심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

Effect of High Carbohydrate Intakes on the Obesity Index, Blood Pressure, and Blood Lipid Levels in Patients with Cardiovascular Disease

Lee,Seung Min,Ahn,Hyang Sook,Lee,Lilha 韓國營養學會 1997 Journal of Nutrition and Health Vol.30 No.4

저온 플라즈마 처리한 쌀국수의 품질 특성

김현주(Hyun-Joo Kim),이병원(Byong Won Lee),백기호(Ki Ho Baek),조철훈(Cheorun Jo),김재경(Jae-Kyung Kim),이진영(Jin Young Lee),이유영(Yu-Young Lee),김민영(Min Young Kim),김미향(Mi Hyang Kim),이병규(Byoungkyu Lee) 한국식품과학회 2020 한국식품과학회지 Vol.52 No.5

쌀국수의 유통 안전성 확보를 위한 기초자료를 확보하기 위하여 최근 각광받고 있는 저온 플라즈마 처리에 의한 쌀국수의 품질 특성 분석을 하였다. 본 연구에서 이용한 플라즈마는 컨테이너형 유전격벽 플라즈마로 방전 가스는 공기를 활용하여 0, 5, 10 및 20분 처리하였고 미생물 감균효과, 색도, 경도 및 지질산패도 변화를 측정하였다. 쌀국수에 B. cereus 및 E. coli O157:H7을 접종한 후 20분간 플라즈마 처리 시 E. coli O157:H7은 2.75 log CFU/g 감소하였고, B. cereus는 검출되지 않았다. 색도 측정결과 플라즈마 처리에 의해 명도(L<SUP>*</SUP>), 적색도(a<SUP>*</SUP>) 및 황색도(b<SUP>*</SUP>) 모두 증가하였으며, 경도는 처리시간이 증가함에 따라 감소하는 경향을 보였다. 하지만 플라즈마 처리에 의해 지질산화가 일어나는 경향을 보였다. 따라서 공기로 방전된 저온 플라즈마 기술은 쌀국수의 품질안전성을 개선될 것이라고 판단되나 관능적 품질 특성 개선을 위한 적합 플라즈마 모델 선정, 포장방법 개선 등의 후속연구가 필요하다고 판단된다. Cold plasma has been applied to improve quality of food product; however, studies on its effects on microbial and physicochemical qualities of rice noodles are rarely conducted. In this study, changes in the quality characteristics of rice noodles treated by cold plasma were determined. Cold plasma was generated in a square-shaped plastic container (250 W, 15 kHz, ambient air), and dielectric barrier discharge plasma treatments were applied to rice noodle samples for 0, 10, or 20 min. Rice noodles inoculated with either Bacillus cereus or Escherichia coli O157:H7 were subjected to plasma treatment for 20 min, and the approximate bacterial count reduction were 4.10 and 2.75 log CFU/g, respectively. The Hunter color values of the sample were increased after cold plasma treatment. Peroxide values and thiobarbituric acid reactive substance (TBARS) were increased with an increase in cold plasma treatment time. Futhermore, lipid oxidation was enhanced. Although further studies are warranted to evaluate changes in chemical qualities, such as lipid oxidation of rice noodles, induced by cold plasma, the results suggest that cold plasma can improve the microbial and physical qualities of rice noodles.

Ascorbin酸의 自動酸化에 依한 Superoxide 이온의 發生

李民化,李起榮,張香模,梁誠烈,朴昞柱 全南大醫大 1985 전남의대학술지 Vol.22 No.2

특발성 과호산구 증후군 환자의 치료 도중 발생한 간혈종 1례

이영태,김동기,박지훈,김윤정,김기향,박보민,권민정,김애란,이원식,주영돈,손창학 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Idiopathic hypereosinophilic syndrome is characterized by marked elevation of eosinophil count ( >1,500/㎣) in peripheral blood without explaining etiology. It shows tissue involvement in many organs such as liver, G-I tract, myocar dium, lung, skin, kidney and nerve. Some case of hypereosinophilic syndrome with hepatic involvement have been reported, but not much. We have recently experienced a case with idiopathic hypereosinophilic syndrome of a 40 year old man who presented with RUQ pain. By abdominal CT, ill- defined subcapsular hematoma was detected. Liver biopsy showed eosinophilic infiltration within the portal tract and sinusoid. Drain procedure and corticosteroid adminiiatbrought marked improvement of clinical manifestation, hematologic abnormality and radiologic abnormality.

