진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과

정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.

편측안면경련에 대한 미세혈관압술시 수술시야 확보를 위한 방법으로서 소뇌피질동맥 박리술 - 수 술 수 기 -

김범태,임수빈,장재칠,신윈한,최순관,변박장 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.11

아로마테라피를 활용한 등 관리의 항스트레스작용에 관한 연구

장태수,김경란 서라벌대학 2001 논문집 Vol.20 No.-

미다졸람의 비강 내 추가투여가 소아의 경구 진정요법에 미치는 영향

장수영,김지연,박기태 大韓小兒齒科學會 2012 大韓小兒齒科學會誌 Vol.39 No.1

Effect of supplementary intranasal midazolam on oral sedation of children The purpose of this study was to compare the cardiopulmonary parameters of two sedation regimens during dental treatment: (1) Oral chloral hydrate(CH) and hydroxyzine(HZ) with nitrous oxide-oxygen(N2O/O2) inhalation( CH-HZ group); (2) Oral chloral hydrate(CH) and hydroxyzine(HZ) with nitrous oxide-oxygen(N2O/O2) inhalation and supplementary intranasal(IN) midazolam administration(MIDA group). Among the patients of OO hospital who received dental treatment under sedation over the past 5 years, 44 patients were selected for each group of CH-HZ and MIDA according to their age, gender and weight. Following parameters that were recorded every 5 minutes were compared: 1) Heart rate(HR) 2) O2 saturation 3) End tidal carbon dioxide concentration(EtCO2) 4) Respiratory rate(RR) 33 patients of Group MIDA who have complete data of 15 minutes before and after supplementary IN midazolam administration were selected. And measurements 15 minutes before and after midazolam administration in same patient were evaluated. The results were as follows: 1. Heart rate was significantly higher in MIDA group than in CH-HZ group, but it was within normal range. 2. Comparing HR, O2 saturation, EtCO2, RR between before and after of supplementary IN midazolam administration in the same patient, the differences were not statistically significant. 이 연구는 소아환자의 경구 진정요법 시 미다졸람의 비강 내 추가 투여가 심폐기능에 미치는 영향을 알아보기 위한 것으로 5 년간 삼성서울병원 소아치과에서 chloral hydrate와 hydroxyzine을 경구투여하고 N2O/O2 inhalation을 추가로 사용한 진정요법으로 치료 받은 환자 중 미다졸람을 추가투여 받은 실험군(MIDA군)과, 미다졸람을 추가 투여하지 않은 대조군 (CH-HZ군)을 각각 44명씩 선정하여 서로 비교하였다. 진정요법 중 5분마다 측정된 1) Heart rate(HR) 2) O2 saturation 3) End tidal carbon dioxide concentration (EtCO2), 4) Respiratory rate(RR)의 평균값을 비교하였다. 또한 동일 환자에서의 미다졸람 투여 전 후의 심폐기능지표의 변화 양상을 평가하기 위해 MIDA군 중에서 미다졸람 투여 전 후 15분 이상의 기록이 존재하는 33명을 선정하여 미다졸람 투여 전 후 15분 시점의 측정값을 각각 비교하였다. 결과는 다음과 같다. 1. Heart rate는 미다졸람을 추가 투여한 군에서 유의하게 높았으며 나머지 심폐기능 지표의 측정값들은 차이가 없었다. 두 군의 측정값들은 모두 정상범위 안에 있었다. 2. 동일 환자에서 미다졸람 투여 전 후 15분의 측정값을 비교한 결과 두 시점간에 측정된 값들은 유의한 차이가 없었다.

상악동에 발생한 낭종과 술후낭종에 대한 임상병리학적 연구

김수관,박정열,강태호,장현선 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The purpose of this study is to evaluate the frequency of cysts and postoperative cyst in maxillary sinus and compare between cysts and postoperative cyst in maxillary sinus. Of 3,218 biopsy cases, 23 cases of cysts and 9 cases of postoperative cyst in maxillary sinus were found. Males were affected significantly more than females. The age distribution of the 23 patients was in a range of 13 to 76 years. Most of them were in the second and third decades. The postoperative maxillary cyst was occurred most frequently during ten years after Caldwell-Luc operation. Females were affected more than males. The age distribution of 9 patients was in a range of 29 to 64 years. Most of them were in the 6th decade. The most common symptoms were pain and swelling, and the sites were the molar area and vestibule of the maxilla. Radiographically, the lesions occurred most frequently unilateral radiopaque. The cysts were treated surgically in all cases. The literatures were reviewed regarding etiology, frequency, and radiologic and microscopic findings of those cysts.

