만성신부전증에서 혈청 CEA치에 관한 연구

이정상,신영태,정순일,고창순,김성권,표희정,권인순 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2

저자들은 1979년 3월부터 1980년 10월까지 서울대학교병원내과에 입원하여 만성신부전증으로 진단받고 혈액투석요법을 받지 않은 환자 15예, 혈액투석요법을 시행중인 환자 39예 및 신장이식술을 받고 신장능이 호전된 환자 23예에서 혈청 CEA치를 방사면역측정법으로 측정하여 정상대조군과 비교하여 다음과 같은 결과를 얻었다. 1) 정상 성인 65명의 혈청 CEA치의 범위는 1.0∼4.3 ng/ml이었으며 평균은 1.6±0.66 ng이었다. 2) 혈액투석요법을 시행치 않은 만성신부전증 환자 15예의 혈청 CEA치는 0.3∼8.3 ng/ml이었고 평균은 3.6±2.10 ng/ml로써 정상대조군에 비하여 유의하게 증가되어 있었다(p$lt;0.001). 3) 혈액투석요법으로 치료중인 만성신부전증 환자 39예의 혈청 CEA치는 0.7∼6.7 ng/ml로 평균이 3.0±1.52 ng/ml이며, 정상대조군에 비하여 유의하게 상승되어 있으나(p$lt;0.001), 혈액투석을 받지 않은 환자군과는 유의한 차이가 없었다. 4) 신이식 환자 23예의 혈청 CEA치의 분포는 1.8∼10.8 ng/ml이고 평균은 3.8±1.96 ng/ml로 역시 정상대조군에 비하여 유의하게 증가되어 있으나(p$lt;0.001), 만성신부전증 환자군과는 유의한 차이가 없었다. 5) 이상의 혈청 CEA치가 정상범위 이상으로 상승된 49명��환자중 이학적 소견이나 검사소견상 악성종양은 발견되지 않았다. The serum CEA levels were measured by radioimmunoassay technique in 15 patients with chronic renal failure, who were not treated with hemodialysis, in 39 patients under hemodialysis and in 23 patients who received renal transplantation. The results were compared with those in 65 normal adults and the following results were obtained. 1) Serum CEA concentrations in 65 normal adults were in the range of 1.0 to 4.3 ng/ml with a mean value of 1.6±0.66 ng/ml. 2) Serum CEA concentrations in 15 chronic renal failure patients who were not treated with hemodialysis, were in the range of 0.3 to 8.3 ng/ml with a mean value of 3.6±2.10 ng/m1 which was significantly higher than those of normal controls(P$lt;0.001). 3) Serum CEA concentrations in 39 chronic renal failure patients under hemodialysis were also much higher than normal controls(p$lt;0.001), but not significantly different from those of the patients who were not under hemodialysis(P$gt;0.05). 4) In 23 patients who received renal transplantation, serum CEA levels were snificantly higher than normal controls(P$lt;0.001), but not significantly different from those of chronic renal failure patients.

Gentamicin 투여에 따른 혈중 및 요중 β2-Microglobulin 동태에 관한 연구

이정상,신영태,정순일,이문호,김병국,김승택,최경원 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2

