2009년 인플루엔자 대유행 중 인플루엔자 진료소 방문자의 연령 분포 변화

김백남,곽이경,문치숙,김연숙,김의석,배인규,염준섭,이창섭,허지안 대한감염학회 2010 감염과 화학요법 Vol.42 No.2

The pandemic influenza (H1N1 2009) virus, after being introduced in Korea in April, 2009, spread rapidly nationwide in mid-2009. This study was conducted to characterize trend in age distribution of visitors to Flu-clinics during the pandemic. Demographic, clinical and laboratory data of visitors to flu clinic from Week 36 to 52 (August 30 to December 26) of 2009 were retrieved and collected from electronic databases at 9 hospitals. Visitors 0-6, 7-12, 13-18, 19-29, 30-64, and 65 years or more of age were classified into group I to VI, respectively. A total of 107,467 visitors were seen at Flu-clinics for a 17-week study period. Of those, 32,485 were laboratory-confirmed. Antivirals were prescribed for 62,533 visitors. Numbers of visits, prescriptions of antivirals, and laboratory-confirmed cases of the pandemic influenza (H1N1 2009) peaked at Week 44. A large number of visits by group II and III were followed by those of group I and V, especially around the peak. Numbers of visits by group VI were lowest in all hospitals. In some hospitals, higher number of visits lasted longer in children than in adults while vice versa in other hospitals depending on the location. In summary, the pandemic influenza (H1N1 2009) was presumed to peak in late October and involved majorly children and students in Korea. Unique age distribution of visitors to flu clinic was observed in some hospitals.

원발성 유방암에서 Sodium Iodide Symporter의 발현과 ^(99m)Tc-MIBI 유방스캔의 관계

석주원,김성장,곽희숙,이창훈,김인주,김용기,배영태,김동수 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.6

목적: hNIS는 갑상선 조직 외에 다른 조직들에서도 발현된다고 알려져 있다. 유방암 세포는 그런 조직들 중에 하나이며, 그에 의한 유방암의 방사성옥소치료의 가능성이 제시되고 있다. 본 연구에서는 유방암 조직에서 hNIS의 발현정도를 알아보고, ^99mTc-MIBI 유방스캔과 hNIS의 발현 정도와의 관계를 조사하여 보았다. 대상 및 방법: 본 연구에서는 유방암으로 수술을 시행했던 56명의 환자를 대상으로 하였다. hNIS의 발현은 면역조직화학염색에 의해서 평가되었으며, 그 결과를 ^99mTc-MIBI 유방스캔의 판정 결과와 비교하였다. 결과: 전체 56명의 환자에서 hNIS의 발현율은 41.1%였다. 병리학적 진단에 의해 침윤성관상피암종이었던 49명에서의 발현율은 42.9%, 관상피내암종이었던 7명에서의 발현율은 28.6%였다. ^99mTc-MIBI 유방스캔에서 국소섭취 소견이 관찰되었던 41명에서의 hNIS의 발현율은 31.7%였다. 비정상적인 섭취 소견이 관찰되지 않았던 15명의 환자에서의 hNIS의 발현율이 의미있게 높게 관찰되었다(66.7%, p>0.05). 결론: 유방암 환자에서의 hNIS의 발현율은 그다지 높지 않았다. ^99mTc-MIBI 유방스캔에서 섭취증가 소견이 없을 때 hNIS의 발현율이 더 높았다. Purpose: Human Na^+/I- symporter (hNIS) is known to be expressed in many tissues other than thyroid gland. The breast cancer cells are one of them and the possibility of radioiodine therapy in treatment of the breast cancer may be suggested. We investigated the expression rate of hNIS and the relationship between the expression of hNIS and the finding of 99mTc-MIBI scintimammography in the breast cancer. Materials and Methods: Surgically proved 56 patients with breast cancer were the subjects of this study. The expression of hNIS were evaluated by immunohistochemistry and the results were compared to the findings of 99mTc-MIBI scintimammography. Results: Overall expression rate of hNIS was 41.1% in 56 patients. According to the pathologic diagnosis, it was 42.9% in 49 patients with invasive ductal carcinoma and 28.6% in the 7 patients with ductal carcinoma in situ. The expression rate of hNIS in the 41 cases with a focal increased uptake at he breast lesion on 99mTc-MIBI scintimammogram was 31.7%. That in the 15 cases without any abnormal uptake on the scan was significantly higher(66.7%, p<0.05). Conclusion: The expression rate of hNIS in the patients with breast cancer was not so high. The rate was higher in the patients with no increased uptake at the breast lesion on 99mTc-MIBI scintimammography. (Korean J Nucl Med 2002;36;325-32)

Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid

( Kicheol Yoo ),( Kang Yeol Suh ),( Gi Hun Choi ),( In-suk Kwak ),( Dong Kook Seo ),( Dohern Kym ),( Hyeon Yoon ),( Yong Se Cho ),( Hye One Kim ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.2

Background: It has been reported that heat shock protein 70 (HSP70) and interleukin-8 (IL-8) play an important role in cells during the wound healing process. However, there has been no report on the effect of HSP70 and IL-8 on the blisters of burn patients. Objective: This study aimed to evaluate the serial quantitative changes of HSP70 and IL-8 in burn blisters. Methods: Twenty-five burn patients were included, for a total of 36 cases: twenty cases on the first day, six cases on the sec-ond, five cases on the third, three cases on the fourth, and two cases on the fifth. A correlation analysis was performed to de-termine the relationship between the concentration of HSP70 and IL-8 and the length of the treatment period. Results: The HSP70 concentration was the highest on the first day, after which it decreased down to near zero. Most HSP70 was generated during the first 12 hours after the burn accident. There was no correlation between the concen-tration of HSP70 on the first day and the length of the treat-ment period. No measurable concentration of IL-8 was de-tected before 5 hours, but the concentration started to in-crease after 11 hours. The peak value was measured on the fourth day. Conclusion: While HSP70 increased in the first few hours and decreased afterwards, IL-8 was produced after 11 hours and increased afterward in burn blister fluid. These findings provide new evidence on serial changes of in-flammatory mediators in burn blister fluid. (Ann Dermatol 29(2) 194∼199, 2017)

교사양성과장에서 예비유아교사들의 경험과 노력에 대한 탐색

차영숙 ( Young Suk Cha ),곽정인 ( Jung In Kwak ),유희정 ( Hee Jung You ) 한국유아교육학회 2013 유아교육연구 Vol.33 No.6

본 연구는 교사양성과정에 대한 반성과 개선을 위하여 유아교사양성과정에서 예비유아교사들의 경험과 그들의 효율적인 학과생활을 위한 노력에 대해 알아보고자 하였다. 이를 위하여 2012년 9월 10일부터 12월 21일까지 유아교사양성과정에 재학하고 있는 19명의 연구 참여자를 중심으로 심충면담과 저널쓰기, 간접적 참여관찰을 통해 자료를 수집하였다. 연구결과, 예비유아교사들은 교사양성과정에서 혼란과 갈등, 고통과 인내, 다채로움의 보람, 호기심과 흥미 등의 경험을 하였다. 또한 이들은 효율적인 학과생활을 위해 긍정의 마음 가지기, 확고한 목표 다지기, 성공 체험하기, 멘토와 공유하기 등의 노력을 하고 있었다. 이러한 연구결과를 통해 교사양성과정에서 예비유아교사들의 보다 의미 있는 경험에 대해 이해하고 그들이 긍정적이고 효율적인 학과생활을 영위하도록 도울 수 있는 구체적 방안들을 제시하엿다. With the aim of improving pre-service kindergarten training courses, this analysis identifies and reflects upon the nature of students` efforts involved during teacher training and the experiential characteristics of pre-service kindergarten teachers attending a 3-year teacher training course. Collected data consists of in-depth interviews, journal writing, and indirect participant observations performed from September 10th, 2012 to December 21st, 2012. Subjects were 19 student participants attending a 3-year teachers training course. Analysis reveals that pre-service kindergarten teachers experienced confusion and conflict, pain and endurance, a variety of feelings of satisfaction, curiosity, and interest throughout the teacher training course. They also made efforts on to have and maintain positive thinking, establish firm goals, achieve success and share experiences with mentors in order to develop a sense of efficacy during their training. These results suggest specific guidelines to assist students in understanding their meaningful experiences and to help them view their student life during the teacher training period as positive and efficacious.

