조직구 증식증 X

전혜경,김일규,오성섭,노상엽 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

Histiocytosis X is the abnormal proliferation of histiocytes and usually a massive aggregation of eosinophilic leukocytes. The clinical features and prognosises of subclasses of histiocytosis X depend on the severity and extent of the organ involvement. The subclasses include Letterer-Siwe disease(Acute disseminated histiocytosis X), eosinophilic granuloma, Hand-Schuller-Christian disease. Hand-Schuller-Christian desease(acute, subacute form) refers to the form of disease that is most often fatal because of the widespread skeletal, extraskeletal lesion; this usually affects infants and children less than 3 years of age. Eosinophilic granuloma(histiocytosis X, localized) refers to a chronic form of disease with skeletal lesion; It usually affects children and young adult. Hand-Schuller-Christian disease(chronic form) refers to a chronic form of disease with skeltal, extraskeletal lesions. It usually affects children over the age of 3 years. In our hospital, 8 year old female patient visited complaining of painful swelling of mandibular angle, right side. We diagnosed eosinophilic granuloma and curetted the lesiones and refered to Dept. pediatrics for chemotherapy. We present 2 cases to you with literatures.

하악전돌증의 악교정수술후의 회귀성향에 관한 연구

서연호,서혜경,문선혜,박노부,이용오 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2

저자등은 악교정수술후에 발생하는 희귀성향에 관한 연구를 위하여 계명대학교 의과대학 치과학교실에 내원하여 하악전돌증으로 진단되어 하악후퇴술을 받은 7명의 환자를 대상으로 하여 수술전, 후의 경조직의 변화를 계측, 분석하여 다음과 같은 결과를 얻었다. 수술직후 Gn(H)는 평균 8.2mm 후방이동되었고 SNB는 평균 4.4 감소하였다. SNB는 장기간 경과후 수술직후보다 평균 0.9 증가되었으며 21.1%의 희귀율을 나타내었다. Gn(H)는 장기간 경과후 수술직후보다 6례에서 평균 1.3mm 전방희귀되었으며 나머지 1례에서 4mm 후방이동되었다. SN-MP 및 gonial angle 은 장기간 경과후 수술 직후보다 각각 평균 2.2 ,5.8 증가되었다. Gn(V)는 장기간 경과후 수술직후와 비교하여 변화가 없는 경우가 4례, 증가 2례, 감소 1례로 나타났다. 상하악 중절치는 장기간 경과후 수술직후보다 각각 순측 혹은 설측으로 경사되었다. This study was undertaken to examine relapse tendency after mandibular setback. Seven cases were selected from patients who underwent orthodontic treatment and mandibular setback surgery in our department. The serial lateral cephalogram of each patient were obtained and analyzed: The result were as follows; 1. By operation, Gn(H) moved backward (average 8.2mm), SNB angle decreased(average 4.4˚). 2. When the long term follow-up measurements were compared with the immediate postop, mesurements. ·SNB angle increased on average by 0.9˚and relapse tate was 21.1%. ·GN(H) returned foward on average by 1.3mm in 6 cases, moved backward by 4mm in 1 case. ·SN-MP and gonial angle increased on average by 2.2˚, 5.8˚respectively. ·Gn(V) stayed unchanged in 4 cases, increased in 2 cases, decreased in 1 case. ·Upper and lower incisors slightly moved labially or lingually.

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

Clinical and genetic characteristics of BRCA1/2 mutation in Korean ovarian cancer patients: A multicenter study and literature review

( Hye Kyung No ),( Byung Su Kwon ),( Jung Mi Byun ),( Hyun Joo Lee ),( Dae Hoon Jeong ),( Tae Hwa Lee ),( Kyung-hwa Shin ),( Ki Hyung Kim ),( Dong Soo Suh ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: The aims of this study were to investigate the clinical relevance and spectrum of BRCA1/2 mutations in Korean ovarian cancer (KoOC) patients. Methods: Two hundred seventy-nine KoOC patients were enrolled from three university hospitals between 2012 and 2017. Their peripheral blood samples were obtained for BRCA1/2 mutation analysis by direct sequencing. Clinicopathological characteristics were retrospectively reviewed, and spectrum analyses of BRCA1/2 mutation were assessed by systematic literature review. Results: Frequency of BRCA1/2 mutations was 16.5% in KoOC patients. BRCA1/2 mutations were significantly associated with family history of breast/ovarian cancer (p < 0.001), serous histology (p=0.044) and advanced FIGO stage (III/IV, p=0.018) but not with early age-of-onset (age < 50, p=0.729). A literature review of BRCA1/2 mutations in KoOC patients found 111 (55 distinct) mutations. The proportion of Korean-specific mutations (24/55 distinct, 43.6%) was high. Comparing the spectrum of BRCA1/2 mutation between KoOC and Korean breast cancer (KoBC) patients, the ratio of BRCA1-to-BRCA2 mutations was different, with BRCA1 (78.4%) being predominant in KoOC and BRCA2 being predominant in KoBC (59.2%). The most common mutation also differed between the two (c.3627insA of BRCA1 in KoOC and c.7480C >T of BRCA2 in KoBC). Conclusion: The clinical relevance of BRCA1/2 mutations in KoOC patients was confirmed but that of early age-of-onset was not. Inconsistency in the ratio of BRCA1-to-BRCA2 mutations and the most common mutation between KoOC and KoBC may suggest possible presence of mutation sequence-associated penetrance tendency in hereditary KoBOC. These data may provide insights for optimal genetic counseling and prophylactic treatment for at-risk relatives of KoOC patients. Acknowledgements: This research was supported in part by a Biomedical Research Institute Grant (2017-01), Pusan National University Hospital and the Bio & Medical Techn

