석류씨 추출물의 항산화 및 항균활성

고종호,황명오,문주수,황성연,손종연 한국조리과학회 2005 한국식품조리과학회지 Vol.21 No.2

This study was investigated on antioxidative and antimicrobial activities of PSW(pomegranate seed water extract), PSE(pomegranale seed ethanol extract) and PSO(pomegranate seed oil). 'rile extraction yields of PSW, PSE and PSO were 28,9, 13.0 and 4.9%, respectively. Total phenol contents of PSW, PSE and PSO were 47, 78 mg/g(dry basis) and 40 mg/g, respectively. Electron donating abilities of PSW, PSE and PSO at 1,000 ppm were 18.8, 28.5 and 9.7%, respectively. Antioxidative activities in linoleic acid substrates at 500 ppm were in order of 1'SE > a-tocophcrol > PSW > PSO. Antioxidative activities in linoleic acid emulsion substrates at 200 ppm were in order of α-tocopberol > PSE > PSW > PSO, In antimicrobial activity, PSO showed growth inhibition effect against Micrococcus luteus, Salmonella enteritidis and PSW showed growth inhibition effect against Bacillus cereus, Escherichia coll. Whereas antimicrobial activity' of PSE was not observed. The nitrite-scavenging abilities of PSW, PSE and PSO at 2,000 ppm were 27.5, 23.7 and 39.6%, respectively. And the SOD-like activities of PSW, PSE and PSO at 1,000 ppm were 15.9, 34.9 and 0.10%, respectively.

DDC,MEA,WR-2721의 放射線 防護效果에 關한 硏究

柳星烈,陳秀一,鄭鉉佑,鄭引溶,高柱煥,고경환 대한방사선 방어학회 1986 방사선방어학회지 Vol.11 No.2

放射線障害 豫防藥劑의 人體適用은 副作用으로 臨床的 利用이 되지 못한 實情으로서 生理學的 및 藥理學的 毒性, 物理學的 諸性質, 藥劑의 作用機轉究明 및 臨床的 技術開發이 未洽하여 放射線 障害者에 對한 治療는 對症療法에 不過한 實情이다. 著者들은 放射線에 依한 人體障害豫防에 必要한 基礎資料를 얻기 위하여 現在까지 比較的 毒性이 적고 化學的으로 安定하며 藥效가 優秀하다고 알려진 DDC, MEA, WR-2721을 選定하여 實驗動物 非近交系 Swiss Webster(NIH-GP)마우스에 利用한 放射線 防護作用에 關한 實驗結果는 다음과 같다. 1) 各種 放射線 防護劑(DDC, MEA, WR-2721)의 마우스에 대한 適定 投與量은 各各 DDC; 1,000, MEA; 200, WR-2721; 400mg/kg이었다. 2) 實驗動物에 放射線 反致死線量 LD50/10에 對한 藥劑의 防護效果을SMS DDC;1.2, MEA; 1.4, WR-2721; 1.9이었고 LD50/30에 對 한 DMF는 DDC; 1.7, MEA; 1.8, WR-2721; 2.5이었다. 3) 空腹 小?腺(Jejunum crypt)의 放射線平均致死線量(Do)에 對한 防護效果 DMF는 DCC; 1.07, MEA; 1.21, WR-2721; 1.76이었고, 小?腺細胞의 致死線 平均致死線量에 對한 DMF는 DDC; 1.04, MEA; 1.08, WR-2721; 1.38이었다. 4) 以上으로 上記 3種의 放射線 防護劑中 WR-2721의 放射線 防護效果가 가장 優秀하였고 이 結果는 向後 臨床的 適用에 關한 硏究의 基礎資料가 될 것으로 思料된다. At present, the treatments of the radiation-induced diseases are only performing by the palliative treatment technique. Moreover, radiation protective agents are a little toxic for human being and this seriously limits their applicability with various complications in clinical uses. Accordingly, as a part of the aim of gain of the basic data for protective roles of some radioprotectors, the present investingation was carried out to evaluate the comparative radioprotective effects by the administration of DDC, MEA, WR-2721. Results are shown for statistically significant analysis and correlation with each group as follows; 1. The proper doses of the radioprotectors were DDC; 1,550mg/kg, MEA; 450mg/kg, WR-2721; 780mg/kg of the mouse body weight. 2. DMF(Dose modification factor) of LD50/10 and LD50/30 for whole body irradiation was DDC; 1.2, MEA; 1.4, WR-2721; 1.9 and DDC; 1.7, MEA; 1.8 and WR-2721; 2.5 respectively. 3. DMF for radiation reaction of jejunal crypt was DDC; 1.07, MEA; 1.21 and WR-2721; 1.76 and that of jejunal crypt cell was DDC; 1.04, MEA; 1.08 and WR-2721; 1.38 respectively. 4. Conclusively, WR-2721 was the most effective drung among the three radioprotectors and this result must be a supportive data for further study for clinical application.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

