네모나프라이드의 유효성 및 추체외로 부작용 : Haloperidol 및 Risperidone과의 자연관찰적 개방형 비교연구 A Naturalistic Open Comparative Study with Haloperidol and Risperidone

서영수,김용관,신동환,공보금,이정구,박정환,윤성환,정치영,이상경,김영훈 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

Objectives : This open prospective study was performed in order to evaluate the efficacy and extrapyramidal adverse effects of nemonapride in the schizophrenic patients, and was compared wit one of typical antipshchotics. haloperidol and one of atypical antipsychotics, risperidone. Methods : Thirty male and female schizophrenic patients(DSM-Ⅳ) were treated for 12 weeks with haloperidol(n=10), risperidone(n=10) and nemonapride(n=10). The overall efficacy was assessed at baseline, 1st week, 2nd week, 4th week, 8th week, and 12th week by the Positive and Negative Syndrome Scale for Schizophrenia(PANSS). Also the overall safety was assessed in the same time period by the Extrapyramidal Symptom Rating Scale(ESRS). Results : There were no significant differences in PANSS scores(total, positive, negative, and general psycho­pathology subscale) among haloperidol, risperidone, and nemonapride groups, Treatment responders, defined as at least 20% reduction of baseline total PANSS score, were achieved by 8 patients(80%) in haloperidol group, 10 patients(100%) in risperidone group, and 8 patients(80%) in nemonapride group. And there were no significant differences in ESRS total scores among haloperidol, risperidone, and nemonapride group. Inter-group comparison among haloperidol, risperidone and nemonapride group, as assessed by the ESRS, revealed no significant differences in the shifts to the maximum score, 9.4(±9.4), 6.2(±8.4), and 11.3(±8.1) respectively, and also revealed no significant differences in the mean time reaching the maximum score, 4.5(±4.5) week, 7.8(±4.8) week, and 4.6(±4.4) week, respectivily. Conclusion : There wee no significant differences in the efficacy and extrapyramidal adverse effects among haloperidal, rispecridone and nemonapride groups. These results suggest that nemonapride was as efficacious and safe in he treatment of schizophrenia, as well known and widely used antipsychotics, haloperidol and risperidone.

관상동맥 질환에서 SDF-1α의 농도

김보영,박용규,박형서,노상필,정승현,이유선,이정우,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Atherosclerosis is now viewed as an inflammatory disease of the vascular system. Expression of several chemokines, including monocyte chemoattractant protein(MCP)-1, MCP-4, RANTES(regulated on activation normal T-cell expressed and secreted), and interleukin-8(IL-8) are increased in human atherosclerotic plaques compared with normal vessels. They are involved in the pathogenesis of atherosclerosis and plaque rupture by activating and directing leukocytes into the atherosclerotic lesions. However, some are involved in homeostatic functions such as normal leukocyte traffic and growth regulation. SDF-la is a multi-functional cytokine that is involved in myelogenesis, hematopoiesis, angiogenesis and injured gastric mucosal regeneration in the gastric ulcer patient. SDF-la is recently shown to be highly expressed in atherosclerotic plaques and a potent platelet agonist. At least in high concentrations, SDF-la may mediate antiinflammatory and matrix stabilizing effects in unstable angina. Many studies are going on to know the function of SDF-la in coronary artery diseases. I investigated the difference of the plasma level of SDF-la between control group and coronary artery disease group. Total 75 subjects were enrolled. The diagnosis of coronary artery disease was confirmed in all patients by coronary angiography. Control subjects in this study were confirmed normal by coronary angiography. Clinical profile and risk factors were also reviewed. Control subjects in this study were 27 (M=10, F=17). Plasma for the study was collected before the angiography and centrifuged. SDF-la analysis was performed by ELISA. Plasma level of SDF-la is significantly increased in patients with stable angina(n=20) and unstable angina group(n=28) compared with healthy control group(n=27). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases. In this study, plasma level of SDF-la is increased in patients with stable angina and unstable angina groups compared with healthy control group(P<0.05). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases.

