긴 스텐트는 관상동맥 스텐트 재협착의 유일한 예측 인자

정명호(Myung Ho Jeong),조정관(Jeong Gwan Cho),강정채(Jung Chaee Kang),이승현(Seung Hyun Lee),홍영준(Young Joon Hong),박옥영(Ok Young Park),정우곤(Woo Kon Jung),이상록(Sang Rok Lee),김원(Woen Kim),김계훈(Kye Hun Kim),강경태(Kyung Tae 대한내과학회 2001 대한내과학회지 Vol.60 No.6

N/A Background : Coronary stenting is one of the most effective methods of percutaneous coronary interventions (PCI) in the treatment of intimal dissection and prevention of restenosis after balloon angioplasty. However, coronary stent restenosis still remains a major clinical limitation. Methods : Three hundreds seventy three patients who underwent coronary stent implantations and follow-up coronary aniograms at Chonnam National University Hospital between June 1996 and December 1999, were divided into two groups: 123 patients with restenosis (Group A: 98 male, 25 female, 58.5±9.4 year-old) and 240 patients without restenosis (Group B: 193 male, 47 female). Results : The prevalence of clinical diagnosis and risk factors for the atherosclerosis were not different between two groups. The indications for stenting and stent types, reference vessel diameter and minimal luminal diameter before stenting were not different. However, stent length was 23.4±7.57 mm in Group A and 20.8±6.58 mm in Group B, which were longer in Group A than in Group B (p=001). By multiple logistic regression analysis for the independent predictive factors for stent restenosis, the long stent more than 25mm in length was the only significant predictive factor after correction according to age, sex, risk factor, lipid profiles (OR=2.590, 95% C.I.=1.40-4.78). Conclusion : The long coronary stent more than 25 mm in length is a predictive factor of restenosis after coronary stenting.(Korean J Med 60:529-536, 2001)

원저 : 헬리코박터 파일로리의 3차 구제요법에서 리파부틴과 레보플록사신의 비교

정명호 ( Myung Ho Jeong ),정준원 ( Jun Won Chung ),이상진 ( Sang Jin Lee ),하민수 ( Minsu Ha ),정석후 ( Seok Hoo Jeong ),나선영 ( Sunyoung Na ),나병수 ( Byung Soo Na ),박성근 ( Sung Keun Park ),김윤재 ( Yoon Jae Kim ),권광안 ( Kwa 대한소화기학회 2012 대한소화기학회지 Vol.59 No.6

Background/Aims: There is increasing need for third-line therapy of Helicobacter pylori due to increasing level of antibiotics resistance. The aim of this study was to compare rifabutin and levofloxacin rescue regimens in patients with first- and second-line Helicobacter pylori eradication failures. Methods: Patients, in whom a first treatment with proton pump inhibitor-clarithromycin-amoxicillin and a second trial with proton pump inhibitor-bismuth-tetracycline-metronidazole had failed, received treatment with either rifabutin or levofloxacin, plus amoxicillin (1 g twice daily) and standard dose proton pump inhibitor. Eradication rates were confirmed with 13C-urea breath test or rapid urease test 4 weeks after the cessation of therapy. Results: Eradication rates were 71.4% in the rifabutin group, and 57.1% in the levofloxacin group, respectively. Although there was no significant difference in Helicobacter pylori eradication rates between two groups (p=0.656), rifabutin based regimen showed relatively higher eradication rate. Conclusions: Helicobacter pylori eradication rates of rifabutin- or levofloxacin-based triple therapy could not achieve enough eradication rate. Further studies would be needed on combination of levofloxacin and rifabutin-based regimen or culture based treatment. (Korean J Gastroenterol 2012;59:401-406)

심혈관계 건강문제 진단 및 치료 최신지견

정명호(Myung Ho Jeong) 성인간호학회 2016 성인간호학회 학술대회 Vol.2016 No.11

급성 심근경색증 환자에서 치료 시간 지연을 줄일 수 있는가? -한국인 급성 심근경색증 등록 연구의 경험-

정명호 ( Myung Ho Jeong ) 대한내과학회 2010 대한내과학회지 Vol.78 No.5

Time delay between medial contact and treatment in symptomatic patients with acute myocardial infarction (AMI) is the most important factor in the prediction of short and long-term mortality. The incidences of AMI have been increased in Korea rapidly. According to Korea Acute Myocardial Infarction Registry (KAMIR), pre-hospital delay is longer in Korean patients compared with Western patients, especially in patients with non-ST elevation myocardial infarction and in elderly female patients. Prompt seeking medical care in patients with suspected symptom of AMI can be achieved through patient and patient`s family education, active transportation system of ambulance, and good cooperations of regional emergency centers. Shortening time delay in treatment of AMI will save patient`s life and reduce medical costs in the future, especially in Korea. (Korean J Med 78:582-585, 2010)