血栓 誘發性 疾患들에서 protein C와 protein S의 抗原濃度와 機能的 活性에 關한 硏究 : 韓國人 正常 成人, 慢性 肝疾患, 正常 姙娠, 姙娠 中毒症, 癌疾患, 播種性 血管內 凝固病症을 對象으로 Normal Korean adults, Chronic liver diseases, Pregnancy, Toxemia of pregnancy, Malignancy, and Disseminated intravascular coagulopathy

金蕙慶,李甲魯 고려대학교 의과대학 1993 고려대 의대 잡지 Vol.30 No.1

The purpose of this investigation was to evaluate the antigenic level and functional activity of protein C, protein S and free protein S in various thrombogenic disease states. Also, the study on the reference values of protein C and protein S in normal Korean adults was included. The results were summarized as follows ; 1. The antigenic level and functional activity of protein C in normal Korean male were 100±20.9% (mean±2SD), 99.9±22.8% and those in female 97.4±18.4%, 97.4±24.2%. Those of the female appeared to be lower than those of the male but it was statistically of no difference. The average antigenic level and functional activity of normal Korean adults were respectively 99.0±20.1% and 98.9±23.6%. The antigenic level and functional activity of protein S in normal Korean male were 102.8±23.7%, 104.6±16.2%, and those in female 99.5±26.7%, 99.3±31.3% The female showed significantely lower value than male (p<0.05). The average were 100.7±25.4%, 102.6±28.6%. Free protein S antigenic level were 42.4±11.4% in normal male and 40.3±12.3% in normal female. The female showed little lower value than the male, but it was not statistically different. The average was 41.5±12.1%. 2. Protein C antigenic level and functional activity decreased very significantly in toxemia (84.8±8.5%, 80.6±15.3%), chronic liver diseases (44.6±19.3%, 43.6±19.0%), disseminated intravascular coagulopathy (54.7±19.4%, 53.3±19.1%), hepatoma, acute and chronic myelogenous leukemia, malignant lymphoma and lung cancer (66.9±58.6%, 65.7±62.2%) (p<0.001), but showed no change in acute lymphoblastic leukemia, stomach, colon and ovarian cancers. Protein S antigenic level and functional activity decreased very significantly in normal pregnancy (67.9±18.6%, 50.1±22.4%), toxemia (66.3±8.5%, 61.7±25.3%), chronic liver diseases (62.8±12.2%, 62.9±12.9%), disseminated intravascular coagulopathy (67.2±13.1%, 67.5±11.7%), toxemia, acute and chronic myelogenous leukemia, malignant lymphoma, lung cancer (p<0.001), and significantly decreased in acute lymphoblastic leukemia (94.5±30.9%, 96.2±35.1%), but showed no change in stomach, colon and ovarian cancers. Free protein S antigenic level very significantly decreased in normal pregnancy (21.9±9.2%), toxemia (24.8±14.6%), chronic liver diseases (22.4±5.0%), disseminated intravascular coagulopathy (22.7±4.2%), hepatoma, acute and chronic myelogenous leukemia, malignant lymphoma and lung cancer (33.3±24.1%) (p<0.001), but showed no change in stomach, colon and ovarian cancers. 3. There was good correlation between protein C antigenic level and functional activity, and between protein S antigenic level and functional activity (r>0.6). Our results showed the decreased antigenic level and functional activity of protein C and S, and free protein S antigenic level in various thrombogenic disease states except few non-hematologic malignancy. Such results might be helpful to understanding the pathogenesis of thrombogenic phenomena in various diseases and might be useful guide to therapeutic management.

