한국 범불안장애 환자의 자율신경심장기능

추정숙,이승환,김현,이강준,남민,정영조,Choo, Chung-Sook,Lee, Seung-Hwan,Kim, Hyun,Lee, Kang-Joon,Nam, Min,Chung, Young-Cho 대한생물정신의학회 2005 생물정신의학 Vol.12 No.1

Objective:The purposes of this study were to investigate heart rate variability(HRV) in patients with generalized anxiety disorder(GAD) compared with major depressive disorder in Korea. Methods:Fifty-six GAD patients(20 male and 36 female) was classified into their comorbid psychiatric illness. Among them, Twenty-five patients(10 male and 15 female) who do not have any psychiatric comorbidity were compared with 30 major depressive disorder patients(12 male and 18 female). Clinical symptoms, HRV and MMPI were analysed between two group. Results:Comorbid psychiatric illnesses of GAD were ranked into no diagnosis(44.6%), MDD(32.1%), panic disorder(10.7%), social phobia(5.3%), PTSD(1.7%), OCD(1.7%), MDD+panic disorder(1.7%) and MDD+specific phobia(1.7%). GAD patients showed low functioning in HRV, but degree of decreasing HRV is not so severe compared with MDD patient. Balance of sympathetic and parasympathetic nerve tone is more severely impaired in GAD patients compared with MDD patient. The score of MMPI did not reveal any differences between two groups. Conclusions:The result showed that HRV can differenciate GAD and MDD patients. GAD patients could show decreased HRV functioning, less than MDD patients. But autonomic imbalance could be more severe in GAD than MDD patients.

우울과 불안의 뇌 기능 - EEG, ERP, Functional Neuroimaging, HRV 소견을 중심으로 -

추정숙,이승환,정영조,Choo, Jung-Suk,Lee, Seung-Hwan,Chung, Young-Cho 대한불안의학회 2008 대한불안의학회지 Vol.4 No.1

The purpose of this review was to investigate the neurophysiological and neuroimaging characteristics of patients with depression and anxiety reported in previous studies. A literature search was conducted using Medline and psychiatric textbooks. "Electroencephalography (EEG)", "Event Related Potentials (ERP)", "functional neuroimaging", "heart rate variability (HRV)" and "depression or anxiety" were used as key words. A physiological finding indicated that there was a higher degree of relativity with regards to prefrontal dysfunction in patients with depression. Right prefrontal lobe hyperactivity and left prefrontal hypoactivity were consistently observed, and abnormalities were observed in other regions (ACC, hippocampus, amygdala, etc.). Therefore, dysfunctions in these areas are related to depressive symptoms. In patients with anxiety disorder, each emotional condition showed specific activation patterns in different brain regions, such as the prefrontal cortex, occipital lobe, temporal lobe, hippocampus, and limbic system, including the amygdala. However, in the majority of patients with anxiety disorder, the degree of activation was higher in the right hemisphere than in the left hemisphere. The current data supports that there is a difference in brain dysfunction characteristics between depression and anxiety and that the different activations of various brain regions would play a significant role in the pathophysiology of depression and anxiety disorder.

Relationship between the spatial distribution of coastal sand dune plants and edaphic factors in a coastal sand dune system in Korea

황정숙,최덕균,최성철,박한산,박용목,배정진,추연식 한국생태학회 2016 Journal of Ecology and Environment Vol.39 No.1

We conducted the study on the relationship between the distribution of coastal sand dune plants and edaphic factors from the shoreline to inland in sand dune ecosystem. The application of TWINSPAN classification based on 10 species, led to the recognition of three vegetative groups (A-C), which associated with their habitats (foredune, hummuck in semistable zone and stable zone). The associations were separated along soil gradient far from the seashore. The relationships between species composition and environmental gradients were explained by canonical correspondence analysis (CCA). Distance from the shoreline was an important indicator to determine soil properties (pH, total ion contents, sand particle sizes, organic matters and nitrogen contents) from the seaward area to inland area and distribution pattern of coastal sand dune plants. Group A is foredune zone, characterized by Calystegia soldanella; group included typical foredune species such as Elymus mollis, Carex kobomugi, Ixeris repens, C. soldanella and Glehnia littoralis. Group B on semi-stabilized zone was characterized by Vitex rotundifolia, a perennial woody shrub. This group was associated the proportion of fine sand size (100 to 250 μm). The results on the proportion of soil particle size showed a transition in sand composition, particularly with respect to the proportion of fine sand size that occurred from the foredune ridge at 32.5 m to the Vitex rotundifolia community at 57.5 m from the shoreline. Group C on stabilized zone was characterized by Zoysia macrostachya, Lathyrus japonicus and Cynodon dactylon and were associated soil organic matter and nitrogen contents. The spatial distribution of plants in the Goraebul coastal sand dune system may result from the interactions between the plant species and environmental heterogeneity.

