니코틴 의존자에서 인지행동 단독치료와 Naltrexone 추가치료 간의 흡연행동 비교

성종호(Jong-Ho Sung),이영식(Young-Sik Lee),조근호(Keun-Ho Joe),나 철(Chul Na) 한국중독정신의학회 2003 중독정신의학 Vol.7 No.1

Objectives:The present study was performed to evaluate the effectiveness of naltrexone combined CBT(cognitive behavior therapy). Method:This study design was double blind placebo controlled method. Naltrexone(n=13) and placebo(n=12) were added to CBT for 2 weeks in 25 subjects. Administered Naltrexone dosage was 23.4 mg/day in 1st week and 37.1 mg/day in 2nd week. Multimodal CBT technique was conducted for three times once every week. Total cigarette consumption amounts per a week, Brief Questionnaire for Smoking Urge (B-QSU), and expiratory CO levels, Fagerstrom Tolerance Questionnaire (FTQ) were checked at baseline and 4 weeks later. Results: 1) There were no differences between naltrexone add-on CBT group and CBT alone group in nicotine withdrawal symptoms and drug side effects containing GOT/GPT levels. 2) In Naltrexone add-on CBT group, total cigarette consumptions (p=0.021), the expiratory CO levels (p=0.039), B-QSU score (p=0.036), and FIQ scores (p=0.028) were significantly lower than CBT alone group. 3) Subjective reports about the smoking reduction are greater in naltrexone add-on CBT group than CBT alone (53.0% vs. 16.7%). Conclusions: Naltrexone and CBT combined therapy could be a effective and safe treatment in nicotine dependence.

특집논총 : 월남에 있어서의 게릴라전

성종호 ( Jong Ho Sung ) 국방대학교 안보문제연구소 1969 국방연구 Vol.27 No.-

과민성 대장증후군에서 대장 통과시간 측정

구철(Cheol Koo),김미정(Mi Jung Kim),성종호(Jong Ho Sung),안영주(Young Ju Ahn),최성규(Sung Kyu Choi),유종선(Jong Sun Rew),김세종(Sei Jong Kim),윤종만(Chong Mann Yoon) 대한내과학회 1991 대한내과학회지 Vol.41 No.3

N/A To evaluate the colonic transit in patients with irri- table bowel syndrome, the authors measured the colonic transit time with radioopaque markers. The segmental colonic transit time with commercially available radioopaque markers (Sitzmarks) was studied in 28 healthy volunteers and 41 patients with irritable bowel syndrome (19 constipation dominant types and 22 diarrhea dominant types). The subjects ingested capsule (20 radioopaque 0-ring) at 9:00 a.m. on 3 successive days while they were fully ambulatory. A plain radiography of the abdomen was obtained on the 4th day. Using the modified Arhan and Wald method, the colonic transit was assessed. The results were as follows: 1) The total colonic transit was 22.4±4.9 h(Mean SE); segmental transits were 8.7±4.2 h for the right colon, 9.9±4.3 h for the left colon, and 3.9±4.8 h for the rectum in the normal control group. Age and sex did not influence transit significantly, 2) The total colonic transit was 50.8±12.0 h in the constipation group and 2. 5±1.7 h in the diarrhea group, and it was significantly different from that of the nor- mal control group. 3) Comparison between the normal contral group and patients with irritable bowel syndrome revealed that the right colonic transit time ratio significantly decreased in the constipation group, while the left colonic transit time ratio increased in the constipation group and significantly decreased in the diarrhea group, and the rectal transit time ratio significantly increased in the diarrhea group, This study suggests that the left colonic segment may be a major lesion site in irritable bowel syndrome.

스트렙토조토신 유도성 당뇨쥐의 췌장 선포세포에서 Cholecystokinin이 유도한 Calcium Signal의 변화

김명준 ( Kim Myeong Jun ),류경렬 ( Lyu Gyeong Lyeol ),성종호 ( Seong Jong Ho ),민도식 ( Min Do Sig ),이덕주 ( Lee Deog Ju ),윤신희 ( Yun Sin Hui ),한상준 ( Han Sang Jun ),조양혁 ( Jo Yang Hyeog ),김명석 ( Kim Myeong Seog ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.6

