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난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화
이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3
Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.
이우형(Woo-Hyung Lee),오상학(Sang-Hak Oh) 한국문화역사지리학회 2004 문화 역사 지리 Vol.16 No.1
This article is about the cartohistorical value and significance of the 『Joseon-jido. 朝鮮地圖, Map of Korea』, the copy of the 『Dongguk-daejeondo, 東國大全圖 Great map of Korea.』 by Jeong Sang-Gi(鄭尙驥), which is the collection of the National Museum of Korea. The conclusions are as follows. First, by the contents of the map, it is presumed that the map was made between the years 1757-1767. Therefore, it is easy to assume that the map was made in 1740s. Among the others, the map was made in the earliest days. Second, the 『Joseon-jido』 was drawn on the fine silk with the delicate lines, and the map has rvtanchuria of China and Japan, which were presumed to be included in the original map. Also, comparing the copies of 『Paldo-bundo, 八道分圖 Maps of Eight Provinces』 by Jeong to the map by trigonometry calculation, we can presume that both of the map were made by the same scale. By these reasons, the 『Joseon-jido』 is presumed to be the Dongguk-daejeondo in 『YoungJo Sillok, Annals ofKing YoungJo』, which Jeong Hang-Ryung(鄭恒齡). son of Jeong Sang-Gi(鄭尙驥). brought from home and copied it to provide the map to the HongMoonKwan(弘文館, Office of Special Advisers) in 1957(33th year of King YoungJo) Third, there are over 2200 place names mentioned in the 『Joseon-jido』, and these names are also mentioned in the Dongguk-daejeondo and the Paldo-bundo. Most of the place names of the natural features were that of the mountains. and the name of the hills were mentioned in detail. Most of the place names of the civil features were that of the military facilities, such as military camps and the mountain castles. Therefore. it can be said that the map had administrative and military purpose. Fourth, the expression of the landscape followed the classic mountain range-centered understanding while at the same time stressing the six Jeongmaks(正脈, Secondary Mountain Range), the important military defence line. The traffic route was expressed in detail among the other civil features, and the mountain castles. military camps and the signal fire were also expressed in detail with the more symbolized marks. Fifth, unlike the existed articles. the map expressed the changes in the military camps, mountain castles, traffic routes, stations and the signal fires.
추황배(Pyrus pyrifolia Nakai cv. Chuhwangbae) 과피로부터 1종의 Sterol과 3종의 배당체 화합물의 단리·동정
이유건(Yu Geon Lee1),조정용(Jeong-Yong Cho),이현주(Hyun Joo Lee),이용현(Yong Hyun Lee),이상현(Sang-Hyun Lee),한태호(Tae-Ho Han),김월수(Wol-Soo Kim),박근형(Keun-Hyung Park),문제학(Jae-Hak Moon) 한국식품과학회 2013 한국식품과학회지 Vol.45 No.5
본 연구에서는 배의 유용성 증명을 위한 일환으로 배의 화학성분을 분자수준에서 밝히고자 하였다. 이에 배 과피 MeOH 추출물을 용매분획하여 얻은 EtOAc-산성 분획과 EtOAc-중성분획을 대상으로 Sephadex LH-20, silica gel, 그리고 ODS colmn chromatography와 HPLC를 이용하여 정제 및 단리하였다. 그 결과, EtOAc-산성 분획과 EtOAc-중성 분획으로부터 각각 2종씩의 화합물을 단리하였다. 단리된 화합물 1-4는 1H- 및 13C-NMR 분석을 통하여 각각 (S)-(+)-2-cis-abscisic acid O-β-D-glucopyranosyl ester (화합물 1), 1-[4-O-β-D-glucopyranosyl]phenyl ethanone(piceoside, 화합물 2), β-sitosterol (화합물 3), 그리고 β-sitosteryl 3-O-β-D-glucopyranoside (화합물 4)로 동정되었다. 단리된 3종의 배당체 화합물(화합물 1, 2, 4)들은 본 연구에 의해 배로부터 처음 동정되었으며, 화합물 3은 추황배로부터 처음 동정되었다. 본 연구결과가 배 함유 성분연구는 물론 배의 기능성 해명 연구에도 추후 중요한 기초자료로 활용되길 기대한다. We isolated and identified antioxidants from acidic and neutral ethyl acetate fractions of the peel of pear (Pyrus pyrifolia N. cv. Chuhwangbae). We isolated 4 compounds from the methanol extract, by using 3 different types of column chromatography (Sephadex LH-20, silica gel, and octadecylsilane) and preparative HPLC. We identified the isolated compounds as (S)-(+)-2-cis-abscisic acid O-β-D-glucopyranosyl ester (compound 1), 1-[4-O-β-D-glucopyranosyl]phenyl ethanone (picroside, compound 2), β-sitosterol (compound 3), and β-sitosteryl 3-O-β-D-glucopyranoside (compound 4) by nuclear magnetic resonance analysis. We are the first to report the identification of compounds 1, 2, and 4 from pear.
