자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과

박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.

제14회 부산 아시아 경기대회 남자 태권도 경기 공격기술 및 득점 분석

허정석,황영성,박재성,김도호,한성유,이수판 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

The purpose of this study was to analyze attack skills and scores in 8 weight classes of male Taekwondo athletes who participated in the semi-final and final matches(48 athletes) in the 14the Asian Games(2002, Busan). The 14th Asian Games was chosen for this study because it is in these games that the rules were revised to a variable scoring system. The results obtained from this analysis were as follows; 1. There is a sinificant difference of attack skill frequency per Korean(Foreign) male athlete was 50.00(51.38) times and scores obtained were an average of 5.06(4.25) points per athlete. 2. There is a significant difference in attack frequency between the light weight group and heavy weight group of Korean and Foreign male athletes. Korean male athletes: Between groups, in case of momtong-dolryeochagi, naraechagi and tchikeachagi, the frequency of the light weight group was shown to be higher. The frequency of momtong-dolryeochagi was shown to be higher in the heavy weight group. 3. There is a significant difference in attack frequency between Korean male athletes and Foreign male athletes in the light weight group and heavy weight group. The light weight group: Between groups, in case of momtong-dolryeochagi and eolgul-dolryeochagi, the frequency of Korean male athletes was shown to be higher and in case of naraechagi, dwitchagi and dolgaechagi, the frequency of Foreign male athletes was shown to be higher. The heavy weight group: Between groups, in case of and eolgul-dolryeochagi, naraechagi and dwitchagi, the frequency of Korean male athletes was shown to be higher and in case of momtong-dolryeochagi, tchikeachagi and dolgaechagi, the frequency of Foreign male athletes was shown to be higher.

제14회 부산 아시아 경기대회 여자 태권도 경기 공격기술 및 득점 분석

허정석,황영성,박재성,김도호,한성유,이수판 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

The purpose of this study was to analyze attack skills and scores in 8 weight classes of female Taekwondo athletes who participated in the semi-final and final matches(48 athletes) in the 14th Asian Games(2002, Busan). The 14th Asian Games was chosen for this study because it is in these games that the rules were revised to a variable scoring system. The results obtained from this analysis were as follows; 1. Korean female athletes: No significant difference was found in attack frequency in the light weight class and the heavy weight class. The attack frequency in the light weight class was shown to be in the following order: momtong-dolryeochagi(217 times), naraechagi(48 times) and dichagi(15 times). The attack frequency in the heavy weight classwas shown to be in the following order: momtong-dolryeochagi(263 times) and tchikeachagi(15 times). 2. Foreign female athletes: No significant difference was found in attack frequency in the light weight class and the heavy weight class. The attack frequency in the light weight class was shown to be in the following order: momtong-dolryeochagi(555 times), naraechagi(32 times) and dichagi(12 times). The attack frequency in the heavy weight class was shown to be in the following order: momtong-dolryeochagi(555 times), tchikeachagi{35 times) and naraechagi(35 times). 3. There is a significant difference in attack frequency in the light weight group of Korean female athletes and foreign female athletes, Between groups, in case of quick body attack, such as momtong-dolryeochagi and naraechagi, the frequency of korean athletes was shown to be higher and scores obtained were higher. In case of high score face attack, such as eolgul-dolryeochagi and tchikki, the frequency of foreign atheletes was shown to be higher 4. There is a significant difference in attack frequency in the heavy weight group of Korean female athletes and foreign female athletes, Between groups, in case of quick body attack, such as momtong-dolryeochagi and naraechagi, the frequency of Korean athletes was shown to be higher and the foreign female athletes' eolgul-dolryeochagi and dwitchagi score rates were shown to be the higher.

사마귀류 추출물의 생물학적 활성 비교

허진철,황재삼,강석우,윤치영,이상한 慶北大學校農業科學技術硏究所 2007 慶北大農學誌 Vol.25 No.-

In order to investigate the availability of insect resources for agrobiotechnological or medical purposes, we examined antioxidant (DPPH and FRAP assay) and cell viability by oxidant stress and NO inhibition assay by treatment of the extracts of Statilia maculata Thunberg, Tenodera angustipennis Saussure and Tenodera aridifolia Stoll. We found that Tenodera angustipennis Saussure and Tenodera aridifolia Stoll extract (DW, etanol, methanol) had high levels of anti-oxidant activity, whereas Tenodera aridifolia Stoll extract showed increased cell viability by hydrogen peroxide and inhibition of NO production. These findings suggest that Statilia maculata Thunberg, Tenodera angustipennis Saussure and Tenodera aridifolia Stoll, extract have potentials to be developed for agrobiotechnology or medicinal use, indicating that mechanistic study including inhibition against molecular inflammation will show a possibility for the development of useful insect resources.