서울시내 고등학교 위탁급식의 급식비와 투자비의 실태 및 위탁업체의 기대수준 비교 분석

양일선,배환미,김현아,신서영,조미나,박수연,차진아,이보숙 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.5

The purposes of this study were to a) find out the operational characteristics of the contract-managed highschool foodservice in Seoul, b) investigate the expected level of meal-price and facilities investment cost perceived by contract-managed highschool foodservice managers c) compare the present level and expected level of meal-price and facilities investment cost. From October 12 to November 13 in 2001, the questionnaires were mailed to 249 high schools which was managed by contract foodservice company with respondent rate 40.2%. Data were analyzed using SPSS Win(10.0) for descriptive analysis and one group paired t-test. The results of this study were as follows ; 1. The student enrollment of highschools run by contract-managed foodservice was 1,243 with 72.6% participation rate of school lunch program. The average meal-price was 2,138 won. The average annual period of school foodservice operation was 156.78 days per year. The average contracting period was about 3 years. 2. The average cost concerned in the facilities investment amounts 169,578,180 won at the initial investment and 25,204,092 won at the repairs and maintenance cost in the course of operation. 3. The present level of meal-price and facilities investment cost were respectively 2,136won/meal and 171,157,336.72 won. And expected level.of meal-price and amount of facilities investment cost were 2,418.75 won and 121,353,215.19 won. Comparing the present level with expected level of the meal-price and facilities investment cost, expected level of meal-price was significantly higher than the present level of meal-price(p<.001) and expected level of facilities investment cost was significantly lower than present level of facilities investment cost(p<.001).

이행성 협심증 환자에서 운동부하 심전도 검사

이정우,박형서,박용규,노상필,이유선,정승현,김보영,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 관상동맥의 경련에 의한 이형성 협심증환자에 있어서 운동부하 심전도 검사의 결과는 매우 다양하다. 이에 저자들은 충남대학교병원 순환기내과에서 관상동맥조영술상 이형성 협심증으로 확진된 환자를 대상으로 운동부하 심전도 검사를 시행하여 이에 대한 결과를 연구하였다. 방법 : 1995년 1월부터 2002년 3월까지 흉통을 주소로 충남대학교병원 순환기 내과에 입원하여 관상동맥조영술을 시행하여 관상동맥의 내경이 50% 미만의 협착이 있고, 에르고노빈(ergonovine) 유발검사도 이형성 협심증으로 진단을 받은 233명중 운동부하 심전도 검사를 시행 받은 183명의 환자를 연구 대상으로 하였다. 운동부하 심전도 검사 결과의 판독시 발생할 수 있는 오류를 줄이기 위해서 운동부하 심전도 검사를 시행하기전 심전도상 ST분절의 상승(5예)이나 하강(8예)이 있는 경우 EH한 T파의 역위(19예)가 있는 32명의 환자를 제외한 총 151명의 환자를 대상으로 하였다. 운동부하는 Marquette사의 case 15 답차를 이용하였고, Bruce protocol에 따라 증상이 나타날 때까지 최대로 실시하였으며 각 stage 및 운동후의 혈압을 측정하고 12 유도 심전도를 기록하였다. 결과 : 1) 임상적 특성 - 내원시 임상 상은 안정형 협심증이 39예(25.8%), 불안정형 협심증이 103예(68.2%), 심근경색증이 9예(6.0%)이었다. 운동부하 심전도 검사 결과 양성 군과 음성군간에 있어서 당뇨병, 고혈압, 비만도, 총 혈청콜레스테롤치, 현재의 흡연 여부, 병력상 운동시 흉통의 유무, 내원시 임상적 진단, 협착의 정도, 연축의 수 등을 조사하였는 바 어떠한 인자들도 유의한 차이를 발견할 수 없었다. 2) 운동부하 심전도 검사 - 운동부하 심전도 검사를 시행 받은 151명의 환자중 음성인 경우는 134예(88.8%)이었고, 양성인 경우는 17예(11.2%)이었다. 양성 소견을 보인 환자들중 ST 분절의 상승이 4예(2.6%), ST 분절의 하강이 13예(8.6%)이었다. 3) 관상동맥조영술 - 관상동맥조영술상에서 혈관 경력 위치는 우관상동맥이 70예(46.1%), 좌전하동맥이 44예(28.9%), 좌회선동맥이 17예(11.2%)의 순으로 나타났다. 운동부하 심전도 검사상 ST 분절의 상승이 있었던 예중 Ⅱ, Ⅲ, aVF에서 ST 분절의 상승이 있었던 1예는 관상 동맥조영술상 우관상동맥에서 경련이 발생하였고, V2-V4에서 ST 분절의 상승이 있었던 2예중 관상동맥조영술상에도 좌전하행동맥에서 경련이 나타난 예는 1예이었으며 다른 1예는 좌회선동맥에서 경련이 나타났고, V5-V6에서 ST 분절의 상승이 있었던 1예는 관상동맥조영술상에도 좌회선동맥에서 경련이 나타났다. 운동부하 심전도 검사상 V5 또는 V6에서 ST 분절의 하강이 있엇던 13예중 6예(46.1%)는 관상동맥조영술상 우관상동맥에서 경련이 발생하였고, 3예(23.1%)는 좌전하행동맥에서, 1예(7.7%)는 좌회선동맥에서, 나머지 3예(23.1%)는 2개의 혈관이나 기타 분지에서 경련이 발생하였다. 결론 : 1) 이형성 협심증 환자는 운동부하 심전도 검사에서 11.2%의 양성소견을 보였다. 이중 ST 분절의 상승은 2.6%이었고, ST 분절의 하강은 8.6%이었다. 2) 이형성 환자중 운동부하 심전도 검사를 실시하여 음성을 보이는 경우 다혈관 관상동맥질환이기 보다는 이형성 협심증일 가능성이 더 높다고 예측할 수 있을 것으로 생각된다. 3) 이형성 협심증 환자중 운동부하 심전도 검사를 실시하여 ST 분절의 상승을 보이는 경우 다혈관 관상동맥질환이기 보다는 이형성 협심증일 가능성이 더 높다고 예측할 수 있을 것으로 생각된다. 4) 운동부하 심전도 검사 결과에 대한 당뇨병, 고혈압, 비만도, 총 혈청콜레스테롤치, 현재의 흡연여부, 병력상 운동시 흉통의 유무, 내원시 임상적 진단, 협착의 정도 등 어떠한 인자들도 3그룹(ST 분절의 상승, ST 분절의 하강, 음성)간에 유의한 차이를 발견할 수 없었다. 5) ST 분절의 상승 부위와 관상동맥조영술상 관상동맥의 연축이 일어나는 혈관과의 상관관계는 매우 높았다. No reports in the literature describe the results of exercise testings in a large number of patients with pure variant angina(coronary stenosis <50%) in Korea. In this report, We present the results of treadmil exercise testing in 151 patients with variant angina. 151 patients with angiographically proven coronary artery spasm underwent a treadmil exercise test. The clinical characteristics of variant angina patients classified according to ST-segment response to exercise were analyzed. Of 151 patients underwent a treadmil exercise test, negative result was seen in 134 patients(88.8%) and positive result was in 17 patients(11.2%). Of 17 patients saw positive result, exercise-induced ST segment elevation was present in 4 patients(2.6%) and ST segment depression was seen in 13 patients(8.6%). There was not a significant relationship between the ST segment response to exercise and the clinical variables(diabetes, hypertension, obesity, total cholesterol, current smoking, effort angina, clinical diagnosis, and degree of stenosis) assessed. Of 4 patients with ST segment elevation in treadmil exercise test, 1 patient with ST segment elevation in Ⅰ,Ⅲ,aVF had spasm in right coronary artery(100%) on coronary angiography, of 2 patients in V2-V4 had spasm in left anterior descending coronary artery in 1 patient(50%) and 1 patient in V5-V6 had spasm in left circumflex artery(100%). Positive treadmil exercise test was present in 11.2% of variant angina patient. If we have negative treadmil exercise result in patients with clinical manifestation of unstable angina at admission, we may have a suspicion of variant angina rather than multi-vessel disease. If we have exercise-induced ST segment elevation in patients with clinical manifestation of unstable angina at admission, we have a suspicion of variant angina rather than multi-vessel disease. Our result suggests that the correlation between the site of the ST segment elevation and the artery involved is quite good.