이공계열 전공 공부에 필요한 고등학교 물리 선수과목에 대한 대학생들의 인식에 대한 질적 탐구

곽영순 ( Youngsun Kwak ),조향숙 ( Hyang-suk Cho ),이일 ( Il Lee ),손미현 ( Mihyun Son ) 한국현장과학교육학회 2019 현장과학교육 Vol.13 No.4

본 연구의 목적은 고교-대학 연계성 제고를 위해 고등학교 학생들의 교과목 선택권을 실질적으로 보장하는 방안을 탐구하려는 것이다. 이를 위해 총10명의 이공계열 학부 3, 4학년 및 대학원 재학생을 추천받아 초점집단 심층면담을 실시하였으며 대학전공 공부를 위한 고교 물리 선수과목 이수의 필요성, 대학 전공공부에 필요한 물리 선수과목을 고등학교에서 이수하지 않은 이유, 물리 선수과목 이수를 고등학교 후배들에게 권장할 의사, 대학전공 공부에 필요한 고교 물리 선수과목 이수를 보장하는 방안 등을 탐구하였다. 연구결과 물리 과목의 필요성은 인지하고 있으나, 현실적 이유로 인해 물리과목을 기피하고 있으며, 이를 개선하기 위해서 고등학교 교육과정 편성 · 운영 정상화 방안을 소수 선택과목 개설 보장, 과학Ⅱ 과목 내신 및 수능 성적 산출 방식 개선, 고교 필수선수과목에 대한 이공계열별 진로 안내, 과학교사의 수업전문성 및 진로지도 전문성 제고, 이공계열 전공공부에 필요한 필수선수과목 이수를 보장하기 위한 대입전형 시스템을 마련의 필요성 등을 제안하였다. The purpose of this study is to explore ways to secure highschool students’ choice of courses in order to improve highschool - university linkage. For this purpose, we conducted in-depth focus group interviews with a total of 10 students in the second or the third year or graduate student at the science and engineering college, and these interviewees were recommended by their professors. Through interviews, we explored the necessity to complete highschool Physics prerequisite courses, reason for not completing highschool Physics prerequisite courses necessary for college major, their intention to recommend highschool juniors to complete Physics prerequisite courses, and ways to guarantee prerequisite course completion for college major studies. Based on the results, we suggested ways to link highschool - university curriculum for science & engineering majors. Discussed in the conclusion are ways to stabilize highschool curriculum organization and implementation such as opening elective courses with a few students without disadvantage in the school record, improving the grading system for Science Ⅱ courses in the school record as well as the College Scholastic Ability Test, providing career guidance about prerequisite courses by science & engineering majors, improving the science teacher’s professionalism on teaching and career guidance, and developing college entrance systems to guarantee the completion of prerequisite courses for science & engineering college studies.

갱신 효율을 위한 엘리먼트 ID 상속 기반의 XML 저장

강인석,권훈,김정희,곽호영 제주대학교 공과대학 첨단기술연구소 2004 尖端技術硏究所論文集 Vol.15 No.2

In this thesis, ID inheritance storage system modelbase on XML document and information of schema element structure has proposed. proposed system parse XML document and read in DOM type then assign ID to element by using analysis module.at this time, ID assigned to child element is inherited from parent element ID and assigned ID will be saved to database as form of defined schema structure proposed for efficient search and updates of document. As results, when specific element has inserted or updated, location information are not required to configured again.

도시주부의 환경친화적 행동과 영향요인에 관한 연구

곽인숙,이경희,홍성희 대한가정학회 2003 Family and Environment Research Vol.41 No.12

The purpose of this study were (1) to examine the level of housewives' pre environmental behavior, and (2) to analyze the effect of the selected variables on pro-environmental behavior. 941 sample were selected from housewives living in urban area. For the analysis of data, frequencies, means, one-way ANOVA, DMR test, Chisquare test, and multiple regression analysis were used. The major findings were as follows : 1. The level of housewives' pro-environmental behavior was lower than that of pro-environmental attitude. 2. The level of housewives' pro-environmental behavior was mainly affected by their environment-related variables, for example, pro-environmental attitude, and experience of environmental education. Most of socio-demographic variables and family-related variables didn't have significant effects on the level of pro-environmental behavior.

