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RISS 인기검색어
- 검색키워드
- 저자 : Myeong-Won Suh(Myeong-Won Suh) (검색결과 52 건)
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Suh, Young Ho,Kim, Younyoung,Bang, Jeong Hyun,Choi, Kyoung Suk,Lee, June Woo,Kim, Won-Ho,Oh, Tae Jeong,An, Sungwhan,Jung, Myeong Ho Journal of Endocrinology (Ltd. by Guarantee) 2005 Journal of molecular endocrinology Vol.34 No.2
<P>Insulin resistance occurs early in the disease process, preceding the development of type 2 diabetes. Therefore, the identification of molecules that contribute to insulin resistance and leading up to type 2 diabetes is important to elucidate the molecular pathogenesis of the disease. To this end, we characterized gene expression profiles from insulin-sensitive tissues, including adipose tissue, skeletal muscle, and liver tissue of Zucker diabetic fatty (ZDF) rats, a well characterized type 2 diabetes animal model. Gene expression profiles from ZDF rats at 6 weeks (pre-diabetes), 12 weeks (diabetes), and 20 weeks (late-stage diabetes) were compared with age- and sex-matched Zucker lean control (ZLC) rats using 5000 cDNA chips. Differentially regulated genes demonstrating > 1.3-fold change at age were identified and categorized through hierarchical clustering analysis. Our results showed that while expression of lipolytic genes was elevated in adipose tissue of diabetic ZDF rats at 12 weeks of age, expression of lipogenic genes was decreased in liver but increased in skeletal muscle of 12 week old diabetic ZDF rats. These results suggest that impairment of hepatic lipogenesis accompanied with the reduced lipogenesis of adipose tissue may contribute to development of diabetes in ZDF rats by increasing lipogenesis in skeletal muscle. Moreover, expression of antioxidant defense genes was decreased in the liver of 12-week old diabetic ZDF rats as well as in the adipose tissue of ZDF rats both at 6 and 12 weeks of age. Cytochrome P450 (CYP) genes were also significantly reduced in 12 week old diabetic liver of ZDF rats. Genes involved in glucose utilization were downregulated in skeletal muscle of diabetic ZDF rats, and the hepatic gluconeogenic gene was upregulated in diabetic ZDF rats. Genes commonly expressed in all three tissue types were also observed. These profilings might provide better fundamental understanding of insulin resistance and development of type 2 diabetes.</P>
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Suh, Jun Min,Sohn, Woonbae,Shim, Young-Seok,Choi, Jang-Sik,Song, Young Geun,Kim, Taemin L.,Jeon, Jong-Myeong,Kwon, Ki Chang,Choi, Kyung Soon,Kang, Chong-Yun,Byun, Hyung-Gi,Jang, Ho Won American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.1
<P>The utilization of p-p isotype heterojunctions is an effective strategy to enhance the gas sensing properties of metal-oxide semiconductors, but most previous studies focused on p-n heterojunctions owing to their simple mechanism of formation of depletion layers. However, a proper choice of isotype semiconductors with appropriate energy bands can also contribute to the enhancement of the gas sensing performance. Herein, we report nickel oxide (NiO)-decorated cobalt oxide (Co<SUB>3</SUB>O<SUB>4</SUB>) nanorods (NRs) fabricated using the multiple-step glancing angle deposition method. The effective decoration of NiO on the entire surface of Co<SUB>3</SUB>O<SUB>4</SUB> NRs enabled the formation of numerous p-p heterojunctions, and they exhibited a 16.78 times higher gas response to 50 ppm of C<SUB>6</SUB>H<SUB>6</SUB> at 350 °C compared to that of bare Co<SUB>3</SUB>O<SUB>4</SUB> NRs with the calculated detection limit of approximately 13.91 ppb. Apart from the p-p heterojunctions, increased active sites owing to the changes in the orientation of the exposed lattice surface and the catalytic effects of NiO also contributed to the enhanced gas sensing properties. The advantages of p-p heterojunctions for gas sensing applications demonstrated in this work will provide a new perspective of heterostructured metal-oxide nanostructures for sensitive and selective gas sensing.</P> [FIG OMISSION]</BR>
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Won, Ba Da,Jeong, Min Hye,Kim, Myeong Hun,Chung, Chan-Hwa,Moon, Dong Ju,Suh, Young-Woong,Baik, Joon Hyun,Bae, Jong Wook Elsevier 2018 Microporous and mesoporous materials Vol.255 No.-
<P><B>Abstract</B></P> <P>Effects of the crystalline tungsten carbide (WxC) phases on an ordered mesoporous bimetallic Rh-Mn/WxC, which were prepared by changing carbon source to tungsten (C/W) ratios of the WxC support using a hard-template of an ordered mesoporous SBA-15, were investigated for a direct synthesis of mixed alcohols by CO hydrogenation from syngas. The C/W ratios on the mesoporous Rh-Mn/WxC showed a significantly different catalytic activity, especially on the C<SUB>1</SUB> - C<SUB>3</SUB> alcohol productivity. The Rh-Mn/WxC prepared at C/W molar ratio of 10 having a metastable W<SUB>2</SUB>C main phase (Rh-Mn/WxC(10)) revealed a higher CO conversion of 8.1% and selectivity to higher alcohols of 54.4% compared to other catalysts having a main crystalline phases of WO<SUB>3</SUB> or