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솔잎(Pinus densiflora leaf) 추출물의 항비만효과
최민영(Min Yeong Choi),신별(Byel Shin),유주형(Ju Hyeong Yu),여주호(Joo Ho Yeo),이재원(Jae Won Lee),금나경(Na Gyeong Geum),안미연(Mi-Yun An),정진부(Jin Boo Jeong) 한국자원식물학회 2022 한국자원식물학회지 Vol.35 No.2
In this study, we measured the inhibitory activity of Pinus densiflora leaf (PDL) against excessive lipid accumulation in mouse preadipocyte, 3T3-L1 cells to investigate whether PDL exerts anti-obesity activity. Lipid accumulation and the protein level were measured using Oil red O staining assay and Western blot analysis, respectively. We observed that PDL inhibited excessive lipid accumulation and decreased the expression of CEBPα, PPARγ and perilipin-1 related to lipid accumulation in 3T3-L1 cells. Therefore, considering these results, PDL can be used as a potential agent for anti-obesity.
원발성 알도스테론증으로 부신 절제술 받은 환자의 수술 후 결과에 대한 분석
류재민,정승필,이정희,김지영,최민영,이세경,길원호,최준호,이정언,김지수,남석진,양정현<SUP>1<.SUP>,김정한,Jai-Min Ryu,M.D.,Seung-Pil Jung,M.D.,Jeong-Hee Lee,M.D.,Ji-Yeong Kim,M.D.,Min-Yeong Choi,M.D.,Se-Kyung Lee,M.D.,Won-Ho Kil,M.D.,Jun-Ho C 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.4
Purpose: Primary aldosteronism (PA) is characterized by hypertension (HTN), hypokalemia, suppressed plasma renin activity, and inappropriate aldosterone secretion. The purpose of this study was to analyze postoperative results on blood pressure (BP), and to determine the factors associated with resolution of HTN after adrenalectomy for PA. Methods: One hundred eight patients (66 females and 42 males) with a mean age of 46 years underwent adrenalectomy for PA between January 1, 1996 and September 30, 2009. Their clinical characteristics and biochemical parameters were reviewed retrospectively. Results: All patients had HTN preoperatively and 20 patients (18.1%) had uncontrolled HTN. Hypokalemia was evident in 89.1% of patients, cardiovascular events in 4.5% and cerebrovascular events in 8.2%. There was a significant decrease in both systolic BP and diastolic BP postoperatively, as compared with that before operation. Median systolic BP decreased from 150 mmHg to 125 mmHg at the last follow-up (P<0.01), and median diastolic BP decreased from 93.5 mmHg to 81.5 mmHg (P<0.01). Sixty two (57.4%) patients were cured of HTN and did not require any hypertensive agent, and 38 (35.1%) patients had an improvement in BP control, whereas 9 (8.3%) patients had no change in BP. Univariate analysis showed that duration of HTN and more than two HTN treatment agents were independent factors predicting sustained hypertension after surgery. Conclusion: The duration of HTN and the severity of HTN are factors influencing persistence of HTN after operation for a PA. (Korean J Endocrine Surg 2011;11:276-282)
소나무 담쟁이덩굴(Parthenocissus tricuspidata (Siebold & Zucc.) Planch) 줄기 추출물의 항비만 효과
여주호(Joo Ho Yeo),유주형(Yu Ju Hyeong),최민영(Min Yeong Choi),이재원(Jae Won Lee),금나경(Na Gyeong Geum),안미연(Mi-Yun An),정철의(Chuleui Jung),정진부(Jin Boo Jeong) 한국자원식물학회 2022 한국자원식물학회지 Vol.35 No.2
In this study, we investigated in vitro anti-obesity activity of Parthenocissus tricuspidata (Siebold & Zucc.) Planch stem (PTS) in mouse adipocytes 3T3-L1 cells. PTS inhibited lipid accumulation and reduced the expression level of the proteins such as C/EBPα, PPARγ and FABP4 associated with adipogenesis in 3T3-L1 cells. In addition, PTS increased lipolysis-related protein expression such as p-AMPK, ATGL and p-HSL, and reduced perilipin-1 in 3T3-L1 cells. Taken together, PTS may have anti-obesity activity through inhibiting adipogenesis and inducing lipid lipolysis in adipocytes. Based on these results, PTS is expected to be used as a potential functional agent for anti-obesity.