피로와 의료이용, 업무상 사고 및 질병결근

장세진,고상백,강동묵,김성아,정진주,이철갑,강명근,현숙정,조정진,차봉석,박종구 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study examined the relationship of fatigue to medical utilization, occupational accident and sickness absence. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project, 2002~2004). A total of 30,146 employees categorized within the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were recruited. A structured-questionnaire was used to assess the participants' sociodemo-graphics, job-related factors, health-related behaviors, personality trait, self=perceived fatigue (MFS) and the frequency of medical utilization, occupational accident and sickness absence. Data on medical utilization and occupational accident were confirmed from company health records. Chi-square test and logistic regression analysis were used to elucidate the relationship of self-perceived fatigue to medical utilization, occupational accident and sickness absence. Results: In logistic regression analyses, self-perceived fatigue was associated with medical utilization (outpatient), occupational accident and sickness absence although the strength of the associations was higher in the blue collar workers except for medical utilization. For medical utilization, the white collar worker's adjusted odds ratios of outpatient utilization for workers scoring in the third quartile and the highest quartile, compared to workers scoring in the lowest quartile were 1.50 (95% CI: 1.20-1.87) and 2.16 (95% CI: 1.69-2.75), respectively. The blue collar workers' adjusted odds ratios of outpatient utilization for workers scoring in the second (OR: 1.23, 95% CI: 1.06-1.43), third (OR: 1.42, 95% CI: 1.22-1.66) and highest quartile (OR:1.83, 95% CI: 1.55-2.17), respectively, compared to workers scoring in the lowest quartile were statistically significant. However, no associations were found between fatigue and inpatient utilization for either the white or blue collar workers. The blue collar workers' adjusted odds ratios of being injured for workers scoring in the second, third and highest quartile were 1.41 (95% CI: 1.00-2.00), 1.57 (95% CI: 1.10-2.22) and 2.41 (95% CI: 1.69-3.44), respectively, compared to those scoring in the lowest quartile, but, those of the white collar workers were not significant. There was more likely to an increased risk of sickness absence in workers scoring in the second, third and highest quartile compared to those scoring in the lowest quartile in both white and blue collar workers, but the magnitudes of risk were higher in the blue collar workers than the white collars workers. Conclusion: This result suggests that fatigue is a determinant predictor of medical utilization, occupational accident and sickness absence, and that the pattern of risks for the three outcomes differs according to the occupational type. Some limitations of this study and considerations for future study were also discussed.

처분장근처에서 침식에 의한 Sr 화학종의 평형

조윤정,김성현,이인화,김시욱,고문주,박성규,이범규 조선대학교 환경공해연구소 2000 環境公害硏究 Vol.16 No.1

Leaching and adsorption equilibria of Sr Chemical Species from the near field of a repository has been studied in solidified cement with Fe and oxidized Fe. The absorption percent, Ads %, and distribution coefficient, K_(d) were calculated using equilibrium concentration to predict the extent of leaching and adsorption. In the mixed aqueous solutions the Ads % increase as Cement(C)/Water(W) ratios increase and K_(d) was decreased for Sr. These behaviors were discussed by adsorption and equilibrium of spiked ions. Oxides Fe promoted the adsorption of spiked ions, but pure Fe had no effect. E_(h) values were also estimated and discussed to elucidate oxidation-reduction environment of experimental system.

