Trends, Characteristics, and Clinical Outcomes of Patients Undergoing Percutaneous Coronary Intervention in Korea between 2011 and 2015

한승봉,박경민,김용균,박만원,허성호,이승환,김영학 대한심장학회 2018 Korean Circulation Journal Vol.48 No.4

Background and Objectives: We sought to evaluate nationwide trends, characteristics, and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) in Korea. Methods: From National Health Insurance claims data in Korea, 81,115 patients, who underwent PCI for the first episode of coronary artery disease between 2011 and 2015, were enrolled. Patients were categorized into angina (n=49,288) or acute myocardial infarction (AMI, n=31,887) groups and analyzed. Results: The mean age of patients was 64.4±12.2 years and 56,576 (69.7%) were men. Diabetes, hyperlipidemia, and hypertension were observed in 27,086 (33.4%), 30,675 (37.8%), and 45,389 (56.0%) patients, respectively. There was a 10% increase in the number of patients undergoing PCI for angina between 2011–2012 and 2014–2015 (11,105 vs. 13,261; p=0.021). However, the number of patients undergoing PCI for AMI marginally decreased between 2011–2012 and 2014–2015 (8,068 vs. 7,823; p=0.052). In procedures, drug-eluting stent was the most frequently used device (93.2%), followed by balloon angioplasty (5.5%) and bare metal stents (1.3%). The mean number of stents per patient was 1.39±0.64. At discharge, dual-anti platelet therapy, statin, beta-blockers, and angiotensin converting enzyme inhibitor or angiotensin receptor blocker were provided to 76,292 (94.1%), 71,411 (88.0%), 57,429 (70.8%), and 54,418 (67.1%) patients, respectively. The mean in-hospital and 1-year total medical costs were 8,628,768±4,832,075 and 13,128,158±9,758,753 Korean Won, respectively. In-hospital mortality occurred in 2,094 patients (2.6%). Conclusions: Appropriate healthcare strategies reflecting trends, characteristics, and clinical outcomes of PCI are needed in Korea.

Differences in Abdominal Body Composition According to Glycemic Status: An Inverse Probability Treatment Weighting Analysis

한승봉,전영지,박경민,이태영,박순은,유경석,강병주 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.4

Background: Several studies have reported that abdominal fat and muscle changes occur in diabetic patients. However, there arefew studies about such changes among prediabetic patients. In this study, we evaluated the differences in abdominal fat and musclesbased on abdominopelvic computed tomography in prediabetic and diabetic subjects compared to normal subjects. Methods: We performed a cross-sectional study using health examination data from March 2014 to June 2019 at Ulsan UniversityHospital and classified subjects into normal, prediabetic, and diabetic groups. We analyzed the body mass index corrected area of intra-abdominal components among the three groups using inverse probability treatment weighting (IPTW) analysis. Results: Overall, 8,030 subjects were enrolled; 5,137 (64.0%), 2,364 (29.4%), and 529 (6.6%) subjects were included in the normal,prediabetic, and diabetic groups, respectively. After IPTW adjustment of baseline characteristics, there were significant differencesin log visceral adipose tissue index (VATI; 1.22±0.64 cm2/[kg/m2] vs. 1.30±0.63 cm2/[kg/m2] vs. 1.47±0.64 cm2/[kg/m2], P<0.001)and low-attenuation muscle index (LAMI; 1.02±0.36 cm2/[kg/m2] vs. 1.03±0.36 cm2/[kg/m2] vs. 1.09±0.36 cm2/[kg/m2],P<0.001) among the normal, prediabetic, and diabetic groups. Prediabetic subjects had higher log VATI (estimated coefficient=0.082, P<0.001), and diabetic subjects had higher log VATI (estimated coefficient=0.248, P<0.001) and LAMI (estimatedcoefficient=0.078, P<0.001) compared to normal subjects. Conclusion: Considering that VATI and LAMI represented visceral fat and lipid-rich skeletal muscle volumes, respectively, visceralobesity was identified in both prediabetic and diabetic subjects compared to normal subjects in this study. However, intra-muscularfat infiltration was observed in diabetic subjects only.

Propensity Score (PS) Matching

한승봉 대한간학회 2013 임상연구방법론워크숍 Vol.2013 No.1

다양한 생존 분석

한승봉 ( Seungbong Han ) 대한간학회 2021 임상연구방법론워크숍 Vol.2021 No.2

초음파 센서를 이용한 이동로봇의 Map Building 알고리즘 및 주행 알고리즘에 관한 연구

한승봉(Seung-bong Han),이성구(Sung-gu Lee),임재권(Jae-kwon Lim),김대영(Dae-young Kim),김종화(Jong-hwa Kim) 한국마린엔지니어링학회 2006 한국마린엔지니어링학회 학술대회 논문집 Vol.2006 No.-

Today, robots have been applied in FA field and HA field. Especially, various mobile robots have been developed and applied in HA. In this paper, we suggest a map building algorithm and a traveling algorithm based on A* algorithm for stable traveling in the unknown environment.