저자는 1980년 3월부터 7월까지 서울대학교병원 내과에 입원하여 게타마이신을 투여받았던 각종 감염증환자 10예를 대상으로 겐타마이신의 혈중농도, 혈청크레아티닌, 혈중 및 24시간 요 베타-2-마이크로글로불린을 측정하여 다음과 같은 결론을 얻었다. 1) 겐타마이신의 혈중농도는 최고농도(peak level)는 4.5∼8.2μg/ml, Trough치는 0.2∼2.1μg/ml를 유지하여 안전치료 영역내에 있었다. 2) 혈청 크레아티닌(creatinine)치는 겐타마이신 투여기간중 대상 전원에서 통계학적으로 유의한 증가를 보이지 않았다. 3) 혈중 베타-2-마이크로글로블린치는 겐타마이신 투여기간중 대상 전원에서 통계학적으로 유의한 증감을 보이지 않았다. 4) 24시간 요 베타-2-마이크로 글로블린은 겐타마이신 투여후 전예에서 통계학적으로 유의한 증가를 보여 제 5일에 기저치보다 평균 5.8±1.62배 증가하였으며, 그 이후로는 감소하는 경향을 보였다. 이상의 결과를 종합하면 24시간 요 베타-2-마이크로글로블린 측정은 겐타마이신의 초기 신독성을 예민하게 반영한다는 사실을 알 수 있었으며, 이의 임상적 신독성과의 관계는 앞으로 추시가 필요하다고 생각된다. Gentamicin is useful to the Gram negative bacterial infection, but its nephrotoxicity is a serious problem and the incidence is probably increasing. The toxicity of gcntamicin to the kidney is site-specific to the proximal tubule. In this study, we measured daily peak and trough level of gentamicin, serum creatinine, serum Beta2-microglobulin and 24-hr urine Beta2-microglolbulin in 10 gentamicin treated patients. All the patients had their peak levels of gentamicin in the safe therapeutic range, and their trough level showed no evidence of gentamicin accumulation. There was no patient who showed his daily serum creatinine and Beta2-microglobulin rise significantly. But 24-hour urine Beta2-microglobulin showed significant rise from basal level(mean 5.8±1.62×) on the 5 th day of gentamicin treatment. Thus, serial monitoring of proximal tubular function with urinary Beta2-microglobulin excretion has potential value in the assessment of insults of gentamicin to this site. But clinical significance of raised uriry Beta2-microglobulin excretion in relation to the serum creatinine should be further studied.

급성 골수성 백혈병(M6)에 합병된 중추성 요붕증 1 예

김성연,조보연,이홍규,고창순,민헌기,김병국,김노경,신찬수,이명식,강덕현,조종태 대한내과학회 1989 대한내과학회지 Vol.37 No.2

Leukemia is known to be an extremely rare cause of diabetes insipidus. We report a case of diabetes insipidus as a complication of leukemia. An 18 year-old man was admitted because of polyuria polydipsia and fever. Bone marrow aspiration and biopsy revealed the diagnosis of acute erythroleukemia (AML, M6). On the water deprivation test, the diabetes insipidus was confirmed to be of the central type. He was managed with intranasal vasopressin for diabetes insipidus with good response. Induction chemotherapy was administered without response, and the patient died of septicemia and respiratory failure 2 months after initial diagnosis. A short review of the literature related to this subject is also presented.

운동후 측복통과 함께 발생한 급성 신부전 1 예

김종순,박영주,조종태,이정임,신민호,구천희,박태용,한승수,강진화 대한내과학회 1996 대한내과학회지 Vol.50 No.6

We report a case of acute renal failure with severe loin pain and patchy renal vasoconstriction after exercise. An immediate postcontrast computed tomogram of this case shows multiple patchy areas of poor contrast enhancement in the cortex of the both kidneys. A 24-hours delayed scan without further injection of contrast dye shows multiple wedge-shaped contrast enhancement in the coincident areas of poor enhancement in the immediate scan. The 2 and 5 days delayed scans show that wedge-shaped contrast enhancement becomes disappeared gradually to the renal cortex, and the 8 days delayed scan shows complete disappearance of contrast enhancement. The renal scintigrams with technetium-99m-methylene diphosphonate and dimercaptosuccinic acid show diffuse increased uptakes and multiple patchy photon deficient areas in the both kidneys respectively. The follow-up renal scintigrams show nearly normal findings, This patient had an uneventful hospital course and recovered completely without dialysis.

