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Perspectives of Integrative Cancer Genomics in Next Generation Sequencing Era
Kwon, So-Mee,Cho, Hyun-Woo,Choi, Ji-Hye,Jee, Byul-A,Jo, Yun-A,Woo, Hyun-Goo Korea Genome Organization 2012 Genomics & informatics Vol.10 No.2
The explosive development of genomics technologies including microarrays and next generation sequencing (NGS) has provided comprehensive maps of cancer genomes, including the expression of mRNAs and microRNAs, DNA copy numbers, sequence variations, and epigenetic changes. These genome-wide profiles of the genetic aberrations could reveal the candidates for diagnostic and/or prognostic biomarkers as well as mechanistic insights into tumor development and progression. Recent efforts to establish the huge cancer genome compendium and integrative omics analyses, so-called "integromics", have extended our understanding on the cancer genome, showing its daunting complexity and heterogeneity. However, the challenges of the structured integration, sharing, and interpretation of the big omics data still remain to be resolved. Here, we review several issues raised in cancer omics data analysis, including NGS, focusing particularly on the study design and analysis strategies. This might be helpful to understand the current trends and strategies of the rapidly evolving cancer genomics research.
권상호,조경열,김소연,김미정 대구효성가톨릭대학교 식품과학연구소 1993 식품과학지 Vol.5 No.-
식생활에서 대추의 이용성확대 방안을 살펴볼 목적으로 대추와 관련한 그간의 문헌들을 정리해 보았다. 그 결과 대추는 한방에서도 사용빈도가 가장높은 약재이면서 식품으로서도 가치성이 매우 커서 일상의 식생활에서 주식과 함께 이용함으로서 한방식생활의 보편화를 기하는데 가장 편리한 식품으로 평가되었다. 그러므로 대추를 식생활에 쉽게 이용할 수 있는 다양한 가공품의 개발과 응용방법의 확대방안 모색이 요망되었다. The review was summarized to investigate extensive possibilities of jujube fruit for the application of dietary life. Seventy seven referances were organized and discussed in this paper. Jujuba fruits have been used as the famous herb medicine and food materials in Korea, China, and Japan because they contain many kinds of nutrients and components which have a tonic action, urination action, and strength of physical recovery etc. In addition, it was estimated as the most desirable food materials for the dietary life together with the staple foods. Therefore, many studies for processing and application of jujuba fruits on the dietary life were required.
암환자에게 제공된 다빈도 간호중재 분석 : 5개 종합병원을 중심으로
문경희,안미정,김필자,박정연,김명애,박인숙,배수현,이소정,권인각,김소선 병원간호사회 2009 임상간호연구 Vol.15 No.1
Purpose: The purpose of this study was to identify nursing interventions frequently used with cancer patients. Nursing records from 5 general hospitals for patients with stomach, liver, lung or colon cancer were analyzed. Method: A descriptive study methodology was used and nursing records for 15 patients in each disease category at each hospital, who were admitted and discharged during June 2007 were analyzed. Results: Five domains of NIC were found and the physiological(basic) domain was most frequent (31.52%). Twenty two classes of NIC were identified with risk management for safety being most frequent (22.49%). For the 119 nursing interventions identified, the most frequent was pain management with 7,827 (12.31%), followed by prevention of falls (11.76%), surveillance (6.79%) and wound care (5.12%). Nursing activities of pain management and prevention of falls were comparable to activities listed in literature on guidelines for evidence based and best practices in nursing care. Eight of the 17 nursing activities for pain management, and 9 of 14 for fall prevention were consistent with these guidelines. Conclusion: In this study, nursing interventions were found to be focused on physical care, monitoring patients' condition and education. We have to develop diverse nursing interventions and a convenient recording process.