베체트병 환자에서 Azathioprine으로 유발된 급성 췌장염 1례

김기향,권민정,김동기,김애란,김윤정,박지훈,이영태,박보민,김동욱 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Although many drug are thought capable of initiating acute pancreatitis, following azathioprine administration represents the 5% incidence by far the highest recorded incidence to date. We report a 35-year-old male who developed acute pancreatitis in the course of treatment with azathioprine for Behcet's disease. He was admitted due to abdominal pain, diarrhea, and fever for 10 days. Serum amylase and lipase levels were 510U/L and 3702U/L respectively. The abdominal CT scan revealed diffuse enlargement of the pancreas. There was no history of alcohol use or gall bladder disease. We considered drugs, especially azathioprine, as the cause of acute pancreatitis. We diagnosed it as acute pancreatitis. The patient was treated conservatively with hydration and analgesics. The symptom subsided within four days. Five days later, azathioprine was resumed. And the patient complained of abdominal pain. The elevated levels of serum amylase and lipase confirmed the recurrence of pancreatitis. His symptom subsided when azathioprine intake the stopped, and the serum amylase and lipase levels returned to normal level within five days.

폐경 전 호르몬 수용체 양성 유방암 환자의 난소기능 측정을 위한 방법

김현아,우주현,최향숙,이석준,최지혜,박찬섭,성민기,노우철 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

The evaluation of menopausal status is an important subject in the field of treatment of hormone receptor positive breast cancer. According to the menopausal status, endocrine therapy should be categorized by individual patient. However, the gonadal injury caused by various therapeutic drugs and its recovery would confuse the interpretation of clinical and biological markers for ovarian reserve. There are some methods to examine the functional ovarian reserve indirectly. Ultrasonography for counting follicles is a relatively reliable procedure, although it is not feasible because of time-labor consumption and high cost. Biological marker from blood samples such as serum follicle stimulating hormone (FSH), serum estradiol (E2), serum inhibin, or anti-Müllerian hormone (AMH) would be a better choice. The examination of serum FSH and E2 is already recommended as biomarkers for measuring functional ovarian reserve in many guidelines. However, there are limitation of serum FSH and E2 in patients with chemotherapy- induced amenorrhea and treated by tamoxifen. AMH is promising biomarker in the field of infertility treatment even in the patients treated by chemotherapy. It might be a possible biomarker to determine the menopausal status for decision-making whether aromatase inhibitor could be applicable or not in hormone positive breast cancer patients with chemotherapy induced amenorrhea or treated by tamoxifen.

전자의무기록의 충실성 검토를 통한 미비기록 개선 활동

조윤정,김경숙,이향숙,이진영,김태민,김민순 한국의료QA학회 2008 한국의료질향상학회지 Vol.14 No.1

문제: 전자의무기록(EMR) 시행 후 의무기록 정리율의 저하와 질적인 측면에서의 충실성과 정확성에 대한 문제점이제기되었다. 목적: 전자의무기록의 정리율과 충실성 검토를 통하여 문제점을 파악하고개선점 찾아 의무기록 정리율을 향상시키고 충실성을 높이고자 하였다. 의료기관: 서울시에 소재한대학병원 의무기록과 질 향상 활동: 전자의무기록의 문제점을 개선히키 위하여 사용자 편의를 위한 EMR프로그램 수정 및 보완, 진단·수술 관련 작업, 업무개선, 교육, 홍보 등의 활동을실시하였다. 개선효과: 의무기록 정리율, 전자인증미비, 경과기록 기재일수, 퇴원요약주진단적합률, 기록지별 필수항목기 재율, 충실성에서 향상이 이루어졌다.

