고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.

홈 네트워크에서 스케일러블 어플리케이션 서비스 방법

이윤주(Yun-Ju Lee),임태범(Tae-Beom Lim),김경원(Kyung-Won Kim),문재원(Jae-Won Moon),이석필(Seok-Pil Lee) 한국멀티미디어학회 2010 한국멀티미디어학회 학술발표논문집 Vol.2010 No.2

홈 네트워크 상에서 다양한 디지털 기기들 간에 멀티미디어 콘텐츠를 공유/연동하는데 있어, IPTV환경에서 응용프로그램을 비디오, 오디오, 그리고 이미지 파일과 같이 공유/연동할 수 있도록 하는 방법을 제안하고 사용자의 편의성을 증진시키고 시청 환경이 서로 다른 디지털 기기에 동시 적용 가능하며 다양한 시청 환경에 최적화된 사용자 인터페이스를 제공하도록 한다.

사용자 상황 정보 기반 음원 추천 방법

이윤주(Yun-Ju Lee),임태범(Tae-Beom Lim),이석필(Seok-Pil Lee) 한국멀티미디어학회 2010 한국멀티미디어학회 학술발표논문집 Vol.2010 No.2

기존의 음원 추천 방법은 사용자 프로파일, 사용자 선호도, 사용자가 오디오 컨텐츠를 재생한 히스토리 목록, 전문가들의 추천 음악 등을 고려하여 각 사용자가 좋아할 만한 음악을 추천해 주는 방법을 사용해 왔다. 이 논문에서는 상황 정보를 이용한 음원 추천 방법을 바탕으로 사용자가 처한 상황을 고려하여 사용자에게 더 큰 만족을 줄 수 있는 음원 추천 방법을 제안한다.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

수의근의 근섬유형에 따른 재생 능력

이석범 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.1

The repair of striated muscle after injury by trauma or chemicals occurs simultaneously by the regeneration of disrupted muscle. Tlthough the efects of various external factors e.g. denervation, irradiation and steroid upon the repair of striated muscle injury has been previously studied, no attention has been focused on the effect of trauma and local anesthetics on the regenearted muscle fiber. The author induced a constant contusion injury on the calf of rats using Drop-Weight method Lidocaine and/or epinephrine was intramuscularly injected at the site of injure. The results of morphological and histochemical observation were as follows: 1) The striated muscle showed histological and histochemical evidences of the healing process for 90 days. 2) Formation of myotube appeared on 7th day and decreased on 15th day. Myotube persisted upto 30 days. 3) The cross sectional area of the muscle fibers was measured days 30 and 90. Local anestetic injection groups showed mire muscle fiber atrophy than trauma alone groups. Muscle fibers were significantly more atrophied on day 90 in all types of fiber after injection of mixture of lidocaine and epinephrine and on type B after injection of mixture of lidocaine and epinephrine and in type B after injection of epinephrine compared to control group. 4) Regenerative capacity of the injured muscle piber was correlated with the formation of myotubes.

류마티스성 관절염 및 퇴행성 골관절염에 있어서의 Tenoxicam(Tilcotil^(�))제제의 임상적 연구

이준규,임현수,이정웅,김석범 최신의학사 1988 最新醫學 Vol.31 No.6

편측하지의 대퇴골 및 경골골절에 대한 임상적 고찰

이준규,김석범 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

The fracture of the ipsilateral femur and tibia is ususlly produced by violent external forces. It has many problems in the treatment, and may produce many complications. There are no many literatures about the method of treatment, and it may produce variable prognosis with different treatment. The most important objectives of the treatment is the restoration of the function. It can be obtained by early exercise therough the rigid fixation of the both fractures. The authors reviewed 18 cases of fracture of the ,ipsilateral femur and tibia treated at the department of orthopaedic surgery CNUH. and compared the results according to the method of treatment. The results were as follows: 1. Fifteen patients were male, and three patients were female. Of the eighteen patients, eleven patients were at their third and fourth decades. 2. The causes of the injury were traffic accident in fifteen cases, and industrial injuries in three cases. 3. The femoral fractures were open in five cases, and in twelve cases of the tibial fractures. 4. The femur fractures wer treated by internal fixation in sixteen cases, and by conservative treatmentin two cases. 5 The tibial fractures were treated by internal fixation in eight cases, by external fixtion in eight cases, and by conservative treatment in two case. 6. After follow up, the restoration of the function was maximum in the group of femoral internal fixation and tibial internal fixation, and the restoration of the function was minimum in the group of conservative treatment of the femur fractures. 7. The most important point of the treatment was early exercise through the rigid fixatioo of the both fractures.

