Accuracy of frozen section diagnosis and factors associated with final pathological diagnosis upgrade of mucinous ovarian tumors

박정열,이상훈,김규래,김영탁,남주현 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.6

Objective: To determine the accuracy of frozen section diagnosis and factors associated withfinal pathological diagnosis upgrade in patients with mucinous ovarian tumors. Methods: This study included 1,032 patients with mucinous ovarian tumors who underwentfrozen section diagnosis during surgery. Sensitivity, specificity, and diagnostic accuracy offrozen section diagnosis was calculated. Univariate and multivariate regression analyses wereperformed to determine factors associated with diagnosis upgrade in the final pathology report. Results: The sensitivity and specificity of frozen section diagnosis were 99.1% (95%confidence interval [CI]=98%–99.6%) and 82.2% (95% CI=77.9%–85.7%), respectively, forbenign mucinous tumors; 74.6% (95% CI=69.1%–79.4%) and 96.7% (95% CI=95.2%–97.8%),respectively, for mucinous borderline ovarian tumors; and 72.5% (95% CI=62.9%–80.3%)and 98.8% (95% CI=97.9%–99.3%), respectively, for invasive mucinous carcinomas. Themultivariate analysis revealed that mixed tumor histology (odds ratio [OR]=2.8; 95%CI=1.3–6.3; p=0.012), tumor size >12 cm (OR=2.5; 95% CI=1.5–4.3; p=0.001), multiloculartumor (OR=2.9; 95% CI=1.4–6.0; p=0.006), and presence of a solid component in the tumor(OR=3.1; 95% CI=1.8–5.1; p<0.001) were independent risk factors for final pathologicaldiagnosis upgrade. Conclusions: Mixed tumor histology, tumor size >12 cm, multilocular tumor, and presence ofa solid component in the tumor were independent risk factors for final pathological diagnosisupgrade based on frozen section diagnosis.

Synthesis of Benzoisoxazole Derivatives and Evaluation of Inhibitory Potency against Cholinesterase for Alzheimer's Disease Therapeutics

박정열,신수정,김재관,Kyoung Chan Park,박정호 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.9

To improve Alzheimer's disease (AD) therapeutics, we have designed and synthesized new benzoisoxazole derivatives that are potent inhibitors of cholinesterase (acetylcholinesterase [AChE] and butyrylcholinesterase [BuChE]). Since inhibition of cholinesterase (ChE) is still considered to be one of the most effective ways of treating AD patients, many new classes of ChE inhibitors have been synthesized. To identify a new type of cholinergic drug, the benzoisoxazole moiety which is the pharmacophore moiety of Risperidone was coupled with natural antioxidants. Some benzoisoxazole derivatives (26–28 and 30) were found to effectively inhibit BuChE (IC50 < 20 μM), and some (20 and 26–28) to moderately inhibit AChE (IC50 < 100 μM). Furthermore, compound 28 showed better inhibitory activity against BuChE (IC50 = 0.72 ± 0.11 μM) than galantamine (IC50 = 8.4 ± 0.1 μM). The new benzoisoxazole derivatives showing BuChE inhibitory activity represent a new class of ChE inhibitor and can be used to create novel compound derivative drugs for treating AD patients.

인공 위장 스킨을 위한 유연한 전기 가변 광결정

박정열,장형관 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.5

인상형성의 능동적 정보탐색: 남녀 차이와 세대 차이를 중심으로

박정열,허태균,김지혜,김용희,김민종,최은수 한국여성심리학회 2007 한국심리학회지 여성 Vol.12 No.2

Comparison of outcomes between radical hysterectomy followed by tailored adjuvant therapy versus primary chemoradiation therapy in IB2 and IIA2 cervical cancer

박정열,김대연,김종혁,김용만,김영탁,김영석,김하정,이정원,김병기,배덕수,허승재,남주현 대한부인종양학회 2012 Journal of Gynecologic Oncology Vol.23 No.4