Effects of an aqueous red pine (Pinus densiflora) needle extract on growth and physiological characteristics of soybean (Glycine max)

황정숙,배정진,추연식 한국생태학회 2011 Journal of Ecology and Environment Vol.34 No.3

The effect of allelochemicals on growth, root nodule nitrogen fixation activity, and ion patterns of soybeans were investigated. We prepared 50 g/L (T50), 100 g/L (T100), and 200 g/L (T200) extract concentrations by soaking fresh red pine needles in a nutrient solution. Adding needles to the nutrient solution increased the content of total phenolic acids,osmolality, and total ions. The total phenolic content in the T50, T100, and T200 extracts were 206 ± 12.61, 335 ± 24.16,and 603 ± 12.30 mg gallic acid equivalents, respectively. The K^+, Mg^(2+), Ca^(2+), and PO_4^(3-) content increased by adding needles to the nutrient solutions, whereas SO_4^(2-) content decreased. The growth inhibition of soybeans was proportional to the needle extract concentrations, and the T100 and T200 concentrations resulted in remarkable growth inhibition. On day 20 after treatment, dry weight and nitrogen fixation activity of the root nodules were reduced by the T100 and T200 treatments,whereas the T50 treatment was not difference from the control. After day 10, total ion content in all treatment groups was not different in comparison with the control. However, total ionic content in all treatment groups decreased significantly compared with that in the control after day 20. The lowest total ion value was found for the T200 concentration. The T200 treatment also resulted in significantly reduced SO_4^(2-) content. The amounts of Mg^(2+), Ca^(2+), and Mn^(2+) were higher than those of the control for the T50 treatment on day 10 and for T100 on day 20 after treatment. A significant increase in osmolality was observed in the T200 treatment on day 10 and in the T100 treatment on day 20. These results suggest that under severe allelochemical stress conditions, a remarkable reduction in nodule formation, nitrogen fixation activity, and ion uptake eventually resulted in a decrease in leaf production. Furthermore, increased K+, Mg2+, Ca2+,Mn2+, and osmolality in soybeans exposed to lower concentrations of allelochemicals than the critical stress level helped overcome the stress.