Ti(4) 및 Fe(3) 이온을 함유한 황산 수용액중에서 D2EHPA 에 의한 용매추출에 관한 연구

신영훈,유영홍,이철태,김재용,유정근 고려대학교 공학기술연구소 1991 고려대학교 생산기술연구소 생기연논문집 Vol.27 No.1

This study was carried out to find fundamental conditions for effective solvent extraction of Ti and Fe components from leaching solution of reaction product of (NH₄)₂SO₄ and titaniferous magnetite ore. In experiment of solvent extraction of Ti and Fe components, new aqueous phase which contains only Ti(IV), Fe(III) was used instead of leaching solution of sulfation product. The extraction of Ti(IV) and Fe(III) components from aqueous phase with D₂EHPA (Di-2-ethyl hexyl phosphoric acid)-kerosine system was carried out as function of concentration of extractant in the organic phase, pH of agueous phase and shaking time. The maximum value of separation factor(β) was 102.6 at 0.05 M D₂EHPA, aqueous phase pH 1.0, and 30 min was sufficient for the condition of shaking time. In stripping of Ti and Fe components from organic phase; the higher temperature and more concentration of H₂SO₄ increased the stripping percent of Ti and Fe components and the stripping percent of Fe was always higher than that of Ti. In separation process of Ti and Fe components, when 2 step stripping process was used, 93.7%, 99.5% Ti and Fe components was obtained respectively. While, 3 stage continuous countercurrent process was used, 96.3%, 84.7% of Ti and Fe components was obtained respectively.

사료내 아미노산비가 흰쥐의 성장 , 도체성분 , 조직 유리아미노산 농도 및 뇨내 질소배설량에 미치는 영향

신종서,라창식,김창혁,김병완,송영한 한국영양사료학회 1999 韓國營養飼料學會誌 Vol.23 No.4

본 논문에서는 아미노산 혼합사료를 이용하여 사료내 질소 수준을 1.6N%로 일정하게 조절한 후 ET%의 단계적 변화(30, 50, 70ET%)가 휜쥐의 성장, 체성분, 혈중요소태 질소, 조직내 유리아미노산 농도 및 뇨중 질소량 변화에 미치는 영향을 검토하였다. 그 결과는 다음과 같이 요약되었다. 1. 증체량은 30ET%구에서 유의적으로 낮게(P<0.05) 나타났으나 사료섭취량은 50ET%구에서 유의적으로 높게 나타났으며(P<0.05), 증체량과 사료섭취량간에는 높은 상관이 인정되었다. 2. 도체 및 간장의 성분은 사료내 ET%의 변화에 의한 영향이 없는 것으로 나타났다. 3. 혈중 유리아미노산의 농도는 사료내 ET%의 변화에 민감하게 반응하였으며 특히 threonine 농도는 30ET%구에 비하여 70ET%구가 약 35배 정도로 유의적으로 높게 나타났다(P<0.05). 또한 총 필수아미노산의 농도는 사료내 ET%의 증가에 따라 유의적으로 증가하였으나 비필수아미노산 농도는 유의적으로 감소하였다(P<0.05). 간장 및 근육내 총필수아미노산과 비필수아미노산의 농도도 혈중 아미노산의 농도 변화와 비슷한 경향을 보였다. 4. 사료내 ET%에 따른 질소 배설량은 저 ET%구에 비하여 고 ET%구에서 높게 나타났으며 사육초기 보다 사육후기에 높은 질소 배설량을 보였다. 이와 같은 결과로 미루어 사료내 아미노산 조성은 중체량과 사료섭취량에 영향을 미칠 뿐만 아니라 조직내 아미노산 농도 및 질소 배설량에도 영향을 주기 때문에 정제 아미노산을 사료에 첨가할 때에는 비필수아미노산의 함량도 고려함으로서 효율적으로 사료의 이용성을 중진시키는 방향을 모색하는 것이 바람직 할 것으로 사료된다. The objective of this study was to investigate the effect of ET(essential amino acid/total amino acid) ratio variations (30, 50, 70 ET%) in the feeds on growth, body composition, blood urinary nitrogen, concentration of free amino acids in tissues and urinary nitrogen of rats. The nitrogen level in feed was constantly maintained at 1.6% with a purified amino acid, despite the difference in ET ratios. The results obtained are summarized as follows; 1. Body weight gain and feed intake was significantly lower and higher in 30 and 50 ET% than in other groups, respectively(P<0.05), and body weight gain was highly correlated with feed intake. 2. No ET% ratio effects on composition of carcass and liver were observed. 3. The concentration of plasma free amino acids varied with ET% ratios in the feeds, especially the concentration of threonine in 70 ET% was 35 times higher than that in 30 ET%. The concentration of total essential amino acids was significantly elevated by increasing ET% ratios in the feeds. In liver and muscle, the patterns of total essential amino acids and nonessential amino acids were similar to that of plasma amino acids. 4. Urinary nitrogen concentration increased with higher ratios of ET% in the feeds, and was higher in early growth stage than in late growth stage. These results indicate that the amino acid composition in the feeds influence the concentration of amino acids in tissue and urinary nitrogen as well as body weight and feed intake.