처분장근처에서 침식에의한 Sr 화학종의 평형

조윤정,김성현,이인화,김시욱,고문주,박성규,이범규 조선대학교 환경연구소 2000 環境硏究 Vol.16 No.1

Leaching and adsorption equilibria of Sr Chemical Species from the near field of a repository has been studied in solidified cement with Fe and oxidized Fe. The absorption percent, Ads %, and distribution coefficient, K_d were calculated using equilibrium concentration to predict the extent of leaching and adsorption. In the mixed aqueous solutions the Ads % increase as Cement(C)/Water(W) ratios increase and K_d was decreased for Sr. These behaviors were discussed by adsorption and equilibrium of spiked ions. Oxides Fe promoted adsorption of spiked ions, but pure Fe had no effect. E_h values were also estimated and discussed to elucidate oxidation-reduction environment of experimental system.

해수에 잠겨 있는 제주화산체의 범위 추정

고창성(Chang-Seong Koh),박원배(Won-Bae Park),고기원(Gi-Won Koh),박준범(Jun-Beom Park),문덕철(Duk-Chul Moon),한희주(Hee-Joo Han) 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10

180여 만 년에 달하는 화산활동을 통해 형성된 제주화산체는 바다 속 어디까지 분포하고 있는 것일까? 제주도의 지질에 대한 조사·연구가 진행된지 100년이 지났지만, 아직도 이 궁금증은 풀리지 않고 있다. 우리는 2000년대에 들어오면서 진행된 심부 시추조사 및 용암류 연대측정, 부속도서의 지질과 연대측정에 대한 연구결과, 2007년 국립해양조사원에 의해 발견된 탐라해저분화구, 제주도 동-서부 연안 해상풍력발전기 설치를 위한 시추조사 등으로부터 얻어진 정보와 제주도 주변해역 수심정보(전자해도)를 이용하여 제주화산체의 범위를 추정하였다. 우리는 제주도 주변 (-)60 m 등수심선까지 제주화산체가 연장되어 있음을 제시한다. 통계상의 제주도 면적은 1,850.16 km²(지적면적)이나, (-)60 m 등수심선까지 연장할 경우 화산체의 면적은 2,646.2 km²로 현 면적보다 약 796 km²가 더 넓다. (-)60 m 등수심선은 대체로 남-북보다는 동-서지역이 현 해선에서 바다 쪽으로 더 멀리 확장되며, 이는 구성암석의 차이에 의한 것으로 해석되며, 이러한 차이는 동-서쪽으로 신장된 섬의 모양을 만든 것으로 보인다. 특히, 애월·모슬포·위미·표선·월정리 지역은 현재의 해안선에서 약 3-4 km 거리까지 연장되며, 다음의 몇 가지 사항은 우리의 제안을 뒷받침해준다. 첫째, 제주도 동북부 김녕리-한동리 앞 수심 20~40 m 지점에서 시행된 해상시추에서 해수면 하 (-)50~70 m 깊이까지 육상 환경에서 정치된 용암류, 용암류가 바다 속으로 유입되는 과정에서 형성된 유리쇄설성 각력 암층(hyaloclastite breccia), 육상환경을 지시하는 고토양층이 시추코아로 확인되었다. 이 같은 양상은 해발 50 m 이하 해안저지대에서 이루어진 해수면 하 (-)100~150 m 심부시추조사에서도 확인되었다. 둘째, 유리쇄설성 각력암층은 서귀포 일대의 남부지역을 제외한 제주도 해안지역 65개 시추공에서 그 존재가 보고되었고, 그 중 19개 공에서는 2개의 층준에서 확인되었다. 이는 제주화산체의 수평적 성장이 (1) 육상환경에서 분출한 용암류에 의한 성장, (2) 육상 분출 용암이 바다로 유입되고 용암삼각주를 만들면서 성장하는 과정을 겪은 것으로 해석된다. 셋째, 탐라해저분화구는 표선항에서 남동쪽으로 4 km 떨어진 수심 60여 m 지점에 위치해 있으며, 용암채널, 용암팽창구조, 투물러스 등의 용암지형이 보고되었는데, 이는 육상환경에서의 용암분출과 정치를 의미한다.

Matricellular protein periostin promotes colitis-associated colon tumorigenesis in mice

Koh, Seong-Joon,Kim, Ji Won,Kim, Byeong Gwan,Lee, Kook Lae,Kim, Dae Woo,Kim, Joo Sung Oxford University Press 2019 Carcinogenesis Vol.40 No.1

Multiple Hepatocellular Carcinoma within the Milan Criteria: When to Consider Surgical Resection?

