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윤웅,김재규,박수민,김윤현,강형근,Yoon, Woong,Kim, Jae-Kyu,Park, Soo-Min,Kim, Yun-Hyeon,Kang, Heoung-Keun 대한영상의학회 1996 대한영상의학회지 Vol.34 No.2
Purpose : The purpose of this study was to determine the safety and efficacy of the percutaneous transluminalangioplasty(PTA) in patients with chronic arterial occlusive disease below the knee joint. Materials and Methods :We retrospectively analyzed the results of 36 procedures in 16 patients. There were 15 men and one woman, aged57-75 years(mean, 62 years). Indications were disabling claudication(SVS/ISCVS grade 1, category 3) in five cases,rest pain(grade 2, category 4) in three cases, and non-healing ulceration or gangrene(grade 3, category 5) ineight cases. PTA was performed by using small vessel balloon catheter of 2-4 mm and 3 mm monorail balloon catheterin tibioperoneal vessels and 5-6 mm balloon catheter in distal popliteal artery and tibioperoneal trunk. Combinedthrombolytic therapy with Urokinase was performed in 14 patients. Results : Involved infrapopliteal vessels werefour distal popliteal arteries, 15 tibioperoneal trunks, six anterior tibial arteries, five posterior tibialarteries, and seven peroneal arteries. Technical success was determined when post-PTA angiogram showed less than30% of residual stenosis. Clinical success was defined as improvement of clinical symptoms, such as disappearanceof claudication or rest pain, and healing of ulceration. Technical success was achieved in 30 of 36 arteries(83%).Clinical success was achieved in 12 of 16 patients(75%) at an average follow-up of 13.3 months(range, 2-46months). Clinical success rate was 100% in grade 1 category 3 patients, 67% in grade 2 category 4 patients, and63% in grade 3 category 5 patients. Complication included two distal emboli, one vessel rupture, one vesselthrombosis, and one occluding intimal flap. Conclusion : PTA was an effective method for treatment of chronicarterial occlusive disease below the knee joint and considered as the procedure of first choice. Severeclaudicant(grade 1) should be included in the indication of the tibioperoneal PTA.
양릉천(陽陵泉) 우슬(牛膝) 약침이 흰쥐의 고지혈증에 미치는 영향
최준수 ( Joon Soo Choi ),임윤경 ( Yun Kyung Yim ),이병렬 ( Byung Ryul Lee ),양기영 ( Gi Young Yang ),김재규 ( Jae Kue Kim ) 대한경락경혈학회 2010 Korean Journal of Acupuncture Vol.27 No.3
Objective & Methods: The purpose of this study is to observe the effects of herbal- acupuncture with Achyranthis Radix(AR-HA) at GB34(Yangleungchean) on hyperlipidemia in rats. The author performed several experimental items to analyze the levels of various components and enzymes in serum and liver, as well as the histological changes of liver and aorta. Results: 1. Achyranthis Radix herbal acupuncture solution increased DPPH radical scavenging activity and HMG-CoA reductase inhibition rate in rat liver cells. 2. AR-HA at GB34 decreased the level of serum total cholesterol, and increased the ratios of HDL-cholesterol to total cholesterol, phospholipid to total cholesterol in hyperlipidemic rat. 3. AR-HA at GB34 decreased the hepatic HMG-CoA reductase activity in hyperlipidemic rat. 4. AR-HA at GB34 increased the hepatic GSH level in hyperlipidemic rat. Conclusion: From the above results, it is suggested that AR-HA at GB34 has a therapeutic effect on hyperlipidemia.
