Long-Term Oncologic Outcomes after Radical Cystectomy for Bladder Cancer at a Single Institution

권택민,정인갑,유달산,홍범식,홍준혁,안한종,김청수 대한의학회 2014 Journal of Korean medical science Vol.29 No.5

The aim of this study was to evaluate our experience using radical cystectomy to treatpatients with bladder cancer and to describe the associations between pathologic featuresand clinical outcomes. All 701 patients who underwent radical cystectomy for bladdercancer were evaluated. The patient population consisted of 623 men and 78 women. Theoverall 5 and 10 yr recurrence-free survival (RFS) rates were 61.8% and 57.7%, respectively,and the 5 and 10 yr cancer-specific survival (CSS) rates were 70.8% and 65.1%, respectively. Multivariate analysis showed that factors significantly predictive of RFS and CSS includedextravesical extension (P = 0.001), lymph node metastasis (P = 0.001), and lymphovascularinvasion (P < 0.001 and P = 0.007). The 5 and 10 yr RFS rates for patients with lymphnode metastasis were 25.6% and 20.8%, respectively, and the 5 and 10 yr CSS rates were38.6% and 30.9%, respectively. Adjuvant chemotherapy significantly improved RFS(P = 0.002) and CSS (P = 0.001) in patients with lymph node metastasis. Radical cystectomyprovides good survival results in patients with invasive bladder cancer. Pathologic featuressignificantly associated with prognosis include extravesical extension, node metastasis, andlymphovascular invasion. Adjuvant chemotherapy improves survival in patients withadvanced stage disease.

식물체의 면역반응 기작 (총설)

권택민,남재성 한국식물생명공학회 2005 JOURNAL OF PLANT BIOTECHNOLOGY Vol.32 No.2

Disease resistance in plants is often controlled by gene-for-gene mechanism in which avirulence (avr) gene products encoding by pathogens are specifically recognized, either directly or indirectly by plant disease resistance (R) gene products and sequential signal transduction pathways activating defense responses are rapidly triggered. As a results, not only exhibit a resistance against invading pathogens but also plants maintain the systemic acquired resistance (SAR) to various other pathogens. This molecular interaction between pathogen and plant is commonly compared to innate immune system of animal. Recent studies arising from molecular characterization of a number of R genes from various plant species that confer resistance to different pathogens and corresponding avr genes from various pathogens resulted in the accumulation of a wealth of knowledge on molecular mechanism of gene-for-gene interaction. Furthermore, new technologies of genomics and proteomics make it possible to monitor the genome-wide gene regulation and protein modification during activation of disease resistance, expanding our ability to understand the plant immune response and develop new crops resistant to biotic stress.

초고속 인터넷 시장의 성장과 하나로통신의 경영전략

권택민 한국통신학회 2000 정보와 통신 Vol.17 No.5

경피적 신쇄석술: 단일 병원 610례의 경험

권택민,방정균,김성철,심명선,하성헌,홍범식,박형근 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.7

Purpose: We performed this study to evaluate the outcomes and complications of percutaneous nephrolithotomy (PCNL) at a single institute with a large series. Materials and Methods: We reviewed the medical records of 610 patients who underwent PCNL between March 1995 and June 2008 for staghorn calculi in 139 (22.8%), partial staghorn calculi in 104 (17.0%), renal pelvis stone in 222 (36.4%), proximal ureter calculi in 60 (9.8%), and calculi within a caliceal diverticulum in 85 (13.9%) patients. Stone-free status was defined as no visible residual calcification or remnant calcification smaller than 4 mm in diameter (clinically insignificant residual fragment) on a plain KUB (X-ray examination of the kidney, ureter, and bladder) image. Characteristics of the stones, operation time, stone-free rate, and complications were evaluated. Results: Initial stone burden was 665.9±600.6 mm2. Average operation time was 103.2±58.6 minutes. The mean hospital stay was 7.9 days. The stone- free rate was 84.9%, and ancillary procedures were required in 66 patients (10.8%), including 34 (5.6%) second-look PCNL and 26 (4.3%) ureteroscopic procedures. In the univariate analysis for prediction of stone-free rate, hydronephrosis, stone type, stone composition, and stone burden were significant prognostic factors. In the multivariate analysis, initial stone burden was the only independent factor affecting the stone-free rate. Complications were found in 95 patients (16.1%), 5 (0.8%) of whom needed embolization due to bleeding and 23 (3.8%) of whom showed pleural complications. Conclusions: PCNL is an effective method for the treatment of staghorn, large calyceal, and some upper ureteral stones with acceptable complication rates.

