In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent

Yoonhyeong Byun,Eun Jin Kim,Areum Lee,Young-Ah Suh,Hee Ju Sohn,Jung Min Lee,Jae Seung Kang,Yoo Jin Choi,Youngmin Han,Hongbeom Kim,Wooil Kwon,Jin-Young Jang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.2

Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects. Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model. Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6–10] minutes vs. 8 [6–10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656). Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.

간암 환자에 합병된 Citrobacter braakii 패혈증 1례 보고

이해미,배성하,이수남,이정우,신아영,류시영,이수연,윤문희,한선영,한남익,이영석,유진홍 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Citrobacter species is a gram-negative bacilli that can cause opportunistic infections in immunocompromised hosts. Citrobacter braakii refers to the genomospecies 6 of the Citrobacter freundii complex. There are no detailed studies on infections caused by this newly identified specific genetic species in Korea. We herein report a case of a patient with hepatocellular carcinoma who, after undergoing transcatheter arterial chemoembolization, developed biloma which later progressed to C.braakii sepsis and did not respond to treatment. To our knowledge, this is the first reported case in Korea on C. braakii infection resulting in septic shock in a patient with malignancy in Korea.

경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

임부의 연령에 따른 보완대체요법에 관한 인식 태도 경험 비교 연구

김연진,김지연,노경민,신혜리,유예지,이지민,장희조,정아인,최소정,강숙정,이향연,민혜영 이화여자대학교 간호과학대학 2016 이화간호학회지 Vol.- No.50

Purpose: This study aims to test if the age of pregnant women affects the perception, experience, and attitude towards complementary alternative therapy (CAT), by investigating the perception, experience, and attitude of pregnant women under the age of 35, and above 35 (Advanced Maternal Age). The study will 1) find the general characteristics of pregnant women under and over the age of 35 2) compare the perception, behavior, and experience of pregnant women under and over the age of 35, and 3) find the comparison of the perception, behavior, and experience according to the general characteristics of pregnant women under and over the age of 35. Method: The subjects of this study are composed of 44 women under the age of 35 and 44 women above the age of 35, totaling 88 pregnant women visiting midwiferies, obstetrics and gynecology, and baby fairs in Seoul and Gyeong-Gi area. Data for this study was collected from November 28, 2015 to January 6, 2016 for 40 days. The collected data analyzed mean, standard deviation, t test, ANOVA, and chi-square by using SPSS 23.0. Result Results show that there is a significant difference in the perception, attitude, and experience of the two-sample groups in the use of CAT. The question of “what is most necessary when applying CAT in a hospital clinical environment” for the perception criteria came out with the results of t=9.980, p<.05. For the attitude, results showed that the answers of pregnant women under the age of 35 displayed a more positive attitude towards CAT. (t=2.421, p<.05) Lastly, in the experience section, pregnant women under the age of 35 showed more CAT use than the other sample group. Conclusion Results have shown that there is a difference in the perception, behavior, and experience between the two sample groups. Therefore further research on the efficacy and the adverse effects of CAT needs to be done.

상암 새천년주거단지 현상설계에서 나타나는 우리나라의 지속가능한 주거단지계획 적용특성

이아영,김진균 대한건축학회 2004 대한건축학회논문집 Vol.20 No.1

The Design competition of Sangam residential area held by SMDC is representative of Korean sustainable housing design. 31 entries were proposed by many well-known architects groups. For that reason, this is a good object to explore the cognition and applications of sustainable housing design in Korea. Through literature studies, it can be said that sustainable housing could be fulfilled when energy, environment, ecology and humanity would be in harmony mutually in a circular system. These four sections are categorized by several factors like passive design, microclimate, traffic, cycle of water, etc. Index was made after analyzing the index of the domestic verifications and foreign sustainable housing examples. And then, all designs of Sangam were explored and compared with foreign examples within this index. These results are followings: The prize-winning designs are specially apt to enlarge the underground built area to remove lots of parking areas on the ground, finally reduce the natural land area. When the frequency of the use of factors was analyzed as a whole, total frequencies of Sangam and foreign ones are similar. In sections, ecology in Sangam shows higher frequency than foreign ones. But in the design methods, Sangam designs are poorer than foreign ones. Therefore it can be said that the principles of sustainable housing are applied roughly and there are many complications and contradictions in determining building forms, floors and uses of natural environment.

영동 국악체험촌 조경기본계획

"이시영", "박진아", "련등", "김대수" 배재대학교 자연과학연구소 2015 自然科學論文集 Vol.26 No.1

21세기는 지식 정보화와 병행하여 문화의 세기가 될 것으로 예견된다. 문화상품의 고부가가치를 창출하기 위하여 영동군이 보유하고 있는 국악 인프라와 연계하여 국가 문화산업의 전략적 우위를 도모하고 전통문화의 전승과 발전에 일익을 담당코저 한다. 난계 박연 선생의 탄생지인 심천면 고당리 일원에 국악을 테마로 하는 체험촌 조성이 필요하였다. 영동군에서는 한국의 정신세계를 재조명하고 전통문화에 대한 이해와 접근이 용이한 관광자원으로 국악체험촌을 건립하여 관광명소를 육성하고자 한다. The 21st century is predicted to be the century of knowledge and information and culture. To create high value of cultural goods, in conjunction with Korean Classical Music infrastructures which Yeongdong County has, this proposal was planning to be contributed to the development of traditional culture and folklore. Yeongdong County revisited in the spirit world and build an understanding of Korea and Experience Music Village with easy access to the traditional culture and tourist resources and to foster the attractions.

