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P024 Increased expression of TRPV3, PAR2 and NK1R in burn scars with post burn pruritus
( Yong Se Cho ),( Yong Won Choi ),( Jee Hee Son ),( Yun Sun Byun ),( Bo Young Chung ),( Hee Jin Cho ),( Chun Wook Park ),( Hye One Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Post burn pruritus is a common distressing sequela of burn wounds. Empirical antipruritic treatment often fails, as the mechanism has not been fully elucidated. Objectives: The aim of this study was to evaluate the manifestation of transient receptor potential vanilloid 3 (TRPV3), transient receptor potential ankyrin 1 (TRPA1) and other related receptors in post burn pruritus. Methods: Sixty-five burn patients with (n=40) or without (n=25) pruritus were investigated, including skin biopsy and clinical assessments such as VAS (Visual analogue scale) for pruritus, PSAS (Patient scar assessment scale), and OSAS (Observer scar assessment scale). Keratinocytes and fibroblasts from skin biopsy samples were separated and real time PCR, western blotting, intracellular Ca2+ measurements were performed. Results: Real time-PCR showed that mRNA of TRPV3 was significantly increased in keratinocytes from pruritic burn scars than in keratinocytes from non-pruritic burn scars. With TRPV3 activation, intracellular Ca2+ concentrations were more significantly increased in keratinocytes from pruritic burn scars than in those from non-pruritic ones. Additionally, mRNA and protein levels of protease-activated receptor 2 (PAR2) and neurokinin-1 receptor (NK1R) were also significantly increased in pruritic burn scars. Conclusion: We confirmed that TRPV3, PAR2, and NK1R were highly expressed in pruritic burn scars. These results may help determine a novel mechanism for post burn pruritus.
송우정,Mira Choi,Dong Hun Lee,Jae-Woo Kwon,Gun-Woo Kim,Myung Hwa Kim,Mi-Ae Kim,Min-Hye Kim,Byung-Keun Kim,Sujeong Kim,Joung Soo Kim,Jung Eun Kim,Ju Young Kim,Joo Hee Kim,Hyun Jung Kim,Hye One Kim,Hyo-Bin 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.4
Chronic spontaneous urticaria (CSU) is defined as the occurrence of spontaneous wheals, angioedema, or both for >6 weeks in the absence of specific causes. It is a common condition associated with substantial disease burden both for affected individuals and societies in many countries, including Korea. CSU frequently persists for several years and requires high-intensity treatment; therefore, patients experience deteriorations in quality of life and medication-associated complications. During the last decade, there have been major advances in the pharmacological treatment of CSU and there is an outstanding need for evidence-based guidelines that reflect clinical practice in Korea. The guidelines reported here represent a joint initiative of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Dermatological Association, and aim to provide evidence-based guidance for the management of CSU in Korean adults and children. In Part 1, disease definition, guideline scope and development methodology as well as evidence-based recommendations on the use of antihistamines and corticosteroids are summarized.
Food Hypersensitivity in Patients with Childhood Atopic Dermatitis in Korea
( Hye One Kim ),( Soo Ick Cho ),( Jin Hye Kim ),( Bo Young Chung ),( Hee Jin Cho ),( Chun Wook Park ),( Cheol Heon Lee ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.2
It is well known that atopic dermatitis (AD) is related to food hypersensitivity, although its prevalence varies among several studies according to age group, severity, country, survey time, and test method. Objective: To examine the prevalence and status of food hypersensitivity among childhood AD patients in Korea. Methods: A total of 95 patients were enrolled in the study. The history of food hypersensitivity was collected by interviews. The severity of AD was evaluated by eczema area and severity index (EASI). We took blood samples to measure serum total and food-specific immunoglobulin E (IgE) levels. Based on the histories and serum IgE levels, open oral food challenge (OFC) testing was performed to confirm food hypersensitivity. Results: Forty- two (44.2%) of the 95 AD patients had histories of food hypersensitivity. They reported that the most common suspicious foods were egg (n=13, 13.7%), pork (n=9, 9.5%) and cow milk (n=8, 8.4%). The mean EASI score was 16.05±9.76. Thirty-nine (41.1%) of the 95 patients showed elevated serum food-specific IgE levels. The specific IgE levels were elevated for egg (n=17, 17.9%), milk (n=12, 12.6%), peanut (n=10, 10.5%) and wheat (n=8, 8.4%). Fifty-one (53.8%) of 95 patients underwent open OFC, and only 7 (13.7%) of these patients showed positive reactions. Conclusion: The overall prevalence of food hypersensitivity in patients with childhood AD in Korea was 8.3% (7/84). The most common foods causing food hypersensitivity were egg and milk. Among the foods causing hypersensitivity, AD patients in Korea often underestimated peanut, while they overestimated pork.
