당화가 rV1a 바소프레신 수용체의 세포내 이동에 미치는 효과

이기봉,진원주,김용석,박미자,이상훈,이용성 漢陽大學校 精神健康硏究 1998 精神健康硏究 Vol.17 No.-

기능성 소화불량증환자에서 Winstal® 투여에 관한 임상경험

이창형,김영탁,금민수,권중구,안병철,윤영미,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1994 慶北醫大誌 Vol.35 No.3

목적 : 기능성 소화불량증은 소화, 흡수등 장관의 기능적인 이상과 관련되어 있을 것으로 생각되며 복합소화효소제(Winstal®)를 투여하여 그 임상효과를 평가하고자 본 연구를 실시하였다. 대상 및 방법 : 1994년 3월 부터 6월까지 경북대학교병원 내과를 방문한 기능성 소화불량증을 호소하는 환자 20명을 대상으로 Winstal®을 1회 1정씩, 1일 3회 식후 30분내에 경구로 2주간 투여하였다. 결과 : 소화불량증의 증상은 복부불쾌감, 복부팽만감, 식욕부진 및 오심, 복부동통, 공기연하증, 고창 및 구토순이었으며, 증상의 개선은 복부불쾌감이 76.4%(13/17)로 가장 높았으며, 그 다음으로 복부팽만감 및 공기연하증이 66.5%(10/15, 6/9)이었고, 오심 61.5%(8/13), 식욕부진 53.8%(7/13), 복부동통 41.6%(5/12), 고창 37.5%(3/8)이었다. 각 환자별 종합적인 증상의 개선도는 현저한 개선이 2예(10%), 중등도 개선이 3예(15%), 약간개선이 11예(55%), 불변이 4예(20%)이었으며 종합적인 유효율은 80%(16/20)이었다. 부작용은 한 예에서도 관찰되지 않았다. 결론 : 본 제제는 기능성 소화불량증 환자의 증상개선에 추천할 만한 유효한 약제로 생각된다. Dyspepsia is a common symptom in gastroenterologic practice and trigger for numerous consultations with physician. The treatment of chronic functional dyspesia is unsatisfactory. This study was performed to evaluate the efficacy of the digestive compound (Winstal®) on 20 functional dyspepsia patients. On open trial, all patients were given 6 tablets daily for 2 weeks and we evaluated the efficacy of this preparation according to the degree of the improvement. The improvement of symptoms was 76.4%(13/17) in abdominal discomfort, 66.5%(10/15, 6/9) in abdominal distension and aerophagia, 61.5%(8/13) in nausea, 53.8%(7/13) in abdominal pain, and 37.5% (5/12) in flatulence, respectively. Overall effectiveness of subjective symptoms was 80% (16/20) and there were no untoward effects of the preparations during this study. As a result, We think that this preparation is an effective one to relieve symptoms of functional dyspepsia.

전압의존성 칼슘채널 α1 subunits(α1D, α1B, α1A, α1E) 유전자들의 발현에 관한연구

김창미,이혜경,김현,김형래,유임주,전용혁 대한해부학회 1996 Anatomy & Cell Biology Vol.29 No.1

중추신경계에 침범한 속립성 결핵 : 증례보고

이태환,김헌주,허철,한용표,홍순기,변진수,김명순,조미연,김윤미 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.11

in recent times, central nervous system(CNS) tuberculosis has been rare and the prevalence of the focal form, the tuberculoma, varies from 1 per 200 to 1 per 1000. CNS tuberculosis occurs as a result of hematogenous spread from a primary focus. mostly pulmonary tuberculosis. It can be diffuse exudative leptomeningitis or a localized tuberculoma ; the former is more common. We report a case of miliary cerebral tuberculosis in a 24-year-old female who had been having headaches for 4 months. Magnetic resonance imaging showed numerous small round Gadolinium-enhanced supratentorial and infratentorial lesions scattered throughout the brain. Histologic examination confirmed well defined tuberculous granulomas with central caseous necrosis in open biopsy, containing several acid-fast bacilli, the patient was treated with isoniazid, rifampin, ethambutol, pyrazinamide in combination with prednisolone.

