고로슬래그시멘트를 사용한 다공성 황토콘크리트의 성능 평가

김황희,강수만,박종식,박상우,전지홍,이진형,차상선,박찬기,Kim, Hwang-Hee,Kang, Su-Man,Park, Jong-Sik,Park, Sang-Woo,Jeon, Ji-Hong,Lee, Jin-Hyung,Cha, Sang-Sun,Park, Chan-Gi 한국농공학회 2010 한국농공학회논문집 Vol.52 No.3

This study aims to evaluate a porous concrete using hwang-toh, blast furnace slag and blast furnace slag (BFS) cement instead of type I cement. The tests that were carried out to analysis the properties of porous hwang-toh BFS cement concrete included compressive strength, continuous void ratio, absorption rate, and pH value, repeated freezing and thawing test were conducted. Test results indicated that the performance in porous hwang-toh concrete are effective on the kaoline based binder materials. The pH value were shown in about 9.5 ~ 8.5. The compressive strength was increased and void ratio was decreased with increasing the kaoline based binder materials, respectively. The void ratio and compressive strength were in the range of about 21 ~ 30 %, 8 ~ 13 MPa, respectively. The increased in void ratio of more than 25 % is showed to reduce the resistance of repeated freezing and thawing. Also, the resistance of repeated freezing of thawing and the compressive strength of porous hwang-toh BFS cement concrete are independent with hwang-toh content and BFS cement amount. But, the void ratio was decreased with increasing the high volume hwang-toh contents (more than 15 %).

Recombinant canstatin inhibits angiopoietin‐1‐induced angiogenesis and lymphangiogenesis

Hwang‐,Bo, Jeon,Yoo, Ki Hyun,Park, Jong‐,Hwa,Jeong, Han‐,Sin,Chung, In Sik Wiley Subscription Services, Inc., A Wiley Company 2012 International journal of cancer: Journal internati Vol.131 No.2

<P><B>Abstract</B></P><P>We describe the effect of recombinant canstatin, the NC1 domain of the α2 chain of Type IV collagen, on suppression of angiogenesis and lymphangiogenesis both <I>in vitro</I> and <I>in vivo</I>. Recombinant canstatin produced from stably transformed <I>Drosophila</I> S2 cells reduced the expression of angiopoietin‐1 in hypoxia mimetic agent, CoCl<SUB>2</SUB>‐treated CT‐26 cells. Recombinant canstatin inhibited proliferation, tube formation and migration of human angiopoietin‐1 (rhAngpt‐1)‐treated human umbilical vein endothelial cells (HUVEC) and lymphatic endothelial cells (LEC). Recombinant canstatin suppressed the expression of Tie‐2 and vascular endothelial growth factor‐3 (VEGFR‐3) transcripts in rhAngpt‐1‐treated HUVEC and LEC, respectively. The inhibitory effect of recombinant canstatin on tumor growth was also investigated using a heterotopic CT‐26 colon carcinoma animal (BALB/c mice) model. Recombinant canstatin reduced the final volume and weight of tumors, and blood and lymphatic vessel densities of tumors, which were evaluated by CD‐31 and LYVE‐1 immunostaining. Immunohistochemical analysis showed that recombinant canstatin dramatically reduced the expression of angiopoietin‐1 in CT‐26 colon carcinoma‐induced tumor, but not the expression of VEGF‐C. Tie‐2 and VEGFR‐3 expressions were also reduced in recombinant canstatin‐treated tumors. These results indicate that recombinant canstatin has anti‐tumoral activities against CT‐26 colon carcinoma cells. Recombinant canstatin reduces the expression of angiopoietin‐1 in hypoxia‐induced CT‐26 cells and inhibits the angiogenic and lymphangiogenic signaling induced by angiopoietin‐1. Recombinant canstatin probably inhibits angiogenesis and lymphangiogenesis <I>via</I> suppression of the integrin‐dependent FAK signaling induced by angiopoietin‐1/Tie‐2 and/or VEGFR‐3.</P>