Objective: The purpose of this study was to determine the predictive factors for residual/recurrent disease and to analyze the timing for Pap smears and human papillomavirus (HPV) testing during follow-up after loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN) 2 or worse. Methods: We retrospectively analyzed 183 patients (mean age, 39.3 years) with CIN 2/3 who were treated with LEEP. Post-LEEP follow-up was performed by Pap smear and HPV hybrid capture2 (HC2) testing. The definition of persistent/recurrent disease was biopsy-proven CIN 2 or worse. Results: Among 183 patients, punch biopsies were CIN 2 in 31 (16.9%) and CIN 3 in 152 (83.1%). HPV HC2 tests before LEEP were positive in 170 (95.5%) of 178 patients. During follow-up, 12 patients (6.6%) had residual/recurrent CIN 2+. LEEP margin status was a significant predictive factor for persistent/recurrent disease. Other factors such as age, HPV HC2 viral load (≥100 relative light units), and HPV typing (type 16/18 vs. other types) did not predict recurrence. Early HPV HC2 testing at 3 months after LEEP detected all cases of residual/recurrent disease. The sensitivity and negative predictive value of the HPV HC2 test for residual/recurrent disease were both 100% at 3 and 6 months. Conclusion: Margin involvement in conization specimens was a significant factor predicting residual/recurrent disease after LEEP. HPV test results at 3 and 6 months after treatment were comparable. Early 3-month follow-up testing after LEEP can offer timely information about residual/recurrent disease and alleviate patient anxiety early about treatment failure. Objective: The purpose of this study was to determine the predictive factors for residual/recurrent disease and to analyze the timing for Pap smears and human papillomavirus (HPV) testing during follow-up after loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN) 2 or worse. Methods: We retrospectively analyzed 183 patients (mean age, 39.3 years) with CIN 2/3 who were treated with LEEP. Post-LEEP follow-up was performed by Pap smear and HPV hybrid capture2 (HC2) testing. The definition of persistent/recurrent disease was biopsy-proven CIN 2 or worse. Results: Among 183 patients, punch biopsies were CIN 2 in 31 (16.9%) and CIN 3 in 152 (83.1%). HPV HC2 tests before LEEP were positive in 170 (95.5%) of 178 patients. During follow-up, 12 patients (6.6%) had residual/recurrent CIN 2+. LEEP margin status was a significant predictive factor for persistent/recurrent disease. Other factors such as age, HPV HC2 viral load (≥100 relative light units), and HPV typing (type 16/18 vs. other types) did not predict recurrence. Early HPV HC2 testing at 3 months after LEEP detected all cases of residual/recurrent disease. The sensitivity and negative predictive value of the HPV HC2 test for residual/recurrent disease were both 100% at 3 and 6 months. Conclusion: Margin involvement in conization specimens was a significant factor predicting residual/recurrent disease after LEEP. HPV test results at 3 and 6 months after treatment were comparable. Early 3-month follow-up testing after LEEP can offer timely information about residual/recurrent disease and alleviate patient anxiety early about treatment failure.

나노스케일 동전기를 이용한 광촉매 반응 향상연구

박정열 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-

We propose a novel microfluidic reactor assisted by nanoelectrokinetics for enhancing the photocatalytic reaction. The proposed reactor uses a porous carbon cloth as a substrate for coating TiO2 nanoparticles to improve photocatalytic activity owing to high surface-to-volume ratio, high oxygen permeability from high porosity and activity of carbon-doping source enabling to narrow the bandgap of TiO₂. Concentration polarization, nanoelectrokinetic phenomena under the forward potential bias was utilized to improve the mass transfer and increase the contact between photocatalyst and ion/ molecules. The resulting high ionic conductance in fluid channel by the applied potential bias caused large potential drop across the photocatalyst film, which can address the problem of the recombination of photo-excited electrons and holes and induce the synergistic effect of photocatalysis and electrocatalysis.

