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김중환,양홍윤,소순남,백혜승,황유정,김지현,김영태,김재홍 ( Joong Hwan Kim,Hong Yoon Yang,Soon Nam Soh,Hae Seung Paik,Yoo Jung Hwang,Ji Hyun Kim,Young Tae Kim,Jae Hong Kim ) 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.6
N/A In view of high prevalence of penicillinase producing Neisseria gonorrhoeae(PPNG) and chromosomally mediated resistant Neisseria gonorrhoaea(CMRNG) among circulating N. gonorrhoeae and emergence of spectinomycin resistant strains in Korea, more effort is needed to seek new effective treatment regimens for gonorrhea. The objective of this trial was to establish the efficacy of enoxacin, one of new fluoroquinolones, in the treatment of uncomplicated male gonorrhea. A total of 112 male uncomplicated gonorrheal patients were treated with one of the two dose regimens at the VD Clinic, Choong-Ku Public Health Center, in Seoul, between January and August, 1990. The patients were divided randomly into two groups and assigned to one of the two different dose regimens of enoxacin: 300㎎, PO(group A) and 600㎎, PO(group B). One of 47 patients treated with enoxacin, 300㎎, PO, failed(2.1%) and two of 46 patients treated with enoxacin, 600㎎, PO, failed (4.3%) to recover. A single dose regimen of enoxacin, 300㎎, PO is exellent, sa?e and relatively inexpensive in the treatment of male uncomplicated gonococcal urethritis in Korea.
김중환(Joong Hwan Kim),노영석(Young Suck Ro),황도헌(Do Hun Hwang),김영태(Young Tae Kim),김광수(Kwang Soo Kim),신동헌(Dong Hun Shin),계영철(Young Chul Kye) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.1
In this study, the effect of kanamycin sulfate was compared with fortified penicillin G in the treatment of uncomplicated penicillinase negative Neisseria gonorrhoeae(nonPPNG) urethritis in male. The subjects were 250 male patients with uncomplicated non-PPNG urethritis, at the Venereal Disease Clinic of Choong-ku Public Health Center in Seoul from May 1982 to August 1982. Among 103 patients treated with kanamycin sulfate, 2. 0 gm, IM, 92 recovered and 11(10. 7%) failed. Among 100 patients treated with fortified penicillin G, 6 megaunits IM, plus probenecid, l. 0 gm, 92 recovered and 8(8%) failed. No significant difference in the effect was found between these two regimens for non-PPNG urethritis. It is concluded that kanamycin sulfate as well as fortified penicillin G. have a good effect in the treatment of non-PPNG urethritis.
황유정(Yoo Jung Hwang),양홍윤(Hong Yoon Yang),김중환(Joong Hwan Kim) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.5
Background : Vitiligo is riot quite a rare diseasep; it has about 1% prevalence. The cause of vitiligo is not clear, however, in recent studies an autoimmune origin is freqluei itily mentioned. Object : We tried to an lyze some clinical features of vitiligo and relate them with the presence of autoantibodies. Methods : A total of 381 vitiligo patients was included for the analysis of clinical features. A laboratory study included rhumatoid factor, antinuclear antibocoly, antithyroglobulin antibody and antimicrosome antibody. Some 62 patients were examined for opl thmologic changes. Results : One hundred and one(26.5%) of 381 patients exam ned showed at least one of the autoantibodies tested. Twenty nine pateints showed 2 different aitintibodies. The age at aonset of vitiligo in the autoantibody positive group was 6.6 years later than that of the autoantibody negative group. Autoimmune and/or endocrine diseases were more frequinty found among aut.oantibody positive patients. These diseas s included hyperthyroidism, diabetes me litus and alopecia areata. One patient revealed retinal hypoigmentation and showed no autoantibcidics. Conclusion : About 9% of vitiligo patients who were autoantiocyte positive had clinical evidence of diseases associated with the autoantibody. However, it is prudent. to xpect that more patients with t.he autoantibody may develop later systemic autoimmune diseases or endocrinopathies. A long term follow-up of these patients seem:, to be very important. (Kor J Dermatol 1993;31(5):657-663)
피부진균증에 대한 경구용 Ketoconazole의 치료효과
전장원(Jahng Won Junn),황도헌(Do Hun Hwang),곽창훈(Chang Hoon Kwak),김재홍(Jae Hong Kim),김중환(Joong Hwan Kim) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.1
Seventeen volunteers with cutaneous dermatophytosis were enrolled in a clinical trial to evaluate the effectiveness of oral ketoconazole. The group included six patients with tinea cruris(6 malcs), four with tinea corporis, including one with tinea faciai, (3 males, 1 female), three with tinea versicolor(3 males) and four with tinea capitis(3 males, 1 female). The oral ketoconazole was taken within 10 minutes after a meal. The patients under the age of 10 received 100mg of ketoconazole per day, whereas those aged over 11 received 200mg of ketoconazole until the skin lesions are cured. Seventeen patients had complete clinical and mycologic cure, one responded clinically. It required one to four weeks to become culturally negative for tinea cruris, four to seven weeks for tinea corporis, three to eight weeks for tinea capitis. For tinea versicolor it required three to five weeks to become negative by scotch tape method. Adverse reactions to ketoconazole were absent and no patients required discontinuation of the drug. The results indicate that ketoconazole is a safe and effective drug for the treatment of dermatophytosis.
양홍윤(Hong Yoon Yang),이창우(Chang Woo Lee),김영태(Young Tae Kim),김재홍(Jae Hong Kim),강형재(Hyung Jai Kang),김원석(Won Suk Kim),유태연(Tae Yun Yoo),김중환(Joong Hwang Kim) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.3
Among 13 patients with pemphigus : 8 of pemphigus vulgaris(PV), 4 of pemphigus foliaceus(PF), l of pemphigus erythematosus(PE), we have examined the sites of early lesions and the clinical appearances of the skin lesions. The most common site of the early lesions in PV was the oral mucosa, however, in PF and PE the face was affected first. The clinical appearances of the early lesions were flaccid bullae, erythematous papules and eczematoid patches. Clinicians should be aware of these clinical features of pemphigus for a more precise diagnosis and better management.
