축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

Clinical impact of admission hyperglycemia on in-hospital mortality in acute myocardial infarction patients

Kim, Eun Jung,Jeong, Myung Ho,Kim, Ju Han,Ahn, Tae Hoon,Seung, Ki Bae,Oh, Dong Joo,Kim, Hyo-Soo,Gwon, Hyeon Cheol,Seong, In Whan,Hwang, Kyung Kuk,Chae, Shung Chull,Kim, Kwon-Bae,Kim, Young Jo,Cha, Kwa Elsevier 2017 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.236 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Acute hyperglycemia on admission is common in acute myocardial infarction (AMI) patients regardless of diabetic status, and is known as one of prognostic factors. However, the effect of hyperglycemia on non-diabetic patients is still on debate.</P> <P><B>Methods</B></P> <P>A total of 12,625 AMI patients (64.0±12.6years, 26.1% female) who were enrolled in Korea Acute Myocardial Infarction Registry-National Institute of Health between November 2011 and December 2015, were classified into 4367 diabetes (65.4±11.6years, 30.4% female) and 8228 non-diabetes (63.3±13years, 23.9% female). Patients were analyzed for in-hospital clinical outcome according to admission hyperglycemic status.</P> <P><B>Results</B></P> <P>In diabetic patients, independent predictors of in-hospital mortality were old age, high HbA<SUB>1</SUB>C, pre-Thrombolysis In Myocardial Infarction (TIMI) flow 0, left ventricle ejection fraction<40%, cardiogenic shock and ventricular tachycardia. In non-diabetic patients, independent predictors of in-hospital mortality were old age, high admission glucose (≥200mg/dL), pre TIMI flow 0, failed percutaneous coronary intervention, low left ventricle ejection fraction<40%, cardiogenic shock, stent thrombosis and decreased Hb≥5g/dL. In hospital mortality was significantly higher in diabetic patients compared to non-diabetic patients (5.0% vs. 3.4%, <I>p</I> <0.001). However, non-diabetic patients with hyperglycemia have significantly higher mortality compared to diabetic patients (17.4% vs. 7.2%, <I>p</I> <0.001). Comorbidity including cardiogenic shock (<I>p</I> <0.001), cerebral hemorrhage (<I>p</I> =0.012), decreased Hb≥5g/dL (<I>p</I> =0.013), atrioventricular block (<I>p</I> <0.001) and ventricular tachycardia (<I>p</I> =0.007) was higher in non-diabetic with hyperglycemia than in diabetic patients.</P> <P><B>Conclusions</B></P> <P>These findings underscore clinical significance of admission hyperglycemia on in-hospital mortality in non-diabetic AMI patients.</P>

내원시 저혈당이 당뇨병을 동반한 심근경색증 환자의 예후에 미치는 영향

김은정 ( Eun Jung Kim ),정명호 ( Myung Ho Jeong ),정인석 ( In Seok Jeong ),오상기 ( Sang Gi Oh ),김상형 ( Sang Hyung Kim ),안영근 ( Young Keun Ahn ),김주한 ( Ju Han Kim ),김영조 ( Young Jo Kim ),채성철 ( Shung Chull Chae ),홍택종 대한내과학회 2014 대한내과학회지 Vol.87 No.5

