2001년 경상북도에서 발생한 콜레라 유행에 관한 역학조사

이준호,이관,김준철,이상원,고운영,양병국,이종구,김문식,임현술,Lee, Jun-Ho,Lee, Kwan,Kim, Jun-Chul,Lee, Sang-Won,Go, Un-Yeong,Yang, Byung-Kuk,Lee, Jong-Koo,Kim, Moon-Sik,Lim, Hyun-Sul 대한예방의학회 2002 예방의학회지 Vol.35 No.4

Objectives : This study was carried out to investigate the cause, magnitude and transmission route of the cholera outbreak in 2001 Methods : The study population were those persons who ingested foods at the restaurant, were confirmed as cholera patients, had symptoms of diarrhea and sewed as workers at the restaurant. A questionnaire survey and microbiological examinations on the microbes isolated from rectal swabs were conducted. Of the cases, 316 food histories were surveyed by an analysis of the restaurant menu. Results : There were 139 confirmed cases of cholera reported in Korea in 2001. Of these, 104 were related to the restaurant. By region, Gyeongsangbuk-do had the highest incidence with 91 cases. Of these 91 cases, 74 had ingested foods at the restaurant, 2 were employees and 3 were secondary infection cases within the families. The results of the odds ratio analysis of the 316 persons having ingested foods at the restaurant were as follows: sandwiches 5.07 (95% CI, 1.85-14.59), soybean curd 2.45 (95% CI, 1.09-5.56), noodles 2.34 (95% CI, 1.24-4.42), steamed squid 2.01 (95% CI, 1.17-3.47) and vinegared rice 1.82 (95%, CI, 1.08-3.09). It was certain the restaurant in question was the cause of the 2001 outbreak. Conclusions : We suspected that more than one restaurant employee contaminated foods served at the restaurant. In addition, eating raw fishes purchased at the Pohang Fisheries infected the employees of the restaurant. There is a possibility that these raw fishes were themselves contaminated by cholera bacilli in the sea.

Experimental Evaluation of Q-Parameterization Control for the Imbalance Compensation of Magnetic Bearing Syatem

이준호,김현기,이정석,이기서,Lee, Jun-Ho,Kim, Hyeon-Gi,Lee, Jeong-Seok,Lee, Gi-Seo 대한전기학회 1999 전기학회논문지A Vol.48 No.3

This paper utilizes the method of Q-parameterization control to design a controller which solves the problem of imbalance in magnetic bearing systems. There are two methods to solve this problem using feedback controal. The first method is to compensate for the imbalance forces by generating opposing forces on the bearing surface (imbalance compensation). The second method is to make the rotor rotate around its axis of inertia (automatic balancing);in this case no imbalance forces will be generated. In this paper we deal with only imbalance compensation. The free parameter of the Q-parameterization controller is chosen such that these goals are achieved. After the introduction of a model of the magnetic bearing system, we explain the Q-parameterization controller design of the magnetic bearing system with emphasis on the rejection of sinusoidal disturbance for imbalance compensation design. The design objectives are formulated as a linear equations in the controller free paramete Q. Finally, simulation and experimental results are presented and showed the robustness and effectiveness of the proposed controllers.

A 37Ch Visible Adaptive Optics System for Wavefront Compensation

이준호,Byung Tae Choi,Eung Cheol Kang,Hae Seog Kho,Ho Jung Cheon,Jae Il Lee,Joon Won Kim,Kyung Muk Lee,Sung Jin Kim,Young Cheol Lee,Young Il Cho 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.1

A visible adaptive system was developed to compensate for phase distortions of a visible (He-Ne) laser. The visible adaptive optics (AO) system consists of 5 subsystems: a Shack-Hartmann wavefront sensor, a deformable membrane mirror of 15 mm with 37 actuators, a high-speed tip/tilt mirror of 20 mm, a position sensor and a control & display unit. The lab-developed Shack-Hartmann sensor was experimentally shown to have a measurement accuracy of better than RMS /50 at 0.6328 μm over the maximum phase distortion that the deformable mirror could generate, i.e., approximately /4. The adaptive optics system operated the deformable mirror at 10 Hz and the tip/tilt mirror at 30 Hz, which were, respectively, closed by the Shack-Hartmann sensor and the position sensor. The closed adaptive optics system was demonstrated to compensate for time-varying wavefront aberrations of PV (Peak-to-Valley) 1.2 μm with a time frequency of 1.4 Hz. The residual RMS wavefront error was shown to be smaller than 0.014 μm, i.e., /45 at 0.6328 μm.