팥 품종의 이화학적 특성 및 항산화 활성 변이

성정숙,송석보,김지영,안연주,박재은,최명은,추지호,하태정,한상익 한국작물학회 2020 한국작물학회지 Vol.65 No.3

This research was conducted to evaluate the physicochemical properties, antioxidant components, and their activities for more taking advantage of small redbean cultivars. Seed size, 100 seeds weight, and hardness on the 8 cultivars were measured. The free sugar and crude protein contents were evaluated using HPLC and protein analyzer, respectively. Amylose content, antioxidant components, and activities were analyzed by spectrophotometer. The range of 100 seeds weight and hardness were 12.55-18.81 g and 9,527.38-14,341.25 gf, respectively. Total free sugar, amylose, and crude protein were showed 22.49-31.07 mg/g, 13.53-15.67%, and 21.27-23.30%, respectively. The cultivar ‘Hongeon’ was higher antioxidant component and activity more than others. In clustering the cultivars based on the results, the tree showed four major clades. The ‘Huinnarae’ group was high in total free sugar and amylose content. The ‘Hongeon’ group were high in 100 seeds weight, antioxidant component. and activity, while amylose content was lower than that in the other groups. The results of the cultivars can be utilized for research of functional materials. The findings of this study will provide valuable information for expansion of functional food industry related on small redbean. 아리리 등 최근 육성된 팥 품종들을 대상으로, 이화학적특성을 검토하여 보다 다양한 식품소재로 활용하기 위한기초자료로 제공하고자 본 연구를 수행하였다. 1. 검구슬과 홍진의 종실이 길이와 폭이 컸으며 충주팥은 두께가 두꺼웠고, 백립중은 흰구슬(18.81 g) 및 홍진(17.48 g)이 충주팥보다 높았다. 경도는 14,341.25 gf인충주팥보다 모든 품종이 낮은 값을 보여 앙금 제조 등에용이한 형질을 보였다. 2. 총유리당은 22.49 - 31.07 mg/g로 분포하였으며 연두채, 검구슬, 흰나래, 홍언 및 흰구슬이 충주팥(25.32 mg/g)에비해 높은 값을 보였다. 아밀로오스는 13.53 - 15.67%로분포하였고, 연두채, 홍언 및 검구슬이 충주팥(15.24%) 에 비해 높았다. 조단백질은 21.40 - 23.30%로 분포하였으며, 흰구슬을 제외한 나머지 품종들이 충주팥에 비해낮은 함량을 보였다. 3. 항산화 성분인 폴리페놀 및 플라보노이드 함량은 각각0.52 - 4.28 mg GAE·g-1와 0.12 - 2.62 mg CAE·g-1로분포하였다. 홍언, 검구슬, 흰구슬, 연두채 등이 충주팥에비해 항산화성분 함량 및 항산화 활성이 높은 편이었다. 4. 팥의 항산화성분과 활성간에는 높은 정의 상관관계를보였으나 조단백질과는 부의 상관을 보였다. 또한, 주성분 분석결과, 제1주성분인 항산화성분 및 활성과 제2주성분인 조단백질 및 백립중이 변이값 해석에 대해 기여도가 높았다. 5. 팥 품종들의 평가를 바탕으로 cluster를 분석한 결과, 흰나래, 홍언이 각각 분리되었고 검구슬과 연두채 그룹 및홍진, 아라리, 충주팥, 흰구슬 그룹 등 총 4개의 그룹으로 나뉘었다. 흰나래 그룹은 총유리당 및 아밀로오스 값이 높은 반면, 홍언 그룹은 백립중과 항산화성분 및 활성이 높았다.

Changes in ROS-Scavenging Enzyme Activity in Rice (Oryza sativa L.) Exposed to High Salinity

구정숙,추연식,이신범 한국생태학회 2007 Journal of Ecology and Environment Vol.30 No.4

(superoxide dismutase, catalase and peroxidase) activity in leaves and roots of rice (Oryza sativa L.) plants ex-posed to high salinity. Under salt stress, the reduction in RWC (relative water content) in leaves was relatively severe in comparison with that of roots. The proline content was also significantly higher in leaves of rice plants following salt treatment. The activities of CAT and POX in roots increased with increasing NaCl concentration, but the activity of SOD decreased. These results suggest that the increase of endogenous proline is closely associated with the increase of CAT and POX activities, which may play important roles in salt tolerance. Therefore, we conclude that the alleviation of oxidative damage and increased resistance to salinity may result from the presence of efficient antioxidative systems.

Mortality of Community-Acquired Pneumonia in Korea: Assessed with the Pneumonia Severity Index and the CURB-65 Score

김혜인,추은주,김효열,김영근,김신우,장현하,차승익,이재희,기현균,정혜숙,유광하,류성열,권기태,이병기,김도진,강철인,정두련,백경란,송재훈,서지영,심태선,문치숙,이현경,박성연,오진영,정숙인,박경화,윤나라,윤성호,손경목,김연숙,정기석 대한의학회 2013 Journal of Korean medical science Vol.28 No.9