부모 기록용 아동 행동 조사표에 의한 초등학교 어린이들의 정서와 행동문제 연구

여순,홍유라,박재선,이용환,김민향 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

목적: 외견상 정상으로 간주되는 일정 지역사회 어린이들을 대상으로 문제성 정서․행동의 빈도를 알아보고, 이들 정서․행동 문제의 빈도와 사회경제적 요인들과의 관계를 알아보고자 하였다. 방법: 부산광역시의 일개 초등학교 1, 3, 5학년 어린이 700명을 대상으로 아동 행동 증상 목록표(Pediatric Symptom Checklist, PSC)로 된 설문지를 배부하였다. 설문지에는 50 항목의 행동 증상을 짧게 적고 부모가 각각의 행동 빈도에 “전혀 아님”, “가끔”및 “자주” 중 하나를 표시하도록 하였고, 아동의 건강상태, 부모 자녀간의 대화방식, 부모의 수입과 교육수준도 함께 조사하였다. 또한 일부 항목에 대해 원하는 경우, 담임선생님에 의해 이중으로 기록하게 하였다. 회수된 설문지 609매를 대상으로 빈도가 “전혀 아님”은 0, “가끔”은 1점, “자주”는 2점을 부과해 합산한 뒤 분석하였다. 결과: 피검아동 609명이 50개 문항의 행동들에서 “가끔” 또는 “자주”에 응답한 예의 빈도는 0.9-65.3%의 분포를 보였으며, 응답률에서 5%미만이 4개, 5-20%가 15개, 21-50%가 27개, 51%이상이 4개 문항이었고, 문제행동 총점들의 평균은 14.03(범위 0-43, 표준편차 8.96)점이었다. 빈도가 50%이상이었던 행동들은 “잘 울고 화내고 짜는 소리하기(총 65.2%, 남 62.75%, 여 67.9%)”, “부끄럼을 타고 남 앞에 나서기 두려움(총 60.9%, 남60.0%, 여 61.8%)”, “머리, 배, 다리가 자주 아프다(총55.8%, 남 53.1%, 여 58.8%)”, “집중하기 힘들다(총53.0% 남 55.5%, 여 50.4%)”의 4문항이었다. 성별 비교에서, 여아는 “새롭고 낯선 환경에서 겁이 많고 적응하기 힘들다”, “아무도 자신을 좋아하지 않아 희망이 없다고 느낀다”라는 두 문항에서만 남아에 비해 빈도가 높았으며(P<0.05), 문제 행동 유형별 비교시 주의산만 유 형, 공격성 유형은 남아에서, 불안은 여아에서 유의하게 높았다. 그러나 문제 행동 총점의 평균은 남녀 각각 14.44, 13.60로 유의한 차이가 없었다. 건강한 피검자 군의 총점 평균은 13.64로 이상이 있는 군의 17.29와 유의한 차이를 보였다(P=0.007). 건강한 친부모와 생활하는 피검자 군에서의 총점 평균은 13.68로 그 외 군에서의 15.92와 유의한 차이를 보였다(P=0.025). 부모자녀간의 대화방식에서 비효율적인 방법을 많이 사용하는 경우(4점이상군), 문제 행동의 총점이 16.77로서 3점 이하군의 9.48과 현저한 차이를 보였다(P<0.001). 결론: 조사 대상 어린이들의 과반수 이상은 잘 울고, 부끄러워 남앞에 나서길 두려워하며, 신체 통증을 자주 호소하고, 주의산만하다는 정서․행동의 특성을 가지고 있었다. 전체 문제 행동들의 빈도에 영향을 주는 인자로는 어린이의 외관상 건강상태, 가족 구성원의 구조, 부모의 대화습관이었고 부모의 경제력이나 학력과는 유의한 상관관계가 없었다. 문제성 정서․행동의 빈도에 가장 강력한 변인은 부모의 효율적 대화능력으로 생각되었다. Background : This study was conducted to identify the types and prevalence of emotional and behavioral problems in primary school children based on a Pediatric Symptom Checklist (PSC) which was filled out by parents. Methods : The subjects were 609 children between the age of 7 to 11 in one primary school in Busan, Korea. The PSC containing 50 behavior items were initially rated by parents and checked again by teachers in 17 items for the children whose parent consented to review. The PSC is scored by assigning 0 for never, 1 point for sometimes, and 2 point for often, and then adds the points for overall score. Parental attitudes of communication with their children were also assessed by scoring of parental responses to the questionnaire. Comparison of total behavior scores and other factors including parental competency scores were also made. Results : In each items of 50 behavioral problems, the frequency which is comprised of often true and sometimes true were widely distributed from 0.9% to 65.3%. The most common problem behavior was "crying easily and become angry"(often+sometimes: 65.2%) The next common problem behaviors