목적: 당뇨병 환자에게 철저한 혈당 조절은 논란의 여지가 있으며, 이에 당뇨병을 동반한 급성 심근경색증 환자의 내원 시 저혈당과 병원 내 주요 임상 사건 및 사망률 그리고 추적관찰 1년간 사망률과의 관계를 알아보고자 하였다. 방법: 2005년 11월부터 2012년 3월까지 KAMIR에 등록된 당뇨병이 동반된 급성 심근경색증 환자 5,249명을 혈당 수치에 따라서 저혈당을 보인 환자(≤ 70 mg/dL)를 I군(93명, 72.6± 11.0세, 여성 46.2%), 정상혈당을 보인 환자(> 70 and < 140)를 II군(1,262명, 71.3 ± 10.7, 여성 34.3%), 고혈당을 보인 환자(≥ 140)를 III군(3,894명, 70.3 ± 11.1, 여성 36.0%)으로 분류하여, 병원 내 주요 임상사건 및 1년 후 사망률과의 관계를 비교하였다. 결과: 각 군의 평균 연령은 I군(72.6 ± 11.0세), II군(71.3 ±10.7세), III군(70.3 ± 11.1세)으로 I군에서 연령이 높았다(p =0.006). I군에서 내원 시 비전형적인 증상 양상(p = 0.002), Killip class III-IV (p = 0.003), 심초음파을 이용한 좌심실 구혈률 40% 미만의 환자(p = 0.002), NSTEMI가 많았다(p = 0.001). 전체 대상 환자 5,249명 중 344명(6.6%)이 입원 중 사망하였으며, 이 중에서 I군 12명(12.9%), II군 66명(5.2%), III군 266명(6.8%)으로 I군에서 사망률이 유의하게 높았다(p = 0.006).다변량 회귀분석에서 나이(p = 0.001), Killip class III-IV (p =0.001), 뇌혈관 질환(p = 0.002), 만성 신부전증(p = 0.001), 급성 신부전증(p = 0.001), 심인성 쇼크(p = 0.001), 심실성 빈맥증(p = 0.005), 좌심실 구혈률 40% 미만(p = 0.001), 내원시 혈당 70 mg/dL 미만(p = 0.005)은 추적관찰 한 달간 사망률에 독립적인 예측인자이었다. 정상 혈당군에 비하여 저혈당 군에서 사망률이 유의하게 증가하였고(OR 3.571, 95% CI1.465-8.705, p = 0.005). 고혈당군에 비해 저혈당군에서 사망률이 유의하게 증가하였다(OR 4.088, 95% CI 1.757-9.511, p= 0.001). 그러나 추적관찰 1년간에서 내원시 혈당은 사망률의 유의한 예측인자가 아니었다(p = 0.428). 결론: 당뇨병을 동반한 심근경색증 환자의 내원 시 저혈당은 입원중과 추적관찰 한 달간의 사망률을 예측할 수 있는 예후인자였다. Methods: We analyzed 5,249 diabetic patients who enrolled in the Korean Acute Myocardial Infarction Registry from November 2005 to March 2013. The patients were divided into three groups according to their blood glucose level at admission; Group I:hypoglycemia (≤ 70 mg/dL), Group II: normoglycemia (70-140 mg/dL) and Group III: hyperglycemia (≥ 140 mg/dL). We assessed in-hospital mortality and the major adverse cardiac events based on blood glucose levels at admission. Results: The mean age was older in group I at 72.6 ± 11.0 years compared to 71.3 ± 10.7 in group II and 70.3 ± 11.1 in group III (p < 0.006). A total of 344 patients died during hospitalization. In-hospital mortality was higher in group I at 12.9%, compared to 5.2% in group II and 6.8% in group III (p < 0.006). Multivariable logistic regression analysis determined that the independent predictors of 1-month mortality were age, Killip class III-IV, cerebrovascular disease, chronic renal failure, acute renal failure, cardiogenic shock, ventricular tachycardia, ejection fraction < 40% and hypoglycemia in admission. The mortality rate at 1 month was significantly higher in group I compared to group II (odds ratio [OR] 3.571; 95% confidence interval [CI] 1.465-8.705, p = 0.005) compared to group II and group III (OR 4.088; 95% CI 1.757-9.511, p = 0.001). Conclusions: Hypoglycemia on admission was an important predictor of in-hospital and one-month mortality in AMI patients with diabetes mellitus. (Korean J Med 2014;87:565-573)

초등 과학 생명 영역 내용에 대한 학생들의 의문 유형과 해결방법에 관한 연구

임채성,최은아,박정인,이수진 부산교육대학교 과학교육연구소 2004 科學敎育硏究 Vol.29 No.-

In this study, the frequencies and types of questions about LIFE areas of the Science Curriculum of elementary school students were investigated through in-depth interviews with twelve 4th and 5th graders. The results of the research can be summarized as follows: (1) In conjectural question, the proportions of 'object exploration question' and 'object verification question' were high in all of the 4th graders and the students of low achievement level. (2) The numbers of causal questions generated by the 4th graders were much higher than those of the 5th graders. (3) The frequencies of the predictive, methodological, applicative questions were very low both in 4th and 5th grade students. (4) The numbers of conjectural questions were more in all students except the low achievement level of 4th graders at not-yet-taken contents than at already-taken ones. (5) The numbers of causal questions were more in all students except the low and middle achievement levels of 4th graders at not-yet-taken contents than at already-taken ones. (6) The numbers of the predictive, methodological, applicative questions of the 4th graders were more at not-yet-taken contents than at already-taken ones, whereas opposite trend in the 5th graders. (7) The numbers of students' curriculum-related questions were more in all students except the low and middle achievement levels of 4th graders at not-yet-taken contents than at already-taken ones. (8) As ways for solving or seeking answers about questions, the 4th graders suggested methods of consulting experts or teachers (23.9%), internet searching (21.6%), and books or science-related encyclopedia (20.3%), while the 5th graders suggested the internet searching (36.5%), consulting experts or teachers (24.8%), and books or science-related encyclopedia (17.7%). Based an these results, we suggest several ways for improving the question-posing abilities of the students and adequate use of students' questions in the process of science teaching learning.