뇌진탕후 증후군 환자의 임상심리학적 특성

김영미,이기철,이정호,홍승범 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

본 연구는 1990년부터 1994년까지 인제대학교 의과대학 상계백병원 신경정신과에서 치료받았던 환자 중, 두부 외상의 기왕력이 있고, ICD-9의 뇌진탕후 증후군의 진단기준을 만족하는 환자 28명과 무작위로 선정된 32명의 신경증 대조군에게 시행했던 K-WAIS alc MMPI의 결과로, 두 집단을 비교하여 다음과 같은 결과를 얻었다. 1) 인구동태학적 지표에서 뇌진탕후 증후군 집단이 신경증 대조군에 비해 평균 연령, 교육 연한에서 의미있는 차이를 보였다. 2) 한국판 웩슬러지능검사(K-WAIS)에서 뇌진탕후 증후군 집단이 언어성 검사 중 기본 지식 문제와 숫자 외우기, 어휘 문제, 동작성 검사중 빠진곳 찾기, 바꿔쓰기에서 보통 범위 이하의 점수를 보였으나 신경증 대조군 집단은 보통범위 이상의 점수를 보였다. 3) 다면적 인성 검사(MMPI)에서 뇌진탕후 증후군 집단은 타당도 척도에서 역전된 V자형을 보였고, 하위척도 중 Hs척도가 의미있게 높은 결과를 보였다. 4) 뇌진탕후 증후군 집단의 군집 분석에서 첫번째 군은 타당도 척도에서 낮은 정도의 V자형을 보였고 Hs척도가 상승하였고, 두번째 군은 타당도 척도에서 역전된 V자형을 보였고 하위척도중 Hs, D, Pa, Pt, Sc척도가 의미있는 상승을 보였다. 이상의 결과로 보아, 뇌진탕후 증후군 환자들은 신경증 대조군 환자들과 비교하였을때 자신의 증상으로 인한 정서적인 고통을 많이 받을 뿐만 아니라, 인지 기능상의 손상이 심함을 알 수 있었다. Object : This study was conducted to investigate the clinicopsychological characteristics of patients with postconcussional syndrome. Methods : K-WAIS and MMPI were applied to 28 patients with postconcussional syndrome and 32 random-sampled neurotic controls. The means between two group were compared by ANCOVA. Cluster analysis was also applied to T-scores of the MMPI in patients with postconcussional syndrome. Result : 1. In demographic data, there were significant differences in mean age and education period between postconcussional syndrome group and the control group. 2. In postconcussional syndrome, Information, Arithmatics, Vocabulary and Picture Completion and Digit Symbol scores of K-WAIS were lower than that of mean score. 3. In MMPI profiles, reliability scale was inverted ‘V’pattern, and Hs scale was highly significant for postconcussional syndrome. 4. In postconcussional syndrome, cluster analysis was applied to each subscale of the T-score of MMPI, and two subgroups were extracted. 1) The first subgroup showed that reliability scale was low V pattern, and Hs scale elevated. 2) The second subgroup showed that reliability scale was inverted V pattern, and Hs, D, Pa, Pt, Sc scale elevated significantly. Conclusion : The patients with postconcussional syndrome were more severely ill, not only in emotional distress but also in cognitive dysfunction, than that of neurosis control.

위암종과 Epstein-Barr 바이러스와의 연관성에 대한 연구

심광용,김호영,김효열,백순구,권상옥,조미연,이창훈,이종인 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Objectives: Epstein-Barr virus (EBV) has been known to be linked to a spectrum of neoplastic conditions, including nasopharyngeal carcinoma, Burkitt's lymphoma, peripheral T-cell lymphoma and Hodgkin's disease. This study aims to investigate the association of EBV with gastric carcinoma in Korea. Methods: Fifty-three cases of gastric adenocarcinoma were studied for evidence of EBV infection by EBV-encoded small RNA (EBER) in situ hybridization (ISH) on the paraffin sections and amplifying the EBV genome encoding envelop glycoprotein (gp220) with polymerase chain reaction (PCR) in fresh gastric cancer specimens. Results: EBER was detected in 7 (13.2%) of 53 gastric carcinomas and all cases were male. In 6 (85.7%) of 7 EBER-positive cases, the tumors were located in the upper and middle part of the stomach. EBER ISH study showed strong positivity in all the tumor cells, but negativity in surrouning lymphocytes, stromal cells and normal gastric mucosa. DNA PCR was positive in 23 (43.4%) of 53 gastric carcinomas, including all of 7 EBER-positive cases. Conclusion: We could observe some association of EBV with gastric carcinoma, and our findings about the charateristics of EBV-positive gastric cancers involving sex, site and histological type are similar to those in Japan. However, EBV-positive rate of gastric cancer is higher than in Japan and lower than in Western countries. Further studies to elucidate oncogenic mechanism of EBV in gastric cancer should be performed.