WC. The enhanced catalytic activity and selectivity to mixed alcohols on the Rh-Mn/WxC(10) were attributed to the largely exposed smaller active Rh nanoparticles with its stronger interactions with the metastable W<SUB>2</SUB>C phases. The superior activity was originated from the intimate interactions of Rh nanoparticles with Mn promoter by maintaining proper oxidation states confirmed by surface ratios of the metallic Rh to oxidized Rh<SUP> <B>n+</B> </SUP> species. The stable preservation of the ordered mesoporous structures of the W<SUB>2</SUB>C phase in the amorphous carbon matrixes significantly altered the chemical states of the small Rh nanoparticles below 2 nm in size by preferentially existing on the outer surfaces of the W<SUB>2</SUB>C support, which resulted in showing an enhanced productivity of higher C<SUB>1</SUB> –C<SUB>3</SUB> alcohols with 171.8 g/(kg<SUB>cat</SUB>·h).</P> <P><B>Highlights</B></P> <P> <UL> <LI> WxC phases on mesoporous Rh-Mn/WxC changed C<SUB>1</SUB>-C<SUB>3</SUB> alcohol selectivity from direct CO hydrogenation. </LI> <LI> Metastable W<SUB>2</SUB>C phase is beneficial for a higher productivity of mixed alcohols. </LI> <LI> Different oxidation states of strongly interacted small Rh nanoparticles are well correlated with catalytic activity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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김명기(Myeong-Ki Kim),신영섭(Young-Seop Shin),원용재(Yong-Jae Won),안억근(Eok-Keun Ahn),서정필(Jung-Pil Suh),정국현(Kuk-Hyun Jung),이점호(Jeom-Ho Lee),전용희(Yong-Hee Jeon),윤영환(Young-Hwan Yoon),윤광섭(Kwang-Sup Yoon),장재기(Jae-Ki 한국육종학회 2015 한국육종학회지 Vol.47 No.2
There are farmer’s demands to develop early-maturing cultivar in order to replace Odae variety to mid-northern inland plain and southern mountainous area of Korea. Saeodae was developed by the rice breeding team of Cheolwon Substation, National Institute of Crop Science (NICS), RDA in 2012. This cultivar was derived from the cross between Geuroobyeo and Suweon 472 in 2001 summer season, and selected by a promising line, SR27376-2-2-1-3, was selected and designated as the line of Cheolweon 81 in 2010. The local adaptability test of Cheolweon 81 was carried out at four locations from 2010 to 2012 and it was named as Saeodae. The heading date of Saeodae is July 25 in Cheolwon area, which is 2 days earlier than that of Odae. This variety has 66cm in culm length and 77 spikelets per panicle. Its 1,000 grain-weight of brown rice is 26.5 g, which is similar to that of Odae. Germination rate at low temperature of this variety is about 70%, and viviparous germination is 17.7%. Cold tolerance of this cultivar is still not good, just mediocre. It shows strong lodging resistance. And premature heading, occurrence of wilting during ripening stage, and leaf senescence at maturing are similar to those of Odae. This variety shows resistance to leaf blast disease, but susceptible to bacterial blight, virus disease and insect pest. This variety has translucent and clear milled rice kernel without white core and belly rice. The yield potential of Saeodae was about 5.26 MT/ha at ordinary fertilizer level in local adaptability test for three years. This variety would be adaptable to mid-northern inland plain and southern mountainous area of Korea.
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Hoyoun Won,Yongsung Suh,Gwang Sil Kim,Young-Guk Ko,Myeong-Ki Hong 대한심장학회 2020 Korean Circulation Journal Vol.50 No.6
Background and Objectives: Whether beta blockers favorably impact the clinical outcome in patients with acute myocardial infarction (AMI) remains in debate. We investigated the impact of beta blocker on major clinical outcomes during 2 years after percutaneous coronary intervention (PCI) in patients with AMI. Methods: All patients with the first AMI treated with PCI for the period of 2005 to 2014 from the Korean National Health Insurance Service claims database were enrolled. We defined the regular user as medication possession ratio (MPR) ≥80% and non-user as MPR=0%. We compared the occurrence of all cause death, myocardial infarction (MI) and stroke according to adherence of beta-blockers. A 1:1 propensity score-matching was conducted to adjust for between-group differences. Results: We identified a total 81,752 patients with met eligible criteria. At discharge, 63,885 (78%) patients were prescribed beta blockers. For 2 years follow up period, regular users were 53,991 (66%) patients, non-users were 10,991 (13%). In the propensity score matched population, regular use of beta blocker was associated with a 36% reduced risk of composite adverse events (all death, MI or stroke) (hazard ratio [HR], 0.636; 95% confidence interval [CI], 0.555–0.728; p<0.001). Compared to no use of beta blocker, regular use significantly reduced all death (HR, 0.736; 95% CI, 0.668–0.812; p<0.001), MI (HR, 0.729; 95% CI, 0.611–0.803; p<0.001) and stroke (HR, 0.717; 95% CI, 0.650–0.791; p<0.001). Conclusions: Prescription of beta blocker in patients with AMI after PCI was sequentially increased. Continuous regular use of beta blocker for 2 years after AMI reduced major adverse events compared to no use of beta blocker.