김상균 ( Sang Gyun Kim ),김재규 ( Jae Gyu Kim ),신성관 ( Sung Kwan Shin ),김현수 ( Hyun Soo Kim ),설상영 ( Sang Young Seol ) 대한소화기학회 2009 대한소화기학회지 Vol.54 No.5
Peptic ulcer is one of the most prevalent diseases in gastrointestinal field. Recently, evolution was made for path-ophysiology of peptic ulcer from no acid, no ulcer to Helicobacter pylori and non-steroidal anti-inflammatory drugs. The prevalence of peptic ulcer disease is estimated about 10% in Korea, and has declined due to Helicobacter pylori eradication therapy. Peptic ulcer has the cycle of exacerbation and improvement in the clinical course, and has not occasionally any clinical symptom. Helicobacter pylori eradication has made the marked reduction of relapse of peptic ulcer disease. Although nationwide endoscopic screening has enabled accurate diagnosis of peptic ulcer disease, general guideline for diagnosis of peptic ulcer has not made in Korea. Herein, we propose a guideline for the diagnosis of peptic ulcer according to domestic, international clinical studies, and experts opinions with level of evidence and grade of recommendation. (Korean J Gastroenterol 2009;54:279-284)
궤양성 대장염에서 점소 당항원 sTn 과 Tn 의 발현에 관한 연구
장무선(Moo Sun Chang),도재혁(Jae Hyuk Do),김형준(Hyung Jun Kim),유경금(Kyung Kum Yoo),박수정(Soo Jeong Park),문철(Cheol Moon),허철행(Cheol Heang Heo),김재규(Jae Gyu Kim),장세경(Sae Kyung Chang),박실무(Sil Moo Park),김미경(Mi Kyung K 대한내과학회 1997 대한내과학회지 Vol.52 No.1
N/A Objectives: Long standing observation, which may relate either to the causes or the effects of UC, reveals that there is a pronounced alteration of mucin such as quantitative and qualitative abnormalities of mucin glycoprotein. But recently in situ hybridization technique showed no specific difference in the expression of apomucin mRNA in UC. Therefore we investigated whether abnormality of mucin was originated from defect in glycosylation. And we also tried to find differences in the expression of Tn and sTn antigens between Korean and Jewish patients with UC. Methods: We performed the immunohistochemical staining using the monoclonal antibody of mucin carbohydrate antigens Tn and sTn in 19 patients with UC. Results: Tn and sTn antigens were not expressed throughout the crypt and surface epithelium in normal colon but both of mucin carbohydrates antigens were well expressed in mild UC, Tn antigen was seen in the surface epithelium with perinuclear pattern and sTn antigen was shown not only in surface but also in crypt epithelium. In severe UC, Tn antigen was well expressed, but sTn antigen was not expressed. Tn antigen seemed to be ex-pressed more frequently than sTn antigen with severity of inflammation. These results were similar in Korean and Jewish patients with UC. Conclusion: These results suggest that inflammatory bowel disease has some deterioration in the step of glycosylation in the cytoplasm and there was no racial difference in the expression of Tn and sTn antigen in Korean and Jewish patients with UC.
하순옥(Soon-Ok Ha),박인혜(In-Hye Park),이용석(Yong-Seok Lee),김재규(Jae-Kyu Kim),정수열(Soo-Yeol Chung),최용락(Yong-Lark Choi) 한국생명과학회 2008 생명과학회지 Vol.18 No.7
캥거루의 수입육 중 꼬리의 식품학적 이해를 위해 콜라겐 및 콘드로이친황산 함량, 단백질 및 지질 함량, 미량원소 함량 그리고 CLA 함량을 조사한 결과 황산분해시료의 콜라겐 함량은 캥거루꼬리, 소꼬리 시료 모두에서 고기보다 뼈에 월등히 함량이 높았다. 캥거루꼬리와 소꼬리의 시료 사이에는 캥거루 꼬리가 고기 및 뼈에서 모두 약 1.7배 1.2배로 높은 함량을 나타냈다. 캥거루 꼬리 고기시료 수용액 추출의 콘드로이친황산 함량 성분이 소꼬리고기 보다 1.3배 정도 높았다. 또한 뼈 수용액 추출은 캥거루꼬리가 소꼬리 보다 콘드로이친황산 함량 성분이 2.4배 이상 높았다. 캥거루꼬리에서 다양한 기능을 가지는 CLA는 4가지이성체가 주성분이고, 함량은 소고기꼬리의 0.92%에 비하여 5.3배 정도나 많은 4.9%의 높은 비율로 존재하였다. To get the nutritional data of hot water extract from imported kangaroo tails, research was done about contents of collagen, chondroitin sulfate, protein, fat, mineral ions, and conjugated linoleic acid (CLA) in tails. Collagen content of sulfuric acid digested sample was way higher at bones than meats in both kangaroo tail and cow tail. Comparing kangaroo tail and cow tail, meat of kangaroo tail have 1.7 times higher collagen content than that of cow tail. Content of collagen in bone parts of kangaroo tail was also higher 1.2 times than that of cow tail. Meat sample of kangaroo tail (liquid extraction) have 1.3 times higher content of muco-polysaccharide than that of cow tail. In the born part, kangaroo tail was 2.4 times higher than cow tail in its content of muco-polysaccharide. The CLA content of the kangaroo tail showed the content that was higher than 0.9% of the cow tail for 4.9% and showed about 5.3 times high ratios. Especially in kangaroo tail, a band with high content of CLA was found between C18:1 and C18:2.