영양사 유무에 따른 재가노인 급식서비스 제공기관의 실태 분석

정현영,양일선,채인숙,이해영 대한영양사협회 2004 대한영양사협회 학술지 Vol.10 No.2

The purposes of this study was to analyze the operational difference of foodservice center for homebound elderly by the presence of the dietitian. The questionnaire was developed to measure all variables for menu management and distributed to 103 meal service centers in charge of congregate meal service program and 57 centers for home-delivered meal service program. The data of 160 centers in charge of congregate meal service and home-delivered service centers were usable for analysis. Statistical data analysis was completed using the SAS 8.1 package program for descriptive analysis and chi-square test. Only 2 1.9% meal service centers had dietitians, what is more, they were not professionals who did menu management but foodservice managers, volunteers, cook or social workers. The current foodservice programs for the homebound elderly were operated without professional. In the part of menu management, dietitians were more actively involved in menu planning in the elderly foodservice center in the presence of the dietitians. The performance level of healthcare service was not significantly different, but the nutrition education in the elderly foodservice center with the dietitians was more frequently performed than that without the dietitians(p<0.05). In the food purchasing and food production management, the significant differences were shown that in the elderly foodservice centers in the presence of the dietitians, the proportion of the contract purchasing was significantly higher than that of direct purchasing(p<0.01). In food sanitaq management, the significant differences were not shown in the part of management of keeping meal for identifying the cause of food-borne illness and left-over, but the sanitation education for the foodservice employees was performed more frequently by the presence of the dietitians(p<0.01). In conclusion, the foodservice management was more systematically conducted in the elderly foodservice centers in the presence of the dietitians than that without dietitians. The elderly foodservice program has offered the health-related support for homebound elderly. Although there were several problems in elderly foodservice management, the program delivered well-targeted, effective, and efficient nutrition services and wide range of supportive service to the at-risk older population. It needs to be managed by professional for the improvement in the elderly foodservice.