의학강좌 : 개원의를 위한 모범처방 ; 흉통의 진단적 접근

정명호 ( Myung Ho Jeong ) 대한내과학회 2010 대한내과학회지 Vol.79 No.4

의학강좌-개원의를 위한 모범처방 : 새로운 관상동맥 스텐트의 개발 및 가능성

정명호 ( Myung Ho Jeong ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5

관동맥질환의 진단에 있어서 Exercise Treadmill Score 의 의의

서정평(Jeong Pyeong Seo),조인종(In Jong Cho),류문희(Mun Hee Rheu),박종수(Jong Soo Park),이명곤(Myung Kon Lee),정명호(Myung Ho Jeong),조정관(Jeong Gwan Cho),박종춘(Jong Chun Park),강정채(Jung Chaee Kang) 대한내과학회 1997 대한내과학회지 Vol.52 No.3

N/A Objectives: The treadmill exercise eletrocardiography(ECG) is the most commonly used non- invasive method in the evaluation of patients with chest pain. But the accuracy of treadmill exercise ECG in detecting the coronary artery disease(CAD) is still controversial. To improve the accuracy of the treadmill exercise test, exercise treadmill score(ETS) based on exercise duration, degree of ST deviation, and treadmill anginal index during treadmill exercise ECG has been used. Methods: The authors calculated ETS by simple equation(total exercise duration-5×maximal ST- segment deviation during or after exercise-4×treadmill angina index) and analyzed coronary angiograms of 173 patients(mean age '55.5±8.7, male: female=2.7: 1) who underwent treadmill exercise ECG and coronary angiography in Chonnam University Hospital from January, 1990 through March, 1993. Results. 1) The studied subjects were subdivided into 3groups according to ETS. Group A(high risk, ETS≤11) were composed of 15cases(mean age 60.2±7.4, male: female = 1.2: 1), group B(moderate risk, 5>ETS≥11) 71cases(mean age 60.2±7.4, male: female=3.3:1), group C(low risk, ETS>5) 87cases(mean age 54.8±9.2, male-female =2.5:1). Clinical diagnoses of the studiedsubjects were 63stable angina, 61unstable angina, 3acute myocardial infarction, and 46 old myocardial infarction. On coronary angiographic findings, 61patients had single vessel disesase, 23patients had two vessel disease and 13patients had three vessel disease. 2) The sensitivity of the treadmill exercise ECG in diagnosing coronary artery disease was 88% and the specificity was 46%. 3) One hundred percent of group A patients had CAD and 54% of them had multivessel disease, 75% of group B had CAD and 27% of them had multivessel disease, and 33% of group C had CAD and 10% of them had multivessel disease. 4) There were no significant differences in the siite of stenotic lesion and degree of stenosis according to ETS in the patients with single vessel disease. 5) There were no significant differences in left ventricular ejection fraction and left ventricular end-diastolic pressure among three groups. Conclusion: Exercise treadmill score is useful in predicting the presence and severity of CAD and that low ETS less than -11 may be an indicator of multivessel coronary disease.

경남 남부지방의 흑염소 사양관리 및 내부기생충 감염실태 조사

허정호 ( Jeong Ho Heo ),정명호 ( Myung Ho Jung ),조명희 ( Myung Heui Cho ),안동원 ( Dong Won Ahn ),이순선 ( Sun Seon Lee ) 한국가축위생학회 1999 韓國家畜衛生學會誌 Vol.22 No.1

Research results on actual management situation of 16 goat farms and internal parasite infection of 155 goats from January to November in 1997 in southern Kyoungnam area were as follows; 1. An average number of goats was 93. Among them, 81 % were farming the goat as avocation with the income rate less then 50%. Eight-four percent of farms terminated the parasites more than twice a year, and the survey showed the black goats had a high digestive and respiratory disease infection rate. 2. The internal parasite infection rate of the black goat was 96.8%, the goats were infected with 13 types of parasites. Of them, Emeria sp was 87.1%, Ostertagia sp 55.5%, Paraphista-num sp 45.8%, and Moniezia expansa 20%, respectively. 3. On the survey of multiple infection rate, both double and triple infection were 19.4%, more than septuple-infection 15,5%, single infection 13.4%, quintuple infection 12.3%, sextuple infection 9.0% and quadruple infection 7.7%, respectively. 4. Look over on seasonal infection rate, higher in fall and lower in winter. Especially, Paramishi-tom sp was higher in summer and winter, both Moniezia expansan and Bonaostom sp were higher in summer. 5. Research on the infection rate of parasites termination period revealed less-than-l-month period had 10-30 infection rate, the infection rate has increased sharply since 3 months passed after the goats were treated with parasite-cid.