The pneumonia severity index (PSI) and CURB-65 are widely used tools for the prediction of community-acquired pneumonia (CAP). This study was conducted to evaluate validation of severity scoring system including the PSI and CURB-65 scores of Korean CAP patients. In the prospective CAP cohort (participated in by 14 hospitals in Korea from January 2009 to September 2011), 883 patients aged over 18 yr were studied. The 30-day mortalities of all patients were calculated with their PSI index classes and CURB scores. The overall mortality rate was 4.5% (40/883). The mortality rates per CURB-65 score were as follows: score 0,2.3% (6/260); score 1, 4.0% (12/300); score 2, 6.0% (13/216); score 3, 5.7% (5/88); score 4, 23.5% (4/17); and score 5, 0% (0/2). Mortality rate with PSI risk class were as follows: I,2.3% (4/174); II, 2.7% (5/182); III, 2.3% (5/213); IV, 4.5% (11/245); and V, 21.7%(15/69). The subgroup mortality rate of Korean CAP patients varies based on the severity scores and CURB-65 is more valid for the lower scores, and PSI, for the higher scores. Thus, these variations must be considered when using PSI and CURB-65 for CAP in Korean patients.

The effect on photosynthesis and osmotic regulation in Beta vulgaris L. var. Flavescens DC. by salt stress

최덕균,황정숙,최성철,임성환,김종국,추연식 한국생태학회 2016 Journal of Ecology and Environment Vol.39 No.1

This study was to investigate the effect of salt stress on physiological characteristics such as plant growth, photosynthesis, solutes related to osmoregulation of Beta vulgaris. A significant increase of dry weight was observed in 50 mM and 100 mM NaCl. The contents of Chl a, b and carotenoid were lower in NaCl treatments than the control. On 14 day after NaCl treatment, photosynthetic rate (PN), the transpiration rate (E) and stomatal conductance of CO2 (gs) were reduced by NaCl treatment. On 28 day after NaCl treatment, the significant reduction in gs and E was shown in NaCl 200 mM. However, PN and water use efficiency (WUE) in all NaCl treatments showed higher value than that of control. Total ion contents (TIC) and osmolality were higher than the control. On 14 day after treatment, the contents of proline (Pro) increased significantly in 200 mM and 300 mM NaCl concentration compared with control, whereas on 28 day in all treatments it was lower than that of the control. The contents of glycine betaine (GB) increased with the increase of NaCl concentration. The contents of Na+, Cl-, GB, osmolality and TIC increased with the increase of NaCl concentrations. These results suggested that under severe NaCl stress conditions, NaCl treatment did not induce photochemical inhibition on fluorescence in the leaves of B. vulgaris, but the reduction of chlorophyll contents was related in a decrease in leaf production. Furthermore, increased GB as well as Na+ and Cl- contents resulted in a increase of osmolality, which can help to overcome NaCl stress.

Physiological Responses of Calystegia soldanella under Drought Stress

배채연,추연식,황정숙,최성철,임성환,최덕균,배정진,김종국 한국생태학회 2013 Journal of Ecology and Environment Vol.36 No.4

This study was conducted to determine the extent of drought resistance based on physiological responses of Calystegia soldanella under water deficit. In order to investigate the changes of plant growth, stomatal density, photosynthesis, chlorophyll fluorescence, the contents of chlorophyll and carotenoid, osmolality, total ion contents, the contents of carbohydrate and proline, C. soldanella was grown under well watered and drought stressed conditions for 12 days. In this study,water-deficit resulted in remarkable growth inhibition of C. soldanella. The effect of water-deficit on plant growth was associated with low osmotic potential of soil. On day 12 after drought treatment, dry weight, relative water contents, number and area of leaves and stem length were lower than those of control. The stomatal conductance and net photosynthetic rate were significantly reduced in water stressed plant to regulate inner water contents and CO2 exchange through the stomatal pore. Chlorophyll fluorescence and chlorophyll contents were not different in comparison with the control,indicating that the efficiency of photosystem II was not affected by drought stress. This results could be explained that water-deficit in C. soldanella limits the photosynthetic rate and reduces the plant’s ability to convert energy to biomass. A significant increase in total ion contents and osmolality was observed on day 7 and day 12. Accumulation of proline in leaves is associated with the osmotic adjustment in C. soldanella to soil water-deficit. Consequently, this increase in osmolality in water stressed plant can be a result in the increase of ion contents and proline.

손가락조 ‘핑거1호’의 영양, 기능성 및 전분특성 연구

안연주,추지호,최명은,송석보,성정숙,김지영,한상익 한국국제농업개발학회 2020 한국국제농업개발학회 학술대회 Vol.2020 No.12