Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

무용수의 캐릭터 창조를 위한 즉흥(Improvisation, Etude)법 적용 및 비교 분석

홍선미(Hong, Sun-Mi) 한국체육과학회 2023 한국체육과학회지 Vol.32 No.6

This study was conducted by the necessity of concrete ways to create characters of dancers. The purposes of this study are to design a program using Improvisation for the creation of dancers’ characters, to examine the effects of the program, to compare them with the results of a preceding research using Etude by Hong, Sun-Mi(2008) researched for the same purposes, and then to discuss the range of applying both Improvisation and Etude to the creation of dancers’ characters. In the research method, this study designed and applied a program, drew the results of inductive analysis by collecting data from participants’ self-report, in-depth interview, and participant observer’s daily log for 12 weeks, and then comparatively analyzed the results with the preceding research. In the results of this study, first, the expression of impulsivity according to the matter of direction of consciousness was shown in Improvisation. Second, they were compared through analysis, observation, and visual creation. Third, they focused on the set-up of plot and creation of creative movement respectively, which was a difference. Fourth, there was a common feature such as expression of inner feelings and movements by motivation.

Extraction Procedures for Free Radical Scavenging Activity from Noni Fruit (Morinda citrifolia)

Mi-Kyung Gwak,Hee-Sun Choi,Benya Manochai,Jeong-Hwa Hong 한국약용작물학회 2011 한국약용작물학회지 Vol.19 No.1

In this study, we investigated maximum yield of radical scavenging activity (RSA) using each of various extraction solvents and procedure from noni friut (Morinda citrifolia). Noni fruits were either sun-dried (FS) or hot-air dried (FO) at 60℃ after steam blanching. For optimum aqueous extraction, noni fruits should be sun dried and autoclave extraction time should not be over 30 min to produce extraction with high RSA with low cost. In case of 50% ethanol extraction, reflux extracts of FS and FO resulted in IC50 of 1.92 mg/mL and 3.06 mg/mL at 8 hr. When IC50 values were lower than 5 mg/mL, coefficient of correlation was 0.71 indicating that 71% of the phenolic antioxidants in noni fruits were accounted for the activity by scavenging free DPPH. However, coefficient of correlation significantly decreased to 0.63 over IC50 values of 5 mg/mL. Autoclave extraction contained chlorogenic acid of 14.69 μg/mL and scopoletin of 3.86 μg/mL. Reflux extraction showed all three compounds, chlorogenic acid (26.19 μg/mL), quercetin (19.59 μg/mL), and scopoletin (17.4 μg/mL). Therefore, the result of this study indicated that the potential antioxidant activities and functional values were obtained significantly with reflux extraction from noni fruit.

Cytokine and Tumor Environments

Jin Tae Hong1*, Ju Kyung Song, Sun Mi Kwon, Byung Woo Ahn, Youngsoo Kim, Sang Bae Han 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1

Cytokines are known to function as regulatory molecules that can be produced by virtually every nucleated cell type in the body, including lymphocytes, monocytes/macrophages, epithelial cells, fibroblasts, and many others. Cytokines include lymphocyte-derived factors (lymphokines), monocyte-derived factors (monokines), hematopoietic factors (colony-stimulating factors), connective tissue/growth factors, and chemotactic chemokines. Cytokines released in response to infection can affect tumor development in different ways. When exposed to infectious agents, cytokines are secreted by sentinel cells, such as macrophages and dendritic cells. These cytokines include interleukin 1 (IL-1) and tumor necrosis factor-α, as well as others, such as IL-6, IL-12, and IL-18. When released in sufficient quantities, these molecules can cause inflammation. Chronic inflammation is highly associated with tumor initiation, promotion, and progression. In this article, we review the roles and mechanisms of cytokines in tumor development.

비만 개선 효과를 지닌 탄수화물 및 지방 흡수 억제 기능성 식이조성물 개발

윤유식,최선미,홍순복,홍정미,김정원,이홍석,홍성길 한국조리과학회 2002 한국식품조리과학회지 Vol.18 No.3

In a previous study, we developed a new food additive as an egg yolk antibody (IgY) against carbohydrate digestion enzymes for the regulation of blood glucose level and weight control. The IgY delayed and decreased the increment of blood glucose level after administration of sucrose in human being by 30% in 20∼30 min. We also developed a lipase inhibitor as a water extract of two kinds of herb, Platycodon grandiflorum and Solanum melongena. Twenty three volunteers were subjected to the intake of the egg yolk IgY plus the herbal extracts for 50 days. In average, the treated subjects appeared to lose 1.96 ㎏ of body weight and 3.4 ㎏ of body fat mass during the treated period. Furthermore, Panniculus adiposus and breech size were significantly decreased during the experimental period. Above results suggested that the administration of the dietary additives composed of egg yolk IgY and natural herbal extract improve the obesity by the decrement of body weight and body fat mass.

