젊은 성인에서 흡연에 의한 상완동맥 내피기능의 부전에 관한 연구

이상철,권영주,방덕원,이선해,이보영,김지욱,김영훈,온영근,현민수,김성구 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background and Objectives : Cigarette smoking is a major factor and the most modifiable risk factor for atherosclerosis. Endothelial dysfunction is an early event in atherosclerosis, before the structural change of the systemic arteries. We hypothesized that endothelial dysfunction might be present in the systemic arteries of young adult smokers and that this might be dose-dependent phenomenon. Therefore, we try to certify that smoking is associated with endothelial dysfunction in healthy young adults without other risk factor of atherosclerosis. Subjects and Methods : we studied noninvasively 29 subjects aged 3 to 4 decades without other risk factor of atherosclerosis, they were composed of the two groups, current smokers(n=15) and nonsmokers(n=14). Smoking history varied from 3 to 20 pack years. Using high-resolution ultrasound, vessel diameter and mean flow rate were measured at rest, during reactive hyperemia(with flow-mediated endothelium-dependent dilation), and after sublingual nitroglycerin(NG-induced endothelium-independent vasodilation). Result : Flow mediated endothelium dependent dilation was observed in the control subjects (9.4±3.44%) but was impaired in the smokers(5.8±2.51%)(p=0.004). NG-induced endothelium independent dilation is no difference in all subjects. Conclusion : Cigarette smoking is associated with endothelial dysfunction in healthy young adults.

만선신부전 환자에서 관상동맥조영술 소견에 관한 연구

한대희,김성구,박상호,김성한,조원영,방덕원,조윤행,정의룡,은영근,권영구 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : Patients with chronic renal fialure have a substantially elevated risk of death from cardiovascular diseases than do the general population. the patients with chronic renal failure are at significantly increased freqeuncy of hypertension, hyperlipidemia, and diabetes mellitus which are known to the risk factors of the coronary artery diseases, and the prevalence of the coronary artery diseases in chronic renal failure patients is highly associated with the hemodynamic disorder and metabolic abnormalities. therefore we expected that the coronary angiographic findings in patients with chronic renal failure should be different from the general population (control groups) and investigated the risk factors contributing to coronary artery diseases. Method : we have retrospectively compared the coronary angiographic findings of 44 patients with chronic renal failure on hemodialysis with that of 88 patients in the general population and investigated the factors contributing to the development and acceleration of coronary artery diseases in patients with chronic renal failure Result : Hypertension and diabetes mellitus which is risk factors for coronary artery disease is significantly increased in patients with chronic renal failure, in coronary angiographic finding the severity of the lesion is worse. the incidence of PCI or CABG of patients with chronic renal failure is more than that of control group but statistically no difference between patients with chronic renal failure and control group. the sex, the duration of disease, the duration of dialysis, serum creatinine in patients with chronic renal failure have no correlation to the prevalence of coronary artery disease and severity of lesion. hyperglycemic patients with chronic renal failure have high incidence of coronary artery disease and are worse in the severity of lesion Conclusions : There is significantly increased the pevalence and severity of involving multiple coronary artery diseses in hyperglycemic patients with CRF.

영어능력 인증제 능력별 교과과정 그리고 대학 교양영어 교육 : 학생과 교사의 인식에 대한 고찰

방영주 한국영어어문교육학회 2004 영어어문교육 Vol.9 No.2

This study aims to illustrate students' and teachers' perceptions towards Certification of English proficiency and proficiency- based curriculum, and to investigate their needs for developing college English program A total of 597 students and 28 teachers participated in the survey. The findings showed that both groups acknowledged the usefulness of the certification of English proficiency and proficiency-based curriculum However, both groups showed a negative response to 'waive test' (testing for the replacement of English required class). They also expressed high level of needs in increasing the number of courses and credit hours, reducing the class size, and improving facilities. Both groups perceived speaking and listening as more important skills, while students showed various preferences for effective language practice activities. The findings of this study suggest that the introduction of certification of English proficiency should be supplemented with follow-ups both in pedagogical aspect and on administrative level.