석면폐증 1례

이영수,장태원,유호대,정만홍,이용환,서지영,허 방,이재성 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1

Asbestosis is the disease of pulmonary fibrosis caused by the inhaled asbestos fibers, and could be diagnosed clinically, in the case of exposure history to asbestos is proved, by clinical symptoms of dyspnea or dry cough, physical examonation findings, and the radiographic features. But many othder inorganic dusts would show similar findings in the chest radiogram and sometimes the exposure history is obscure, so for the exact diagnosis of asbestosis lung biopsy is needed. In Korea, there have been some reports of survey in the workplace where asbestos is handled or of asbestos related diseases. This is a case report of asbestosis with accompanying pleural plaques, who had the occupational exposure to asbestos for 30 years and the consistent clinical, radiographic and pathological findings in the lung tissue obtained by the videoscope assisted thoracoscopic biopsy(VATS).

폐주변부 병변 진단 시 기관지솔질에 의한 출혈이 병소확인에 주는 유용성 연구

김예나,정수현,김혜수,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background : Diagnosis of peripheral pulmonary lesion by conventional bronchoscopy is still challenging. The sheathed bronchial brush has been used to collect samples from the visible endobronchial lesion. Recently developed endobronchial ultrsonography (EBUS). can obtain image of peripheral pulmonary lesion at bronchus suspected by bleeding sign of sheathed brush. This study evaluated availibility of detected lesions by bleeding after bronchial brushing in pheripehal pulmonary lesions before transbronchial lung biopsy Methods : Between August 2006 and November 2008, 50 patients(38 men and 12 women, median age, 65 yrs) whose peripheral pulmonary lesions could not be detected with flexible bronchoscopy were included in this study. Among 50 patients, 40 cases were malignant lesion(non-small cell carcinoma 35, small cell carcinoma 5), and 10 cases were benign lesions(inflammatory disease 7, others 3) Results : Of the 50 patients, lesions detected bleeding after bronchial brushing was 34 cases(68%) and lesions detected by EBUS was 33 cases(66%). Sensitivity was 90.0-95.4%, Specificity was 83.3-80%, Positive predictive value(PPV) was 83.3-95.4% and Negative predictive value(NPV) was 80-90.9%. Diagnostic rates in visualized lesion by EBUS and otal peripheral lesions were 75%(25/33), 58%(29/50) respectively. There was no significant complication related with bronchial brushing. Conclusions : Bleeding sign by bronchial brushing was safe and effective method to predict location of peripheral pulmonary lesion with sufficient diagnostic yield

WWW 기반의 원격교육시스템 설계 및 구현

박남숙,장기화,곽난희,이수현,우용태 國立 昌原大學校 精報通信硏究所 1998 精報通信論文集 Vol.2 No.-

The purpose of this paper is to develope a distance education that would be a courseware for a specific object, which can be available for student to learn the necessary knowledge or function, with no restriction of time or place, using WWW and Oracle DBMS. The distance education was designed in this paper consists of bulletin board, subject information, lecturing schedule, online instructions, questions and answers, submit and confirmation of reports, evaluation of lecturing, reference sites, chatting and discussion room, and data bank. The distance education coupled by WWW and database will change the educational form from one-direction to bi-direction between a teacher and the students. This can also provide a multimedia information to the students through WWW environment with convenient user interface. Those benefits made it possible to offer animated audio-visual materials and search for the information concerned through a hypertext technique. Besides, various kinds of informations were stored at database to increase an effectiveness in managing data. Since both teacher and students, are easy to add new information using the process of instruction to the database, the amount of the stored information in the distance education can be expanded effectively.

Pd 촉매하에서 allylic alcohol과 hypervalent iodine 화합물의 위치 선택적 vinylation에 관한 연구

강석구,이홍우,장수범,김태현,편성재 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.2

The formation of carbon-carbon bond by palladium-catalyzed coupling of aryl or vinyl halides with olefins, known as the Heck reaction, has become a powerful tool in organic chemistry. In the case of allylic alcohols, palladium-catalyzed reaction of organic halides usually affords β-substituted ketones or aldehydes rether than β-substituted allylic alcohols.

폐쇄성 황달로 내원한 담관내 증식을 동반한 간세포암 1예

김승범,김태년,이호찬,박재현,은종렬,장병익,이헌주,윤성수,배영경 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

The incidence of hepatocellular carcinoma presenting as obstructive jaundice is 0.7 -9% The mechanisms of obstructive jaundice include bile duct invasion by tumor, tumor thrombi, blood clots, direct bile duct compression by tumor, and intraductal tumor growth. We report a rare case of hepatocellular carcinoma with intraductal growth A 46-year-o1d woman was admitted due to colicky right upper abdominal pain and jaundice for 4 days Computed tomography showed dilatation of the left intrahepatic duct, and endoscopic retrograde cholangiography showed a filhng defect in the left main intrahepatic duct. We performed a left lobectomy with a Roux-en-Y hepaticojejunostomy. The tumor was diagnosed as a hepatocellular carcinoma with intraductal growth.