Impact of metformin on survival outcome in ovarian cancer: a nationwide population-based cohort study

박정열,임명철,백민현,박영한,김선옥 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.4

Objective: Investigation of new drugs (INDs) is a tremendously inefficient process in terms of time and cost. Drug repositioning is another method used to investigate potential new agents in well-known drugs. This study assessed the survival impact of metformin medication on ovarian cancer. Methods: A national sample cohort of the Korean National Health Insurance Service Data was analyzed. Cox proportional hazards regression was used to analyzing hazard ratios (HRs) and 95% confidence intervals (CIs) after adjusting for underlying diseases and medications as confounding factors for overall survival (OS) and cancer-specific survival (CSS). Results: A total of 866 eligible patients were included from among 1,025,340 cohort participants. Among them, 101 (11.7%) were metformin users. No difference in OS was observed between non-users and users. No difference in OS was observed according to age and Charlson Comorbidity Index. Long-term metformin use (≥720 days) was associated with better OS (adjusted HR=0.244; 95% CI=0.090–0.664; p=0.006). A multivariate Cox proportional hazards model showed that long-term metformin use was an independent favorable prognostic factor for OS (HR=0.193; 95% CI=0.070–0.528; p=0.001) but not for CSS (HR=0.599; 95% CI=0.178–2.017; p=0.408). Conclusion: Long-term metformin use reduced all-cause mortality, but not CSS in ovarian cancer. Whether metformin itself reduces deaths because of ovarian cancer requires further investigation.

자궁경부에 발생한 배아성 횡문근육종 2예

박정열,조준식,김대연,이동헌,김종혁,김용만,김영탁,목정은,남주현 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.3

횡문근육종은 소아와 청소년기에 가장 흔한 연부조직 육종이다. 발생 부위는 일반적으로 두부 및 경부, 그 다음으로 비뇨생식계이다 조직학적으로 배아성 횡문근육종, 국화상 육종, 폐포성 횡문근육종, 다형성 횡문근육종으로 나누어진다. 횡문근육종의 약 20%가 비뇨생식기에서 발생하고, 50% 이상이 배아성 횡문근육종이다. 여성 생식기의 배아성 횡문근육종은 드문 악성 종양으로,주로 유소아의 질에서 발생하며, 자궁경부에서 발생하는 횡문근육종은 청소년기에 흔하고, 질에서 기원하는 횡문근육종이 자궁경부에 기원하는 경우보다 5배 정도 많다. 폐경기여성에서는 자궁체부에서 가장 흔히 발생한다. 비뇨생식기의 횡문근육종의 치료는 과거에는 골반장기 적출술만으로 치료를 시도하였으나. 서서히 다중 항암화학요법, 방사선요법, 근치적 절제술을 포함한 병합요법으로 바뀌어가고 있으며, 이에 따라 생존율이 현저하게 향상되었다. 이에 저자들은 최근 본원 산부인과에서 자궁경부에 발생한 배아성 횡문근육종 2예를 경험하였기에 문헌 고찰과 아울러 보고하는 바이다. Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and young adult. Genitourinary tract is the econd most common site of rhabdomyosarcoma. Rhabdomyosarcoma can be classified into one of four major types; embryonal, alveolar, pleomorphic and undifferentiated. Embryonal rhabdomyosarcoma of the female genital tract is rare malignant tumor and usually occurs during childhood in the vagina. In rare cases, rhabdomyosarcoma can originate in the uterine cervix, with a peak incidence in the second decade. Recently we have experienced two cases of embryonal rhabdomyosarcoma of the uterine cervix. These cases are presented with a brief review of the literature.

