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조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성
김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3
Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.
Escherichia coli 패혈증 환자에 합병된 대칭적 하지 말단 괴사증 1예
남해성,유진홍,권순석,민준기,조현선,박민경,심병주,남유정,이지인,김진수,길욱현,조근종,신완식 대한감염학회 2005 감염과 화학요법 Vol.37 No.6
We have encountered a rare case of symmetrical peripheral gangrene complicating Escherichia coli sepsis in a 47-years-old male. He was successfully treated with antibiotics, anticoagulants, and vasodilator. To our knowledge, this is the first report on symmetrical peripheral gangrene complicating E. coli sepsis in Korea.
야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로
조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6
Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.
프리스트레스 흙막이工法의 특성 硏究 : 적용사례를 중심으로 Focus on the Case Study
유현경,조성수,강경인 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
The building is getting bigger and higher in urban areas to promote efficiency of land. As a building was built in urban areas. it was built in very close proximity. At stage of underground work, it's extremely necessary to improve retaining wall for raising the quality of construction. The Braced Wall System largely used in Korea because of suitability of construction in close proximity but it can't serve enough space to work. So in this study, a new retaining wall method using Prestress Wales compares with Braced Wall System under several aspects such as time for completion, construction cost, and stability.
조현덕,김유종,용부중,동유게 한국공작기계학회 2005 한국생산제조학회지 Vol.14 No.2
A mirror cam mechanism, a kind of conjugate cam mechanism, consists of two cams, two rollers, and two links. Since profiles of two mirror cams are identical, a simultaneous machining of two cams is achievable. Some machining errors on cam profiles do not result in the internal acting force, which often causes problems in high speed cam mechanism, between two links. Also, since angular accelerations of two links are same, the internal acting force by the difference of the angular accelerations does not occur in the mechanism. Thus the mirror cam mechanism is very useful in high speed machinery. This paper studies a design method as well as a machining method, and develops an exclusive CAD/CAM software for mirror cam profiles. The developed CAD/CAM software is applied to a typical mirror cam mechanism, and a mock-up equipment is built in order to test the machined mirror cam. Experimental investigations show that the contact between cam surface and roller surface according to cam rotation agrees well with the simulation on the developed CAD/CAM software.
투시영상기 조영하에서 외부 강선견인술을 이용한 관골궁 골절의 비관혈적 정복술
조경호,유석근,유병표,최현준 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.1
Recently, facial traumas are increasing due to expansion of motor vehicles and complexity of social life pattern. The zygoma bone is a prominent part of the midface and prone to be traumatized. Numerous approaches for reduction and fixation of zygomatic fractures have been described. Each reduction method has its advantages and disadvantages. The authors employed the extemal wire traction with fluoroscopy in cases of non-comminuted zygomaticarch fracture. The advantages of this method are a more accurate reduction under direct vision and takes a very short time. This procedure also can reduce the pain and edema after postoperation and possible under local anesthesia. With such method, we obtained satisfactory results cosmetically and functionally.
조남규,김현국,권기환,한창수,안유민,이성환,박균명 한국공작기계학회 2000 한국공작기계학회 추계학술대회논문집 Vol.2000 No.-
This paper describes the statistical analysis techniques for the surface roughness assessment of polished surfaces. In experiments, the polishing process of the sample surfaces which are manufactured by ball end mill is consist of two steps; the cusp removal process and the surface finishing process. For the cusp removal process, the criterion of cusp removal was established from the power spectrum analysis to assess the change of the cusp removal rate. For the finishing process, the surface was polished by the rotational CBN tool and vibration wood tool. And the surface quality of polished surface was assessed using the functional parameters based on the statistical values of surface profiles. Consequently, the surface finish performance of the polished surface using the vibration wood tool was improved.
4WD 및 4WS이 가능한 로더 개발(Ⅱ) : 4륜 조향장치 및 로더 구성 4WS System and Construction Loader
조현덕,윤문철,김유종 한국공작기계학회 1999 한국생산제조학회지 Vol.8 No.1
In this study, the loader was completed that has the 4-wheel gear driven drivetrain of study (Ⅰ), the 4-wheel steering with power wheel type, all-wheel traction system, and joy-stick type lever for hydraulic control value. From driving test of the developed 4WD and 4WS type loader, we obtained that the minimum circling radius and the necessary width in circling motion reduced about 40% and 33% compared with 2WS type loader. Also, all-wheel traction system could keep the tires glued to the ground with greater stability, the ower steering allowed a smoother operation, and the joy-stick type lever offered easily to control. Thus, the developed loader having these functions was very fit in a small cattle shed or a rugged ground.