Condition Monitoring of Lithium Polymer Batteries Based on a Sigma-Point Kalman Filter

Seo, Bo-Hwan,Nguyen, Thanh Hai,Lee, Dong-Choon,Lee, Kyo-Beum,Kim, Jang-Mok The Korean Institute of Power Electronics 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.5

In this paper, a novel scheme for the condition monitoring of lithium polymer batteries is proposed, based on the sigma-point Kalman filter (SPKF) theory. For this, a runtime-based battery model is derived, from which the state-of-charge (SOC) and the capacity of the battery are accurately predicted. By considering the variation of the serial ohmic resistance ($R_o$) in this model, the estimation performance is improved. Furthermore, with the SPKF, the effects of the sensing noise and disturbance can be compensated and the estimation error due to linearization of the nonlinear battery model is decreased. The effectiveness of the proposed method is verified by Matlab/Simulink simulation and experimental results. The results have shown that in the range of a SOC that is higher than 40%, the estimation error is about 1.2% in the simulation and 1.5% in the experiment. In addition, the convergence time in the SPKF algorithm can be as fast as 300 s.

Condition Monitoring of Lithium Polymer Batteries Based on a Sigma-Point Kalman Filter

Bo-Hwan Seo,Thanh Hai Nguyen,Dong-Choon Lee,Kyo-Beum Lee,Jang-Mok Kim 전력전자학회 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.5

In this paper, a novel scheme for the condition monitoring of lithium polymer batteries is proposed, based on the sigma-point Kalman filter (SPKF) theory. For this, a runtime-based battery model is derived, from which the state-of-charge (SOC) and the capacity of the battery are accurately predicted. By considering the variation of the serial ohmic resistance (Ro) in this model, the estimation performance is improved. Furthermore, with the SPKF, the effects of the sensing noise and disturbance can be compensated and the estimation error due to linearization of the nonlinear battery model is decreased. The effectiveness of the proposed method is verified by Matlab/Simulink simulation and experimental results. The results have shown that in the range of a SOC that is higher than 40%, the estimation error is about 1.2% in the simulation and 1.5% in the experiment. In addition, the convergence time in the SPKF algorithm can be as fast as 300 s.