단상 유도형 동기 전동기(LSPM)의 특성해석에 관한 연구
정대성,김승주,이진헌,최재학,이주,Jung, Dae-Sung,Kim, Seung-Ju,Lee, Jin-Hun,Choi, Jae-Hak,Lee, Ju 한국조명전기설비학회 2007 조명·전기설비학회논문지 Vol.21 No.3
가전분야에서의 전동기 효율향상을 통한 에너지 소비절감 효과는 상당히 크지만 이를 위한 전동기의 설계/해석 기술 확보가 아직은 미흡한 상태이다. 이에 따라 유도형 동기전동기가 제안되었지만, 유도형 동기 전동기는 유도전동기와 통기전동기의 특성을 동시에 가지고 있어, 해석 및 설계가 쉽지 않다. 따라서 본 논문에서는 기존의 냉장고 압축기용 전동기인 단상유도전동기를 대처할 수 있는 단상 유도형 동기전동기를 이용해 파라미터에 따라 특성이 어떻게 바뀌는가에 대해 서술하였다. 그에 따라 단상유도전동기의 정상상태 특성을 해석하고 제안모델의 성능을 기존모델과 비교하고 실험하여 해석결과의 신뢰성을 검증한다. 또한 본 논문에서는 제안모델의 기존 고정자 형상이나 권선 스팩을 유지하고 회전자의 형상이나 구조만을 변경시켜 성능향상을 도모하였다. 해석방법으로는 전자장 수치 해석적인 방법으로 널리 이용되고 있는 유한요소법(Finite Element Method : FEM)을 이용하였다. Electric motor efficient improvement from home appliance field is important to the effect reducing the energy consumption. But the electric motor design/analysis technology is still insufficient. Specially the electric motor design/analysis technology of satisfying characteristic of both the induction motor and the synchronous motor such as Line start permanent motor. Therefore the electric motor design/analysis technology is urgently demanded reliability. This paper proposes the sing1e-phase line-start permanent magnet motor to develop the motor it with be able to alternate the sing-phase induction motor it is a refrigerator compressor motor. The sing-phase induction motor is analyzed in the steady state. And we have a certification test to compare our single-phase line-start permanent magnet motor with the sing-phase induction motor. In order to improve the performance, the stator of the single-phase line-start permanent magnet motor is same as the stator of the sing-phase induction motor and changes the rotor form and has the permanent magnet. It used the Finite Element Method(FEM) which is widely used with electronic-magnetic field numerical analysis method.
NMR에 依한 trans-2-Butene-dial dioxime의 立體構造에 關한 硏究
李學沂,沈相喆,嚴在國 慶北大學校 1976 論文集 Vol.21 No.-
The structure of trans-2-butene-dial dioxime was investigated by means of NMR spectroscopy. Its conformer was found to have the planar structure conjugated with the double-bonds from the vicinal spin-spin coupling constants. The configurations of two oxime group were investigated from the solvent effects and assigned as the perfect symmetric structures, mixture of "syn-syn" and "anti-anti" forms.
이상학,손범목 한국환경과학회 2003 한국환경과학회지 Vol.12 No.1
Synchronous spectrofluorimetry was carried out for the simultaneous determination of various polycyclic aromatic hydrocarbons(PAHs) in aqueous solution by fluorescence spectrometry have been studied. The optimal wavelength interval(Δλ) for synchronous spectra of acenaphthene, anthracene, benzo[a]anthracene, fluorene and pyrene were investigated in the presence of surfactants. The great enhancement of the fluorescence of these PAHs in Triton X-100 was obtained and optimal wavelength was 50 nm. The calibration curves in synthetic mixture solution of 5 PAHs were linear over the range from 1.0x10^-8M to 1.0x10^-4M. Under the optimal experimental conditions, the detection limits were 4.9x10^-9M, 7.0x10^-9M, 4.7x10^-9M, 1.6x10^-9M and 3.2x10^-9M for acenaphthene, anthracene, benzo[a]anthracene, fluorene and pyrene, respectively.