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Ultrasonic Degradation of Endocrine Disrupting Compounds in Seawater and Brackish Water
So Young Park,Jong Sung Park,Ha Yoon Lee,Ji Yong Heo,Yeo Min Yoon,Kyung Ho Choi,Nam Guk Her 대한환경공학회 2011 Environmental Engineering Research Vol.16 No.3
In this study, a series of experiments was conducted on the relative degradation of commonly known endocrine-disrupting compounds such as bisphenol A (BPA) and 17α-ethinyl estradiol (Ee₂) in a single-component aqueous solution using 28 and 580 kHz ultrasonic reactors. The experiments were conducted with three different types of model water: deionized water (DI), synthetic brackish water (SBW), and synthetic seawater (SSW) at pH 4, 7.5, and 11 in the presence of inert glass beads and humic acids. Significantly higher sonochemical degradation (93-97% for BPA) occurred at 580 kHz than at 28 kHz (43-61% for BPA), regardless of water type. A slightly higher degradation was observed for Ee₂ compared to that of BPA. The degradation rate of BPA and Ee₂ in DI water, SBW, and SSW after 30 min of ultrasound irradiation at 580 kHz increased slightly with the increase in pH from 4 (0.073-0.091 min-1 for BPA and 0.081-0.094 min-1 for Ee₂) to 7.5 (0.087-0.114 min-1 for BPA and 0.092?0.124 min-1 for Ee₂). In contrast, significant degradation was observed at pH 11 (0.149-0.221 min-1 for BPA and 0.147-0.228 min-1 for Ee₂). For the given frequencies of 28 and 580 kHz, the degradation rate increased in the presence of glass beads (0.1 mm and 25 g) for both BPA and Ee₂: 0.018-0.107 min-1 without beads and 0.052-0.142 min-1 with beads for BPA; 0.021-0.111 min-1 without beads and 0.054-0.136 min-1 with beads for Ee₂. A slight increase in degradation of both BPA and Ee₂ was found as the concentration of dissolved organic carbon (DOC, humic acids) increased in both SBW and SSW: 0.107-0.115 min-1 in SBW and 0.087-0.101 min-1 in SSW for BPA; 0.111-0.111 min-1 in SWB and 0.092-0.105 min-1 in SSW for Ee₂. After 30 min of sonicating the humic acid solution, DOC removal varied depending on the water type: 27% (3 mg L-1) and 7% (10 mg L-1) in SBW and 7% (3 mg L-1) and 4% (10 mg L-1) in SSW.
Protective Effects of N-acetylcystenine and Selenium against Doxorubicin Toxicity in Rats
Yeo-sung Yoon,Sun-don Kim,Min-hye Lee,Heung-shik S.Lee,In-se Lee,Je-kyung Sung,Eun-sung Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2
Effects of N-acetylcysteine and Selenium against Doxorubicin Toxicity in RatsEun-sung Park, Sun-don Kim1, Min-hye Lee, Heung-shik S. Lee, In-se Lee, Je-kyung Sung and Yeo-sung Yoon*
고재걸,민경덕,최종락,오대섭,권병규,변창진,여환진,정원우 경북대학교 과학교육연구소 1988 科學敎育硏究誌 Vol.12 No.-
The purpose of this study is to develop models and instruments for teaching and assessing scientific experiments and practices. General objectives for teaching and evaluating scientific experiments and practices in secondary schools were analyzed and categorized into three domains:they were inquiry skill, scientific thinking skill, and scientific attitude. The sub-categories for each domain were constructed, and specific objectives for each general objective were also stated in terms of behavioral objectives according to Mager's suggestion. The tables of specification (content×behavior) were developed in order to assist secondary school teachers to teach and evaluate scientific experiments in class. In addition, we introduced some useful assessment techniques which can be adopted to evaluating learning outcomes of each specific objective. The sample test items corresponding to each objective were listed for practical usage in class.
채영진,남호현,이석모,여성원,한성규,이재원,안민식,정헌영,금경수 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1
The six kinds of natural factors(It refers to wind, cold, summer-heat, dampness, dryness and fire.) is constantly moving to maintain the balance of whole climate of one year. Four seasons are the largest mediation of whole climate of one year. The cold and the heat have the relationship of mutual intervention. The dampness and the dryness have it also. In this process they raise various climate appearance. And that various climate appearance influence the whole lives on the earth. This paper is concerned with the classification of them.
박정섭,정승민,이시형,정기용,여현수,하유군,최유경,전찬용,김동우,박종형,Park, Jung-sup,Jung, Seung-min,Lee, Si-hyung,Jung, Ki-yong,Yeo, Hyun-soo,Hsia, Yu-chun,Choi, You-kyung,Jun, Chan-yong,Kim, Dong-woo,Park, Chong-hyeong 대한중풍순환신경학회 2006 대한중풍.순환신경학회지 Vol.7 No.1
Objectives : This study was prepared for investigating the clinical features of stroke patients. Methods : We retrospectively reviewed the medical records of 102 patients who were admitted to Department of Internal Medicine, College of Oriental Medicine, Kyung-Won University with a diagnosis of stroke from Jan. 1, 2004 to Dec. 31, 2004. Results : Ischemic stroke(include TIA, 82.4%) was more common than hemorrhagic stroke(17.6%). The incidence in male was 41.2%, in female was 17.6% and the most prevalent age group is over-sixties. Cerebral infarction was most frequently noticed in lacunar-infarction and hemorrhage in putamen. Hypertention, the most preceding diseases, followed by diabetes mellitus and CVA. The rate of recurrence was 27.45%. Cerebral infarction and cerebral hemorrhage was much occurred after rising. The most patients visited the hospital within 24 Hours. The most common symptoms in admission time were motor weakness and speech disorder. The complication was mostly mental disorder. Conclusion : Our study on CVA patients was similar to previous studies from 1994 to 2003. In most cases, western and oriental treatment and medicine were given synthetically.