1-교육과정 3년제 교사양성 과정에서 예비유아교사들의 경험과 노력에 대한 탐색

차영숙 ( Young Suk Cha ),곽정인 ( Jung In Kwak ),유희정 ( Hee Jung You ) 한국유아교육학회 2013 정기학술대회 논문집 Vol.2013 No.-

The purpose of the analysis lies on identifying the efforts of course life and experiential characteristics of pre-service kindergarten teachers attending a 3-year teacher training course and reflecting on and improving the pre-service kindergarten training course. To collect data for this analysis, in-depth interviews, journal writing, and indirect participant observations have been performed from September 10th, 2012 to December 21st, 2012; subject to 19 student participants attending a 3-year teachers training course. The following significant points were found through the analysis. Pre-service kindergarten teachers have experienced confusion and conflict, pain and endurance, a variety of satisfaction, curiosity, and interest through the teacher training course. They also made efforts on having positive thinking, establishing firm goals, achieving success and sharing experiences with mentors for their efficient course life. These results suggest specific guidelines to understand the student participants` meaningful experiences and to help them carry on positive and efficient course life.

Lutembacher 증후군 환자 증례 보고

김성범,서정주,곽철훈,김상민,이보라,민선경,황은구,김용인,조욱현,최석구 인제대학교 2008 仁濟醫學 Vol.29 No.-

Lutembacher's syndrome is rare combination of mitral stenosis (MS) and atrial septal defect (ASD). The hemodynamic interplay between the MS and ASD leads to wide variation of clinical presentation. Here we describe a 43-year-old female with Lutembacher's syndrome and tricuspid regurgitation with pulmonary hypertension, who underwent direct closure of ASD and tricuspid valvuloplasty successfully. We also reviewed other literatures in an effort to increase awareness of this condition.

운동 강도의 차이가 제2형 당뇨병 환자와 비만인의 초과산소 섭취량, 안정 시 대사량 및 생화학적 변인에 미치는 영향

곽이섭(Yi-Sub Kwak),구우영(Woo-Young Ku),유병인(Byung-In Yoo),진영완(Young-Wan Jin),최경석(Kyung-Suk Choi),조준용(Joon-Yong Cho),우진희(Jin-Hee Woo),황혜진(Hye-Jin Hwang) 한국생명과학회 2008 생명과학회지 Vol.18 No.10

The purpose of this study was to evaluate the effect of various exercise intensity on Excess post exercise energy expenditure (EPEE), Resting Metabolic Rate (RMR),thyroid hormonal changes and biochemical variables in obese and NIDDM patients. The subject of the present study were divided into four groups and four periods: trained (T; n=10), control (C; n=10), obese (O; n=10) and NIDDM (N; n=10) group. And the periods were divided as follows; Resting (RE), Maximal (MA), High intensity (HI), and Low intensity (LI). There was significant difference in RMR among different intensity of exercise. in the T (p<0.05) not in the C, O, and N groups. however, there was no significant different percent body fat among all groups. In the energy expenditure, there was significant different among C, O, N groups compare to T in HIEE (high intensity exercise energy expenditure), LIEE (low intensity exercise energy expenditure), HIEEPE (high intensity exercise energy expenditure post exercise) and LIEEPE (low intensity exercise expenditure post exercise). In the hormonal level, there was significant different in T4 level in the T group at LI period and there was also significant difference in T4, Free T3, & Free T4 levels in T group at LI period, however there was no significant different in the O and N groups except LI period. In the fatigue variables, there was significant different in lactate and ammonia levels in the N group in the period of HI compare to C. The present cross-sectional study was design to investigate the relationship between exercise intensity and RMR in four groups. The focus of this investigation was to compare RMR in aerobically trained (T), control (C), obese (O) and NIDDM (N) group. The relationship among RMR, exercise intensity and percent body fat would best be investigated using Meta Lyzer 3B, MMX3B and body composition analyzer. Each subject completed measurement of percent body fat, RMR, hormone in the period of maximal oxygen uptake exercise (MA), high intensity exercise (HI), and low intensity exercise (LI). From the results, High and Low intensity of exercise, there was a trend for an increased RMR (kcal/day) in the trained groups and control group (in case of LI) not for the obese and N groups. This is best explained not by the reduced percent body fat but by the highly induced energy expenditure (during exercise and post exercise energy expenditure) and increased T4, Free T3, and Free T4 hormonal levels in the low intensity exercise for the T group and sometimes C group.