Metabolic features and regulation in cell senescence
( So Mee Kwon ),( Sun Mi Hong ),( Young-kyoung Lee ),( Seongki Min ),( Gyesoon Yoon ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.1
Organismal aging is accompanied by a host of progressive metabolic alterations and an accumulation of senescent cells, along with functional decline and the appearance of multiple diseases. This implies that the metabolic features of cell senescence may contribute to the organism’s metabolic changes and be closely linked to age-associated diseases, especially metabolic syndromes. However, there is no clear understanding of senescent metabolic characteristics. Here, we review key metabolic features and regulators of cellular senescence, focusing on mitochondrial dysfunction and anabolic deregulation, and their link to other senescence phenotypes and aging. We further discuss the mechanistic involvement of the metabolic regulators mTOR, AMPK, and GSK3, proposing them as key metabolic switches for modulating senescence. [BMB Reports 2019; 52(1): 5-12]
Inhibitory Effect of Kefiran on Ovalbumin-induced Lung Inflammation in a Murine Model of Asthma
Kwon, Ok-Kyoung,Ahn, Kyung-Seop,Lee, Mee-Young,Kim, So-Young,Park, Bo-Young,Kim, Mi-Kyoung,Lee, In-Young,Oh, Sei-Ryang,Lee, Hyeong-Kyu 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.12
Kefiran is a major component of kefir which is a microbial symbiont mixture that produces jelly-like grains. This study aimed to evaluate the therapeutic availability of kefiran on the ovalbumin-induced asthma mouse model in which airway inflammation and airway hyper-responsiveness were found in the lung. BALB/c mice sensitized and challenged to ovalbumin were treated intra-gastric ally with kefiran 1 hour before the ovalbumin challenge. Kefiran significantly suppressed ovalbumin-induced airway hyper-responsiveness (AHR) to inhaled methacholine. Administration of kefiran significantly inhibited the release of both eosinophils and other inflammatory cells into bronchoalveolar lavage (BAL) fluid and lung tissue which was measured by Diff-Quik. Interleukin-4 (IL-4) and interleukin-5 (IL-5) were also reduced to normal levels after administration of kefiran in BAL fluid. Histological studies demonstrate that kefiran substantially inhibited ovalbumin-induced eosinophilia in lung tissue by H&E staining and goblet cell hyperplasia in the airway by PAS staining. Taken above data, kefiran may be useful for the treatment of inflammation of lung tissue and airway hyper-responsiveness in a murine model and may have therapeutic potential for the treatment of allergic bronchial asthma.
논문 : 외국어로서의 한국어 교육에서 성인학습자의 동기가 학업성취도에 미치는 영향
권미경 ( Mee Kyung Kwon ),이소연 ( So Yeon Lee ) 국제한국어교육학회 2005 한국어 교육 Vol.16 No.3
A learners motivation in learning is very important, particularly in the case of Korean language education, because most of the Korean language courses in Korean Language Institutes are for adults(over 18), they need to analyze the relationship between learners motivation and learning achievement from the viewpoint of adult learning. This study is based on a interview survey on 15 adults foreigners learning Korean as a second language in a university in Busan. The purpose of this study was to analyze and compare the differences of learning achievement among students with different learning motivations in order to find a way to improve the learning achievement. We need to ensure that students in this study have the same degree of motivation as found in adult learners in general, and learners have various motivations for learning Korean as a second language. According to their motivation, there has been difference of interest, participation and attitude, as well as learning achievement in class. Therefore, it`s important to understanding the motivation of learners. Also, it requires that the Korean Institutes have interest in learning achievement, and the teacher needs to give the learners a strong motivation. (Dong-A University, Pusan National University)
Case Report : Endometrial adenocarcinoma in a 13-year-old girl
( Sung Mee Kim ),( So Jin Shin ),( Jin Gon Bae ),( Kun Young Kwon ),( Jeong Ho Rhee ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.2
Endometrial cancer is the third most common gynecologic cancer in the Korea and occurs mainly in menopausal women. Although it can develop in young premenopausal women cancer as well, an attack in the adolescent girl is very rare. A 13-year-old girl visited gynecology department with the complaint of abnormal uterine bleeding. An endometrial biopsy revealed FIGO (International Federation of Gynecology and Obstetrics) grade II endometrial adenocarcinoma. In the treatment of endometrial cancer, conservative management should be considered if the patient is nulliparous or wants the fertility preservation. Therefore, we decided to perform a hormonal therapy and a follow-up endometrial biopsy after progestin administration for eight months revealed no residual tumor. We report a case of endometrial cancer occurred in a 13-year-old girl with a brief review of the literature.
Customer Satisfaction Management and Service Quality According to the DISC Behavior Type
Young-Jin SO,Ji-Yeon LEE,최영진,Woo-Sik Lee,An-Jin CHO,Myoun-Kil YOUN,Lee-Seung Kwon,Eun-Mee Choi 한국유통과학회 2020 유통과학연구 Vol.18 No.12
Purpose: This study aims to explore the service improvement and marketing strategy to measure the effect of the DISC (dominance, influence, steadiness, conscientiousness) behavior type of hair salon workers on service quality and marketing. Research design, data and methodology: 236 responses were analyzed by distributing questionnaires to hair salon workers through SNS. Factor analysis and reliability analysis were applied and the influence of job factors on work satisfaction and turnover intention, and the statistical significance of the DISC behavioral type adjustment effect verified. Results: First, among the general characteristics of the survey subjects, the most common respondents were women and interns in their twenties, with less than four years of experience and less than three years of work experience on site. Second, the working environment, employee relations and compensation policies caused by work-related factors have shown a major influence on work satisfaction. Third, the working environment and human relationships among the job factors have an impact on turnover intention. Conclusions: The working environment, human relations, and compensation system derived as job factors had a crucial effect in service quality and marketing on job satisfaction, and among job factors, working environment and human relations had a significant influence on turnover intention.