금나경(Na Gyeong Geum),여주호(Joo Ho Yeo),류주형(Ju Hyeong Yu),최민영(Min Yeong Choi),이재원(Jae Won Lee),백정규(Jueng Kyu Baek),정진부(Jin Boo Jeong) 한국자원식물학회 2021 한국자원식물학회지 Vol.34 No.3
Bok choy is one of Brassica vegetables widely consumed worldwide. Brassica vegetables have been reported to exert various pharmacological activities such as antioxidant, anti-cancer and cardioprotective activity. However, studies on immunostimulatory activity of bok choy sprout have not been conducted properly. Thus, in this study, we investigated in vitro immunostimulatory activity of bok choy sprout extract (BCS) using mouse macrophage RAW264.7 cells. Our results showed that BCS increased the production of immunomodulators such as NO, iNOS, IL-1β, IL-6, IL-12, TNF-α and MCP-1, and phagocytic activity in RAW264.7 cells. BCS activated MAPK, NF-κB and PI3K/AKT signaling pathways. However, BCS-mediated production of immunomodulators was dependent on JNK, NF-κB and PI3K/AKT signaling pathways. the mRNA expression of TLR2 were significantly increased by BCS, TLR2 inhibition by anti-TLR2 dramatically suppressed the production of immunomodulators by BCS. In addition, TLR2 inhibition by anti-TLR2 significantly reduced BCS-mediated phosphorylation level of AKT, JNK and NF-κB. From these results, BCS may have immunostimulatory activity via TLR2-MAPK, NF-κB and PI3K/AKT signaling pathways. Therefore, BCS expected to be used as a potential immune-enhancing agent.
Immunostimulatory Activity of Hibiscus manihot Flower in Mouse Macrophages, RAW264.7 Cells
금나경(Na Gyeong Geum),유주형(Ju Hyeong Yu),여주호(Joo Ho Yeo),최민영(Min Yeong Choi),박광훈(Gwang Hun Park),홍세철(Se Chul Hong),정진부(Jin Boo Jeong) 한국자원식물학회 2021 한국자원식물학회지 Vol.34 No.6
In this study, we investigated whether Hibiscus manihot flowers (HMF) exhibits immunostimulatory activity in RAW264.7 cells. HMF increased the production of immunostimulatory factors such as NO, iNOS, IL-1β and TNF-α in RAW264.7 cells. TLR2 and TLR4 blocked HMF-mediated production of immunostimulatory factors in RAW264.7 cells. In addition, the inhibition of MAPK signaling pathway reduced HMF-mediated production of immunostimulatory factors. From these results, HMF is thought to promote the production of immunostimulatory factors through activating TLR2/4/MAPK signaling in macrophages. It is believed that HMF can be developed as an agent related to immune enhancement in the future.
정평안 ( Pyung An Jung ),정승필 ( Seung Pil Jung ),이정희 ( Jung Hee Lee ),김지영 ( Ji Yeong Kim ),최민영 ( Min Yeong Choi ),이세경 ( Se Kyung Lee ),최준호 ( Jun Ho Choe ),이정언 ( Jeong Eon Lee ),김지수 ( Jee Soo Kim ),남석진 ( S 대한임상종양학회 2011 Korean Journal of Clinical Oncology Vol.7 No.2
목적: 최근 국내에서 발병이 증가하고 있는 피부암 환자에서 시행한 서혜부 림프절 곽청술의 술기를 소개하고 수술에 따른 합병증 및 수술 결과에 대해 고찰하고자 하였다. 방법: 2002년 3월부터 2010년 7월까지 피부암의 서혜부 림프절전이로 서혜부 림프절 곽청술을 시행한 43예의 환자를 대상으로 수술 후 합병증, 생존률, 재발 유무 등을 후향적으로 분석하였다. 결과: 서혜부 림프절 곽청술을 시행한 43명의 환자 중 편평 세포암 8명, 악성 흑색종 35명이었다. 평균 12.6개의 림프절을 절제하였고 평균 2.46개의 림프절에서 전이가 확인 되었다. 수술 후 35예(81.4%)의 환자에서 하지 림프 부종, 피부 괴사, 장액종의 합병증이 발생하였으나 모두 보존적 치료 후 호전되었다. 평균 24.5(3-83)개월의 외래 추적 관찰 기간 동안 20명(46.5%)의 환자에서 재발이 발생하였고 8명(18.6%)의 환자가 사망하였다. 결론: 림프절로 전이된 피부암은 불량한 예후를 보이고 서혜부림프절 곽청술은 많은 합병증을 동반하는 술식이지만 경험 있는 외과의에 의해 적절히 시행된다면 심각한 합병증과 재발을 줄일 수 있다. 국내에서 피부암은 드물 질환이지만 서혜부 림프절 곽청술의 술기 및 술후 경과에 대해 잘 파악하고 있는 것이 이 질환의 치료를 위해 중요하다. Purpose: To evaluate the results and experience of inguinal lymph node dissection in patients with skin cancer. Methods: 43 patients were underwent inguinal lymph node dissection for skin cancer spread to the lymph nodes in SMC between Mar 2002 and Jul 2010. We investigated postoperative complications, recurrence rate, survival rate from their medical records, retrospectively. Results: Among 43 patients, 35 cases were diagnosed as malignant melanoma and 8 were diagnosed as squamous cell carcinoma. 12.6 lymph nodes were retrieved, and 2.46 lymph nodes were metastasized on average. Complications such as lymphedema in lower extremities, skin necrosis, seroma were occurred in 35 patients (81.4%). But most were recovered with conservative management. During 24.5(3-83) months of follow up periods, 20 patients (46.5%) had recurrences of skin cancer and 8(18.6%) of them were expired. Results: Generally, skin cancer spread to lymph nodes shows poor prognosis and inguinal lymph nodes dissection is a procedure resulting in high rate of complications. However, if this is performed properly by experienced surgeons, the recurrence and serious complications could be reduced.