어머니의 직업구조에 따른 아동의 동조성에 관한 연구

김영심,김혜련,노인숙,배국향,백설경,박미순,성혜영,심은실,정현숙,한인숙,황혜정 연세대학교 생활과학대학 1986 婦學 Vol.19 No.-

The purpose of this study was to examine ⑴ the relationship between the occupational structure of mothers and their children's conformity and ⑵ the relationship between the occupational structure of mothers and their child­rearing attitudes. The subjects were 40 pupils (4 th, 5 th, 6 th graders) and their working mothers. A questionnaire was given to the mothers to determine mother's perception of the degree of self-direction in their occupations and their child­rearing attitudes. A standardized conformity experiment by Kuk­Nam Cho was used to examine the children's conformity. The data was analyzed with t-test. The results were as follows. ⑴ There were significant differences in the conformity of children of high self­directed mother as compared with the children of low self­directed mother. ⑵ There was no significant difference between mother's occupational structure and their child­rearing attitudes.

Activity Improvement of a KRICT-PX1 Xylanase from Paenibacillus sp. HPL-001 by Error-prone PCR

No-Joong PARK,Hee Kyung LIM,Soo Jin CHO,Ja Young SEO,Ji Hye PARK,In Taek HWANG 한국생물공학회 2010 한국생물공학회 학술대회 Vol.2010 No.4

A Study on Occupational Stress and Coping, Turnover, Knowledge and Practice of Infection Control in Dental Hygienists of COVID-19

( Hye-rin Kwon ),( A-young Gil ),( Ji-min Kim ),( Ji-seon No ),( Ga-bin Park ),( Ji-yune Oh ),( Na-kyung Lee ),( Seol-hee Kim ) 한국치위생과학회 2021 치위생과학회지 Vol.21 No.4

Background: The importance of infection with COVID-19 is being emphasized in dentistry with high risks such as aerosols. The purpose of this study is to investigate the knowledge and practice of infection control, stress and coping, and turnover of dental hygienists. Methods: Questionnaire was conducted knowledge and practice of infection control, occupational stress and coping, turnover. Survey data was investigated about 149 dental hygienists from February to March 2021 Data were analyzed t-test, ANOVA, Pearson’s correlation using statistical programs of PASW Statistics ver. 21.0. Results: Regarding occupational stress, relationship conflict was higher in the group with less than 2 years of experience (p<0.05). Job anxiety, organizational system, inadequate compensation, and workplace culture were highly surveyed in the 3 to 5 year of experience. The group with more than 6 years of experience had the highest perception of lack of job autonomy (p<0.05). The group with higher knowledge of infection control had lower mean inappropriate rewards and stress (p<0.05). The group with high infection control performance had a lower average in items such as job instability, organizational system, inadequate compensation, workplace culture, and stress. And problem-focused coping ability was found to be high (p<0.05). Infection control knowledge and performance were positively correlated (r=0.251, p<0.01), infection control practice and stress were negatively correlated (r=-0.264, p<0.01), and stress and emotional coping were positively correlated (r=0.367, p<0.01). Stress was positively correlated with turnover rate (r=0.549, p<0.01). Conclusion: Infection control training was required to reduce occupational stress. Occupational stress was highly correlated with turnover, a holistic and systemic organizational operation and improvement of the quality of medical care were required to reduce stress.

Establishment of a Cisplatin-Resistant Gastric Carcinoma Cell Line YCC-3/R

Park Hyun-Ju,Lee Hye-Ran,No Hyun Kyung 대한약학회 2004 大韓藥學會 總會 및 學術大會 Vol.2004 No.2

중학교 학습부진아의 수학 기피성향 치유방안

박혜숙,박기양,김영국,박규홍,박윤범,권혁천,박노경,백은정,황정연 한국수학교육학회 2004 수학교육 Vol.43 No.2

In this paper, we verified the effect and appropriateness of the scheme to cure the math. disliking disposition which is the cause of underachievement in learning. We choose 3 schools as the subject of experiment for this research. Each experiment experiment class consists of 27~30 students(underachievers) whose final test results of 1st school year in the middle school are 30~60 points. In this case, we also select some middle level students whose test results are more than 60 points for the normal experimental condition. For this research, we developed the suitable test materials to cure the mathematics disliking disposition of underachievers. We applied those test materials to the experiment schools during 2.5 months and we analysed the variation of disliking disposition, the variation of math. dislike students' number and the cure rate of the math. disliking disposition. From the results of this experimental study, we find that the factors of teacher and math recognition environment have only the significant difference of math. disliking disposition between experiment class and comparison class under the 5% significance level in one middle school. We understand that this results caused by teachers' careful advice and guidance in that middle school. We also find that the number of student who dislike mathematics decreased in two middle schools. Furthermore 50% of math. disliking dispositions are cured for 9 disliking factors in the lower grade group(the group of underachievers) and as a whole, we can see that 50% of cure rate for the 7 factors of math. disliking in two middle schools. So we can understand that the experiment of our research was performed successfully in two middle schools. In this research, we find out that the scheme to cure the disliking dispositions for the factors of math. disliking depends on the factors of teacher who take charge of cure. So teachers must take interest in and must have careful concem to students and their math. disliking.