내시경 정맥류 밴드 결찰술을 통한 항문직장 정맥류 출혈 치료 후 시행된 성공적인 경경정맥 간내문맥-정맥 단락술 및 색전술
박상우 ( Sang Woo Park ),전충환 ( Chung Hwan Jun ),최성규 ( Sung Kyu Choi ),김현수 ( Hyun Soo Kim ),박창환 ( Chang Hwan Park ),류종선 ( Jong Sun Rew ),박선영 ( Seon Young Park ),조은애 ( Eunae Cho ),김재규 ( Jae Kyu Kim ),김형욱 ( 대한소화기학회 2018 대한소화기학회지 Vol.71 No.4
Anorectal variceal bleeding is a rare occurrence; however, in such event, it could be fatal due to large size and high blood flow rate of varices. However, to date, there is no standardized treatment modality. Although endoscopic treatment can be provided, in cases of recurrent anorectal variceal bleeding, other therapeutic modalities for hemostasis are necessary. Here, we present a case of 58-year-old female patient with liver cirrhosis, who suffered from massive bleeding of anorectal varices. Endoscopic variceal band ligation was performed for primary hemostasis. Additionally, transjugular intrahepatic portosystemic shunt (TIPS) with embolization was performed to reduce the risk of rebleeding. Following the procedure, she had no further bleeding episodes, and the size of anorectal varices decreased, as seen on an abdomino-pelvic computed tomography. Our case illustrates the effectiveness of combined radiological intervention of TIPS with embolization after endoscopic hemostasis, for variceal obliteration and prevention of rebleeding. (Korean J Gastroenterol 2018;71:234-238)
김신곤,김재규,최수진나,정상영 대한혈관외과학회 1998 Vascular Specialist International Vol.14 No.1
Arterial pseudoaneurysm is an infrequent but potentially catatrophic complication of pancreatitis. A pseudoaneurysm is encountered in 6-9.5% of patient with chronic pancreatitis and as many as 17% of all patients operated on for chronic pancreatitis. A ruptured pseudoaneurysm is the most fatal complication with reported mortality rate as low as 12.5% in treated patients, greater than 90% in patients not receiving treatment. Therefore bleeding pseudoanurysms are required early diagnosis and radical treatment. We reviewed 8 patients who were admitted to Department of Surgery of Chonnam Univetsity Hospital for treatment of pseudoaneurysm complicating chronic pancreatits from January, 1993 to December, 1997. The results were as follows. 1) The patiens were all male, and the age range was 30 to 65 years(mean 47 years). 2) The most prevalent symtom and sign were anemia and abdominal pain(100%). 3) Angiography and abdiminal CT were performed in all patients. 4) Pseudoaneurysms were located in gastroduodenal artery(4 cases), branch of superior mesenteric artery(2 cases), superior mesenteric artery(1 case) and pancreaticoduodenal artery(1 case). 5) Transarterial embolization was performed in 6 cases and reembolization was done in 1 case and 1 rebleeding case was expired. 6) Operative management(aneurysmarrhaphy) was performed without complication in 2 cases. We consider that complete resection of pseudoaneurysm complicating chronic pancreatitis is the treatment of choice but transarterial embolization using coil may be considered as the first method of treatment.