알츠하이머병과 피질하혈관치매의 언어유창성검사 수행능력 차이: 노인성치매임상연구센터 연구

안이서,김종헌,최성혜,정지향,구본대,심용수,나해리,이준홍 대한신경과학회 2016 대한신경과학회지 Vol.34 No.1

Background: The verbal fluency test consists of two separate tests of semantic fluency and phonemic fluency. The performance patterns of these tests differ with the type of dementia. We studied the patterns of verbal fluency between Alzheimer’s disease (AD) and subcortical vascular dementia (SVaD), and assessed the clinical utility of these tests. Methods: The 1,475 selected participants comprised 73 normal control subjects, 673 patients with amnestic mild cognitive impairment (aMCI), 535 AD patients, 42 patients with subcortical vascular mild cognitive impairment (svMCI), and 152 SVaD patients. We analyzed the z-score for the total number of animal items as a semantic fluency index and the z-score of the phonemic total score as a phonemic fluency index. Results: The performance of semantic fluency was lower than that of phonemic fluency in all groups. The SVaD group showed the worst scores and abnormal performances on both tests, while the AD group presented abnormal performance only for semantic fluency. Dividing the patients with dementia according to severity revealed a different pattern between AD and SVaD for the clinical dementia rating (CDR) stage of 0.5. The performance of the AD group declined gradually with CDR. However, the SVaD group performed very poorly in both tests even for very mild dementia (CDR stage of 0.5). The aMCI and svMCI groups exhibited similar performance patterns. Conclusions: The pattern of semantic and phonemic fluency was not clinically useful at the MCI stage, but it could be helpful in differentiating AD and SVaD in the early stage of dementia.

베타 티타늄합금의 준 안정상 TEM 회절도형 분석

최병학,심종헌,김승언,현용택,박찬희,강주희,이용태,김영욱,Choe, Byung Hak,Shim, Jong Heon,Kim, Seung Eon,Hyun, Yong Taek,Park, Chan Hee,Kang, Joo-Hee,Lee, Yong Tai,Kim, Young Ouk 한국재료학회 2015 한국재료학회지 Vol.25 No.8

Metastable phase characteristics of beta Ti alloys were investigated to consider the relationship of the microstructure and diffraction pattern in TEM. TEM analysis showed that the microstructure was mottled as a modulated structure, and the diffraction pattern was composed of spot streaks between the main spots of a stable beta phase with a specific lattice relationship. The modulated structure may be induced by short distance slip or atom movement during a very short interval of solution treated and quenched (STQ) materials. The athermal ${\omega}$ phase, which could be precipitated at low temperature aging, is also analysed by the metastable phase. The metastable phases including athermal ${\omega}$ phase had a common characteristic of hardened and brittle behavior because the dislocation slip was restricted by a super lattice effect due to short distance atom movement at the metastable state.

고대와 현대 방짜수저의 균열발생 원인분석

최병학,이범규,심종헌,고형순,조남철,이재성,박경균,김유찬,Choe, Byung Hak,Lee, Bum Gyu,Shim, Jong Hun,Go, Hyung Soon,Jo, Nam Chul,Lee, Jae Sung,Park, Kyung Gyun,Kim, Yu Chan 한국재료학회 2016 한국재료학회지 Vol.26 No.10

The aim of this paper is to consider the effect of the manufacturing processes on corrosion and centerline cracking of ancient bronze spoons. The ancient bronze spoons in question were made by several steps of forging, in reheated condition with cast ingots. The manufacturing method is similar to that of the modern spoons. The investigations include observations from light and scanning electron microscopes of the microstructure in terms of the crack propagation. Cracks in the centerline are caused by solute segregation in the center-line region; this solute is solidified in the final stage of bronze spoon manufacture. Centerline cracking is also caused by ${\alpha}$ phase segregation, accompanied by forged overlapping along the longitudinal direction of the spoons. A vertical stripe with cracks along the centerline of the spoon's width is formed by folding in the wrought process. The overlapping area causes crack propagation with severe corrosion on the spoon surfaces over a period of a thousand years. The failure mechanisms of ancient bronze spoons may be similar to that of modern spoons, and the estimation of the failure mechanisms of ancient spoons can be appropriate to determine failure causes for such modern spoons.

