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피부진균증에 대한 경구용 Ketoconazole의 치료효과
전장원(Jahng Won Junn),황도헌(Do Hun Hwang),곽창훈(Chang Hoon Kwak),김재홍(Jae Hong Kim),김중환(Joong Hwan Kim) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.1
Seventeen volunteers with cutaneous dermatophytosis were enrolled in a clinical trial to evaluate the effectiveness of oral ketoconazole. The group included six patients with tinea cruris(6 malcs), four with tinea corporis, including one with tinea faciai, (3 males, 1 female), three with tinea versicolor(3 males) and four with tinea capitis(3 males, 1 female). The oral ketoconazole was taken within 10 minutes after a meal. The patients under the age of 10 received 100mg of ketoconazole per day, whereas those aged over 11 received 200mg of ketoconazole until the skin lesions are cured. Seventeen patients had complete clinical and mycologic cure, one responded clinically. It required one to four weeks to become culturally negative for tinea cruris, four to seven weeks for tinea corporis, three to eight weeks for tinea capitis. For tinea versicolor it required three to five weeks to become negative by scotch tape method. Adverse reactions to ketoconazole were absent and no patients required discontinuation of the drug. The results indicate that ketoconazole is a safe and effective drug for the treatment of dermatophytosis.
김중환,전장원 대한피부과학회 1982 대한피부과학회지 Vol.20 No.3
Forty-two volunteers with recurrent herpes simplex virus infections were entolled in a clinical trial to evaluate the effectiveness of topical Ginseng saponin ointment. Ten percent Ginseng saponin in a water-micible ointment base was applied. 3 times daily until crust formation on 42 patients. As control hydrophilic ointment was applied 3 times daily on 10 patients. Author compared the length of time required for the herpetic vesicles to form crust in these two groups. The time required in the group treated with Ginseng saponin for crust formation was 21.9+10.29 houra. In the control group it was 58.2+23.64 hours(P$lt;0.01). There was no untoward effect to Ginseng saponin ointment. The Ginseng saponin ointment seems to be one of the best topieal antiviral agents in the treatment of recurrent herpes simplex virus infections.