기계적 합금화법을 이용한 FeTi 수소저장 합금의 개발

申美植,李龍鎬 弘益大學校 科學技術硏究所 1997 科學技術硏究論文集 Vol.8 No.-

In this study, Fe and Ti powders are mechanically alloyed in order to form the FeTi intermetallic compound at ambient temperatures. Fe and Ti powders were weighted to 1:1 molar ratio and the mecahnical alloying was carried out using the Spex mill. The alloying time was varied from 5 hours to 60 hours. Alloying up to 60 hours did not lead to the formation of single phase FeTi compound, instead the peak broadening continued. Most of the unalloyed Fe phase was found to be due to the contaminations from steel container and balls. The heat treatment of the mechanically alloyed powder to 500℃ at a heating rate of 10℃/min followed by furnace cooling in hygrogen atmosphere resulted in the conversion of unreacted Fe and Ti to FeTi as well as activation. The absorption temperature was kept at 30℃. The absorption pressure was measured to be 15.5 atm, the desorption pressure was measured to be 5.4 atm.

YAG 레이저를 이용한 레이저 유발 형광장치의 개발

김찬미,이영식 慶熙大學校 레이저 工學硏究所 1997 레이저공학 Vol.8 No.-

Laser pump-probe technique is a very important tool for chemical reaction dynamics research. In this article, the details of LIF spectroscopy using one YAG laser are presented. The 4th harmonic of TAG fundamental beam was used as a photolysis light while the 2nd harmonic beam was used for dye laser pumping. In a trial run, OH sample produced a unique OH LIF spectrum. From the result, we conclude that the constructed apparatus works correctly for LIF spectroscopy.

신원방우황청심원의 뇌허혈 및 중추신경계에 미치는 영향

조태순,이선미,이은방,조성익,김용기,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In order to investigate pharmacological properties of New Wonbang Woohwangchungsimwon Pill(NSCH) and Wonbang Woohwangchungsimwon Pill (SCH), the effects of NSCH and SCH on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in mongolian gerbils. The histological observations showed preventive effects of NSCH and SCH treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by SCH treatment. In contrast to what was seen with ATP, lipid peroxide were elevated in vehicle-treated ischemic gerbils. This elevation was inhibited by NSCH and SCH treatments. While NSCH and SCH had no effects on the hexobarbital-induced sleeping time, they prevented the seizures induced by eletric shock and strychnine. NSCH and SCH showed sedative effect in rotarod and spontaneous activity test. Furthermore, NSCH and SCH showed anti-stress effect. Our findings suggest that the pharmacological profiles of NSCH on cerebral ischemia and central nervous system are similar to those of SCH.

청소년자녀와 어머니를 위한 세대간 이해증진 프로그램 개발 및 실시

김명자,이정우,계선자,박미선,송말희,김경아,박수선,유을용,정진희 대한가정학회 2003 Human Ecology Research(HER) Vol.41 No.1

The relationship between adolescent children and parents has a profound effect on not only the adolescents development into healthy adults but also the psychological welfare of the parent. A program focused to improve adolescents relationship with parents has not been developed until now. To achieve the educational goals enhancing mutual understanding, it is more effective to educate both the parents and adolescent childern. Thus, this study developed and carried out a program in which adolescent children and mothers, being fully in charge of raising children, participated. The study analyzed the program effects after implementing on 6 pairs of adolescent children and mothers. The results are as follows: 1) adolescent children and mothers placed high values on the fact that they can understand each other well, 2) both parties accepted each other by recognizing the inevitability of the generation gap, and 3) the program gave them a chance to admit that they should try to communicate openly. Most of all, adolescent children could find self-confidence while mothers could collect valuable data essential to raise children and build a new mother's role model adapting to social changes.