Ti-6Al-4Fe 합금의 가공열처리 미세조직 분석

최병학,최원열,심종헌,박찬희,강주희,김승언,현용택,Choe, Byung Hak,Choi, Won-Youl,Shim, Jong Heon,Park, Chan Hee,Kang, Joo-Hee,Kim, Seung Eon,Hyun, Yong Taek 한국재료학회 2015 한국재료학회지 Vol.25 No.8

Microstructural analysis of a (${\alpha}+{\beta}$) Ti alloy was investigated to consider phase transformation in each step of the thermo-mechanical process using by SEM and TEM EDS. The TAF (Ti-6Al-4Fe) alloy was thermo-mechanically treated with solid solution at $880^{\circ}C$, rolling at $880^{\circ}C$ and annealing at $800^{\circ}C$. In the STQ state, the TAF microstructure was composed of a normal hcp ${\alpha}$ and metastable ${\beta}$ phase. In a rolled state, it was composed of fine B2 precipitates in an ${\alpha}$ phase, which had high Fe segregation and a coherent relationship with the ${\beta}$ matrix. Finally, in the annealing state, the fine B2 precipitates had disappeared in the ${\alpha}$ phase and had gone to the boundary of the ${\alpha}$ and ${\beta}$ phase. On the other hand, in a lower rolling temperature of $704^{\circ}C$, the B2 precipitates were more coarse in both the ${\alpha}$ and the boundary of ${\alpha}$ and ${\beta}$ phase. We concluded that microstructural change affects the mechanical properties of formability including rolling defects and cracks.

NYU 응급환자 분류 알고리즘을 적용한 응급의료 이용 연구

유혜림 ( Yoo Hyerim ),심종헌 ( Sim Jongheon ) 한국사회보장학회 2020 사회보장연구 Vol.36 No.1

본 연구는 환자의 응급의료 이용 현황을 파악하고 유형화하여 우리나라 응급의료 현황을 다각적으로 분석하는 것을 목적으로 한다. 미국에서 주요하게 사용되는 측정도구인 뉴욕대학 응급의료 알고리즘(NYU 알고리즘)을 국내 자료에 적용하였다. 분석자료는 한국 의료패널을 사용하여 2012년부터 2017년에 대하여 분석하였다. 분석 결과를 요약하면 다음과 같다. 첫째, 1인당 응급의료 이용률은 증가하는 추세이며, 응급의료 이용 상위 5개 상병 비중은 100개 경증질환에 속하는 J00(감기)과 A09(위장염 및 결장염)가 차지하는 비중이 높다. 둘째, NYU 알고리즘을 이용하여 응급의료 이용을 9개 분류군으로 구분한 결과, 비응급군(Non-ED) 24.26%, 손상군(Injury) 24.00%, 일차의료가능군(PCT) 23.67%, 응급군(EDNNP) 11.45%등으로 나타났다. 셋째, 1인당 연평균 응급의료비(교통비 포함)는 81,284원을 지출하며 최대 2,961,510원이다. NYU 알고리즘별 응급의료비 발생 비중은 비응급군(Non-ED)과 손상군(injury)에서 큰 것으로 나타났다. 넷째, 비응급군(Non-ED)의 응급의료 이용 요인을 분석하고자, NYU 알고리즘 분류 결과를 비응급군(Non-ED)과 그 외의 경우로 이분형(binary) 종속변수로 구분한 패널 프로빗 확률효과모형 분석 결과, 비응급군(Non-ED)은 다른 범주에 비해 연령이 낮으며, 여성보다 남성이 많으며, 만성질환개수가 많은 것으로 나타났다. 응급의료는 의료 이용의 관문으로 임상적으로 다양한 환자로 구성되며 이용량이 증가하고 있다. 응급실 자원 이용의 효율성 증진을 위해 중증도가 높은 환자가 적시에 이용 가능할 수 있게 해야 하며, 환자의 적정한 응급의료 이용을 유도해야 한다. 응급하지 않은 환자나 질병이 예방가능한 경우와 1차 의료에서 치료가 가능한 경우는 정책적으로 응급실 내원 시 적절한 환자 분류와 경제적 인센티브 등의 기전을 강화하여 적합한 의료이용을 유인해야 한다. The purpose of this study is to analyze the current state of emergency medical services in Korea in a variety of ways by identifying and categorizing patients’ use of emergency medical services. The New York University Emergency Department visit algorithm(NYU Algorithm), a major measurement tool used in the U.S., has been applied. The data were analyzed from 2012 to 2017 using the Korean Health Panel(KHP). The summary of the analysis results is as follows. First, the probability of emergency medical service use per person is increasing, and the proportion of the top five chronic diseases in emergency medical services is high, with J00(Cold Flu) and A09(Cystitis and colonitis). Second, using the NYU algorithm, the use of emergency medical services was divided into nine categories, with 24.26% of non-ED, 24.00% of Injury group, 23.67% of PCT, and 11.45% of EDNNP. Third, considering total medical and transportation costs, the average cost per person is 81,284 won per year and the maximun cost is 2,961,510 won per year. Based on NYU algorithm, the percentage of emergency medical expenses occurred by non-ED group and injury group. Fourth, a panel probabilistic effect model analysis showed that non-ED groups are lower in age than other categories, more men than women, and more chronic diseases, in order to analyze the factors of emergency medical use in non-emergency groups. For the efficiency of the use of emergency room resources, patients with high severity should be made available in a timely manner, and the proper use of emergency medical services should be induced. Where non-emergency patients or diseases are preventable and treatable in primary care, policy should strengthen mechanisms such as appropriate patient classification and economic incentives during emergency room visits to attract appropriate medical use.