Eun Mee Kim(Eun Mee Kim),Jasper Kim(Jasper Kim),Bit-na Choi(Bit-na Choi),Hye In Hong(Hye In Hong),Young One Suh(Young One Suh),Tina Yap Tanhehco(Tina Yap Tanhehco ) 한국캐나다학회 2006 Asia-Pacific Journal of Canadian Studies (APJCS) Vol.12 No.1
Globalization has made the national borders less significant than in the past. Continuous efforts to enhance diversity education are necessary to prepare for the future. Korea, which has experienced rapid and compressed industrialization, attracts tourists from all over the world and many migrant workers from developing countries. However, it seems that Koreans are not yet prepared to welcome these people due to the low levels of English proficiencyprejudice towards foreigners. Canada is known to have a well-established diversity education system. Korean students who are in need of English education can greatly benefit from Canada’s learning environment. This paper explores issues in Korean and Canadian education in order to explore whether Canada can offer Korean students a suitable venue for study abroad opportunities. Considering Canada’s many advantages, including its multicultural atmosphere, low cost of education, and multilingual educational history, this paper found that Korean students Clearly Canadian: How Canada’s Unique Diversity Education Structure can Represent an Ideal Learning Environment for South Korean Students 81 would greatly benefit from choosing to study abroad in Canada. Canada could also take advantage from accepting Korean students to study overseas by further diversifying their classrooms with Korean students, and boosting its economy through an increase in Korean investment into Canadian education. Therefore, Canada’s efforts to enhance exchange programs are needed. These can be accomplished by lowering costs, improving its transitional programs, and more advertising on Korean websites.
( Hye One Kim ),( Yun Sun Byun ),( Jin Hye Kim ),( Chun Wook Park ) 한국피부장벽학회 2014 한국피부장벽학회지 Vol.16 No.2
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that binds to various endogenous and exogenous ligands that are abundant in the skin. The aim of this study was to evaluate the significance of the AhR and its ligands in chronic inflammatory skin disease such as atopic dermatitis (AD) and psoriasis. We recruited AD, psoriasis patients and healthy controls. The clinical severity was assessed and skin samples were taken. Real-time PCR, Immunohistochemical and immunofluorescence staining were performed in each skin sample. Cytokine expression profiles after treatment of normal human epidermal keratinocytes (NHEK) with TCDD or PCBs were measured. The serum levels of TCDD and PCBs were determined using high-resolution gas chromatography and mass spectrometry and both levels were higher in the AD group than in the control group. In the skin, expression of AhR and aryl hydrocarbon receptor nuclear translocator (ARNT) mRNA was increased in lesional skin from patients with AD and psoriasis compared to those of normal skin from healthy controls. The AhR and ARNT were co-localized in the nuclei of keratinocytes at the lower epidermis of psoriatic lesions, which suggested activation of the AhR pathway. After treatment of NHEKs with TCDD or PCBs, IL-6 and IL-8 production were increased. The serum levels of TCDD and PCBs were higher in the AD group than in the control group. The results of this study suggest that the AhR is highly expressed in the acute lesional skin of AD and psoriasis patients and that activation of the AhR increases the expression of inflammatory cytokines in NHEK and may induce the development of chronic inflammatory skin diseases such as AD and psoriasis.