家兎에서 局所 血行遮斷 및 神經切斷이 筋肉變化에 미치는 影響에 關한 實驗的 硏究

蔡仁貞,李弘鍵 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.1

The pathogenesis of the ischemic myositis is still controversial although most agree that arterial obstruction or it’s reflex spasm is the main cause in the development of the ischemic contracture of the muscle. Concomitant venous occlusion and neural interruption must play an important role in the development of the ischemic myositis. In the meanwhile, failure in the early diagnosis and treatment of degeneration, be it due to occlusion of a major peripheral vesseles or to a compartmental compression and to interruption of a major nerves of a limb, may lead to a serious and irreversible change of the muscle. The purpose of this study is to evaluate and compare the degenerative or necrotic changes in skeletal muscles employing HBFP (hematoxylin basic fuchsin picric acid) stain following muscle ischemia or neural interruption and their restorations, either qualitatively and quantitatively. The author has undertaken an experimental study upon morphological changes of the muscle after ligation of vessels and cutting of nerve of the rabbit limb, and attempted to detect sequential changes in the affected muscle by histochemical staining method developed originally by Lie et al., that is, hematoxylin basic fuchsin picric acid (HBFP) staining method. One hundred and two rabbits weighing 2,000~2,500gm were divided into the three groups. In the group 1 which has 51 rabbits, the degenerative or necrotic changes were studied after the ligations of a) both femoral artery and vein b) the femoral artery and c) the femoral vein. Muscle biopsy was carried out of the tibialis anterior muscle after 5, 10 and 30 minutes, and 1,2,3,4,5,6,8,10,12,15,18,21,24 and 48 hours using one rabbit each time. In the group 2 which was 30 rabbits, the degenerative and necrotic or regenerative changes were studied after the release of the ligation of the femoral vessels a) when the degeneration were noted in the whole fibers and b) when the necrosis were noted in the half of whole fibers which are detected by the results of HBFP stain in the group 1. Muscle biopsy was carried out of the tibialis anterior muscle after 1,2,3,5,7 and 9 days using one rabbit each time. In the group 3 which was 21 rabbits, the degenerative of necrotic changes were studied after the cutting of the sciatic nerve. And then, muscle biopsy was carried out of the dame muscle with same intervals as for the group 1 and 2, that is from 5 minutes to 9 days, using one rabbit each time. The biopsied samples were fixed in formalin and stained with H & E and HBFP stain for microscopic evaluation of muscle changes. The results obtained are as follows: 1. After the ligations of the femoral vessels performed in the group 1, the earliest evidences of muscular degeneration were detected by HBFP staining method within 10 minutes. This is the case of the of the simultaneous ligation of the femoral artery and vein which is 32% of the total fibers. This is the case of the femoral artery ligation which is 28% of the whole. This is the case of ligation of the femoral vein which is 12% of the total. However, it was required more than 4 hours, 4 hours and 6 hours repectively to detect such changes by H&E staining method. 2. In the group 1, the degenerative or necrotic changes have progressed with time. In case of the simultaneous ligation of the femoral artery and vein the changes were most remarkable. In the case of the ligation of the femoral artery the changes were moderate. In the case of the ligation of the fenoral vein the changes were the smallest in a certain time. 3. In the group 1, the degenerative changes were detected by HBFP staining method in the whole fibers without evidences of the necrosis after 6 hours in the case of the simultaneous ligation of the femoral artery and vein; after 8 hours in the femoral artery ligation; after 18 hours in the femoral vein ligation. However, it was required 15 hours, 18 hours, and 48 hours respectively to detect such changes by H&E staining method without evidence of the necrosis. 4. In the group 1. the necrotic changes progressed in the half of the entire fibers in the case of the simultaneous ligation of the femoral artery and vein after 12 hours by HBFP staining method; in the case of the femoral artery ligation after 18 hours; in the case of the femoral vein ligation after 48 hours. 5. After the release of the femoral ligation after certain period of time given by the HBFP findings of the group 1, in the group 2, the necrotic changes became worse about 5% to 15% in the first or second days, and the changes were stabilized relatively up to the nineth day after its release by HBFP staining method. 6. After cutting the sciatic nerve in the group 3, the degenerative changes were detected within one hour by HBFP staining method, whereas it requires 9 days by H&E staining method to detect such changes. And as a whole, the degenerative changes progressed more slowly than in the group 1 and 2 in the course of time.

Fosinopril(Monopril^(�))의 강압 효과에 관한 임상적 연구

강정채,조인종,류문회,서정평,길광채,박주형,정명호,조정관,박종춘 최신의학사 1995 最新醫學 Vol.38 No.2

Third-Generation P2Y₁₂ Inhibitors in East Asian Acute Myocardial Infarction Patients: A Nationwide Prospective Multicentre Study

Kang, Jeehoon,Han, Jung-Kyu,Ahn, Youngkeun,Chae, Shung Chull,Kim, Young Jo,Chae, In-ho,Hur, Seung-Ho,Seong, In-Whan,Chae, Jei-Keon,Cho, Myeong Chan F K SCHATTAUER VERLAGSGESELLSCHAFT MBH 2018 Thrombosis and Haemostasis Vol.118 No.3

<P>Third-generation P2Y(12) inhibitors (prasugrel, ticagrelor) are recommended in acute myocardial infarction (AMI). We aimed to evaluate the efficacy and safety of third-generation P2Y(12) inhibitors in East Asian AMI patients. From the Korean AMI Registry, 9,355 patients who received dual antiplatelet agent (aspirin with clopidogrel [AC], 6,444 [70.5%] patients; aspirin with prasugrel [AP], 1,100 [11.8%] patients; or aspirin with ticagrelor [AT], 1,811 [19.4%] patients) were analysed. In-hospital endpoints were all-cause mortality or bleeding events during admission and 1-year endpoints were major adverse cardiac and cerebrovascular events(MACCE) andmajor bleedingevents. Regardingin-hospital events, AP andAT showed similar all-causemortality rates but higher bleeding event rates comparedwith AC. This trend was extended to 1-year endpoints; Cox regression analysis showed that thirdgeneration P2Y(12) inhibitors had significantly higher bleeding risk (AP vs. AC: hazard ratio [HR], 2.14; 95% confidence interval [CI], 1.53-2.99; p < 0.001; AT vs. AC: HR, 2.26; 95% CI, 1.73-2.95; p < 0.001). A propensity scorematched tripletof 572 patients showed similar 1year MACCE and higher bleeding events with third-generation P2Y(12) inhibitors (2.1 vs. 2.6 vs. 2.1%, p = 0.790 for MACCE and 3.1 vs. 8.0 vs. 8.0%, p < 0.001 for bleeding events, in AC, AP andAT groups, respectively). Inverse probabilityweighted regression analysis and pooled analysis after randomly imputing missing variables showed consistent results. Collectively, prasugrel and ticagrelor showed similar rates of 1-year MACCE, but a higher rate of bleeding events, compared with clopidogrel in Korean AMI patients. Further studies are warranted to adapt Western guidelines on third-generation P2Y(12) inhibitors for East Asians.</P>

