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이정임,박영주,박태용,한승수,구천희,신민호,윤순일,이병두 대한소화기내시경학회 1994 Clinical Endoscopy Vol.14 No.4
Primary extrapulmonary small cell carcinoma(SCC) is appearing with increased frequency in the literature. These tumors have been described in the esophagus, stomach, pancreas, larynx, hypopharynx, salivary gland, nasal cavity & paranasal sinus, thymus, small & large bowel, uterine cervix, endometrium, breast, prostate, urinary bladder and skin. Small cell carcinoma of the stomach is extremely rare and a total 9 cases have been reported in the English literature. Like SCC in the lung, SCC in the alimentary tract has a aggresive behavior and prognosis of the patient is poor. We are reported a case of advanced gastric cancer diagnosed as small cell type by endoscopic biopsy. Grossly, the lesion of small cell carcinoma of the stomach, located in the upper body and gastric angle, is ulcerated with irregular margin and dirty surface covered with blodd clots and exudates.
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김종순,이정임,박영주,박태용,김은실,김광회,구천희,신민호 대한내과학회 1995 대한내과학회지 Vol.48 No.6
Polyglandular autoimmune(PGA) syndrome is complex autoimmune disorder that two or more organs are involved by organ specific autoantibodies. We report here 5cases of polyglandular autoimmune syndrome type 3 which consist of autoimmune thyroid disease(Hashimoto's thyroiditis) and other autoimmune diseases(e.g. systemic lupus erythematosus, rheumatoid arthritis and chronic autoimmune hepatitis). The patients of 5 cases were all females, and the age of 3 patients was 4th decade and that of the remainder was 6th and 7th decade. These diseases represented good response to treament with thyroid hormone and glucocorticoid or nonsteroidal antiinflammatory drug. The follow up of anti thyroid autoantibodies titer was significant in evaluation of treatment of autoimmune thyroid disease. We suggest that, if an endocrine autoimmune disease is detected, we should suspect and diagnose another associated autoimmune diseases as soon as possible.
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Tetracycline 경화요법으로 치료한 자율기능성 갑상선 결절 1 예
김종순,이정임,박영주,박태용,한승수,김은실,신민호,구천희 대한내분비학회 1994 Endocrinology and metabolism Vol.9 No.3
Autonomously functioning thyroid nodules(AFTNs) are so named because they presumably are independent of TSH for growth and function. In general, surgery and radioactive iodine are effective therapies but reluctant to use because of complications such as hypothyroidism or cosmetic problems. Percutaneous ethanol injection therapy(PEIT) under sonographic guidance has recently been introduced as alternative therapy. But its adverse effects such as severe local pain, subcutaneous hematoma or palsy of the recurrent nerve are not negligible, therefore sufficient skill is required. In this case, the levothyroxine therapy in reducing the size of colloid thyroid nodules was not apparent within three months. Therefore we selected another sclerosing therapeutic method such as percutaneous tetracycline injection(PTI) and followed up thyroid function test, thyroid scan, ultrasonographical size and volume of nodule. The results were as follows: 1) With 0.5-0.8 cc tetracycline injection for three times, the volume of nodule was reduced after PTI; About 2.3 X 1.7 X 0.7 cm sized nodule was reduced to about 1.3 X 1.0 X 0.5 cm sized nodule. 2) There were significant improvements of TFT(subclinical hyperthyroidism to euthyroidism) and thyroid scan(solitary hot nodule to completely ablated AFTN) during 9 months follow-up after PTI as compared with the base line study. In conclusion, we experienced good results in a 22-year-old woman suffered from AFTN treated with PTI and think that PTI could be the effective, safe, simple, well tolerable procedure in the treatment of AFTN(J Kor Soc Endocrinol 9: 258-264, 1994).
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김종순,박영주,조종태,이정임,신민호,구천희,박태용,한승수,강진화 대한내과학회 1996 대한내과학회지 Vol.50 No.6
We report a case of acute renal failure with severe loin pain and patchy renal vasoconstriction after exercise. An immediate postcontrast computed tomogram of this case shows multiple patchy areas of poor contrast enhancement in the cortex of the both kidneys. A 24-hours delayed scan without further injection of contrast dye shows multiple wedge-shaped contrast enhancement in the coincident areas of poor enhancement in the immediate scan. The 2 and 5 days delayed scans show that wedge-shaped contrast enhancement becomes disappeared gradually to the renal cortex, and the 8 days delayed scan shows complete disappearance of contrast enhancement. The renal scintigrams with technetium-99m-methylene diphosphonate and dimercaptosuccinic acid show diffuse increased uptakes and multiple patchy photon deficient areas in the both kidneys respectively. The follow-up renal scintigrams show nearly normal findings, This patient had an uneventful hospital course and recovered completely without dialysis.
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방사성옥소 투여에 따른 말초혈액 림프구 수의 변화 및 염색체이상 빈도의 관찰
김종순(Chong Soon Kim),한승수(Seung Soo Han),김희근(Hee Geun Kim),강덕원(Duck Won Kang),송명재(Myung Jae Song),구천희(Chun Hee Koo),신민호(Min Ho Shin),박영주(Young Ju Park),이정임(Jung Yim Lee),박태용(Tae Yong Park),이재용(Jae Yong 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.3
N/A Background: For biological dosimetry of radiation exposure, both observing hema-tologic change and calculating Ydr by chromgsomal analysis as biological indicators are widely used. However, due to the lack of studies on biological dosimetry of radiation dose absorbed in the body such as in the cases of radioactive iodine therapy, the maximal and safe dose is not well known, nor is the extent to which the body can safely endure radiation exposure. Purpose: To investegate the practical applicability of hematologic changes and Ydr as an indicator for estimating radiation exposure, to patients with thyroid diseases after doses of radioactive iodine. Material and Methods: 5 patients with hyperthyroidism and 35 patients who have had thyroid cancer operation were under treatment with radioactive iodine, changes in number of lymphocytes were tracked and Ydr was calculated for more than 2 months by chromosomal analysis in peripheral lymphocytes. Results: 1) The number of lymphocytes began to decrease 2 weeks after doses of radioactive iodine, and reached the nadir after 6 and 8 weeks, then gradually recovered. 2) The nadir count of lymphocytes was reversely correlated with the administered dosage of radioactive iodine. 3) Ydr was generally stable between 2 and 8 weeks. 4) The maximal value of Ydr was correlated with the administered dosage of radioactive iodine. 5) Ydr value at the 2nd week increased with augmented dosage of radioactive iodine. 6) Ydr value at the 2nd week was correlated with fall of lymphocyte count. Conclusion: Patients must be closely observed, because temporary bone marrow suppression and slight chromosomal aberration can be produced by even generally used dosages of radioactive iodine for diagnosis and therapy. Maximal percent fall of lymphocyte count, Ydr at the 2 week interval and maximal Ydr can be used as the biological predictor of administered dosage of radioactive iodine.
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