Analysis of trend in the role of national and regional hubs in prostatectomy after prostate cancer diagnosis in the past 5 years: A nationwide population-based study

김성철,한승봉,윤지형,박성찬,문경현,전상현,박경민,권택민 대한비뇨의학회 2024 Investigative and Clinical Urology Vol.65 No.2

Purpose: The regions where patients diagnosed with prostate cancer by biopsy receive prostatectomy are divided into national hub and regional hubs, and to confirm the change in the role of regional hubs compared to national hub. Materials and Methods: Data from July 2013 to June 2017 encompassing 218,155 patients aged ≥18 years diagnosed with prostate cancer were analyzed using the Health Insurance Review & Assessment Service database. The degree of patient outflow was assessed by dividing the regional diagnosis-to-surgery ratio with the national ratio for each year. Based on this ratio, national and regional hubs were determined. Results: Seoul consistently maintained a patient influx with a ratio above 1.6. Busan and Gyeonggi consistently exceeded 0.9, while Ulsan and Daegu steadily increased, exceeding 1.0 between 2015 and 2016. Jeonnam province also consistently maintained the ratio above 0.7. Jeju, Daejeon, Gangwon, and Incheon remained below 0.5, indicative of substantial patient outflows, whereas Gwangju and Gyeongbuk had the highest patient outflows with ratios below 0.15. Therefore, Seoul was designated as a national hub, whereas Busan, Gyeonggi, Ulsan, Daegu, and Jeonnam were classified as regional hubs. Jeju, Daejeon, Gangwon, and Incheon were the dominant outflow areas, while Gwangju and Gyeongbuk were the highest outflow areas. Conclusions: Seoul, as the national hub for prostate cancer surgery, operated on 1.76 times more patients than any other region during 2013–2017. Busan, Gyeonggi, Ulsan, Daegu, and Jeonnam functioned as regional hubs, but approximately 10%–20% of patients sought treatment at national hubs.

생존자료분석에서 성향 점수를 이용한 treatment delay effect 추정법에 대한 연구

정주이,송현진,한승봉 한국통계학회 2023 응용통계연구 Vol.36 No.5

생존 자료에서 Hade 등 (2020) 은 시간-의존 교란 변수가 환자의 처치 시점에 영향을 미칠 때, 해당 효과를 보정하여 treatment delay effect를 올바르게 추정하기 위해 성향 점수 매칭 방법을 이용하였다. 이 때, treatment delay effect란 환자가 관심 있는 지연 시점만큼 늦게 처치를 받는 경우 제 때 받는 경우에 비해 사건 발생 위험에 미치는 영향을 의미한다. 본 연구에서는 또 다른 성향 점수 기반 모형인 Cox-MSM 모형 또한 해당 효과를 올바르게 추정할 수 있는지 모의 실험을 통해 확인 및 기존 매칭 모형과 비교하였다. 모의실험 결과, 세 가지 모형 모두 다양한 시나리오 내에서 treatment delay effect를 올바르게 추정함을 확인하였다. 특히 모든 시나리오 내에서 Cox-MSM의 제곱근평균제곱오차의 값이 가장 낮았으며, restricted Cox matching 모형에서 가장 큰 값을 가지는 것으로 나타났다. 결론적으로, 성향 점수에 기반하나 매칭이 아닌 방법 또한 treatment delay effect 적용이 가능하다는 결과를 제공한다. 추후 G-formula과 같이 성향 점수 기반이 아닌 모형에서도 적용이 가능한지에 대한 상세 연구가 필요하다고 사료된다. Oftentimes, the time dependent treatment covariate and the time dependent confounders exist in observation studies. It is an important problem to correctly adjust for the time dependent confounders in the propensity score analysis. Recently, In the survival data, Hade et al. (2020) used a propensity score matching method to correctly estimate the treatment delay effect when the time dependent confounder affects time to the treatment time, where the treatment delay effects is defined to the delay in treatment reception. In this paper, we proposed the Cox model based marginal structural model (Cox-MSM) framework to estimate the treatment delay effect and conducted extensive simulation studies to compare our proposed Cox-MSM with the propensity score matching method proposed by Hade et al. (2020). Our simulation results showed that the Cox-MSM leads to more exact estimate for the treatment delay effect compared with two sequential matching schemes based on propensity scores. Example from study in treatment discontinuation in conjunction with simulated data illustrates the practical advantages of the proposed Cox-MSM.

Sarcopenia Predicts Prognosis in Patients with Newly Diagnosed Hepatocellular Carcinoma, Independent of Tumor Stage and Liver Function

하연정,김대정,한승봉,전영은,이윤빈,김미나,이주호,박하나,임규성,황성규 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3

Purpose The purpose of this study was to demonstrate the prognostic significance of changes in body composition in patients with newly diagnosed hepatocellular carcinoma (HCC). Materials and Methods Patients (n=178) newly diagnosed with HCC participated in the study between 2007 and 2012. Areas of skeletal muscle and abdominal fat were directly measured using a threedimensional workstation. Cox proportional-hazards modes were used to estimate the effect of baseline variables on overall survival. The inverse probability of treatment weighting (IPTW) method was used to minimize confounding bias. Results Cutoff values for sarcopenia, obtained from receiver-operating characteristic curves, were defined as skeletal muscle index at the third lumbar vertebra of  45.8 cm/m2 for males and  43.0 cm/m2 for females. Sarcopenia patients were older, more likely to be female, and had lower body mass index. Univariable analysis showed that the presence of sarcopenia and visceral to subcutaneous fat area ratio (VSR) were significantly associated with prognosis. The multivariable analyses revealed that VSR was predictive of overall survival. However, in the multivariable Cox model adjusted by IPTW, sarcopenia, not VSR, were associated with overall survival. Conclusion The presence of sarcopenia at HCC diagnosis is independently associated with survival.

巨視經濟變數를 이용한 名目地價 測

최동묵,최기영,한승봉,윤여강 고려대학교 정경대학 통계학과 2001 시계열 분석 사례집 Vol.7 No.-

Impacts of gender on clinical outcome after percutaneous coronary intervention

이권휘,안서희,한승봉,양유진,김용균,원기범,김신재,이상곤,김대원,박만원,허성호,박경민 대한내과학회 2019 대한내과학회 추계학술대회 Vol.2019 No.1