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Kim, Won-Ho,Lee, June Woo,Suh, Young Ho,Hong, Shin Hee,Choi, Joo Sun,Lim, Joo Hyun,Song, Ji Hyun,Gao, Bin,Jung, Myeong Ho American Diabetes Association] 2005 Diabetes Vol.54 No.9
<P>Chronic hyperglycemia is toxic to pancreatic beta-cells, impairing cellular functioning as observed in type 2 diabetes; however, the mechanism underlying beta-cell dysfunction and the resulting apoptosis via glucose toxicity are not fully characterized. Here, using MIN6N8 cells, a mouse pancreatic beta-cell line, we show that chronic exposure to high glucose increases cell death mediated by Bax oligomerization, cytochrome C release, and caspase-3 activation. During apoptosis, glucokinase (GCK) expression decreases in high-glucose-treated cells, concomitant with a decrease in cellular ATP production and insulin secretion. Moreover, exposure to a chronically high dose of glucose decreases interactions between GCK and mitochondria with an increase in Bax binding to mitochondria and cytochrome C release. These events are prevented by GCK overexpression, and phosphorylation of proapoptotic Bad proteins in GCK-overexpressing cells is prolonged compared with Neo-transfected cells. Similar results are obtained using primary islet cells. Collectively, these data demonstrate that beta-cell apoptosis from exposure to chronic high glucose occurs in relation to lowered GCK expression and reduced association with mitochondria. Our results show that this may be one mechanism by which glucose is toxic to beta-cells and suggests a novel approach to prevent and treat diabetes by manipulating Bax- and GCK-controlled signaling to promote apoptosis or proliferation.</P>
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( Jae Myeong Lee ),( Jung Kook Suh ),( Ji Seon Jeong ),( Sang Yun Cho ),( Dong Won Kim ) 대한마취과학회 2010 Korean Journal of Anesthesiology Vol.59 No.2
Background: Reactive oxygen species (ROS) induce lipid peroxidation and tissue damage in the endothelium. We tested the antioxidant effect of lidocaine and procaine on ROS-induced endothelial damage in the rabbit aorta. Methods: Aortic rings isolated from rabbits were suspended in an organ bath filled with Krebs-Henseleit (KH) solution bubbled with 5% CO2 and 95% O2 at 37.5oC. After precontraction with phenylephrine (PE, 10-6 M), changes in tension were recorded following a cumulative administration of acetylcholine (ACh 3×10-8 to 10-6 M). Differences were measured as percentages of ACh-induced relaxation of aortic rings before and after exposure to ROS as generated by electrolysis of the K-H solution. The aortic rings were pretreated with lidocaine or procaine (10-5 M to 3×10-3 M) to compare their effects, as well as ROS scavengers, catalase, mannitol, sodium salicylate, and deferoxamine, and a catalase inhibitor, 3-amino-1,2,4-triazole (3AT). Results: Lidocaine and procaine dose-dependently maintained endothelium-dependent relaxation induced by ACh despite ROS activity (P<0.05 vs control value). The 3AT pretreated procaine (3×10-3 M) group decreased more significantly than the un-pretreated procaine group (P<0.05). Conclusions: These findings suggest that lidocaine and procaine dose-dependently preserve endotheliumdependent vasorelaxation against ROS attack, potentially via hydrogen peroxide scavenging. (Korean J Anesthesiol 2010; 59: 104-110)
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Il Woo Suh,Cheol Whan Lee,Young Hak Kim,Myeong Ki Hong,Jae Won Lee,Jae Joong Kim,Seong Wook Park,Seung Jung Park 대한의학회 2008 Journal of Korean medical science Vol.23 No.2
Pheochromocytoma is a rare disorder and functioning tumor composed of chromaffin cells that secrete catecholamines. Patients with a pheochromocytoma ‘crisis’ have a high mortality in spite of aggressive therapy. We present a case with a severe acute catecholamine cardiomyopathy presenting ST segment elevation with cardiogenic shock after hemorrhage into a left suprarenal tumor. Intra-aortic balloon pump (IABP) support, combined with inotropic therapy, was performed. However, the patient deteriorated rapidly and was unresponsive to a full dose of inotropics and IABP. We decided to apply extracorporeal membrane oxygenation (ECMO) device for the patient. His clinical state began to improve 3 days after ECMO. After achieving hemodynamic stabilization, he underwent successful laparoscopic left adrenalectomy. He needed no further cardiac medication after discharge
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