Radiological Spectrum of Hepatic Mesenchymal Hamartoma in Children
Kim, Soung Hee,Kim, Woo Sun,Cheon, Jung-Eun,Yoon, Hye-Kyung,Kang, Gyeong Hoon,Kim, In-One,Yeon, Kyung Mo The Korean Radiological Society 2007 KOREAN JOURNAL OF RADIOLOGY Vol.8 No.6
<P><B>Objective</B></P><P>A hepatic mesenchymal hamartoma is an uncommon benign tumor in children and little is known about the spectrum of its radiological features. The purpose of this study is to describe the spectrum of radiological features of a hepatic mesenchymal hamartoma in children.</P><P><B>Materials and Methods</B></P><P>Thirteen children with a pathologically confirmed hepatic mesenchymal hamartoma (M:F = 7:6; mean age, 3 years 2 months) were included in our study. Ultrasonography (US) was performed in nine patients including color and power Doppler US (n = 7). CT scans were performed in all patients. We evaluated the imaging findings of the hepatic mesenchymal hamartomas and the corresponding pathological features.</P><P><B>Results</B></P><P>Each patient had a single tumor (mean diameter: 13 cm [1.8-20 cm]). On CT and/or US, four patients (31%) had a 'multiseptated cystic tumor', five patients (38%) had a 'mixed solid and cystic tumor', and four patients (31%) had a 'solid tumor.' The septa of the cystic portion were thin in the multiseptated cystic tumors and irregularly thick in the mixed solid and cystic tumors as seen on US. On a post-contrast CT scan, solid portions or thick septa of the tumors showed heterogeneous enhancement. The amount of hepatocytes was significantly different among the three tumor groups according to the imaging spectrum (<I>p</I> = 0.042).</P><P><B>Conclusion</B></P><P>A hepatic mesenchymal hamartoma in children can show a wide spectrum of radiological features, from a multiseptated cystic tumor to a mixed solid and cystic tumor, and even a solid tumor.</P>
Maintenance Therapy of Facial Seborrheic Dermatitis with 0.1% Tacrolimus Ointment
( Hye One Kim ),( Yoon Seok Yang ),( Hyun Chang Ko ),( Gyung Moon Kim ),( Sang Hyun Cho ),( Young Joon Seo ),( Sang Wook Son ),( Jong Rok Lee ),( Joong Sun Lee ),( Sung Eun Chang ),( Jae We Che ),( Ch 대한피부과학회 2015 Annals of Dermatology Vol.27 No.5
Background: Topical calcineurin inhibitors (TCIs) have been successfully used to treat seborrheic dermatitis (SD) patients. Meanwhile, treatment of atopic dermatitis (AD) with lowdose, intermittent TCI has been proved to reduce disease flare-ups. This regimen is known as a maintenance treatment. Objective: The aim of this trial was to investigate the efficacy and tolerability of a maintenance treatment with tacrolimus ointment in patients with facial SD. Methods: During the initial stabilization period, patients with facial SD or AD applied 0.1% tacrolimus ointment twice daily for up to 4 weeks. Clinical measurements were evaluated on either in the whole face or on separate facial regions. When an investigator global assessment score 1 was achieved, the patient applied tacrolimus twice weekly for 20 weeks. We also compared our results with recent published data of placebo controlled study to allow an estimation of the placebo effect. Results: The time to the first relapse during phase II was similar in both groups otherwise significantly longer than the placebo group. The recurrence-free curves of two groups were not significantly different from each other; otherwise the curve of the placebo group was significantly different. There were no significant differences between the 2 groups in the number of DEs, and treatment days for disease exacerbations (DEs). The adverse event profile was also similar between the 2 groups. During the 20 weeks of treatment, the study population tolerated tacrolimus ointment well. Conclusion: The results of this study suggest that maintenance treatment with tacrolimus may be effective in preventing the occurrence of facial SD exacerbations. (Ann Dermatol 27(5) 523∼530, 2015)