농촌어메니티자원도 정보전략계획 수립을 위한 목표설정

서보환 ( Bo Hwan Seo ),정남수 ( Nam Su Jung ),김종옥 ( Jong Ok Kim ) 한국농촌계획학회 2006 농촌계획 Vol.12 No.2

디지털 세대를 위한 스마트러닝 수업 모형 연구

서보배(Seo, Bo-Bae),채유진(Chea, Yu-jin),반영환(Pan, Young-Hwan),Xu, Ying-Qing,Mai, Long-Hui,Tian, Yi-Bo 한국디자인학회 2016 한국디자인학회 학술발표대회 논문집 Vol.2016 No.5

한국토종닭 3원 교잡종의 부화 및 육성 능력 (pp.399-404)

강보석(Bo-Seok Kang),홍의철(Eui-Chul Hong),김학규(Hak-Kyu Kim),유동조(Dong-Jo Yu),박미나(Mi-Na Park),서보영(Bo-Young Seo),추효준(Hyo-Jun Choo),나승환(Seung-Hwan Na),서옥석(Ok-Suk Seo),황보종(Jong Hwang bo) 韓國家禽學會 2010 韓國家禽學會誌 Vol.37 No.4

본 시험은 한국토종닭 3원 교잡종의 부화 및 육성 능력을 보고자 수행하였다. 공시계는 국립축산과학원에서 생산된 종란을 인수하여 부화시킨 3원 교잡종 병아리 암컷이다. 4가지 교배 조합으로 생산된 360수의 암평아리들을 3반복으로 반복당 30수씩 완전 임의배치하였다. 4개의 교배 조합은 A) 토착겸용종 C계통×재래종 Y계통×토착겸용종 C계통, B) 토착겸용종 C계통×재래종 L계통×토착겸용종 C계통, C) 토착 겸용종 C계통×재래종 G계통×토착겸용종 C계통, D) 토착겸 용종 C계통×재래종 W계통×토착겸용종 C계통이다. 수정률은 A, B, C 및 D에서 각각 89.8, 91.2, 92.4 및 92.8%였으며, 부화율은 각 계통에서 69.8, 70.7, 75.5 및 77.4%였다. 육성률은 계통간 유의적인 차이가 없었다(P>0.05). 20주령 체중은 B계통에서 높게 나타났으며(P<0.05), 0~20주령까지의 사료 요구율은 4계통에서 유의적인 차이는 없었다(P>0.05). 이런 결과들은 한국토종닭 3원 교잡종의 부화 및 육성 성적에 대한 기초적인 자료로서 이용될 것이라 사료된다. This work was conducted to evaluate the hatching and growing performance of Korean native chicken (KNC) 3 strains crossbred. A total of 360 female pullets were produced from CY × C (A), CL × C (B), CG × C (C) and CW × C (D) crossbred kept in National Institute of Animal Science, Korea. Hatchability of A, B, C and D were 69.8, 70.7, 75.5 and 77.4%, respectively. Livability were not significantly different by 20 weeks among 4 strains. Body weight B was high compared to other strains at 20 weeks. The feed conversion ratio of 4 strains was no significantly different among strains at 20 weeks. These results suggested the basic data that needed to develope the new strains.

과전압 해석 시뮬레이터 개발

최보환(Bo-Hwan Choi),서훈철(Hun-Chul Seo),김철환(Chul-Hwan Kim) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.7

최근의 배전계통의 단거리, 고밀도화 현상은 단시간의 전력품질 문제에 대한 피해를 증폭시키고 있다. 또한 현대의 전기, 전자장비들은 전력품질에 매우 민감하게 동작한다. 따라서 이와 같은 전력품질 문제에 대처하기 위해서 전력계통 과도현상의 정확한 해석이 반드시 필요하다. 본 논문은 전력계통에서 발생가능 한 과도현상 중 과전압 해석을 위한 시뮬레이터를 개발하였다. 시뮬레이터는 송전선로에서의 진행파 이론과 Bewley의 격자도를 통한 해석을 기초로 하여 MATLAB을 이용하여 개발하였다. 시뮬레이터의 실행결과를 검증하기 위하여 EMTP의 시뮬레이션 결과 및 수계산 결과와 비교하였다.