Consideration of Diluents Selection and Input Amounts of the Hunter Process for Tantalum Production

Jae‑Jin Sim,Sang‑Hoon Choi,Yong‑Kwan Lee,Sung Gue Heo,Taek‑Soo Kim,Seok‑Jun Seo,Kyoung‑Tae Park 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.7

Tantalum (Ta) is a heavy refractory metal with an atomic weight of 180.95 g/mol, a density of 16.6 g/cm3, and a high meltingpoint of 3017 °C. With its refractory characteristics, it shows excellent chemical and physical stability as well as corrosionand heat resistance at elevated temperatures. The demand for Ta metal and related compounds is increasing with the expansionof the electronics and chemical industries. The Hunter process was proven to be effective in producing Ta powder in1953. Hunter proposed a method in which potassium heptafluorotantalate (K2TaF7) was reduced by sodium (Na). Thus far,this process has been the primary commercial method to produce Ta powder. In this study, quantitative differences wereanalyzed for diluent selection. Additionally, consideration was given to changes in the caloric value depending on the inputamount of diluents. Finally, the optimum material input and the properties of the prepared Ta were analyzed. Stoichiometricratios of K2TaF7(1 mol), NaCl (6.2–6.7 mol), Na (5–7 mol) were weighed, to perform a metallothermic reduction reaction. After the reaction, the tantalum powder was recovered and the flush process was carried out. After that, it was dried in avacuum atmosphere. Physical properties such as oxygen concentration, PSA, ICP-OES, and XRD of powder were conductedto evaluate the characteristics of Ta powder that was finally manufactured.

남조류의 체외 대사부산물이 다른 조류의 광합성에 미치는 타감작용

김범철,허우명,황길순,안태석,심재형 江原大學校 附設 環境硏究所 1994 環境硏究 Vol.11 No.-

The effect of cyanobacterial extracellular byproducts upon the aIgal photosynthesis was assessed to elucidate the allelopathic effect of algal blooms in eutrophic lake. Algal cultures were filtered with 0.2μm membrane filters to remove algal cells and sterilized. 0 to 30m1aliquots of filtrate were added to 25m1 culture suspensions of other algal species, and the (14)^C uptake rates wert measured. The filtrates of cyanobacterial cultures(Anabaena flos-aquae, Phormidium sp.) inhibited the photosynthesis of green algae(Selenastrum capricornutum and Scenedesmus brasiliensis), while the filtrate of Selenastrum capricornutum and Scenedesmuns brasiliensis did not inhibit Anabaena flos-aqiae. In the autoinhibition test Anabaena flos-aquae, Selenastrum capricornutum, and Scenedesmus brasiliensis showed positive, negative, and no effects, respectively.

도암호의 수질과 어류군집 특성 연구

이상하,최재석,이광열,장영수,임인수,허우명,김재구,김범철 강원대학교 부속 환경연구소 2005 Journal of the Environment Vol.2 No.-

To investigate nutrient dynamics of the lake and fish community, both water and fish samples were collected at three different areas (dam site, upper inflowing and downstream of lake outfow) for one year from Sep.2004 to Aug.2005 During the experimental periods, mean concentration of chl, a in epilimnetic layer (0-5m) was 18.5mg^(-3) and transparency ranged from 0.3m to 2.4m, respectively. In nutrient, mean concentrations of TP and TN were 111 mgP m^(-3) and 4.4 mgN L^(-1), respectively. Based on the water quality standard suggested by U.S.EPA(*1976), the trophic state of Lake Doam was classified as eutrophic state. Total number of fish collected in Lake Doam was 9,600 indiveduals in 26 species of 6 family. Sixteen of Korean endemic soecies including H. mylodon, A. signifer, P. tenuicorpa occurred. O. mykiss as introduced fish was also found in Lake Doam. Dominant and subdominant species were P. herzi and Z. platypus that took about 34.6% and 22.5% of total fish composition, respectively. Six species including A. signifer. P. tenuicorpa. and R. kumgangensis were rare in Lake Doam. Pelagic typw of figh commonly occurred at upper regions, whereas benthic type was mainly domenated at downstream area. Therefore, pollution source inflowed from the upper regions did not seriously affect downstream area (Songcheon water system) due to the role of dam as pollutant barrier. In addition high appearance of Comat type of fish that si hybrid between gold fish (C.auratus) and C. auratus was found in the lake, It was unclear the reasons that high prorortion of mutant species apperared in the lake. Further more researches are required in this area.

자연정화공법에 의한 인공습지 하수처리장에서 최적 수생식물의 선정

서동철,장병일,조인성,임석천,이홍재,조주식,김홍출,허종수 한국환경농학회 2006 한국환경농학회지 Vol.25 No.1

정신지체아동의 감각운동에 대한 문헌적 연구

김도호,황영성,박재성,한성유,허정석,이수판 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The purpose or this study is to consider the effect of the sensory exercise which has been judged as improving mentally retarded children's motor ability, social maturity, recognition ability, emotional behavior through stimulation of sensory organs. Result are as follows: 1. (First) Sensory exercise was promoting motor ability of the mentally retarded children. 2. (Second) Sensory exercise was promoting social maturity of the mentally retarded children. 3. (Third) Sensory exercise was promoting recognition ability of the mentally retarded children. 4. (Finally) Sensory exercise was promoting emotional behavior or the mentally retarded children.

Tissue distribution of LOM strain viral antigens using immunohistochemistry in weaned pigs in Jeju

Jae-Sung Heo(Jae-Sung Heo),Jae-Beum Kim(Jae-Beum Kim),Yun-Ho Kim(Yun-Ho Kim),Hyoung-Nam Jo(Hyoung-Nam Jo),Won-Gyu Cho(Won-Gyu Cho),Myeong-Won Suh(Myeong-Won Suh),Hyoung-Seok Yang(Hyoung-Seok Yang),Wan 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-