플라즈마 화학증착법에서 증착변수가 TiN 증착에 미치는 영향(3) : r . f . power 및 전극간 거리를 중심으로 Influence of r . f . power and electrode distance on the Tin deposition

신영식,김문일,김충환 한국열처리공학회 1990 熱處理工學會誌 Vol.2 No.4

To investigate the influence of r.f, power and electrode distance on the TiN deposition, TiN films were deposited onto STC3, STD11 steel and Si-wafer from gas mixtures of TiC₄/N₂/H₂using the radio frequency plasma assisted chemical vapor deposition. The crystallinity of TiN film could be improved by the increase of r.f, power and the decrease of electrode distance. The TiN coated layer contains chlorine, its content were decreased with increasing r.f. power as well as decreasing electrode distance. And the thickness of deposited TiN was largely affected by r.f. power and electrode distance. The hardness of deposited TiN reached a maximum value of about Hv 2,000.

저 헤모그로빈 환자의 수혈거부에 대한 증례보고

박영철,박경숙,문숙희,김순점,길찬일,신정순 대한마취과학회 1982 Korean Journal of Anesthesiology Vol.15 No.3

Jehovah's Witness patients who require an operation represent a challenge to the physician because of the patients' refusal to accept a blood transfusion. We report 5 years experience with a consecutive series of 12 Jehovah's Witness patients in the Obstetric & Gynecological department who underwent operation. In 12 cases, death ensued in one patient who underwent subtotal hysterectomy for ectopic pregnancy. The cause of death was severe anemia & complicated respiratory problems. We discussed the problem of elective & emergency operations on Jehovah's Witness patients. Anesthesiologists must understand legal aspects, as well as and ethical, if they are to conduct their practice as an art as well as science.

위험성 평가 프로그램 PML - Chem 개발

김윤화,고재욱,김형석,신동일,김인원 한국산업안전학회 1999 한국안전학회지 Vol.14 No.2

This study is to develope the quantitative risk assessment program for consequence analysis of fire and explosion (PML-Chem), which is applicable to the chemical plants. The advantages of PML-Chem is easy to use and acquire results. Especially, PML-Chem was embedded real weather condition database for major chemical plants in ○○ complex in country. Also, reliability of PML-Chem was verified through comparing PML-Chem with PHAST-Professional which is already commercial.

LDPE 에서 발생된 전기트리에 수반된 내부 부분방전 펄스 해석

박영국,임기조,강성화,권순석,신태수 한국산업안전학회 1999 한국안전학회지 Vol.14 No.1

전력용 케이블은 전선로의 지중화 추세에 따라 사용이 증가하고 있다. 케이블 절연체의 경우 장기간의 전압인가에 의해 열화 및 절연파괴 된다. 전력용 케이블의 절연파괴시 발생하는 사회/경제적 문제는 매우 심각한 것으로 알려져 있다. 절연체의 열화에 영향을 주는 요인은 매우 복잡하지만 그중에서도 전기트리 열화에 의한 파괴는 비교적 두꺼운 고체 유전체인 경우에 절연파괴 사고의 주된 원인이 되고 있다. 전기트리의 개시나 진전시 부분방전이 발생하므로 부분방전의 검출에 의해 전기트리의 발생 및 진전 양상을 관측할 수 있고 부분방전의 해석에 의해 절연재료의 잔여 수명을 예측할 수 있다. 본 논문에서는 고전압 전력용 케이블 절연재로써 광범위하게 사용되고 있는 저밀도 폴리에틸랜 시편에서의 전기트리 진전 양상을 비파괴 진단 기법에 의하여 검출하고자 내분 부분방전을 관측/해석하였다. The correlation between propagation of electrical tree and internal partial discharges is discussed. We use specimens with needle-plane electrode system made of LDPE(Low Density Polyethylene), observed inception and propagation of electrical tree by optical microscope and investigated the characteristics of the partial discharge (PD) pulses accompanying with propagation of electrical tree. In the specimens with needle-shaped void, the tree propagates branch type. The length of the tree has good linear relation with average discharge power of PD pulses. In the specimens without needle-shaped void, the tree grows bush type tree. The correlation between the area of the tree and the average discharge power of PD pulses has linear relation.