Overexpression of AtCAF1, CCR4-associated factor 1 homologue in Arabidopsis thaliana, negatively regulates wounding-mediated disease resistance

권택민,이영병,남재성 한국식물생명공학회 2011 식물생명공학회지 Vol.38 No.4

The CCR4-CAF1-NOT complex-mediated degradation of mRNA is a fundamental aspect of gene regulation in eukaryotes. We herein examined the role of AtCAF1 in the innate immune and wound responses of plants. Our results showed that overexpression of AtCAF1 significantly downregulated the transcript level of EFR but not FLS2 and BRI1, as well as abolished up-regulated expression pattern of EFR in response to wounding. Consistently, Agrobacteriummediated transient expression of GUS was highly enhanced in the transgenic plants overexpressing AtCAF. Furthermore, JA responsive genes were down-regulated by overexpression of AtCAF, causing the transgenic plants overexpressing AtCAF more susceptible to necrotrophic fungal pathogen, Botrytis cinerea. These results suggest that The CCR4-CAF1-NOT complex-mediated degradation of mRNA negatively regulates wounding-mediated disease resistance in Arabidopsis thaliana.

요도하열 교정수술 후 발생한 요도-피부 누공과 요도협착의 치료

권택민,송기현,송강현,송채린,김건석 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.1

Purpose: Urethrocutaneous fistulas and urethral strictures are the most frequent complications after hypospadias repair. We reviewed outcomes after surgical repair of these complications to evaluate the factors determining successful outcome. Materials and Methods: In 60 patients with fistula or stricture after hypospadias repair performed between September 1993 and January 2008, we reviewed incidences, clinical features, and outcome after repair with respect to initial hypospadias types. Results: Fistulas were observed in 42 patients and were surgically repaired in 39(92.8%). In 8(19.0%) and 3(7.1%) patients, concurrent meatal and urethral strictures were noted, respectively. The number of fistulas was single in 38(90.5%) and 2 in 4(9.5%) patients. Fistulas occurred most frequently from the penoscrotal type hypospadias(22/65, 33.8%) and had initially undergone transverse preputial island flap repair(13/26, 50%). Complete excision of the fistulous tract and multilayer advancement flap closure was the most common method for fistula repair(24), followed by cross-suture in 9 and repeat urethroplasty in 6. Initial management was successful in 35(89.7%) patients. Urethral strictures were observed in 16 patients with equal incidences at the meatus and the other portion of the urethra. Successful outcome was achieved in all metal stenosis after repeat meatoplasty, whereas for urethral strictures, 4(20%) patients who underwent visual urethrotomy experienced recurrent strictures. Conclusions: Urethrocutaneous fistulas can be successfully repaired by complete excision and cross-suture closure and multiple coverage with healthy tissues. In urethral strictures, reconstruction of ample neo-meatus is the key to achieving sufficient stream regardless of the stricture site.

Multiple Human Papillomavirus Infection Is Associated with High-Risk Infection in Male Genital Warts in Ulsan, Korea

권택민,문경현,양성학,노민철,이상훈,김제원,김인규,노경호,박성찬 대한의학회 2016 Journal of Korean medical science Vol.31 No.3