정맥용 면역글로불린 투여 후 발생한 무균성 수막염 3례

이준호,송은경,이진아,김남희,김동호,박기원,최은화,이환종,Lee, Joon Ho,Song, Eun Kyoung,Lee, Jin A,Kim, Nam Hee,Kim, Dong Ho,Park, Ki Won,Choi, Eun Hwa,Lee, Hoan Jong 대한소아감염학회 2005 Pediatric Infection and Vaccine Vol.12 No.2

IVIG 투여에 의해 무균성 수막염은 그 기전이 밝혀지지 않았으나 IVIG 투여와 관련된 신경학적 부작용 중 가장 중한 합병증의 하나이다. 저자들은 서울대학교 어린이병원에서 2003년부터 2004년까지 3명의 환아에서 확인된 IVIG 투여와 관련된 무균성 수막염 4례를 경험하여 보고하였다. 3명의 환아는 ITP, 가와사키병, 중증 근무력증으로 기저질환은 각각 상이하였으나 기저질환에 대한 치료를 위해 모두 고용량의 IVIG를 투여받았으며, IVIG를 투여받은 후 1~2일 이내에 심한 두통과 뇌막자극 징후를 보였다. 척수액 소견상 백혈구 수는 $100/{\mu}L$ 미만에서부터 $1,000/{\mu}L$ 이상까지 다양하였으나 주로 다핵구로 구성된 척수액 백혈구 분포를 보였고(66~98%), 세균 배양검사와 장바이러스 배양과 PCR 검사에서 음성 결과를 보였다. 3명의 환아 모두 수막염 발생 2일 후까지는 증상이 호전되었으며, 후유증 및 장애가 없었다. Intravenous immune globulin(IVIG) is widely used for immune thrombocytopenic purpura (ITP), Kawasaki disease and other autoimmune neuromuscular disease. Aseptic meningitis was one of the most serious neurologic complications reported following the use of IVIG. We experienced 4 episodes of aseptic meningitis associated with IVIG usage in 3 patients from 2003 to 2004. Underlying disease of each patients was ITP, Kawasaki disease and myathenia gravis and all of them received high dose IVIG treatment for their underlying disease. Within a days, they started to complain severe headache and diagnosed meningitis by cerebrospinal fluid analysis. Cerebrospinal fluid leukocyte counts varied from 92 to over a thound per microliter with dominance of polymorphonuclear leukocytes. Microbiologic studies revealed no organisms. All of them were free from headache within 2 days and did not suffer any neurological sequelae.

Roles of Src-family kinase isoforms, Lyn, Fyn, Fgr, and c-Src on degranulation in RBL-2H3 mast cells

이준호,문세환,고나영,김지완,김도균,김주동,허억,최완수,Lee, Jun-Ho,Mun, Se-Hwan,Ko, Na-Young,Kim, Jie-Wan,Kim, Do-Kyun,Kim, Joo-Dong,Her, Erk,Choi, Wahn-Soo Korean Society of Life Science 2007 생명과학회지 Vol.17 No.3