대동작 측정도구의 측정자간 신뢰도

최흥식,이충휘,황선관 한국전문물리치료학회 1995 한국전문물리치료학회지 Vol.2 No.1

Cyanex 301을 이용한 미량 Ni(Ⅱ)의 추출 및 정량에 관한 연구

김황식,이정길,정창웅 순천향대학교 기초과학연구소 2005 순천향자연과학연구 논문집 Vol.11 No.1

A selective and quantitatively atomic absorption spectromethc measurements have been developed for the determination of trace Ni(Ⅱ) with 0.3M thiocyanate and 0.1M Cyanex SOlUMIBK. Ni(Ⅱ)-thiocyanate complex was quantitatively extracted into Cyanex 301-MIBK solution. Beer's law obeys in the range of 16 ppm in organic solvent. Analysis of Ni(Ⅱ) in seawater was performed by the proposed method.

TORC2 Regulates Hepatic Insulin Signaling via a Mammalian Phosphatidic Acid Phosphatase, LIPIN1

Ryu, Dongryeol,Oh, Kyoung-Jin,Jo, Hee-Yeon,Hedrick, Susan,Kim, Yo-Na,Hwang, Yu-Jin,Park, Tae-Sik,Han, Joong-Soo,Choi, Cheol Soo,Montminy, Marc,Koo, Seung-Hoi Elsevier 2009 Cell metabolism Vol.9 No.3

<P><B>Summary</B></P><P>TORC2 is a major transcriptional coactivator for hepatic glucose production. Insulin impedes gluconeogenesis by inhibiting TORC2 via SIK2-dependent phosphorylation at Ser171. Interruption of this process greatly perturbs hepatic glucose metabolism, thus promoting hyperglycemia in rodents. Here, we show that hyperactivation of TORC2 would exacerbate insulin resistance by enhancing expression of LIPIN1, a mammalian phosphatidic acid phosphatase for diacylglycerol (DAG) synthesis. Diet-induced or genetic obesity increases <I>LIPIN1</I> expression in mouse liver, and TORC2 is responsible for its transcriptional activation. While overexpression of LIPIN1 disturbs hepatic insulin signaling, knockdown of LIPIN1 ameliorates hyperglycemia and insulin resistance by reducing DAG and PKCϵ activity in <I>db/db</I> mice. Finally, TORC2-mediated insulin resistance is partially rescued by concomitant knockdown of LIPIN1, confirming the critical role of LIPIN1 in the perturbation of hepatic insulin signaling. These data propose that dysregulation of TORC2 would further exaggerate insulin resistance and promote type 2 diabetes in a LIPIN1-dependent manner.</P>

일부 간호사들에서 교대근무가 수면에 미치는 영향

윤덕로,강대희,이승준,주영수,박진구,황호영,황필규,황은주,황예원,성주헌,홍순범,황승식,황재욱,조수헌 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.1

Industrialization has introduced various working systems into the modern society. Shift work is a good representative among those. So far various adverse health effects, possibly caused by this shift work, have mainly been reported in the fields of manufacturing industry by many other researchers ; sleep disorders, gastrointestinal disorders and cardiovascular disorders and so on, These health effects were thought to be caused by the changes of circadian rhythm on shift working. This study was especially planned to evaluate effects of shift work on sleep disorders among shift-working medical manpower like hospital nurses, important persons dealings with lives, and ultimately to provide them with basic evidence for improving work environment. The study subjects were arbitrarily selected among shift-working female nurses and day-working female pharmacists in one university hospital in Seoul, and finally 79 nurses and 58 pharmacists were enrolled. The research was conducted by using self-administered questionnaire, consisting of items about socio-behavioral factors including demographic factors which can affect sleep patterns and questions which make it possible to evaluate sleep disorders(e.g. sleeping duration, sleep latency, re-sleep latency, days of insomnia per week, drug use for sleep, and subjective symptoms). The result showed that the shift workers had significantly longer sleep and re-sleep latency, more days of insomnia, and a stronger likelihood of using drugs when they had sleep difficulty than day-working pharmacists. And the number of night shift duties per month was discovered as the only significant predictor of sleep latency. Additionally, the subjective symptoms related to sleep disorders when awake and at work, showed negligible differences between the shift workers and dayworkers. In conclusion, we found shift-work was risk factor for sleep disorders.