Further understanding of male human papillomavirus (HPV) infection is necessary to prevent infection in men, as well as transmission to women. In our current study, we investigated patterns of HPV infection and genotype distributions in male genital warts using the Anyplex II HPV28 Detection kit. We reviewed the medical records of 80 male patients who presented to 5 neighborhood clinics in Ulsan, Korea, for the treatment of genital warts between April 2014 and January 2015. All patients underwent HPV genotyping. The prevalence and characteristics of HPV infection were analyzed, and the patterns of HPV infection according to age were assessed. Among the study patients, 13 (16.3%) were negative for HPV infection, 46 (57.3%) were infected with low-risk HPV, and 21 (26.3%) were infected with high-risk HPV. Patients with multiple HPV infection were more likely to have high-risk HPV infection (P = 0.001). The prevalence of HPV infection was much higher in samples obtained by tissue excision due to a definite lesion (P = 0.001). There were no differences in high-risk HPV infection (P = 0.459), multiple HPV infection (P = 0.185), and recurrence at diagnosis (P = 0.178) according to age. HPV-6 and HPV-11 were the most common type overall (39.7% and 13.8%, respectively). HPV- 16 and HPV-18 were the most common high-risk infections (both 3.4%). HPV infection is not only commonly encountered in male genital warts, but is also accompanied by highrisk HPV and multiple infections.

점회절 광간섭계를 이용한 연마된 실리콘 웨이퍼 표면형상 측정

권택민,김승우,김학용,이은상,이상열 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

We devised a vibration-insensitive interferometer with a common-path scheme of generating the reference wave directly by transmitting the measurement wave through a single-mode fiber. This fiber-diffraction interferometer enables to cancel out the dominating vibration effect encountered commonly in both the reference and measurement waves in the due course of the two waves' interference. Besides, to suppresss parasite vibration disturbances caused to interferometer hardware components, a special type of spatial phase-shifter is added to capture four phase-shifter interferograms simultaneously without time delay using a single camera shot.

장무지굴근 통증유발점 주사에 의한 양측성 발뒤꿈치 통증의 치료

권택민,우승훈,홍기혁 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Causes of heel pad pain are variable and there are causative factors; such as spinal nerve root compression, loss of lipid layer of heel pad, trigger point and tendinitis of plantar intrinsic muscles, tendinitis and bursitis of Achilles tendon, and posterior tarsal tunnel syndrome. It is difficult to recognize the cause of heel pad pain and therapeuticmodality is variable in accordance with causative factors. The patient suffering from both heel pad pain was treated with trigger point injection(TPI) of flexor hallucis ongus muscle with 0.5% mepivacaine 2.5㎖. Patient's symptom was improved to a certain extent after repeated 13 times trigger point injection during 66 days.

Prevalence and clinical significance of incidental 18F-fluoro-2-deoxyglucose uptake in prostate

권택민,정인갑,유달산,홍준혁,안한종,김청수 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.4

Purpose: To investigate the prevalence and clinical significance of incidental prostate fluoro-2-deoxyglucose (FDG) uptake and to evaluate its impact on patient management. Materials and Methods: Of 47,109 men who underwent FDG positron emission tomography between 2004 and 2014, 1,335 (2.83%) demonstrated incidental FDG uptake in the prostate, with 99 of the latter undergoing prostate biopsy. The primary end point was the histological presence of prostate adenocarcinoma in the biopsy specimen. Outcomes, including treatment methods, survival, and causes of death, were also assessed. Factors associated with the diagnosis of prostate cancer were evaluated by using logistic regression analysis. Results: Patients with prostate cancer were more likely to have higher serum prostate-specific antigen (PSA) (p=0.001) and focal FDG uptake (p=0.036) than were those without. Prostate cancer occurred in 1 of 26 patients (3.8%) with serum PSA<2.5 ng/mL, compared with 40 of 67 patients (59.7%) with serum PSA≥2.5 ng/mL. Multivariable analysis showed that focal lesions (odds ratio [OR], 5.50; p=0.038), age (OR, 1.06; p=0.031), and serum PSA (OR, 1.28; p=0.001) were independent predictors of prostate cancer diagnosis. Most patients with prostate cancer had organ-confined tumors. Of these, 12 (29.3%) underwent radical prostatectomy and 25 (60.9%) received hormone therapy. Of the 11 patients who died, 9 died of primary cancer progression, with only 1 patient dying from prostate cancer. Conclusions: The prevalence of incidental FDG uptake in the prostate was not high, although patients with elevated serum PSA had a higher incidence of prostate cancer. Patients with FDG uptake in the prostate should be secondarily evaluated by measuring serum PSA, with those having high serum PSA undergoing prostate biopsy.