가와사끼 질환에서 감마글로불린의 대량 정주 용법의 효과에 관한 연구

이경희,하태선,박범수,한헌석,하성훈 충북대학교 의과대학 충북대학교 의학연구소 1994 忠北醫大學術誌 Vol.4 No.1

가와사끼병으로 진단받고 고용량의 감마글로불린(2 gm/㎏)을 정맥주사 받은 17명의 환아를 대상으로 임상적 효과와 관상동맥의 변화에 미치는 영향을 연구하여 다음의 결과를 얻었다. 1. 대상 환아의 연령은 평균 2.03세로 3개월에서 5세 사이에 분포하였고, 2세 이하가 58.8%를 차지하고 남여의 비는 1.125 : 1이었다. 2. 가와사끼 진단 기준의 6가지 주증상 중 5가지는 전환아에서 나타났으며, 경부 림프선 종창만 64.7%에서 나타났다. 발생 계절은 봄과 겨울에 76.5%의 환아가 발생하였다. 3. 대량의 감마글로불린 주사 직후 평균 11.4시간에 고열이 없어지고 다른 주증상들도 없어지기 시작하였으며, 대부분(82.3%)이 주사후 20시간 이내에는 소실되었다. 주사중 3례(17.6%)에서 오한 및 일시적인 체온의 상승을 보였으나 주사를 중단할 필요는 없었다. 4. 발병 4주 이내에 관상동맥의 확장이 관찰된 경우는 8례(47.1%)였으나, 이들은 모두 경도의 확장이었다. 발병 2개월 후에 시행한 심초음파도에서는 2명(11.7%)에서만 경도의 확장을 보였고, 나머지는 모두 정상으로 회복되어 있었다. 5. 최저 헤모글로빈치, 최대 C-반응성 단백질, 최대 총백혈구수, 최고 적혈구 혈침속도, 혈소판 최고치는, 발병 4주 이내와 2개월 후에 관상 동맥의 변화가 있는 군과 정상인 군 사이에 의미 있는 차이는 없었다. 이상의 결과로 가와사끼병의 치료에 있어서 단일 고용량의 감마글로불린을 정맥주사하는 방법이 심각한 부작용 없이 임상적 증세를 빨리 호전시키며, 관상동맥의 합병증을 줄이는데 효과적임을 알 수 있었다. 따라서 모든 가와사끼병의 급성기에 가능한 빨리 단일 고용량의 감마글로불린을 정맥주사하는 것을 추천한다. The authors studied the effect of single high-dose intravenous gammaglobulin(2 gm/㎏) on the clinical symptoms and coronary artery abnormalities in seventeen Kawasaki patients and obtained the following results. 1. The patients' ages ranged from 3-month to 5-year, with mean age of 2.03-year. The patients under 2-years comprised 58.8%. The ratio of male to female was 1.125. 2. All of the patients showed 6 major diagnostic criteria with one exception of cervical lymphadenopathy(64.7%). The disease occurred mainly spring and winter season(76.5%). 3. Fever subsided within 20 hours' of intravenous gammaglobulin infusion in most of the patients(82.3%) with mean value of 11.4 hours, Transient side effects such as fever and chilling sense, developed in 3 cases(17.6%), but there was no need to quit infusion. 4. Echocardiographically, mild coronary arterial dilation was observed in 8 cases(47.1%) within 4 weeks' of onset. After 2 months' of onset, only 2 cases(11.7%) showed mild dilation. 5. There were no significant difference between coronary arterial dilation group and normal group before 4wk and after 2 mo of onset, in terms of hemoglobin nadir, maximal CRP, maximal WBC count, peak ESR, and peak platelet count. Conclusively, single high dose intravenous gammaglobulin infusion in Kawasaki disease showed effective improvement of clinical symptoms and decrease of coronary arterial abnormality. There fore all the children with Kawasaki disease should be treated with single high-dose intravenous gammaglobulin infusion as soon as possible.

敎會 禮拜空間의 採光部에 關한 調査硏究 : 全南 東部圈 敎會를 中心으로 Focused on churches in chonnam eastern region

李碩配,金幸範 순천대학교 공업기술연구소 1998 工業技術硏究所論文集 Vol.12 No.-

We perceive the space through physical sense organs, among them, it is very much and precise to get information through optical sense. The most of visual perception is composed of information obtained by light. Light has important meaning in the architectural space. It sometimes helps to define the space and change the character of space and make the space flexible. Also the light in church architecture represents reciprocal image between goodness and badness, truth and falsehood. The symbol which light has shows that light is a very important element in church architecture and it relates very closely to faithful behavior. Also a good light environment should be equipped for audience to arise an absolute piety to God. To obtain the adoption method of effective light which influences worship behavior, this paper field surveys the elements of light through the adoption case of light in already established church architecture. Also this paper aims to provide basic data for architectural design based on improved light environment.

류마티스성 관절염 및 퇴행성 골관절염에 있어서의 Tenoxicam ^� 제제의 임상적 연구

이준규,임현수,이정웅,김석범 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

The authors have conducted a clinical study to evaluate the efficacy, tolerance and safety with newly developed Tenoxicam^ⓡ to thirty-four cases of the patient of Rheumatoid arthritis and Degenerative osteoarthritis during 4 months from January 1988 to April 1988. Treatment for the patient was done with one tablet of Tenoxicam^ⓡ (20mg) per oral once a day for 4 weeks. The evaluation of the patient was done at second and fourth week after initial administration of the drug. Results were as follows: 1. Out of 34 cases, male were 4(11.8%), female were 30(88.2%), and predominent age group was 40-59 years old 17(50.0%). 2. The diagnosis of these patients were Rheumatoid arthritis 22(64. 7%) and Degenerative osteoarthritis 12(35.3%). 3. Overall efficacy, there was marked improvement in global condition, pain on movement, pain at night and stiffness. 4. Side effects were seen in 4 patients such as 2 case of heartburn, 1 case of nausea and vomiting and 1 case of diarrhea. 5. There were no significant difference between pre-and post-treatment laboratory check. 6. Conclusion: The oral Tenoxicam^ⓡ was very effective for the treatment of Rheumatoid arthritis and Degenerative osteoarthritis, and side effects were few and generally mild.