Background/Aims: Pancreatic acini of streptozotocin (STZ)-induced diabetic rats release amylase less than normal acini on cholecystokinin (CCK) stimulation. Pancreatic enzyme secretion has been closely related to the intracellular calcium concentration ([Ca2+]i) of the acinar cell. In the present study, sequential changes of the intracellular calcium signal which probably underlie the altered enzyme secretion in response to CCK-8 were investigated using pancreatic acini from diabetic rats. Methods: Diabetic rats were prepared by single intravenous injection of STZ (70 mg/kg). Stimulating experiments with CCK-8 were performed 7 days later. Pancreatic acini were isolated by collagenase digestion. Amylase release and [Ca2+]i were measured by colorimethod and calcium imaging, respectively. The geometry of intracellular calcium signal was analyzed. Results: Normal acini exhibited concentration-dependent [Ca2+]i increase and regular oscillatory calcium signal on CCK-8 stimulation. Amylase release was also concentration-dependent. However, diabetic acini showed significantly less [Ca2+]i increase, prolonged time to peak [Ca2+]i, decreased calcium spikes number, and decreased amylase release compared with normal acini. The decreased [Ca2+]i in diabetic acini was restored significantly by insulin treatment. Conclusions: Relatively decreased amylase release in diabetic pancreatic acini in response to CCK, appears to be associated with altered calcium signal due to insulin deficiency. (Korean J Gastroenterol 2003;42:519-526)

청소년의 시험 불안에 영향을 미치는 가정 환경적 요인

이영식,성종호,손인기 대한소아청소년정신의학회 2000 소아청소년정신의학 Vol.11 No.1

연구목적 : 청소년의 시험불안에 영향을 미치는 개인 및 사회환경적 변인 연구의 후속 연구로서 시험불안의 인지적요소, 감정적 요소와 가정환경 요소간의 상관 관계를 알아보고자 학생청소년들을 대상으로 본 연구를 실시하였다. 방법 : 서울 시내 8개 남녀 중고등학교 총 880명을 대상으로 하였다. 시험불안의 정도를 측정하기 위해 Spielberger의 시험불안 목록(Test Anxiety Inventory)을 사용하였고, 가정환경적 요소를 측정하기 위해서는 Moos와 Moos의 가정환경척도(Family Environmental Scale)를 사용하였다. 기타 사항은 저자들이 작성한 설문지를 사용하였다. 결과 : 1) 시험 불안의 총정 및 인지적 요소는 응집력 척도, 독립성 척도와는 부적 상관관계를 보였고, 시험불안의 총점 및 인지, 감정적 요소 모두는 성취 지향성 척도, 조절성 척도와는 정적인 상관관계를 보였다. 2) 시험 불안이 높은 군은 낮은 군에 비해 성취 지향성 척도, 조절성 척도는 노고 웅집력 척도는 낮았다. 3) 시험 불안과 밀접히 연관된 상기 4가지 척도 중 조절성 척도를 제외한 세가지 척도(성취 지향적, 독립성 응집력)는 부모의 학력, 경제력이 높을수록 높은 점수를 보였다. 결론 : 따라서 부모는 아이의 능력에 맞는 성취지향성 목표를 설정하여야 하며, 자녀에 대한 과도한 통제나 조절보다는 독립성을 고취시켜야하며, 가정내 구성원간의 갈등이 없는 응집력을 보여야 하겠다. Objectives : This study was done as a part of investigating individual and socioenvironmental factors affecting test anxiety in adolescent. The focusing of this study was detecting specific family enviromental factors affecting worry and emotionality of test anxiety. Methods : The subjects of this study were 880 middle and high school students in Seoul, Korea. To evaluate test anxiety level, Spielberger's Test Anxiety Inventory was ap-plied and to evaluate familial factor, Moos and Moos' Family Environmental Scale was done. Results : The results were as follows. 1) Total and worry part of test anxiety scores were negatively correlated with cohesion and independence scores. Total, worry, and emotional part of test anxiety scores were positively correlated with achievement orientation and control scores. 2) High test anxiety group showed higher achievement orientation and control scores, and lower cohesion scores than low test anxiety group. 3) The higher socioeducational level of parents were, the higher three subscale(cohesion, independence, and achievement orientation)scores were, except control score. Conclusion : In therapeutic approach of adolescent's test anxiety, the importance of education and treatment of their parents should be emphasized. Parents should set their children's appropriate achievement goal, encourage their children's independency instead of control. Cohesion of familial members are also needed. KEY WORDS : Test anxiety·Family environmental factor·Adolescent.