전문대학 간호과 통합교과과정 개발에 관한 연구

김영희,김정수,김정애,방숙명,배경진,이애경,장은정,정안순,주미경,최나영 경복대학 1998 京福論叢 Vol.2 No.-

교과과정의 조직은 체계적이고 뜻이 있는 순서로 학생들을 가르치기 위해 지식을 어떻게 조직화할 것인지와, 과목들 사이에서 공통된 내용은 통합시켜 중첩되는 일이 없도록 조정할 필요가 있다. 이에 현재 본 대학 간호과에서 운영되었던 97학년도의 17개 전공과목들의 교과과정의 내용을 비교, 분석하여 중복을 줄이며 순차적 지식의 습득을 도모하는 새로운 통합교과과정의 틀을 개발, 제시함으로써 보다 나은 전문직 간호교육이 이루어지도록 하고자 하였다. Most curricula are considered how to teach the student in systematic and meaningful orders. And it is necessary to coordinate the duplicate contents in major subjects in nursing. So this study was designed to set up a new comprehensive curriculum through comparing and ananlyzing each seventeen major subjects in Nursing Department of Kyung-Bok College. Therefore, the purpose of this study is to present the new comprehensive curricula for promoting the efficiency and effectiveness in diploma degree course of nursing education.

서울市 一般在來市場의 要因特性에 關한 硏究

최주영,손방용 대진대학교 1996 大眞論叢 Vol.4 No.-

This study aims to is investigated the factor property of conventional market. The objects of this analysis are 143 conventional markets supplied during 35years from 1960 to 1995 in Seoul City that is one of typical large cities in Korea. Indices which were consisted of 13 physical fastors were established to analyze the conventional market. To understand the interrelation between indicies, 13 indices were grouped into 5 significent fadtors by Factor Analysis.

교육대학생의 스트레스 요인 연구

이영희,조주연,방인태 서울敎育大學校 學生生活硏究所 1998 學生生活硏究 Vol.24 No.-

The purpose of this study was to analyze the stress factors which students at the Universities of Education have. Especially, after developing 'The stress-measurement scale for the students at the Universities of Education', this study identified the stress patterns and perception level on each stress factor of students of the Seoul National Univ. of Education. As a theoretical background, this study discussed researches on meaning of stress, concept/patterns/results of stress, and ways to cope with stress. Some results of this study are: First, the major domain in which students experience the highest level of stress is the domain of individual level, especially regarding personality. Female students experience the more degree of stress than male students do regarding this domain. Second, several stress domains which show high degree of relationship(higher than 60) with each other are domains of ① physical environments and study/work load, ②study/work load and study/work skills, ③ friendship and communication skills, ④ personality characteristics and self-confidence, ⑤ ways of thinking and value system, and ⑥ communication skill and study/work skill. Third, several variables which exert influence on the stress level of students at the Seoul National University of Education are variables on gender, army service experience, and academic year.

미세유화약물송달시스템을 이용한 로바스타틴의 생체이용률 향상

윤복영,강복기,정상영,이영원,이시범,황성주,육순홍,강길선,이해방,조선행 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

A self-microemulsifying drug delivery system (SMEDDS) was developed to increase the dissolution rate, solubility, and ultimately bioavailability of a poorly water soluble drug, lovastatin. SMEDDS was the mixtures of oils, surfactants, and cosurfactants, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal (GI) tract. Various types of self-emulsifying formulations were prepared using four types of oil (Capryol 90, Lauroglycol 90, Labrafil M 1944 CS and Labrafil M 2125), two surfactants (Cremophor EL and Tween 80), and three cosurfactants (Carbitol, PEG 400 and propylene glycol). The efficiency of emulsification was studied using a laser diffraction size analyzer to determine particle size distributions of the resultant emulsions. Optimized formulations selected for bioavailability assessment were Carpryol 90 (40%), Cremophor EL (30%) and Carbitol (30%). SMEDDS containing lovastatin (20 mg and 5 mg) were compared to a conventional lovastatin tablet (Mevacor^? , 20 mg/tab) by the oral administration as prefilled hard gelatin capsules to fasted beagle dogs for in vivo study. The area under the serum concentration-time curve from time zero to the last measured time in serum, AUC_0→24h, was significantly greater in SMEDDS, suggesting that bioavailability increase 130% and 192% by the SMEDDS, respectively. The self-emulsifying formulations of lovastatin afforded the improvement in absolute oral bioavailability relative to previous data of lovastatin tablet formulation. These data indicate the utility of dispersed self-emulsifying formulations for the oral delivery of lovastatin and potentially other poorly absorbed drugs.