부탄연소기 폭발로 인한 인체 상해 평가에 관한 연구

김의수 ( E. S. Kim ),심종헌 ( J. H. Shim ),김진표 ( J. P. Kim ),박남규 ( N. K. Park ) 한국안전학회(구 한국산업안전학회) 2016 한국안전학회지 Vol.31 No.3

The gas leak and explosion accident is able to give a fatal injury to nearby people from the explosion center and interest in effect of the explosion on the human body is increased. Accidents by Portable Butane Gas Range of a gas explosion accident occupy the most share. As a result, the injury on the human body frequently occur. However, It is situation that are experiencing difficulties in consequence analysis of explosion accidents owing to shortage of explosion power data and lack of research on the effect of the human body by the gas explosion. This paper acquire human injury data by performing the actual explosion experiment with Portable Butane Gas Range and evaluate power by explosion and effect of explosion on the human body to perform explosion simulation with LS-DYNA program. It is intended to contribute to the exact cause of the accident investigation and the same type of accident prevention.

조세심판법안과 조세법원설치에 따른 문제점(1)

이상규,김남진,장재식,이태로,전정구,김윤행,심종헌 한국사법행정학회 1969 사법행정 Vol.10 No.5

스테인리스강 316L 배관의 End Grain Attack과 피트부식 손상진단

백운봉 ( Un Bong Baek ),최병학 ( Byung Hak Choe ),이진희 ( Jin Hee Lee ),심종헌 ( Jong Hun Shim ),김의수 ( Eui Soo Kim ),남승훈 ( Sung Hoon Nam ) 대한금속재료학회(구 대한금속학회) 2015 대한금속·재료학회지 Vol.53 No.1

The aim of this paper was to analyze the cause of surface cracks and pit corrosion on 316L pipe. An End Grain Attack (EGA) as a kind of pit mechanism was conducted on the pipe surface. The early stage of the EGA may come from under-deposit of caustic-water formation compositions like Na+, K+, Ca+, and Mg+ etc. The under-deposit corrosion is caused by the corrosion layer on the pipe surface followed by crevice corrosion due to accumulation of Cl-or S-composition between the corrosion layer and the pipe surface. In the early stage, the EGA occurred in all grain boundaries beneath the under-deposit corrosion. In the later stage of EGA, almost all the early attacked grain boundaries stopped at a limited depth of about 10 μm. Meanwhile, only the smallest number of the attacked boundaries progressed into the pipe as pit corrosion and resulted in leak failure. (Received February 24, 2014)

가상 피트데이터 통계처리를 통한 가스배관 고장확률 및 수명평가

최병학 ( Byung Hak Choe ),김성준 ( Seong Jun Kim ),심종헌 ( Jong Heon Shim ),김우식 ( Woo Sik Kim ),김철만 ( Chul Man Kim ) 대한금속재료학회(구 대한금속학회) 2015 대한금속·재료학회지 Vol.53 No.6

Corrosion data obtained from in-line inspection can be applied to assess present integrity as well as to predict future integrity of gas pipelines. This can be accomplished by using a combination of probabilistic analyses and simulation. With a deterministic method, failure models (e.g., NG 18 or ASME B31G)can only provide “Safe or Fail” criteria for corroded pipelines. However, a probabilistic method can offer “Probability of Failure (POF)” using the same models. This paper is focused on determining the POF for hypothetical corrosion-pit data of a gas pipeline. The study presented a ten-step procedure for obtaining the POF of a gas pipeline using three statistical methods (i.e., Monte Carlo, FOSM: First-Order Second-Moment, and FORM: First-Order Reliability Method). Furthermore, the coefficient of variance, regarding the value of POF sensitivity in relation to data variation, was mostly affected by the corrosion-depth parameter of the pit data.

급성심근경색증을 가진 한국인에 있어 Chlamydia Pneumoniae 감염의 영향에 대한 연구

이은미,오동주,황교승,안정천,송우혁,임도선,박창규,김영훈,서홍석,심완주,노영무,정희진,김우주,김종헌,송기준 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4