were "shyness and being afraid of strange people"(60.9%), "complains of bodily aches or pains"(55.8%), "has trouble in concentrating"(53.0%), "be afraid of new situation with uneasiness"(44.5%), and "prefers to spends more time alone indoors"(43.3%) in descending order of frequency. In sexual comparison of frequency of problem behaviors, girls had significantly high frequency in two items-"be afraid of new situation with uneasiness"(P=0.018) and "no one likes him or her and has no hope" (P=0.029). On classifying 50 items into 8 behavior patterns, boys revealed higher frequencies in the behavior of inattention, impulsivity, hyperactivity and anger, aggression, antisocial activity, while girls revealed higher frequencies in the behavior of anxiety. The mean total problem scores were significantly lower in the children of healthy group (healthy 13.64 vs unhealthy 17.29, P=0.007), living with healthy biological parents (biological 13.68 vs others 15.92, P=0.025) and parents who were using less destructive communication (barrier score≤3 9.48 vs barrier score≥4 16.77, P<0.001). There was no significant correlation between the mean total problem scores and variables such as sex, grade, incomes, and educational career of mother. Conclusions : Crying easily, shyness, bodily aches, difficulty in concentrating, being afraid of new situation with uneasiness, and loneliness were commonly prevalent behaviors in the children of the primary school studied. Total problem scores were significantly higher in children with physical handicaps, children living without both biological parents, and most remarkably in children who were cared by parents with poor communication skills

국내 Fabry disease 환자의 a-Galatosidase A 유전자 돌연변이 검색

박기범,최지혜,강윤성,김선미,정향민,문영준,이광호 中央大學校 基礎科學硏究所 2001 基礎科學硏究所 論文集 Vol.15 No.-

Fabry disease(FD) is an X-linked recessive lysosomal disorder caused by a deficiency of a-galactosidase A(a-Gal A), localized at Xq22. Besides onset of pain and paresthesias in the extremities, FD was diagnosed by absence of a-Gal A activity. In this experiment the a-Gal A activity of Korean FD patients was spectrometrically analysed using an artificial substate, 4-Mrthylumbellifery1-a-D-galactoside. As expected, no a-Gal A activity was detected in lymphocytes and lymphoblastoid cells from FD patients. To screen the mutation in their a-Gal A genes, we performed single strand conformation polymorphism(SSCP) and PCR-direct sequencing form seven a-Gal A exons. The nonsense mutation was identified both in classically affected hemyzygotes and a heterozygote. They showed the C to T transition at nucleotide number 11,002, resulting in a arginine-to-stop(R342X). This result will be applicable for pre- and neonatal detection of FD and to define the genotype/phenotype correlation.