허혈성 심질환에서 나타나는 항산화지수, 사이토카인 및 염증지표의 변화

전상훔,안지훈,방덕원,온영근,현민수,김성구,권영주 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Purpose : As diet habits change and the elderly popuation increases conronary artery disease(CAD) has also increased. Recent ongoing studies on varous inflammatory indexes in acute coronary syndrome(ACS) are underway. Several study results have shown that total antioxidant status(TAS) was remarkably lower in unstable angina than in chronic stable angina and levels of interleukin-(IL-6), C-reactive protein(CRP), monocyte chemoattractant protein-1(MCP-1), P-selectin were reported to be elevated in unstable angina and acute myocardial infarction(AMI). In our study, we studied and compared the level changes of cytokines and inflammatory indexes that play important roles inside the blood vessel. Methods : Study subjects were patients who were admitted and underwent coronary angiography at the cardiology department in Soonchunhyang university hospital. Subjects were divided into 4 groups, a control group, a stable angina and unstable angina group and an acute myocardial infarction group. The clinical findings, TAS, inflammatory cytokines(P-selectin, MCP-1, IL-6), anti-inflammatory cytokines(IL-10), Homocysteine and CRP levels in each group were measured and compared. Results : The total number of study participants was 86 patients, with 26 patients in the control group, 21 patients with stable angina, 15 patients with unstable angina, and 24 patients with AMI. There were significant differences in the TAS among the 4 grouops. 1.7±0.51 mmol/L, 1.6±0.60 mmol/L, 1.4±0.20 mmol/L, 1.4±0.29 mmol/L respectively. IL-6 levels also showed a significant difference between groups, averaging 0.8±2.47 pg/ml, 2.7±3.77 pg/ml, 6.8±10.63 pg/ml, 10.9±17.43 pg/ml respectively. Homocysteine levels averaged 8.0±2.47 pg/ml, 6.8±10.63 pg/ml, 10.9±17.43 pg/ml restectively. Homocysteine levels averaged 8.0±1.0 μmol/L in the control group, 14.3±5.14 μmol/L in patients with stable angina, 16.0±4.66 μmol/L in patients with unstable angina, and 17.3±10.08 μmol/L in AMI patients. Conclusion : Compared to the control group, the TAS levels were significantly lower in patients with unstable angina and AMI. there was no difference between the control group and those with stable angina. IL-6 and homocysteine levels were also higher in patients with unstable angina and AMI. Therefore we concluded that measurements of TAS, IL-6 and homocysteine are useful in measuring the inflammatory index of coronary artery diseases and may be important factors in predicting the states and prognosis of cardiovascular disorders.

미세혈관 협심증 환자의 임상상 및 지표에 관한 연구

박상호,온영근,김현정,이태훈,길효욱,김현건,박수진,송해정,한대희,방덕원,신원용,이내희,김성구,권영주 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : Microvascular angina or syndrom X is heterogenous and encompasses different pathogenetic entities. Several studies suggest that microvascular angina have good prognosis and occurs predominantly in postmenopausal women. Lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and fibrinogen are the independent risk factor of acute coronary syndrome and are the chief underlying cause of atherosclerosis. We investigated clinical characteristics and markers in patients with microvascular angina. Methods : We studies 23 patients diagnosed with microvascular angina and 16 control group with negative treadmill exercise test and no significant coronary angiogram. We investigated clinical characteristics in patients group and evaluated symptom during a follow-up period of 4.2± 2.5 month. Exercise time in treadmill exercise test was compared between patients and control group. We assessed the level of markers, such as lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and ESR in two groups. Results : There is no difference in age between two groups. Patients group had a tendency to increase in female, hypertension, DM, and smoking history, but there was no statistical significance difference. Exercise duration time was significantly decreased in patients with microvascular angina (p<0,05). Serum lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholestrol, Triglyceride, ESR, Fibrinogen and Homocystein value were no significant difference between microvascular angina and control group. Only CRP was significantly high in patients with microvascular angina (p<0.05). Conclusion : There was no statistical significance difference in age, sex, hypertension, DM and smoking history between two groups but patients group had a tendency to increase the prevalence in hypertension, DM and smoking history, female. Also, Symptom improvement and disappearance in follow-up was presented in 11 patients of 19(57.9%). Exercise tolerance was worse in patients group than control group. CRP value was significantly higher in patients group than control group. There was no statistical significance difference in lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, ESR and Fibrinogen between two groups.

허혈성 심질환에서 나타나는 황상화지수, 사이토카인 및 염증지표의 변화

전상훈,안지훈,방덕원,온영근,현민수,김성구,권영주 순천향대학교 의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

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