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당뇨병 환자의 피부병변 및 조갑변화에 관한 임상적 고찰
백혜승(Hae Seung Paik),양홍윤(Hong Yoon Yang),김중환(Joong Hwan Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5
Background : Desmosomes are adhesive intercellular junctions that. for mean important component of the junction complexes of epithelial cells. They provide intercellular links between the intermediate filament cytoskeletons of adjacent cells and are has involved in maintaining the stritctural integrity of tissues. Objective : Calcium and retinioids ar:e major regulators of epidermal d fferentiation and their role on keratin proteins are well known. However, their effects on desmosom moleucles are unknown. To address this question we initiated a stdy of the effects of these epidermal differentiation regulators on desmosomal components, i.e., demoplikin, desmoglein, and pemphigus a atigens. Methods : We used monoclorial antibodies against desmoplakin(DF) and desmoglein(DG), and sera from patients with pemphigus vulgaris (PV), pemphigus foliaceus (DF) and paraneoplastic pemphigus (PNP) t,o study the effects of calcium and retinoic acids, which are major regulators of epidermal different,ation, on desmosomat protein formation in human cultured keratinoeytes. We performed immunofluorescence, immunoglotting and immunoprecipitation study using human keratinocytes cultured in high calcium media with or without retinoic acid and in low alcium media with or without retinoic acid. Results : 1. In low calcium (0.15mM) rnedia, PV antigen and DG were produced in a small amount and it appeared that these desmosomal proteins were located in cytosol. Thereas in high calcium (1,8mM) media production of these desmcsomal proteins was increased and they were assembled at, the desmosomal structures located in cell-cell contact margins. 2. PF antigen, which was idntical to the DG, were not producecio expressed in cultured kerati-nocytes even when cultured in high calcium media, 3. PNF antigen and DP were produced in cultured keratinocytes grow in both high and low calcium media but, their production was increased in high calcium media and only in high ealcium media they were assembled at the desninsomai structures. 4. Retinoic acids induced looiening of cell-cell contacts of culture keratinocytes and decreased t,he production of desmosomal grotein Conclusion : Our results suggests calcium is a major regulat,or of the production and assembly of desmosomal proteins including pemphigusantigens, but PF sera and minoclonal antibodies against DG show different, antigen binding characteristics. It appears that rtinvic acids inhibit production of desmosomal proteins. (Kor J Dermatol 1994;32(5):820 831)
원발성 (原發性) 간암 (肝癌) , 각종 간질환 (肝疾患) 및 타장기악성종양 (他臟器惡性腫瘍) 환자의 혈청 Alpha1 - Fetoprotein 에 관한 연구
백승진(Seung Jin Paik),이해선(Hae Sun Lee),최흥재(Heung Jai Choi) 대한소화기학회 1972 대한소화기학회지 Vol.4 No.1
N/A A Survey using Micro-Ouchterlony double immunodiffusion technique for the detection of alphay- fetoprotein in 127 adults including 25 cases of hepatoma, 40 cases of various liver diseases, 22 cases of other malignancies and 40 normal individuals revealed the folloiving results. 1. Serum AFP was positive in 15 out of 25 patients vith hepatoma (60%). 2. Among the 25 patients with hepatoma, the diagnosis was confirmed by biopsy in 12 and ivas made clinically in 13. In 7 of 12 biopsy-confirmed cases (58. 3%), and in 8 out of 13 clinically diagnosed cases (61. 5%), the serum AFP was positive. 3. In all of 40 cases of various liver diseases including metastatic carcinoma, cirrhosis, hepatitis and abscess, 22 cases of other malignancies and 40 normal individuals the serum AFP was negative, 4. There were no definite correlation between laboratory or clinical features and presence of the serum AFP in patients with hepatoma.
거점확산형 주거환경개선 시범사업 실태조사 및 개선방향 연구
백혜선(Paik, Hae-Sun),이영환(Lee, Young-Hwan),김재승(Kim, Jae-Seung) 한국주거학회 2016 한국주거학회 논문집 Vol.27 No.4
This study aims to find out the cause of delay by analyzing the process of 12 Core-based Improvement pilot projects, especially focused on lands, buildings, population status. For this purpose, it performed a literature research on maintenance plan reports, various statistics of building and population status analysis, a field research and an individual interview with public officials in charge at local governments of 12 project districts. The findings are as follows; 1) it was difficult to cope flexibly to environmental changes because the core sector was so large that the plan was led to areal improvement. 2) the project was selected without reflecting the characteristics of the core sector and the area of residents-led renovation properly in terms of building status such as building density and old buildings ratio, 3) the coordinator group for socially disadvantaged class in the district was not operated and thus foundation for residents-led renovation was not set up. In conclusion, it should be presented the proper size of the core sector when the core-based residential environment improvement project is initiated in the future. In addition, building status is taken into consideration when designating the core sector and the area of residents-led renovation. The coordinator group needs to be operated from the early stage of the project as well.
최혜원(Hae Won Choi),이문수(Moon Soo Lee),임명호(Myung Ho Lim),권호장(Ho Jang Kwon),하미나(Mina Ha),유승진(Seung Jin Yoo),김은정(Eun Jeong Kim),백기청(Ki Chung Paik) 대한소아청소년정신의학회 2012 소아청소년정신의학 Vol.23 No.3
Objectives:Childhood depressive disorder one of the most prevalent chronic health conditions affecting school aged children. The objective of this study was to examine the prevalence and epidemiological characteristics of childhood depressive disorder in Korea. Methods:In this study, a survey was conducted of elementary school children in the Cheonan area from September 2009 to August 2010. A total of 12,084 children were included in the analyses. The primary measure of depression was the 27-item Kovacs’ Children’s Depression Inventory (CDI), the Korean Dupaul attention-deficit hyperactivity disorder Rating Scales (K-ARS), Autism Spectrum Screening Questionnaire (ASSQ) and Restless Legs Syndrome Questionnaire (RLSQ) were also administered. Results:The prevalence rate of childhood depressive disorder was 3.07%. The mean age was 9.21±1.81 years for the control group (5,969 male, 6,054 female) and 9.91±1.83 years for the depression group (CDI score≥22 ; 159 male, 210 female). Age, height, weight, and economic status were similar for the two groups. However, there were statistically significant differences in the distribution of sex. The distribution of school grade also differed between the two groups. Scores for CDI, K-ARS, and ASSQ in the depressive group were higher than those of the control group. Conclusions:This is the first large-scale population-based study to report on the prevalence of childhood depressive disorder in South Korea. Increased rates of childhood depressive disorder, as reported by primary caretakers, might reflect the increasing negative impact of environmental risk factors on neurobehavioral health. Longitudinal study of the prevalence of childhood depressive disorder should be considered for further evaluation.