흰쥐유래의 비만세포인 RBL-2H3 세포는 다양한 Src-family kinase를 발현한다. 현재까지의 연구결과에 의하면 비만세포의 초기 활성화에 Lyn kinase가 중요한 역할을 한다고 알려져 왔다. 그러나 그 세포에서 발현되는 다양한 다른 Src-family kinase의 역할은 불분명하다. 본 연구에서는 비만세포에서 다양한 Src-family kinase가 세포내 다른 곳에서 다양하게 발현되고 있다는 사실을 RT-PCR, immunoblotting 그리고 confocal microscopy 기법을 이용하여 증명하였다. 그 결과 Lyn 및 Fgr kinase는 세포막에 위치하고 c-Src 및 Yes kinase는 세포 내 과립에 존재하는 것을 알 수 있었다. 모든 Src-family kinase를 클로닝하고 과발현하여 탈과립 대한 영향을 평가하였다. 그 결과 fyn과 Fgr kinase는 비만세포에서 항원 유도의 탈과립을 증가시켰으며 반면 Lyn kinsae는 탈과립을 억제시키는 것을 확인할 수 있었다. 이러한 결과는 비만세포 초기 신호전달계에서 Fgr가 중요한 역할을 할 가능성을 제시한다. The rat RBL-2H3 mast cells contain various Src-family kinases. Previous reports with this cell line indicated that Lyn activation is an important initial signaling for the activation of the cells. However, the role and location of other Src-family kinase isoforms which are expressed in the cells are not clear. In this study, we now show that isoforms of Src-family kinases, Lyn, fyn, Fgr, c-Src, and Yes are differentially expressed and located differently in the cells as indicated by RT-PCR, immunoblotting analysis, and confocal microscopy. Lyn and Fgr were located on plasma membrane but on the other hand c-Src and Yes were located on intracellular organelle. All of Src-family kinases were cloned and overexpressed for investigating the roles of the isoforms. Overexpression of Fyn and Fgr, not Lyn and c-Src, stimulated Ag-induced degranulation in the cells. Our findings strongly suggest for the first time that each of Src-family kinase isoform can regulate differentially $Fc{\varepsilon}RI$-mediated signaling in RBL-2H3 mast cells.

COLUMN 과학 칼럼 - 인간됨의 유전자

이준호,Lee, Jun-Ho 한국과학기술단체총연합회 2011 과학과 기술 Vol.506 No.-

판상형 격간벽 시스템 건물의 반응수정계수

이준호,전용,김진구,Lee, Joon-Ho,Jeon, Yong,Kim, Jin-Koo 대한건축학회 2011 대한건축학회논문집 Vol.27 No.7

In this study seismic performance and response modification factors of rectangular reinforced concrete staggered wall system (SWS) structures were evaluated. To this end, 5, 9, 15, and 25-story SWS structural models were designed and were analyzed by pushover analysis to observe the force-displacement relationship up to failure and the location of plastic deformation. The response modification factor was computed based on the overstrength and the ductility capacities obtained from capacity envelopes. The analysis results showed that the 5- and 9-story SWS structures failed due to yielding of columns and walls located in the lower stories, whereas in the 15- and 25-story structures plastic hinges were more widely distributed throughout the stories. The response modification factors obtained by multiplying overstrength factor and ductility factor increased as the number of stories decreased.

QFD(Quality Function Deployment)와 시스템 요구분석 기법을 이용한 지능형 병원 시스템 개념 정립

이준호,김대홍,진경훈,함재복,이재우,Lee, Jun Ho,Kim, Dae Hong,Jin, Kyung Hoon,Ham, Jae Bok,Lee, Jae Woo 한국시스템엔지니어링학회 2006 시스템엔지니어링학술지 Vol.2 No.1

In this study, the design concepts for Intelligent Hospital are derived using the Quality Function Deployment(QFD) and System Requirement Analysis Method. First, requirements for important elements of Intelligent hospital are defined. Second, similar systems are compared and user requirement are refined. Through this process, operational requirement for Intelligent Hospital are defined by combining user requirements and similar systems. To analyze operational requirement, the QFD of the system engineering approach are implemented. Alternative design specifications are constructed by implementing the QFD results by building the Morphological Matrix. Various concepts that satisfy the system requirement are derived. Finally the best design concept are obtained using the Pugh concept selection matrix.

Column: 과학칼럼 - 서울대학교 법인화에 대한 단상

이준호,Lee, Jun-Ho 한국과학기술단체총연합회 2011 과학과 기술 Vol.512 No.-

정보은닉기법을 적용한 함정 전투체계 소나 영상의 정보관리 방안 연구

이준호,신상호,정기현,유기영,Lee, Joon-Ho,Shin, Sang-Ho,Jung, Ki-Hyun,Yoo, Kee-Young 한국군사과학기술학회 2015 한국군사과학기술학회지 Vol.18 No.6

The SONAR waterfall image(SWI) is used typically to target detection in SONAR operation and is managed with additional data linked in the naval combat system. The SWI and additional data are very important to classify a kind of target. Although additional data of the SWI is essential and must be kept together with the SWI, it was stored separately in the current system. In this paper, we propose an improved information management method in the naval combat system, where additional data can be contained in the SWI together by using information hiding techniques. The experimental results show that the effectiveness of information hiding techniques in the naval combat system. It is demonstrated that the information hiding techniques can be applied to the SWI that can make the naval combat system to be robust and secure.