Effects of Caffeine and Exercise on Blood Levels of Dopamine and Serotonin in Male Humans

Jeong-Beom Lee,Young-Ki Min,Jeong-Ho Kim,Hee-Jin Lee3,Mi-Young Lee 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.

2차원 및 3차원 초음파를 이용한 태아표면의 해부학적 선별 검사에 관한 연구

윤석범,이해혁,이정재,최경훈,이순곤,이임순,이권해 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Objective : Our purpose of this study was to determine the clarity and consuming time of fetal surface screening in thirty-eight fetuses from 24 to 32 weeks of gestation by use of two and three-dimensional ultrasonography. Methods : From May 1998 to July 1998, we performed the fetal surface screening of the fetal face, extremities, and spine. Thirty-eight fetuses of 24-32 weeks of gestation (thirty-seven normal fetuses and one abnormal fetus) were studied by use two-dimensional (AI 5200S, 3.5-5.0MHz; Acoustic Imaging Technologic Cooperation, U.S.A.) and three-dimensional ultrasonography (Volusion 530D, 3.5-5.0 MHz ; Kretz-Medicine, Korea). On the fetal face, we evaluated both orbits, nose, lips and brow. Both hands and feet, five digits and toes should be seen in this study. We evaluated cervical spine and lumbosacral junction of the spine. Results : The maternal average age of 38 patients was 29.9 years and the average gestational age was 29.7 weeks. The results of fetal surface screening were as follows : face (both orbits 89.5%, lips 92.1%, nose 92.1%, and brow 89.5%), extremities (both hands 68.4% and feet 73.7%), and spine (cervical spine 94.7% and lumbosacral junction 97.4%) by use of two-dimensional ultrasonography. By use of three-dimensional ultrasonography, results were as follows : face (both orbits 76.3%, lips 81.6%, nose 81.6%, and brow 78.9%), extremities (both hands 76.3% and feet 78.9%), and spine (cervical spine 71.1% and lumbosacral junction 73.7%). Consuming time for two-dimensional ultrasonography were 4.7 minutes for face, 11.6 minutes for extremities, and 5.7 minutes for spine. Using three-dimensional ultrasonography results were 12.8 minutes for face, 17.9 minutes for extremities, and 11.7 minutes for spine. Average consuming time of all fetal anatomic screening was 22.0 and 42.4 minutes by use of two and three dimensional ultrasonography. In one abnormal fetus had cleft lip and polydactyly of right foot which were detected all by three-dimensional ultrasonography, but we couldn't detect the polydactyly by two-dimensional ultrasonography. Conclusion : Three-dimensional ultrasonography was more time-consuming method, but we suggested that three-dimensional ultrasonography was superior than two-dimensional ultrasonography in fetal surface screening.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

다치 논리 회로를 이용한 32 × 32 Modified Booth 승산기

이은실,김정범 강원대학교 정보통신연구소 2002 정보통신논문지 Vol.6 No.-

Current mode CMOS multiple-valued logic circuits have various applications in digital signal processing and computing. This paper proposes new multiple-valued current mode CMOS integrated circuits for high-density arithmetic systems. The proposed 32×32 modified Booth multiplier using Radix-4 algorithm give the improved operation speed by using the elimination method of sign-bit extension at the most upper bit of each row. This circuit is simulated with HSPICE under 0.35㎛ CMOS standard technology, 10㎂ unit current, and 3.3V VDD voltage. The simulation results shows the satisfying characteristics.

탄도적인 손가락의 신전움직임에 있어서 신근과 굴근의 협조

이정범,민영기,양훈모 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

In this investigation the temporal-spatial characteristics of muscle isometric contraction of shouting in ballistic movement of the musclus biceps brachii flexion was compared between trained kendo athletes and untrained control subjects by surface electromyographic(EMG) analysis Surface EMG from the mid-point of the triceps muscle and biceps muscle, and a hand wrist flesion signal of the wrist were recorded with a personal computer through AD- conversion (1KHz of sampling frequncy). premotor tiem (PMT), motor time (MT), reaction tiem (RT), Max0tension and integrated electromyogram(I-EMG), during 500msec from the were analyxed by bio-information multi-task analyxing program (BIMUTAS Kissei comtec). In the kendo athletes, reaction time was significantly shorter tham that of control group. The shortening of reaction time in kendo athletes was mainly attributed to the shortening of motor time. In the kendo athletes, motor time was significantly shorter than that of control group. In the kendo athletes, I-EMG was significantly high frequency discharge than that of control group. From these results, it is suggested that motor learning is achieved in kendo trained and the maximal is metirc contraction may play an important role in heghtenning the efficiency of ballistic movement in coordination with the shouting.