Yeo, Kyung Min,Choi, Suhee,Anisur, Rahman Md,Kim, Jongwon,Lee, In Su WILEY‐VCH Verlag 2011 Angewandte Chemie Vol.123 No.3
<P><B>Innere Werte</B>: In einer neuartigen Synthese von Pt‐Nanodendriten vermitteln Au‐Keime das Kristallwachstum im Inneren einer hohlen SiO<SUB>2</SUB>‐Nanokugel (siehe Bild). Das erhaltene Material ist in der Sauerstoffreduktion deutlich aktiver als kommerzielles Platinschwarz. Kolloidale Pt‐Nanodendrite mit abstimmbarer Dispersität sowie Hybridnanokristalle verschiedener Metalle konnten mit der Methode ebenfalls hergestellt werden.</P>
Yeo, Min-Kyung,Jung, Min-Kyu,Lee, Su-Yel,Lee, Yong-Moon,Hur, Gang Min,Kim, Jin-Man BMJ Publishing Group Ltd 2017 Journal of clinical pathology Vol.70 No.3
<P>Introduction The BRAF V600E mutation is the most common genetic event in papillary thyroid carcinoma (PTC). The BRAF V600E mutational status has a significant diagnostic and prognostic role in PTC since it can be detected in 32%-87% of PTC by various molecular methods. Aim(s) A novel, fully automated real-time PCR-based Idylla test is assessed to detect the BRAF mutation in formalin-fixed paraffin-embedded (FFPE) thyroid samples. Methods 99 PTC and 11 nodular hyperplasia FFPE thyroid tissues are evaluated for the BRAF V600E mutation by the Idylla tests and compared with peptide nucleic acid-clamping PCR, real-time PCR and pyrosequencing. Results The sensitivity and specificity of the Idylla test to detect BRAF V600E are 98.8% and 100%, which is superior to real-time PCR and pyrosequencing. The concordance between Idylla and true positive is highest at 0.974. Conclusions This study validates that the Idylla test is a sensitive and specific method to detect BRAF V600E in FFPE thyroid tissues. A simple, quick and easy to handle Idylla test is a useful and reliable molecular technique to evaluate BRAF mutations.</P>
Yeo, Min‐,Kyung,Liang, Zhe Long,Oh, Taejeong,Moon, Youngho,An, Sungwhan,Kim, Min Kyeong,Kim, Koon Soon,Shong, Minho,Kim, Jin‐,Man,Jo, Young Suk Blackwell Publishing Ltd 2011 Clinical endocrinology Vol.75 No.4
<P><B>Summary</B></P><P><B>Context </B> Recently, tremendous efforts have been made towards the development of sensitive techniques to detect the BRAF<SUP>V600E</SUP> mutation in fine needle aspiration biopsy (FNAB) samples. However, newly developed quantitative and semi‐quantitative methods, such as dual‐priming oligonucleotide (DPO)‐based multiplex polymerase chain reaction (PCR), have the potential to generate false‐positive (FP) results.</P><P><B>Objectives </B> To eliminate the possibility of FP results, we generated a receiver operating characteristic (ROC) curve to investigate the diagnostic accuracy of pyrosequencing using quantitative data.</P><P><B>Design </B> Cytological diagnoses of 983 thyroid nodules were made according to the Bethesda System 2007. The BRAF<SUP>V600E</SUP> mutation was analysed by pyrosequencing, and statistical analyses were performed.</P><P><B>Results </B> Of the 983 nodules, 902 were adopted to evaluate the diagnostic value of pyrosequencing. The number of pathologically confirmed malignancies was 192, of which 182 were papillary thyroid cancer (PTC). By generating an ROC curve, we defined the optimal cut‐off value of the mutant allele peak as 5·95% (area under the curve, 0·849; sensitivity, 0·55; 1‐specificity, 0). When we applied this selective cut‐off value, the number of PTCs positive for BRAF<SUP>V600E</SUP> was 99 (54·4% of the total number of PTCs). With cytology alone, the diagnostic sensitivity and specificity of detecting malignancy were 71·2% and 100%, respectively. Pyrosequencing improved the diagnostic sensitivity from 71·2% to 78·5% (McNemar’s test, <I>P</I> < 0·001), without any change in the diagnostic specificity. When ‘suspicious for malignancy’ was considered a positive cytological outcome, pyrosequencing increased the diagnostic sensitivity of cytology from 95·8% to 96·9%; however, this improvement did not show statistical significance (McNemar’s test, <I>P</I> > 0·05).</P><P><B>Conclusions </B> Pyrosequencing is an effective method for detecting the BRAF<SUP>V600E</SUP> mutation in FNAB samples. By allowing the optimal cut‐off value to be determined, pyrosequencing improves the diagnostic sensitivity while eliminating the possibility of FP results.</P>