( Joo Hyun Oh ),( Dong Hyun Sinn ),( Gyu-seong Choi ),( Jong Man Kim ),( Jae-won Joh ),( Wonseok Kang ),( Geum-youn Gwak ),( Yong-han Paik ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Although surgical resection is usually considered for single tumor, several reports suggested that resection can be considered for multiple tumor and may provide better outcome. We analyzed whether resection can provide better long-term outcome for patients with multiple hepatocellular carcinoma (HCC) within the Milan criteria, and looked for factors that may guide treatment selection. Methods: A total of 314 consecutive patients with multiple HCCs within Milan criteria and had preserved liver function, defined by Child-Pugh class A, who underwent resection (n=49), radiofrequency ablation (RFA) (n=97) or transarterial chemoembolization (TACE) (n=168), as an initial treatment, between January 2009 and December 2013 were analyzed. Results: The 5-year overall survival rates were 91.3%, 69.1%, and 61.0%, for patients received resection, RFA and TACE, respectively (P=0.003). Patients who received resection were younger and had more preserved liver function assessed by albumin-bilirubin (ALBI) grade, showed different tumor characteristics (more frequently two tumors and had higher PIVKA-II levels) compared to those received RFA or TACE. Resection was rarely performed for those with ALBI grade 2 (n=2). In multivariable analysis, initial treatment modality was independent factor associated with overall survival, along with ALBI grade and PIVKA-II levels. When stratified according to ALBI grade and PIVKA-II levels, long-term outcome was significantly different (5-years survival rates: 90.7%, 72.6% and 45.7% for resection, RFA and TACE, respectively, P=0.004) by initial treatment modality for those with ALBI grade 1 and high PIVKA-II levels (>40 mAU/ml). For other subgroups, there was no significant different of overall survival by initial treatment modalities. Conclusions: Our findings suggest that resection can provide better long-term outcome than RFA or TACE in selected multiple HCC patients within the Milan criteria. ALBI grade and PIVKA-II levels were factors that can be used to guide initial treatment modalities in this situation, which warrants prospective validation.

Comparison Trial between I-SCAN-Optical Enhancement and Chromoendoscopy for Evaluating the Horizontal Margins of Gastric Epithelial Neoplasms

Koh Myeongseok,Lee Jong Yoon,Han Song-Hee,Jeon Seong Woo,Kim Su Jin,Cho Joo Young,Kim Seong Hwan,Jang Jae Young,Baik Gwang Ho,Jang Jin Seok 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2

Background/Aims: Endoscopic submucosal dissection is a widely used treatment for gastric epithelial neoplasms. Accurate delineation of the horizontal margins is necessary for the complete resection of gastric epithelial neoplasms. Recently, image-enhanced endoscopy has been used to evaluate horizontal margins of gastric epithelial neoplasms. The aim of this study was to investigate whether I-SCAN-optical enhancement (I-SCAN-OE) is superior to chromoendoscopy in evaluating the horizontal margin of gastric epithelial neoplasms. Methods: This was a multicenter, prospective, and randomized trial. The participants were divided into two groups: I-SCAN-OE and chromoendoscopy. For both groups, we first evaluated the horizontal margins of early gastric cancer or high-grade dysplasia using white-light imaging, and then evaluated, the horizontal margins using I-SCAN-OE or chromoendoscopy. We devised a unique scoring method based on the pathological results obtained after endoscopic submucosal dissection to accurately evaluate the horizontal margins of gastric epithelial neoplasms. The delineation scores of both groups were compared, as were the ratios of positive/negative horizontal margins. Results: In total, 124 patients were evaluated for gastric epithelial neoplasms, of whom 112 were enrolled in the study. A total of 112 patients participated in the study, and 56 were assigned to each group (1:1). There was no statistically significant difference in the delineation scores between the groups (chromoendoscopy, 7.80±1.94; I-SCAN-OE, 8.23±2.24; p=0.342). Conclusions: I-SCAN-OE did not show superiority over chromoendoscopy in delineating horizontal margins of gastric epithelial neoplasms.