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스트렙토조토신 유도성 당뇨쥐의 췌장 선포세포에서 Cholecystokinin이 유도한 Calcium Signal의 변화
김명준 ( Kim Myeong Jun ),류경렬 ( Lyu Gyeong Lyeol ),성종호 ( Seong Jong Ho ),민도식 ( Min Do Sig ),이덕주 ( Lee Deog Ju ),윤신희 ( Yun Sin Hui ),한상준 ( Han Sang Jun ),조양혁 ( Jo Yang Hyeog ),김명석 ( Kim Myeong Seog ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.6
Background/Aims: Pancreatic acini of streptozotocin (STZ)-induced diabetic rats release amylase less than normal acini on cholecystokinin (CCK) stimulation. Pancreatic enzyme secretion has been closely related to the intracellular calcium concentration ([Ca2+]i) of the acinar cell. In the present study, sequential changes of the intracellular calcium signal which probably underlie the altered enzyme secretion in response to CCK-8 were investigated using pancreatic acini from diabetic rats. Methods: Diabetic rats were prepared by single intravenous injection of STZ (70 mg/kg). Stimulating experiments with CCK-8 were performed 7 days later. Pancreatic acini were isolated by collagenase digestion. Amylase release and [Ca2+]i were measured by colorimethod and calcium imaging, respectively. The geometry of intracellular calcium signal was analyzed. Results: Normal acini exhibited concentration-dependent [Ca2+]i increase and regular oscillatory calcium signal on CCK-8 stimulation. Amylase release was also concentration-dependent. However, diabetic acini showed significantly less [Ca2+]i increase, prolonged time to peak [Ca2+]i, decreased calcium spikes number, and decreased amylase release compared with normal acini. The decreased [Ca2+]i in diabetic acini was restored significantly by insulin treatment. Conclusions: Relatively decreased amylase release in diabetic pancreatic acini in response to CCK, appears to be associated with altered calcium signal due to insulin deficiency. (Korean J Gastroenterol 2003;42:519-526)
김미경 ( Kim Mi Gyeong ),김명석 ( Kim Myeong Seog ),김현성 ( Kim Hyeon Seong ),정승은 ( Jeong Seung Eun ),윤호중 ( Yun Ho Jung ),정욱성 ( Jeong Ug Seong ),홍순조 ( Hong Sun Jo ) 대한내과학회 2003 대한내과학회지 증례 특집호 65-5 부록3 Vol.0 No.-
Congenital left ventricular aneurysm is rare, poorly understood, and potentially lethal. Also, congenital coronary artery fistula is rare but hemodynamically, it induces myocardial ischemia due to coronary steal syndrome and diastolic volume overload from