Clinical Characteristics of Acute Aortic Syndrome in Korean Patients: From the Korean Multi-Center Registry of Acute Aortic Syndrome

조정래,Sanghoon Shin,Jung-Sun Kim,고영국,홍명기,Yangsoo Jang,승기배,박헌식,Seung-Jea Tahk,임도선,Dong-Wun Jeon,In Ho Chae,김덕경,Junghan Yoon,정명호,최동훈 대한심장학회 2012 Korean Circulation Journal Vol.42 No.8

Background and Objectives: Acute aortic syndrome (AAS) is a heterogeneous group of disorders that often present with severe chest or back pain. It includes acute aortic dissection (AD), intramural hematoma (IMH), dissecting aneurysm, and penetrating aortic ulcer (PAU). The clinical picture of AAS and its prognosis have not been studied in a large number of Korean patients. Therefore, we organized a multi-cen-ter registry to identify the clinical characteristics and treatment patterns, as well as long-term outcomes in Korean patients with AAS. Subjects and Methods: Five-hundred twenty-eight patients, who had been diagnosed with AAS, were enrolled into this registry from 10centers. On a retrospective basis, we collected demographic, laboratory, imaging data, as well as follow-up clinical outcomes by reviewing medical records from individual centers. All the data were collected in core lab and analyzed in detail. Results: The mean patient age was 60.1±14.5 years; the male-to-female ratio was M : F=297 : 231. The prevalent risk factors for AAS in-cluded hypertension (361, 68.4%) and diabetes (52, 11.1%). The components of AAS that are included in this study are acute AD (446, 84.5%),IMH (57, 10.7%), and PAU (11, 2.1%). By type of AAS, patients diagnosed with Stanford A were 45.6% of enrolled patients, whereas those with Stanford B were 54.4% of enrolled patients. Among nearly half of the patients were treated with medicine (55.7%) alone, whereas 40.0%underwent surgery and 4.3% underwent endovascular treatment. Overall, the in-hospital event rate was 21.2% and the in-hospital death rate was 8.1%. The mean follow-up duration was 42.8 months and there showed 22.9% of total event and 10.1% of death during this period. Conclusion: By organizing a multi-center registry of AAS, we could identify the characteristics of AAS in real-world Korean patients. Further,prospective study is warranted with a larger number of patients.

Early Percutaneous Catheter Drainage Reduces Hospital Stay but Not Mortality in Patients with Pyogenic Liver Abscess

( Chang Hun Lee ),( Yun Chae Lee ),( Jaehee Park ),( Song Yi Yu ),( Hun Gil Jo ),( Jae Sun Song ),( Gum Mo Jung ),( Yong Keun Cho ),( Eun Young Cho ),( In Hee Kim ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: To investigate the factors associated with prolonged hospital stay and mortality among patients with pyogenic liver abscess (PLA) who underwent percutaneous drainage (PCD). Methods: We retrospectively reviewed data from PLA patients admitted from 2005 to 2018 at three tertiary hospitals in Jeonbuk province. We selected patients who underwent PCD during the admission period and early PCD was defined whether the procedure was done within 3 days of admission. Results: Among 655 patients diagnosed with PLA, 366 patients who underwent PCD were enrolled for the study. The patients had a mean age of 65.5 ± 14.7 years, and mean maximal diameter of the hepatic abscess was 6.1 ± 2.6 cm and 71.9% of the lesion was single. Next, two groups were divided depending on the time period of PCD and 269 patients (73.5%) underwent PCD within 3 days of hospitalization. In baseline characteristics, early PCD group was significantly higher in the number of abscess as well as the maximal abscess diameter. However, hospitalization period was significantly lower in the early PCD group though in-hospital mortality was not different. We checked laboratory results at 1 week after the admission and CRP levels were significantly lower in the early PCD group. We further analyzed the factors related to the long-term hospitalization more than 14 days. In multivariate analysis, underlying diabetes, lower albumin levels, and PCD inserted after 3 days of admission were independent factors associated with prolonged hospital stay. Conclusions: Early PCD facilitated improvement of inflammatory laboratory markers and shortened the hospital stay. Early PCD may be beneficial in patients with PLA.