젖소 유방염 관리에 따른 세균 및 체세포수 등급 실태 조사 분속

허정호 ( Jeong Ho Heo ),정명호 ( Myung Ho Jung ),박영호 ( Yeong Ho Park ),조명희 ( Myung Heui Cho ),이주홍 ( Ju Hong Lee ) 한국가축위생학회 1999 韓國家畜衛生學會誌 Vol.21 No.3

1. The number of average milking cows, clinical forms of mastitis, mastitis-developing cows, and cows killed by mastitis a year were 25.7, 1.8(7%), 6.3(26%), and 2.7(10.1%)heads, respectively. The annual grade changes of standard plate counts(SPC) and somatic cell counts(SCC) showed the grade 1A of SPC diminished sharply from April to August, we think it was due to the lack of proper management in farming season and the grade 3 of SCC indirectly influenced increased in huge during August. 2. The average number of parturitions of farms was 2.3, but 50% of below 1 parturition were 22 farms(31%), 50% of above 3 parturitions were 16(23%) out of 71 farms. According to grades of the number of parturitions of milking cows per each farm, the farms` grades recording 3 parturitions and 50% were little bit excellent. 3. The actual situation research of foremilking CMT revealed 35 out of 74 farmers didn`t do CMT. Among them(35 out of 74 farmers), 80% did not test thanks to the troublesome process of the CMT. SCC grade 3, among farms who did foremilking CMT once or twice a month and who did not were 29% and 40% respectively and SPC grade 1A were 55% and 9%, respectively. 4. The research of actual situation on milking management let us know 29 farm s(39%) did not do lastmilking, 37 farms(49%) usually did overmilking, and 34 farms(46%) did milking for 4 or 5 minutes. Grades according to average requiring times of milking showed SCC grade 1 of farms milking within 7 minutes was 11% and SPC grade 1A was 34%, on the other side, farms milking more than 7 minutes were 0% in SCC grade 1 and 13% in SPC grade 1A. Grades according to the starting time of milking after rubbing teats showed SPC grade 1A of farms starting milking at about 1 minute and over 2 minutes were 50% and 20%, respectively. 5. The research of actual situation on hygienic milking management uncovered 65 farms(88%) were using one towel which was used in washing teats and udders to wash more than 3 to 4 cows, and 53 farms(72 %) were using one dried towel to dry udders not for each cow but for more than 3 to 4 cows after washing. Also, on milking turns disclosed 30 farms(40%) were milking cows in the order of incoming without isolation of a dominant group. According to grades of towels used in washing teats and udders, farms using a towel for each cow were 56% and a towel for over 3 cows were 31% in SPC grade 1A. According to using-or-not grades of dried towels after washing udders, farms using a towel for each cow were 79% and a towel for over 3 cows were 21% in SPC grade 1A. 6. Farms doing teat-dipping before milking were 7(10%), not doing teat-dipping after milking, or doing sometimes were 9(12%), and doing right after milking were 57(77%). And farms doing teat-dipping after dry cows and before delivery were 21(28%). Farms using bethadine as an antiseptic solution were 70(95%), 40 farms(59%) diluted it with water as weak as 5 to 10 times, and on drying cows 64 farms(87%) slowly did it more than 2 days. Grade 1A of SPC of farms doing teat-dipping at every milking was 38%, farms doing occasionally or not was 33%, and farms doing it right after milking was 37% and doing after milking more than 5 cows was 20%. Grade 1A of SPC among farms diluting bethadine 5 times and diluting 5 to 10 times with water were 36% and 33%, respectively, and Grade 3 of SCC were 35% and 32%, respectively. 7. Studies on nonlactating period medical treatment, as the cows were on dry, 54 farms treated with their own hands. 73 farms(98%) had bovine mastitis treated for themselves. And on applying medicines against mastitis, 55 farmers chose them on the basis of their own experience, 42 farms(57%) were treated more than 3 days. 41 farms(55%) dumped away the mastitis infected milk separately, 24 farms(32 %) were feeding and milking at the same time. 8. Fifty-six farms(76%) always washed and disinfected milking machines after milking. Farms using the milking machines at low, or variable vacuum pressures, or at the vacuum pressure, set at the moment of its installation were 31(42%), and farms that did not know pulsation ratio were 27(37%). Farms changing liners when they were torn 8(11%), 58 farms(78%) said they checked milking system when there were wrong with them, 31 farms(42%) changed milking hoses when they found out problems, and 42 farms(57%) cleaned vacuum and milking systems when they felt dirty. The SPC grade 1A of farms washing and sterilizing milking machines was 38% and farms only washing was 28%.