Macrophge에서 IL-1과 heat shock protein의 상관관계

이정범,민영기,양훈모 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The macrophage plays an important role in lipopolysaccharide (LPS)-induced fever. Fever formation is attributed to macrophage activity. The purpose of this study is to examine whether induced fever has the charateristics of self-restriction during the process of a fever response. The result of methy-[^(3)H]-thymidine incorporation in RAW 246.7 cells showed that the proliferation of the macrohage was suppressed by a heat load of 39℃ for 2 hr. Enzyme-linked immunosorbent assay (ELISA) showed that the activity of IL-1 secretion induced by LPS was also suppressed by heat load. Suppression of activities of the macrophage including proliferation and secretion suggest that negative feedback loops exist where the end product, heat, may act back on the macrophage and finally result in the subsiding of a fever. The induction of heat shock protein (hsp70) by heat shock in the macrophage was detected by Western blot and Northern blot analysis. In U-937 cells, the increase of hsp70 band appears to be related to the extent of inhibition of IL-1 secretion. It is assumed that IL-1 secretion from the macrophage which effects the induction of fever, has a close relationship to the induction of hsp70.

PFA / Silica 유-무기 복합체의 제조 및 표면특성

범정철,하종욱,박인준,이수복 한국공업화학회 2003 응용화학 Vol.7 No.1

Poly(perfluoroalkyl acrylate)(PFA) / silica composites having different silica size were prepared by surface polymerization. In this study, surface characterizations of PFA/silica composites were done by HR-TEM(High Resolution Transmission Microscopy), contact angle measurement, sliding angle measurement, surface roughness measurement, and the relationships between the sliding angle and the contact angle were investigated. In the highly hydrophobic region, the sliding angles of water droplets decreased with increasing contact angle. Their surface free energies were calculated with contact angle data by geometric mean approximation. The composites with super water repellent and sliding could be obtained with contact angle of above 150。and sliding angle of below 10。to water droplets. The ultimate value of surface free energies of the composites reached below ca. ldyn/cm.

전류 모드 CMOS 다치 논리 회로를 이용한 8X8 병렬 승산기

이용섭,곽철호,김정범 강원대학교 정보통신연구소 2001 정보통신논문지 Vol.5 No.-

This paper presents new current-mode CMOS multiple-valued integrated circuits for high-density arithmetic systems. The validity and effectiveness of the proposed circuits are verified through the HSPICE simulation. A 8×8-bit parallel multiplier using the proposed circuits with 2V supply voltage is designed with a 0.25㎛ standard CMOS technology. The performance of the proposed multiplier is evaluated to be about 74% smaller than that of a corresponding binary implementation.

열 관용과 아세티콜린에 대해 발한 반응의 관계

이정범,민영기,양훈모 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

열대 지방에 살고 있는 사람들은 열대 기후에 영구적으로 거주함으로써 열-관용 (heat -tolerance)의 능력을 가지고 있다. 열대 지방의 원주민들에게서 억제된 열적 발한 의 말초 기작을 알아 보기위해서, 발한 신경지배의 주 전달체인 아세티콜린 (acetylcholine, Ach)에 대한 발한 반응을 이온투과법9quantitative sudomotor axon reflex test, QSART, 말초 발한 반응)또는 뜨거운 물에 다리를 담그는 것 (HW test, 43C, 중앙 발한반응)을 통해 건강한 일본인 (15명0과 아프리카인 (10명) 간에 비교하였다. QSART를 실행되는 동안 직접적으로 활성화된 발한 반응과 축색 반사성 매개에 의한 발한 반응이 일어나게 되고 HW test에서의 발한 반응은 용량습도계에 의해 측정된다. 이러한 실험의 결과들은 적어도 아프리카인의 억제된 열적 발한이 땀샘과 각 땀샘당 땀의 배출량의 증가를 통해 ACh에 대한 땀샘의 민감성이 억제되는 부분에 기여하는 것으로 타나났다.