악성흑색점흑색종 19예에 대한 임상 및 병리 조직학적 연구

홍원진 ( Won Jin Hong ),장홍선 ( Hong Sun Jang ),이상희 ( Sang Hee Lee ),이상은 ( Sang Eun Lee ),정기양 ( Kee Yang Chung ),노미령 ( Mi Ryung Roh ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.10

Background: Lentigo maligna melanoma (LMM) is a subtype of melanoma that typically develops on sun-damaged skin. LMM is estimated to comprise 4∼15% of melanomas, but the prevalence is known to be relatively lower in the Korean population than in the Caucasian population. Objective: To review the clinico-pathologic features and treatment outcomes of Korean patients with LMM. Methods: Nineteen patients diagnosed with LMM during 2003∼2015, in the Yonsei University Health System, were included in this study. The age and sex of the patients, lesion location, thickness (Breslow), stage, treatment methods, BRAF, NRAS, and KIT mutation status, and survival rates were analyzed. Results: Among the 19 Korean patients, 11 were male and 8 were female. The median age was 59.2 years. The most common site was the cheek (47.4%), followed by the scalp, eyelid, nose, forehead, lip, and neck. At the time of diagnosis, 13 patients were in localized stages (5 patients, stage 0; 3 patients, stage I; and 5 patients, stage II) and 6 patients were in advanced stages (3 patients, stage III; and 3 patients, stage IV). Patients in the localized stages showed better overall survival (OS) than those in the advanced stages (p=0.012). Nine patients were treated with a wide excision, and 6 using Mohs micrographic surgery. Three patients received high-dose interferon-α therapy; 6, chemotherapy; and 4, radiotherapy. Two patients in stage 0 were treated with topical ingenol mebutate. Two patients had BRAF V600E mutation; 1, NRAS G12R mutation; and 1, KIT mutation. Median OS of the patients was 40.8 months. Conclusion: Our analysis provides additional information about clinical characteristics, treatment, and prognosis of LMM in Korean patients. (Korean J Dermatol 2016;54(10):769∼775)

북한의 교육사상과 체계

홍순미 연세대학교 대학원 1989 원우론집 Vol.16 No.1

자폐아를 위한 무용치료 프로그램 연구

홍선미 韓國舞踊敎育學會 1999 韓國舞踊敎育學會誌 Vol.10 No.1

This study is for autistic children with dance therapy program from the related literature and an interview with a dance teacher who teaches dance for autistic children at the Hospital of Seoul national University. Recebtkt, dance has developed in many ways-educational, professional, and therapeutic, Dance therapy, the use of dance and movement as a healing tool, is rooted in the idea that the body and the mind are inseparable. Autistic children are often described as living in their own world However, the goal of this study is to have dance programs with easy and fun, so they can have a chance to experience with other people in another world. ChapterⅠ is an introduction of this study, and chapterⅡ contains a definition of autistic and chapterⅢ is a comparison of characteristics from other's on different age levels. In chapterⅣ, there is a research of special education programs from a collection of other centers. In chapterⅤ, the investigator develops five dance therapy programs for autistic children-tactual grouping dance-which help them to express themselves and to organize thoughts and feelings. Finally, chapterⅥ is on conclusions arrived at by the investigator.

Duchenne형 進行性 筋異養症 保因者 檢出에 Restriction Fragment Length Polymorphism 이용에 관한 硏究

李美正,朴吉洪,朴善華,柳總根 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.3

We performed genetic analysis for detection of carrier state of Duchenne's muscular dystrophy (DMD). As genetic markers of the disorder, We used DNA-sequence polymorphisms detected with 6 different DNA probes derived from the vicinity of the DMD locus at genetic distance less than 15 cmo or from within the gene. on the short arm of X chromosome. In the family we studied. a consultand was a 29 years old woman whose maternal grandfather was a DMD patient who was unavailable. Therefore, all of her maternal aunts were DMD carriers whose next generations were requested for DNA studies. On the basis of linkage analysis. a proband and her niece were deemed to be unaffected with an accuracy of more than 99%, and we anticipated another two femals and one malt to be unaffected with 98% probability (normal serum creatine kinase level) where crossover events between intragenic(pERT 87.30) and flanking probes(pXUT23) were detected. but carrire risk of a female with the same haplotype was elevated to 41% taking account of an increased serum creatine kinase level. Two other females were predicted to be affected with 99.9 and 97.1% probabilities each. However. a genetic interpretation was impossible for one male in which a crossover breakpoint could not be determinied because of his mother's homozygosity of the alleles between crossovered alleles where hitherto pessibility of intragenic crossover could not be ruled out Our experience suggests that genetic diagnosis based on recombinant deoxyribonucleic acid techniques are assuming increasing importance. and provide a highly accurate method for carrier detection and prenatal diagnosis of DMD. By the way, despite the large number of intragenic and flanking DNA polymorhpisms available, uncertainties often remain in the genetic diagnosis of DMD. Pitfalls are presented by the large size of the region in which Duchenne's mutations can occur. Crossover events in this region. especially intragenic ones, which result in an exchange of DNA between two X chromosomes, can,rener DNA-marker studies inaccurate.

일개 대학 병원 종사자의 직종별 직무스트레스 수준

심미선,이강숙,홍현숙,이경숙 가톨릭대학교 산업의학센터 2000 韓國의 産業醫學 Vol.39 No.4

This study was carried out to find out the job stress factors, coping skill, stress symptom, stress results at a university hospital workers and to develop the goal of health promotion including stress management program. The data for job stress were collected from 61 doctors, 141 nurses, and 84 assistant-nurses in a university from March, 2000 to April, 2000. The results of the study were summarized as follows; 1.The stress scores from job internal factors were highest in doctor group for variety, in nurse group for significance, and assistant-nurse group for identity. 2.The hospital workers felt high stress from promotion and salary but there was no difference from professional groups. There were significant differences in interpersonal relation and organizational norm between nurse and assistant-nurse group and in job-home conflict between doctor and assistant-nurse group. 3.The stress symptoms such as anxiety, depression, and physical symptom were highest in assistant-nurse group. 4.The coping skill was highest in nurse group. 5.The result of stress such as work performance, job involvement and organization commitment was highest in nurse group. The intention to change the job was highest in doctor group. 6.The stress scores had positive correlations with various symptoms. In conclusion, the hospital workers felt high stress from job, interpersonal relation, and organizational norm. In order to relive the stress, the stress management program including to improve coping skill and strategy would be necessary.