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RISS 인기검색어
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- 저자 : 황도헌(Do Hun Hwang) (검색결과 6 건)
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피부진균증에 대한 경구용 Ketoconazole의 치료효과
전장원(Jahng Won Junn),황도헌(Do Hun Hwang),곽창훈(Chang Hoon Kwak),김재홍(Jae Hong Kim),김중환(Joong Hwan Kim) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.1
Seventeen volunteers with cutaneous dermatophytosis were enrolled in a clinical trial to evaluate the effectiveness of oral ketoconazole. The group included six patients with tinea cruris(6 malcs), four with tinea corporis, including one with tinea faciai, (3 males, 1 female), three with tinea versicolor(3 males) and four with tinea capitis(3 males, 1 female). The oral ketoconazole was taken within 10 minutes after a meal. The patients under the age of 10 received 100mg of ketoconazole per day, whereas those aged over 11 received 200mg of ketoconazole until the skin lesions are cured. Seventeen patients had complete clinical and mycologic cure, one responded clinically. It required one to four weeks to become culturally negative for tinea cruris, four to seven weeks for tinea corporis, three to eight weeks for tinea capitis. For tinea versicolor it required three to five weeks to become negative by scotch tape method. Adverse reactions to ketoconazole were absent and no patients required discontinuation of the drug. The results indicate that ketoconazole is a safe and effective drug for the treatment of dermatophytosis.
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김중환(Joong Hwan Kim),노영석(Young Suck Ro),황도헌(Do Hun Hwang),김영태(Young Tae Kim),김광수(Kwang Soo Kim),신동헌(Dong Hun Shin),계영철(Young Chul Kye) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.1
In this study, the effect of kanamycin sulfate was compared with fortified penicillin G in the treatment of uncomplicated penicillinase negative Neisseria gonorrhoeae(nonPPNG) urethritis in male. The subjects were 250 male patients with uncomplicated non-PPNG urethritis, at the Venereal Disease Clinic of Choong-ku Public Health Center in Seoul from May 1982 to August 1982. Among 103 patients treated with kanamycin sulfate, 2. 0 gm, IM, 92 recovered and 11(10. 7%) failed. Among 100 patients treated with fortified penicillin G, 6 megaunits IM, plus probenecid, l. 0 gm, 92 recovered and 8(8%) failed. No significant difference in the effect was found between these two regimens for non-PPNG urethritis. It is concluded that kanamycin sulfate as well as fortified penicillin G. have a good effect in the treatment of non-PPNG urethritis.
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피부단순포진 진단을 위한 Tzanck 도말, 바이러스배양 및 면역형광검사의 비교 연구
黃道憲,金永泰,金在烘 한양대학교 의과대학 1991 한양의대 학술지 Vol.11 No.1
Although Herpes Simplex Virus (HSV) infection is one of the most common infectious diseases, its two main laboratory diagnostic methods-Tzanck smear is a simple, inexpensive and rapid method, but it shows relatively low positivity. Similarly, the viralculture is the most accurate and definitive method, but it is expensive and relatively time-consuming test. There is a demand for more practical laboratory diagnostic methods for cutaneous herpes simplex infections. The purpose of this study is to examine the effectiveness of the indirect immunofluorescence (IIF) staining with monoclonal antibodies, which is suggested as a practical method. For the study, 103 patients suspected HSV infection were sampled at the Department of Dermatology in Hanyang University Hospital from March 1987 to July 1990. In the 60 specimens for Tzanck smear and viral culture, Tzanck smear was 35(58.3%) positivities, and viral culture was 56(93.3%) positivities(p〈0.05). In the 43 specimens for viral culture and IIF staining, viral culture was 40(93%) positivities and IIF staining was 37(86%) positivities(p〉0.05). In the 25 specimens, which viral culture was positivities, IIF staining showed 22(88%) positivities and Tzanck smear was 16(64%) positivities(p〈0.05). In summary, the result of Tzanck smear showed relatively high correlation to the results of IIF staining and viral culture. However, the result of IIF staining showed a significant agreement with the result of viral culture. It is suggested that the IIF staining with monoclonal antibodies is a simple, inexpensive, but accurate and relatively rapid method for the diagnosis of cutaneous HSV infections.
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Cefoperazone(Cefobid^(�) 0.5gm single i.m. for Uncomplicated male Urethritis due to PPNG
Kim, Joong Hwan,Kim, Young Tae,Hwang, Do Hun 대한화학요법학회 1983 대한화학요법학회지 Vol.1 No.1
Penicillin에 저항하는 β-lactamase 생성임균이 최근 세계적으로 증가추세에 있다. 또한 non-PPNG균주의 penicillin, 기타 항생제에 대한 감수성도 극도로 저하하고 있다. Spectionmycin은 이런 균주에 좋은 효과가 있으나, 이에 저항하는 PPNG 균주가 우리 나라에서도 발견된 이 시점에서 다른 새로운 치료제의 개발이 절실히 요구되고 있다. 저자들은 한국에 만연하는 PPNG 요도염에 대한 치료제로서 제3세대 cephalosporin 제재의 하나인 cefoperazone의 효능을 검사하였다. 1982년 9월과 10월에 중구보건소 성병진료실에 내원하여 요도분비물의 Gram염색과 임균배양검사 및 chromogenic cephalosporin법으로 확진된 남성단순 PPNG요도염환자 32명을 대상으로 cefoperazone 0.5㎎의 1회 근주요법을 시행하였다. 32명 중 추적관찰된 29명에서 2명(6.9%)이 치료에 실패하였으며, 임질 후 요도염은 7명(25.9%)이었다. 평염희석법에 의한 cefoperazone의 MIC검사 결과는 0.03㎍/㎖ 3주, 0.06㎍/㎖ 11주 0.12 ㎍/㎖ 9주, 0.25㎍/㎖ 및 0.5㎍/㎖ 각 1주이었다. Thirty two male umompkated gonorrheal patients who are found to be infected by PeniciUinase Produchg Nekswia gonorrhea (PPNG) were treated with single i.m. of 0.5 5gm cefoperazone. Twenty nine patients were followed. Two patients(6.9%) failed to be cured. Seven patients (25.9%) were found to have postgonomcal ux-ethritis (PGU). The cefoperazone MPCS were 0. @3pg/ml in 3, 8.06pg/ml in 11, 0. 12pg/ml in 9, 0.25pg/d in 1, and 0.5pg/ml in 1 strains
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김중환,한기철,전장원,황도헌 대한피부과학회 1982 大韓皮膚科學會誌 Vol.20 No.1
The recent discovery of plasmid derived beta-lactamase production by N. gonorrhoeae has changed the outlook of treatment of gonococcal infections and may well become the single most important factor in gonorrhoea control. Penicillinase is a beta-lactamase that splits the beta-lactam ring of penicillin hetween the C and N atoms to form penicilloic acids. We have been trying to assess the prevalence of PPNG in Korea since May 1980. We report here 7 strains of beta-lactamase producing N. gonorrhoae detected by chrornogenic cephalosporin method from Jan. 1981 to Mar. 1981 at the Joong Ku puhlic health center in Seoul. In January, I strain (l.3%); February, 2 strains (5.0%); and March, 4 strains .(6 4%) have been isolated. All restrains were confirmed by sugar feriventation test. Previously only one strain of PPNG had been reported among Korean laymen. The sudden appearance of PPNG among Korean laymen in 1981 may mean the barruer between U.S. Army enc1aves and Korean public has been broken recently and/or direct irnport of PPNG frorn abroad especially from South East Asia.
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