Dynamic 3D Motion Graphic

Hwang, Min Sik 한국콘텐츠학회 2018 ICCC International Digital Design Invitation Exhib Vol.2018 No.12

Leak behavior of SCC degraded steam generator tubings of nuclear power plant

Hwang, Seong Sik,Kim, Hong Pyo,Kim, Joung Soo,Kasza, Kenneth E.,Park, Jangyul,Shack, William J. Elsevier 2005 Nuclear engineering and design Vol.235 No.23

<P><B>Abstract</B></P><P>A forced outage due to a steam generator tube leak in a Korean nuclear power plant has been reported <ce:cross-ref refid='bib3'>[Kim, J.S., Hwang, S.S., et al., 1999. KAERI Internal Report (Korean). Destructive analysis on pulled tubes from Ulchin unit 1. Korea Atomic Energy Research Institute]</ce:cross-ref>. Primary water stress corrosion cracking has occurred in many tubes in the plant, and they were repaired using sleeves or plugs. In order to develop proper repair criteria, it is necessary to understand the leak behavior of the tubes containing stress corrosion cracks. Cracked specimens were prepared using a room temperature cracking technique, and the leak rates and burst pressures of the degraded tubes were determined both at room temperature and at a high temperature. Some tubes with 100% through wall cracks did not show a leakage at 10.8MPa, which is the typical pressure difference of the pressurized water reactors (PWRs) during a normal operation. In some tests, the leak rates of the tubes increased with time at a constant pressure. In a high temperature pressure test at 282°C one specimen showed a very small leakage at 18.6MPa, which stopped after a small increase in the test pressure. Because stress corrosion cracks can develop at relatively low stresses, even 100% through wall cracks can be so tight that they will not leak at a normal operating pressure.</P>

<i>NOTCH2</i> missplicing can occur in relation to apoptosis

Hwang, In Sik,Shin, Saeam,Min, Yoo Hong,Lee, Seung-Tae,Choi, Jong Rak American Society of Hematology 2015 Blood Vol.126 No.14

Impact of diabetes, obesity, and dyslipidemia on the risk of hepatocellular carcinoma in patients with chronic liver diseases

Hwang Sik Shin,Baek Gyu Jun,Sang-Wook Yi 대한간학회 2022 Clinical and Molecular Hepatology(대한간학회지) Vol.28 No.4

Despite the increasing prevalence of metabolic disorders, the potential effects of metabolic factors on hepatocellular carcinoma (HCC) development in individuals with chronic liver diseases (CLDs) are not well understood. For a metabolic factor to be identified as a risk factor for HCC in patients with CLDs, such as hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, there should be a strong synergistic interaction between the carcinogenic mechanisms of the metabolic factor and the CLD itself. This review aims to comprehensively summarize the published data on the relationship between metabolic factors such as diabetes mellitus (DM), obesity, and blood lipids and the risk of HCC in patients with CLDs. DM consistently increases the risk of HCC in patients with CLD. When associated with DM, the risk of HCC seems to be highest in HCV and non-alcoholic fatty liver disease (NAFLD), followed by alcoholic liver disease (ALD) and HBV. Obesity may increase the risk of HCC. Among CLDs, the evidence is relatively consistent and clear for ALD, while clear evidence is limited in other CLDs including HBV, HCV, and NAFLD. Total cholesterol, potentially low-density lipoprotein cholesterol and triglyceride, seems to have strong inverse associations with HCC in individuals with CLDs. Despite evidence from observational studies, statins had no effect in preventing HCC in randomized controlled trials. Whether statins have a preventive effect against HCC is unclear. A better understanding and management of metabolic factors may be beneficial to reduce the risk of HCC in patients with CLDs.