김중환,한기철,전장원,황도헌 대한피부과학회 1982 大韓皮膚科學會誌 Vol.20 No.1
The recent discovery of plasmid derived beta-lactamase production by N. gonorrhoeae has changed the outlook of treatment of gonococcal infections and may well become the single most important factor in gonorrhoea control. Penicillinase is a beta-lactamase that splits the beta-lactam ring of penicillin hetween the C and N atoms to form penicilloic acids. We have been trying to assess the prevalence of PPNG in Korea since May 1980. We report here 7 strains of beta-lactamase producing N. gonorrhoae detected by chrornogenic cephalosporin method from Jan. 1981 to Mar. 1981 at the Joong Ku puhlic health center in Seoul. In January, I strain (l.3%); February, 2 strains (5.0%); and March, 4 strains .(6 4%) have been isolated. All restrains were confirmed by sugar feriventation test. Previously only one strain of PPNG had been reported among Korean laymen. The sudden appearance of PPNG among Korean laymen in 1981 may mean the barruer between U.S. Army enc1aves and Korean public has been broken recently and/or direct irnport of PPNG frorn abroad especially from South East Asia.
김재홍,김한중,노영석,김영태,김중환,황규홍,이정덕,백승철,김건우,조상현,김준영,김석민,김영호,김상순,이승한,김방순,전덕규,하상근 대한화학요법학회 1992 대한화학요법학회지 Vol.10 No.2
The prevalence of PPNG among pretreated gonorrhoeae cases isolates at the VD clinic of Choong-ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1990, 162 strains of N.gonorrhoeae were isolated, among which 80 were PPNG. The prevalence of PPNG in Seoul showed increased tendency till 1987, thereafter, it has been stationary.
김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1
The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.
임질의 임상적 고찰(제7보) : Cefotaxime과 Kanamycin의 Penicillinase-Producing Neisseria Gonorrhoeae 요도염 치료효과
김중환,황도헌 한양대학교 의과대학 1983 한양의대 학술지 Vol.3 No.1
Recent rapid increase of penicillin-resistant beta-lactamase producing Neisseria gonorrhoeae in Korea makes it urgent to find suitable treatment regimens, especilly because spectionmycin-resistant PPNG has been found in Seoul. Newer generation of cephalosporins are found to be effective in the treatment of gonorrhoea, especially against PPNG urethritis. In this study, the effect of cefotaxime was compared with kanamycin in the treatment of uncomplicated male PPNG urethritis. 85 male patients with uncomplicated PPNG urethritis, which was detected by chromogenic cephalosporin method, at the Veneral Disease Clinic of Chook-Ku Public Health Center in Seoul were subjected to this study. 45 patients were treated with 1.0 gm cefotaxime i.m. plus 1.0 gm probenecid p.o., and 34 patients were followed. There were no treatment failurea and 17(50.0%) postgonococcal urethritis (PGU). Other 40 patients were treated with 2.0 gm kanamycin i.m., and 36 patients were followed. There were 10(27.8%) treatment failures and 11(42.3%) PGU. Cefotaxime gave significantly (p<0.001**) superior result to kanamycin in the treatment of PPNG urethritis.
Cefoperazone(Cefobid^(�) 0.5gm single i.m. for Uncomplicated male Urethritis due to PPNG
Kim, Joong Hwan,Kim, Young Tae,Hwang, Do Hun 대한화학요법학회 1983 대한화학요법학회지 Vol.1 No.1
Penicillin에 저항하는 β-lactamase 생성임균이 최근 세계적으로 증가추세에 있다. 또한 non-PPNG균주의 penicillin, 기타 항생제에 대한 감수성도 극도로 저하하고 있다. Spectionmycin은 이런 균주에 좋은 효과가 있으나, 이에 저항하는 PPNG 균주가 우리 나라에서도 발견된 이 시점에서 다른 새로운 치료제의 개발이 절실히 요구되고 있다. 저자들은 한국에 만연하는 PPNG 요도염에 대한 치료제로서 제3세대 cephalosporin 제재의 하나인 cefoperazone의 효능을 검사하였다. 1982년 9월과 10월에 중구보건소 성병진료실에 내원하여 요도분비물의 Gram염색과 임균배양검사 및 chromogenic cephalosporin법으로 확진된 남성단순 PPNG요도염환자 32명을 대상으로 cefoperazone 0.5㎎의 1회 근주요법을 시행하였다. 32명 중 추적관찰된 29명에서 2명(6.9%)이 치료에 실패하였으며, 임질 후 요도염은 7명(25.9%)이었다. 평염희석법에 의한 cefoperazone의 MIC검사 결과는 0.03㎍/㎖ 3주, 0.06㎍/㎖ 11주 0.12 ㎍/㎖ 9주, 0.25㎍/㎖ 및 0.5㎍/㎖ 각 1주이었다. Thirty two male umompkated gonorrheal patients who are found to be infected by PeniciUinase Produchg Nekswia gonorrhea (PPNG) were treated with single i.m. of 0.5 5gm cefoperazone. Twenty nine patients were followed. Two patients(6.9%) failed to be cured. Seven patients (25.9%) were found to have postgonomcal ux-ethritis (PGU). The cefoperazone MPCS were 0. @3pg/ml in 3, 8.06pg/ml in 11, 0. 12pg/ml in 9, 0.25pg/d in 1, and 0.5pg/ml in 1 strains