집합주거단지의 치유조경 계획요소에 관한 연구

이은엽, 박진아, 심준영, 이시영 배재대학교 자연과학연구소 2014 自然科學論文集 Vol.25 No.1

본 연구는 집합주거를 대상으로 그 외부공간에 치유환경을 제공하고자 함이 궁극적 목표이며, 본 연구는 그 이전에 치유환경설계에 앞서 치유정원의 환경적 특성과 치유정원의 계획요소를 밝히고자 한다. 본 연구를 통해 치유공간계획을 위한 기초적 지침을 제시하고자 한다. 연구방법으로서, 기존 학자들의 치유정원에 관한 특성을 분석하여 공통적인 환경특성 요소들을 도출하고, 이를 바탕으로 국내·외의 문헌을 참조하여 세부항목을 설정하고 치유정원의 특성을 파악하였다. 치유정원의 계획원칙 및 요소를 도출하기 위해 문헌조사와 전문가의 의견을 취합하여 공동 집합 주거단지에 적용 가능한 조경계획요소를 설정하였다. 치유환경의 환경특성의 계획요소는 총 6가지의 항목을 설정하였다. 안전한 환경, 치료적 환경, 보조적 환경, 지남력 강화환경, 쾌적성, 사회적 환경으로 구분하였다. 계획원칙으로는, 안전감, 이용자 그룹과 요구에 대한 인식, 다양한 활동패턴의 제공, 다양하게 경험할 수 있는 치유공간, 휴식과 활동공간에 대한 특성부여, 사적공간과 사회적 교류, 주변환경과 전망, 유니버셜 디자인, 셉테드 디자인으로 구분하였다. The purpose of this study is to figure out planning guidelines and environmental characteristics of healing garden for providing healing surroundings on outdoor spaces of multiple housing complex. To do this, this study examined previous research papers and scholastic writings, related to healing environment and garden, and analyzed case studies. As a result, composition elements of planning for healing garden were classified 6 types; safe, therapeutic, assistance, orientation strengthen, comfort and social environment. Planning principles of healing landscape are set for 9 types; sense of safe, recognition of the user group and demand, offers a variety of activity patterns, healing space for various ways to experience, characteristics for relaxation and activities, private space and social interaction, surroundings and views, universal design and cpted design. From the precedent review and literature view planning guidelines for creating healing gardens will be created. These guidelines will then be applied to an existing healing site to create an informed design solution.

구내 절개법에 의한 악하선 적출

이국엽,진우정,백진아 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.4

Surgical removal of the submandibular gland via intraoral approach was performed. The surgical procedure to be used for removal of submandibular gland had been performed via extraoral approach for many centuries. Disadvantages of extraoral technique are the esthetic distress due to an external scar, residual inflammation in Wharton's duct, and neurological complications. Indications of intraoral approach are unlimited in surgical cases of submandibular gland. Advantages of intraoral approach are esthetic satisfaction due to no remaining scars, preservation of adjacent anatomical structures and preservation of lower facial contour. This paper describes the surgical technique of the submandibular gland excision through an intraoral approach and variable incision lines tried. In 7 cases, excellentresults were obtained after removal of the submandibular gland through an intraoral approach.

생태학적 관점에서 고찰한 국내주거단지 설계과정의 문제

이아영,김진균 대한건축학회 2004 대한건축학회논문집 Vol.20 No.10

Despite persistent discussion for the past decade on the sustainable housing designs, little change has been made at the fundamental level To examine the constraints, research efforts have to be focused on illuminating the problems in the total process of housing design in Korea Therefore, this study examined the design process, from inception to its detail design, of the Sang-Am New Millenium Residential Area to identify its inherent constraints Its logical framework laid upon two types of information, 'image information' and 'test information' To identify the problems in the design process, 'test information' was produced through interviews, a qualitative research method First of all, the planning index of ecological housing was constructed by examining the literature, existing studies and foreign housing cases and constituted of 24 factors in 4 sectors Based on this index, the discrepancies between schematic design and construction documents were investigated The causes for these differences can be accepted to precisely match the test information Then, interviews were conducted with groups participating in the design Factors identified as the test information were the residents' consciousness, the limits of regulation and system, the consciousness and organizational system of clients or operator, the design capabilities of designers and the technical limits of engineers This test information was produced by the participating parties In the design process except the residents In conclusion, the subject of sustainable development and ecological architecture has so far achieved only a vague awareness, for its necessity still lacks practical and systematic efforts for fruition Therefore, expediting the realization of ecological housing require an unequivocal clarification of the roles of participating groups within the design process and a research on the practical planning goal and methods