청소년의 시험불안에 영향을 미치는 개인 및 사회환경적 변인

성종호,이영식,이길홍 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.3

연구목적: 시험 불안의 인지적, 감정적 두 요소와 상호 관련이 있으리라 예상되는 수험생들의 개인적 변인과 수험생들을 둘러싼 환경적 변인간의 상호 관련성 여부를 알아보고자 하였다. 개인적 변인으로는 성별, 나이, 학업 성적, 지능(I.Q), 심리 상태(자존심, 강박 성향, 일반적 불안 성향, 사회적 인정 욕구)이며, 환경적 변인으로는 수험생의 거주 지역, 학교 특성(인문계/실업계), 부모의 학력, 직업, 경제 상태이다. 또한 본 연구를 통해 시험 불안의 인지적, 감정적 두 요소가 명확히 구분되는 것인지에 대해 알아보고자 하였고, 시험 불안이란 시험에 국한된 특수 불안인지 아니면 일반적 불안의 한 단면인지에 대해 알아보고자 하였다. 방 법: 서울 시내의 강남과 강북에 소재한 남·녀 중학교, 고등학교 그리고 실업계 고등학교에 재학 중인 학생 880명을 대상으로 하였다. 검사 도구는 Spielberger의 시험 불안 목록(Test Anxiety Inventory), 심리적 요인을 평가하기 위해 Rosenberg의 자존심 척도(Self-Esteem Scale), Hodgson과 Rachman의 Maudsley Obessive-Compulsive Inventory, 이영식과 이철원의 한국형 소아 공포-불안 주제 목록, Ellis의 비합리적 신념(Irrational Belief)중 사회적 인정 욕구(Demand for Approval)의 척도를 사용하였다. 결 과: 1) 시험불안의 감정적 요소, 인지적 요소, 총점 모두 여학생이 남학생보다 높은 점수를 보였다. 2) 시험불안은 인문계와 실업계간, 강남과 강북간에 유의한 차이를 보이지 않았다. 3) 시험불안은 중학교 1학년이 2학년보다 높은 점수를 보였으며, 고교 1학년과 2학년 사이에는 유의한 차이를 보이지 않았다. 4) 시험불안은 자존심 척도, 지능지수와 부적 상관관계를 보이고, 강박 장애 척도, 사회적 인정 욕구 척도, 소아불안 척도와 정적 상관관계를 보였으며, 그 중에서 소아 불안 척도와 가장 큰 상관 관계를 보였다. 5) 시험 불안의 인지적 요소, 감정적 요소, 총점 모두는 어머니의 학력과는 의미 있는 관계를 보였고, 경계 상태와는 시험 불안의 감정적 요소가 의미있는 관계를 보였다. 6) 시험 불안의 인지적 요소와 학업 성적 사이에는 의미있는 관계를 보였다. 결 론: 상기 결과들을 종합하여 본다면, 첫째, 시험 불안의 인지적 요소, 감정적 요소가 청소년의 심리적 요소, 환경적 요소에 따라 명확히 구분되는 것이 아니지만, 학업 성취 면에서는 인지적 요소가 유의한 상관관계를 보이고 있다. 둘째, 시험 불안은 시험이라는 특정한 상황에서 발생한다고 하지만 개인의 전반적인 심리적 상황에 의하여 영향을 받는 특성 불안의 요소를 가자고 있으며, 소아, 청소년에서 나타나는 불안 장애의 일종이라고 정의 내릴 수가 있다. 셋째, 시험 불안의 인지적 요소만이 청소년의 학업 능력과 상관관계를 보이며, 인지적 요소와 감정적 요소 모두는 심리적 요인과 유의한 상관 관계를 보였다. 넷째, 청소년의 환경적 변인 중 어머니의 학력이 시험 불안에 의미있는 상관관계를 보이고 있으며, 이것은 어머니가 자녀를 통해 보상을 받고자 하는 욕구를 가지고 있으며, 따라서 자녀의 심리 상태에 가장 큰 영향을 미친다고 할 수 있다. 그 외의 환경적 변인은 큰 상관을 보이지 않았다. Objectives : This study was done to investigate the relationship between test anxiety and individual, socioenvironmental factors in adolescents. Also, this study assessed whether two components, worry and emotionality, of test anxiety were distinctly distinguished or not, and whether test anxiety was specific state anxiety limited to test situation or a part of general trait anxiety. Methods : The subjects of this study were 880 middle and high school students in Seoul. To evaluate test anxiety level, we used Spielberg's Test Anxiety Inventory. For the evaluation of individual psychological factors, Rosenberg's self-esteem scale, Maudsley's Obsessive-Compulsive Inventory, Lee's the Korean version of Fear-Anxiety Survey Schedule for Children, and Ellis' Demand for Approval scale were applied. Results : The results were as follows, 1) Test anxiety level was higher in girls, first grade middle school students, offspring's of high school graduate mother, and high economic class but there was no significant difference in school graduate mother, and high economic class but there was no significant difference in school characteristics and residence location. 2) Test anxiety was correlated negatively with self-esteem, I.Q. and correlated positively with obsessive-compulsiveness, demand for approveness, especially general fear-anxiety(r=0.47). So although test anxiety occurs in test situation, test anxiety is a part of general trait anxiety affected by individual psychologic factors. 3) The better school achievement subjects showed the lower worry component of test anxiety. 4) Two components, worry and emotionality, of test anxiety were not distinctly distinguished in this study. Conclusion : In summary, first, Worry and Emotionality of test anxiety were not markedly different from according to adolescent's psychological factor, sociodemographic factor but performance achievement was significantlycorrelated with Worry of test anxiety. Second, although test anxiety was occurred in specific situations as test, test anxiety was affected individual psychological factor so defined by a series of anxiety disorder. Third, only Worry of test anxiety was correlated with performance achievement and Worry and Emotionality were correlated with psychological factor. Forth, mother's education level was significantly correlated with test anxiety, this means that mother has the wish to compensate the her inferiority through her offspring and mother strongly affect to adolescent's psychological state.