원발성 비후형 심근증에서 심근비후 형태에 따른 임상상의 차이

이명곤(Myung Kon Lee),박종수(Jong Su Park),안영근(Young Keun An),박주형(Ju Hyung Park),정명호(Myung Ho Jeong),조정관(Jeong Gwan Cho),박종춘(Jong Chun Park),강정채(Jung Chaee Kang),박옥규(Ock Kyu Park) 대한내과학회 1993 대한내과학회지 Vol.45 No.4

N/A Background; The idipathic hypertrophic cardiomyopathy(HCM) is characterized by inappropriate myocardial hypertrophy of unknown cause. It may presents a variety of clinical and morphologic features according to the site and extent of the hypertrophy. The widespread application of echocardiography has made it possible to diagnose HCM earlier and easier, even in asymptomatic patients. However, clinical reports on the relationship between the distribution of left ventricular hypertrophy (LVH) and the clinical features are few in Korea. Therefore, the present clinical stu4y was performed to characterize more completely the distribution of LVH and to determine whether different patterns of hypertrophy are of particular clinical significance. Methods: The clinical, electrocardiographic and echocardiographic features were reviewed in 32 patients with idipathic HCM of Chonnam National University Hospital from July 1983 to August 1992. Results: 1) There were 23 males and 9 females. The mean age was 45.4±16.5 ranging from 15 to 74 years. There were no significant difference in age distribution according to the patterns of LUH. 2) Based on M-mode and 2-dimensional echocardiographic findings. The 32 patients were divided into 2 groups; 16 patients in the obstructive HCM group and the other 16 patients in the non-obstructive HCM group. Among the 16 patients with non-obstructive HCM, there were 6 patients with asymmetric septal hypertrophy(septal HCM), 7 patients with apical hypertrophy (apical HCM), 3 patients with symmetric (concentric) hypertrophy (symmetric or concentric HCM). 3) The cardinal clinical symptoms were dyspnea (71.9%), chest pain (59.5%), palpitation(37.5%) and syncope (12.5%). There were no significant difference in the frequency of symptoms according to the patterns of LCH. 4) On chest X-ray examination, the enlargement of cardiac silhoutte (C/T ratiok≥0.55) was observed in 32% of the cases. There wedre 4 patients with C/T ratio ≥0.6, and all had obstructive HCM. 5) In conventional 12 leads electrocardiograms, abnormal electrocardiographic findings were obtained in 94% of the cases. Among them repolarization abnormalities and left ventricular hypertrophy were most common, occuring in 80.6% and 64.5%, respectively. This was followed by abnormal Q waves (37.5%), atrial fibrillation (29.0%) and giant T wave inversion (29.0%). Giant T wave inversion was significantly more common in patients with apical HCM than in any other patients. 6) On the M-mode echocardiograms, the ratio of left ventricular septal thickness to left ventricular posterior wall thickness (IVS/LVPW) was 1.58±0.36 in obstructive HCM, 1.55±0.08 in septal HCM, 1.05±0.14 in apical HCM, and 1.13±0.08 in symmetric HCM. 7) On the 2-dimensional echocardiograms, the ventricular septum and anterolateral free wall were significantly thicker compared to left ventricular posterior wall in patients with obstructive and septal HCM (p<0.001, p<0.01 respectively). The apical wall was significantly thicker compared to the other regions in patients with apical HCM. 8) Mital regurgitation was detected by Doppler echocardiography in 13 (40.6%) of the total 32 cases of HCM and especially in 11 (68.8%) of the 16 cases with obstructive HCM. 9) Continuous wave Doppler echocardiography of left ventricular outflow tract was performed in 10 patients with obstructive HCM and revealed a mean peak pressure gradient of 50.1±39.9mmHg (13~130mmHg) between the left ventricular (LV) mid cavity and the LV outflow tract. Conclusion: Clinical features are very similar in every pattterns of LVH. But the above results suggested that depending on the extent and distribution of LVH, the functional and morphologic features of HCM may differ considerably. It is still questionable whether identifiable patterns of hypertrophy are of clinical significance.