일상재구성법을 통한 경력단절 여성의 일상생활과 정서경험 분석

박정열,손영미 여가문화학회 2015 여가학연구 Vol.13 No.2

This study was conducted to investigate what was career interrupted women’ main activities in everyday life and what and how they felt in those activities. 724 married career interrupted women were participated in this DRM(day reconstruction method) research. The major findings of this study were as follows. While they were more inclined to experience positive emotion, they were less inclined to experience negative emotion. Secondly, only a few of participants selected ‘learning’, ‘job hunting activities’ among everyday activities. Worst of all, it was revealed that they felt anxious, stressful and worried as they were doing job hunting activities. Thirdly, the most frequent activities such as cooking, cleaning, childcare etc were showed to be felt less positive and more negative emotions. Forth, participants experienced different positive and negative emotions depending on person(husband, children, friend etc). It was worthy of notice that their children were the objects that they had an ambivalent emotion that is affective and confident as well as tired, bored and anxious. Finally, It was revealed that am 8-11 and pm 6-8 were burnout time zones where participants experienced the most negative and the least positive emotion all over the day. 본 연구는 일상재구성법을 활용하여 경력단절 여성의 일상생활의 주요 활동(가사 및 육아, 여가, 학습 및 구직활동 등)을 탐색하고, 정서경험의 질을 측정하는 것을 목적으로 한다. 이를 통해 이들의 현재의 행복수준을 진단하고, 재취업과 관련한 시사점을 도출하고자 하였다. 직장을 그만 둔지 1년 이상 된 30대, 40대, 50대 경력단절 여성 724명의 자료가 분석되었으며, 그 결과는 다음과 같다. 먼저, 경력단절 여성들은 평상시 긍정적인 정서수준이 높고, 부정적인 정서수준은 낮은 것으로 나타났다. 다음으로, 경력단절 여성 중 ‘교육 및 학습’, ‘구직활동’에 참여하는 여성이 극소수인데, 참여하는 여성들도 학습활동이 구직활동으로 이어지지 못하는 경향을 보였다. 구직활동은 경력단절 여성에게 상당한 걱정과 긴장, 스트레스를 주는 활동이었다. 셋째, 경력단절 여성들은 음식준비, 청소, 자녀보살피기 등의 활동에 가장 빈번하게 참여하면서도 그것에 대해 긍정 정서는 적게 느끼고, 부정 정서는 더욱 느끼는 경향을 보였다. 넷째, 주요 상호작용 대상자에 따라 느끼는 정서가 서로 다름을 알 수 있었다. 특히 자녀는 애정/우호, 유능/자신감을 주는 대상임과 동시에 피곤함, 지루함, 긴장/스트레스를 느끼게 하는 부정적인 정서대상으로 드러나 가장 양가적인 감정을 느끼는 대상이었다. 마지막으로, 남편의 출근과 자녀의 등교를 위해 바쁘게 움직여야 하는 8시~11시, 저녁식사를 준비하고 정리해야 하는 저녁 6시~8시가 경력단절 여성이 가장 높은 수준의 정서노동을 하는 시간대임을 확인할 수 있다.

우리나라 온천호텔의 사업환경 변화에 따른 테마파크 도입방안에 관한 연구

박정열 한국관광정보학회 1999 觀光情報硏究 Vol.- No.3

The change in social structure leads to the significnat change in the perceptions of general public about tourism. Changes in the pattern of spa tour and tourists' needs require an introduction of the facilities with a new concept and the development of theme park, which extends the concept from remedy and invigoration further to an area of leisure. The purpose of this study is to present alternatives and a plan for heightening the competitiveness in the context of the change in environments surrounding spa hotel business. As a result, first, the conditions regarding the medical benefits, the quantity and the temperature of hot springs ate 1) it should be mediclly effectivee, 2) the quantity should be affluent, 3) it maintains moderate temperature. Sencond, the conditions involving the environment of spa attraction are 1) sanitary conditions should be satisfactory, 2) it has beautiful scenery, 3) the weather should be appropriate for recuperation, 4) facilities for remedy and recuperation are present, 5) it should be easy to access. Under the assumption that the conditions mentioned above are met and there exist attractive tour products, government's active involvement and successful inducement of private investment, Korean spa tourist business with its high quality hot springs could play an important role in the international tourism market and contribute to the revitalization of Korean economy.