Accuracy of frozen section diagnosis and factors associated with final pathological diagnosis upgrade of mucinous ovarian tumors

다국어 초록 (Multilingual Abstract)

Objective: To determine the accuracy of frozen section diagnosis and factors associated withfinal pathological diagnosis upgrade in patients with mucinous ovarian tumors.
Methods: This study included 1,032 patients with mucinous ovarian tumors who underwentfrozen section diagnosis during surgery. Sensitivity, specificity, and diagnostic accuracy offrozen section diagnosis was calculated. Univariate and multivariate regression analyses wereperformed to determine factors associated with diagnosis upgrade in the final pathology report.
Results: The sensitivity and specificity of frozen section diagnosis were 99.1% (95%confidence interval [CI]=98%–99.6%) and 82.2% (95% CI=77.9%–85.7%), respectively, forbenign mucinous tumors; 74.6% (95% CI=69.1%–79.4%) and 96.7% (95% CI=95.2%–97.8%),respectively, for mucinous borderline ovarian tumors; and 72.5% (95% CI=62.9%–80.3%)and 98.8% (95% CI=97.9%–99.3%), respectively, for invasive mucinous carcinomas. Themultivariate analysis revealed that mixed tumor histology (odds ratio [OR]=2.8; 95%CI=1.3–6.3; p=0.012), tumor size >12 cm (OR=2.5; 95% CI=1.5–4.3; p=0.001), multiloculartumor (OR=2.9; 95% CI=1.4–6.0; p=0.006), and presence of a solid component in the tumor(OR=3.1; 95% CI=1.8–5.1; p<0.001) were independent risk factors for final pathologicaldiagnosis upgrade.
Conclusions: Mixed tumor histology, tumor size >12 cm, multilocular tumor, and presence ofa solid component in the tumor were independent risk factors for final pathological diagnosisupgrade based on frozen section diagnosis.

참고문헌 (Reference)

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