Kawasaki병의 임상적 관찰

최병준,성종호,이윤희,오창규,양만규 최신의학사 1989 最新醫學 Vol.32 No.7

고양이 위 평황근에서 Potassium Channels의 Fluoxetine에 의한 조절작용

최진성,김명석,조양혁,성종호,윤신희,한상준,심상수,최재천,최복희 대한소화기학회 2000 대한소화기학회지 Vol.35 No.2

Background/Aims: In this study, the effects of fluoxetine on voltage-activated potassium channels and Ca2+-activated potassium channels were examined in isolated gastric smooth muscle cells of cat. We measured intracellular calcium levels. The effects of fluoxetine on contractile activity of circular smooth muscle strips were also studied. Methods: We have used the whole-cell recording and excised inside-out patch clamp technique and dual wavelength ratio technique. We also measured isometric contraction of the muscle strips. Results: In whole-cell recordings, fluoxetine had a dual action on voltage-activated potassium currents. At lower concentration, fluoxetine (3-30 μM) decreased outwardly delayed rectifier potassium currents in a concentration-dependent manner with an IC50 value of 5.5 μM. However, at 100 μM, fluoxetine slightly increased potassium currents. Exposure of the cells to fluoxetine (100 μM) resulted in an increase in intracellular calcium levels. In excised inside-out recordings, applicatof fluoxetine (10 μM) to bath solution had no effect on single-channel conductances of Ca2+-activated potassium currents but increased noise level of open state (flicker block). Finally, fluoxetine did not show any effect on KCl-induced muscle contraction. Conclusions: We conclude that fluoxetine has inhibitory effects on outwardly delayed rectifier potassium currents and blocks the open state of Ca2+-activated potassium currents in isolated gastric smooth muscle cells of cat.

흰쥐 이자에서 Nitric Oxide ( NO )가 Insulin분비에 미치는 영향

김명준,조양혁,성종호 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.4

Background: NO (nitric oxide), derived from L-arginine through the action of nitric oxide synthase (NOS), is a short-lived free radical transmitting cellular signals for vasodilation, neurotransmission, and cytotoxicity. Recently, this molecule has been reported to be involved in the various glandular secretion. Although the relationship between NO and the pancreatic endocrine secretion has been widely investigated, the role of NO on insulin secretion has not been elucidated. Therefore, the present study was designed to reveal the precise action of NO on the secretion and synthesis of insulin following administration of NAME (L-NG -nitroarginine methyl ester) or L-arginine using immunocytochemistry and in situ hybridization techniques. Methods: NAME or L-arginine was administered into jugular vein of the male Sprague-Dawley rat (180~200 g, b,w.) exhibiting normoglycemia (80~120mg/dL). Blood glucose concentrations were measured at intervals of 30 minutes for 2 hours after drug treatment. The pancreatic tissues were taken out at 30 and 90 minutes following drugs administration for insulin immunocytochemistry and in situ hybridization. Results: Both NAME and L-arginine treatments diminished blood glucose levels. The decrease of blood glucose level was more prominent in NAME-treated rats than that of L-arginine. Insulin immunoreactivity in drugs-treated rat pancreas decreased compared to that in normal control, while the expression of insulin mRNA was significantly increased. Conclusion: On the basis of present study, it is concluded that the transient changes of NO con- centration, regardless of increase or decrease, in Langerhans islet might act as a potent stimulant in insulin secretion and its synthesis (J Kor Soc Endocrinol 14:719-72S, 1999).

공장에 발생한 혈관이형성증 1예

김영진,범희승,조규혁,정용환,정상우,김세종,유종선,신동현,윤종만,양대현,성종호,안영주 대한소화기내시경학회 1993 Clinical Endoscopy Vol.13 No.1

Angiodysplasia of the small bowel is an uncommon disorder in Korea, and is often found to be the cause of unexplained gastrointestinal bleeding. A 53-year-old male patient visited an emergeney room because of repeated melena and dizziness, He underwent selective superior mesenteric arterial angiography which revealed abnormal clusters of small arteries and early opacification of veins draining a segment of lower jejunum. An exploratory laparotomy was performed under the impression of angiodysplasia. An ulceration on the lower jejunum was found, and was resected. Subsequent jejunojejunostomy was performed. Histology of the resected specimen showed an irregularly dilated vessels in mucosa and submucosa.