치는 영향: 자녀 관련 스트레스와 분노의 이중매개효과

박한솔,김정민 미래를 여는 청소년학회 2023 미래청소년학회지 Vol.20 No.3

The purpose of this study was to examine the dual mediating effect of child-related stress and anger on the relationship between maternal child-based worth and maternal psychological control over adolescent children. Data were collected through an online survey from 294 mothers with adolescent children and analyzed using descriptive statistics, Pearson’s correlation analysis, and SPSS Macro Process. The main findings of the study are as follows. First, for mothers with adolescents, maternal child-based worth, child-related stress and anger showed significant positive correlations with maternal psychological control over adolescent children, respectively. Second, child-related stress and anger were found to have individual mediating effects on the relationship between maternal child-based worth and maternal psychological control over adolescent children, respectively. Third, child-related stress and anger were found to have sequential dual mediating effects in the pathway where maternal child-based worth affect the maternal psychological control over adolescent children.

임베디드 소프트웨어 디버깅을 위한 연관 마이닝기반 시험 데이터 수집 및 분석 방법

박한솔,박한준 한국차세대컴퓨팅학회 2017 한국차세대컴퓨팅학회 논문지 Vol.13 No.6

산업용 시스템과 군용 무기체계에서 사용되는 임베디드 시스템들은 높은 신뢰성을 요구하며, 탑재 소프트웨어의 비중이 높아지면서 소프트웨어 품질확보를 위한 테스트의 중요성이 강화되고 있다. 임베디드 소프트웨어에 대한 테스트는 하드웨어와 소프트웨어의 결합력이 매우 높다는 특성 때문에 통합 테스트를 통해 검증되어야 한다. 기존의 통합 테스트에서는 결함이 발생하더라도 디버깅을 위한 정보를 제공해 줄 수 있는 방법이 고려되지 않아 디버깅을 수행하는 데에 많은 시간과 비용이 소모된다는 문제점이 있었다. 본 논문에서는 임베디드 소프트웨어의 통합 테스트단계에서 발생한 결함에 대해 시험 데이터와 소프트웨어 로그를 통합하여 수집하고 연관 규칙을 이용한 마이닝 기반의 분석 방법을 제공함으로써 임베디드 소프트웨어의 디버깅을 보다 원활하게 할 수 있는 방법을 제안한다. 그리고시험을 통해 제안한 방법이 단일 결함에 대해서 디버깅을 위한 정보의 식별이 가능함을 확인하였다. The embedded systems used in industry systems and military weapon systems require high reliability, and increasing the proportion of the embedded software increases the importance of testing to ensure software quality. Testing for embedded software should be validated through integration testing because of the tight coupling of hardware and software. There was a problem with the existing integration tests that it was not considered a method to provide information for debugging, even if a defect occurred, so it was time consuming and costly to perform debugging. In this paper, we suggest a method to make debugging of embedded software more seamless by integrating test data and software logs for defects occurred in the integrated testing phase of embedded system, and by providing a mining-based analysis method using associative rules. Through the test, it is confirmed that the proposed method can identify information for debugging with respect to single defect.

TMO 모델 기반 무장 관리 시스템 소프트웨어 설계

박한솔,Park, Hansol 한국시스템엔지니어링학회 2017 시스템엔지니어링학술지 Vol.13 No.1

A stores management software which is embedded in the stores management system requires high-level reliability and real-time processing. It also required to implement and verify protocols which requires timing constraints to control various weapons. In this paper, we propose design methodology to design a stores management software and its support middleware based on the TMO (Time-triggered Message-triggered Object) model.

동결 전처리가 유자과피 당절임 삼출액의 품질 특성에 미치는 영향

박한솔,김동섭,김한수,이영근,정헌식 한국식품저장유통학회 2020 한국식품저장유통학회지 Vol.27 No.1

In this study, we assessed the effect of freezing pretreatment on the quality of osmotically extracted syrup from Citrus junos peels. Sliced peels were frozen for 7 days at –20℃ or –70℃, mixed with sucrose and then stored for 40 days at 15℃. Syrups were prepared from these mixtures after osmotic treatment. Non-frozen fruits were used as control. The initial freezing point of C. junos peels was –4℃. Nominal freezing times were 42 and 13 min for –20℃ and –70℃, respectively. The osmotically extracted syrup from the frozen peels was reddish brown while that of the untreated peels was yellow. The titratable acidity of the pretreated syrups was significantly higher than that of the untreated syrup, but clarity, vitamin C content, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity were considerably lower. The pretreated syrups showed no notable difference in color, titratable acidity, clarity, and DPPH activity. Furthermore, contents of soluble solids, phenolic compounds, and flavonoids were unaffected. These results suggest that freezing before osmotic extraction affects the quality, producing syrups with higher acidity, reddish brown color, and lower antioxidant activity.

한국판 자기자비척도의 요인구조 검증: 자기자비와 자기냉담의 차별적 효과

박한솔,김은하,신희천 한국상담학회 2020 상담학연구 Vol.21 No.3

Nowadays, Self-Compassion is widely discussed in counseling and psychotherapy studies. Nevertheless, inconsistent results have been reported on the factor structure of the Self-Compassion Scale. The purpose of this study was to examine the factor structure of the Korean version Self-Compassion Scale and observe the distinctive influence of self-compassion and self-coldness. For this, in Study 1, we conducted confirmatory factor analysis to evaluate 8 models in a sample of 457 undergraduate students. The results showed that a second-order structure consisting of 2 general factors(Self-Compassion and Self-Coldness) and 6 domain-specific factors(Self-Kindness, Common humanity, Mindfulness, Self-judgment, Isolation, Over-identification) was the most suitable. In Study 2, the researchers investigated whether Self-Compassion and Self-Coldness respectively predict the mental well-being and depression through the mediation of positive and negative emotions. The results indicated that Self-Compassion was related to mental well-being mediating by positive emotions but Self-Coldness was related to depression mediating by negative emotions. Based on these results, the implications of counseling practices and the directions for further studies were discussed with suggestion for using the K-SCS. 최근 자기자비가 상담 및 심리치료 분야에서 활발하게 논의되고 있지만, 아직까지 자기자비를 측정하는 척도들의 요인구조에 대해서는 비일관적인 결과들이 보고되고 있다. 이에 본 연구에서는 자기자비척도 중 가장 많이 사용되고 있는 한국판 자기자비척도의 요인구조를 검증하고, 자기자비와 자기냉담의 차별적인 영향력에 대해 살펴보았다. 먼저, 연구 1에서는 대학생 457명을 대상으로 한국판 자기자비척도의 8개 요인구조 모형에 대해 확인적 요인분석을 실시하였고, 그 결과, 2개의 일반요인(자기자비, 자기냉담)과 6개의 영역특성요인(자기친절, 보편적 인간성, 마음챙김, 자기판단, 고립, 과잉동일시)으로 구성된 second-order 모형이 가장 적합한 것으로 나타났다. 다음으로, 연구 2에서는 자기자비와 자기냉담이 각각 정적정서와 부적정서를 매개로 정신적 웰빙과 우울을 예측하는지 살펴보았다. 그 결과, 자기자비는 정적정서를 매개로 정신적 웰빙과 관련이 있는 반면 자기냉담은 부적정서를 매개로 우울과 관련이 있는 것으로 나타났다. 이러한 연구 결과를 바탕으로 자기자비척도의 활용 방안, 상담에 대한 시사점 및 후속 연구의 방향에 대해 논의하였다.

좌파, 대안이 될 수 있는가 토론회 후기 2

박한솔 현장과광장 2021 현장과광장 Vol.- No.5